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  1. Article ; Online: Yes, It Does.

    Cummins, Nathan W

    Mayo Clinic proceedings

    2021  Volume 96, Issue 12, Page(s) 2934–2935

    Language English
    Publishing date 2021-12-01
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2021.10.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article: Metabolic Complications of Chronic HIV Infection: A Narrative Review.

    Cummins, Nathan W

    Pathogens (Basel, Switzerland)

    2022  Volume 11, Issue 2

    Abstract: As persons who are HIV positive and on suppressive antiretroviral therapy live longer, there is increased incidence and recognition of several metabolic complications of this chronic infection. These metabolic complications of HIV infection can result ... ...

    Abstract As persons who are HIV positive and on suppressive antiretroviral therapy live longer, there is increased incidence and recognition of several metabolic complications of this chronic infection. These metabolic complications of HIV infection can result from the infection itself and/or otherwise effective antiviral treatment and can have significant impacts on morbidity and mortality. Some metabolic complications of HIV infection are preventable but most are modifiable, and therefore, active surveillance and screening are warranted. The purpose of this narrative review is to highlight the most common metabolic complications of chronic HIV infection, associated risk factors, diagnosis, and management.
    Language English
    Publishing date 2022-02-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens11020197
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Remdesivir: An Antiviral Still Seeking a Raison d'Être.

    Cummins, Nathan W

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2021  Volume 73, Issue 10, Page(s) 1857–1859

    MeSH term(s) Adenosine Monophosphate/analogs & derivatives ; Alanine/analogs & derivatives ; Antiviral Agents/therapeutic use ; Humans
    Chemical Substances Antiviral Agents ; remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; Alanine (OF5P57N2ZX)
    Language English
    Publishing date 2021-03-22
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciab220
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 480: Show issues

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  4. Article ; Online: Metabolic Complications of Chronic HIV Infection

    Nathan W. Cummins

    Pathogens, Vol 11, Iss 197, p

    A Narrative Review

    2022  Volume 197

    Abstract: As persons who are HIV positive and on suppressive antiretroviral therapy live longer, there is increased incidence and recognition of several metabolic complications of this chronic infection. These metabolic complications of HIV infection can result ... ...

    Abstract As persons who are HIV positive and on suppressive antiretroviral therapy live longer, there is increased incidence and recognition of several metabolic complications of this chronic infection. These metabolic complications of HIV infection can result from the infection itself and/or otherwise effective antiviral treatment and can have significant impacts on morbidity and mortality. Some metabolic complications of HIV infection are preventable but most are modifiable, and therefore, active surveillance and screening are warranted. The purpose of this narrative review is to highlight the most common metabolic complications of chronic HIV infection, associated risk factors, diagnosis, and management.
    Keywords HIV ; cardiovascular disease ; dyslipidemia ; diabetes mellitus ; osteoporosis ; Medicine ; R
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Metabolic Complications of Chronic HIV Infection: A Narrative Review

    Cummins, Nathan W.

    Pathogens. 2022 Feb. 01, v. 11, no. 2

    2022  

    Abstract: As persons who are HIV positive and on suppressive antiretroviral therapy live longer, there is increased incidence and recognition of several metabolic complications of this chronic infection. These metabolic complications of HIV infection can result ... ...

    Abstract As persons who are HIV positive and on suppressive antiretroviral therapy live longer, there is increased incidence and recognition of several metabolic complications of this chronic infection. These metabolic complications of HIV infection can result from the infection itself and/or otherwise effective antiviral treatment and can have significant impacts on morbidity and mortality. Some metabolic complications of HIV infection are preventable but most are modifiable, and therefore, active surveillance and screening are warranted. The purpose of this narrative review is to highlight the most common metabolic complications of chronic HIV infection, associated risk factors, diagnosis, and management.
    Keywords HIV infections ; antiretroviral agents ; monitoring ; morbidity ; mortality ; therapeutics
    Language English
    Dates of publication 2022-0201
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens11020197
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Could proteasome inhibition improve therapeutic vaccine response in HIV?

    Cummins, Nathan W / Badley, Andrew D

    Vaccine

    2022  Volume 40, Issue 26, Page(s) 3514–3515

    MeSH term(s) HIV Infections/drug therapy ; HIV Infections/prevention & control ; HIV-1/physiology ; Humans ; Proteasome Endopeptidase Complex ; Vaccines/therapeutic use
    Chemical Substances Vaccines ; Proteasome Endopeptidase Complex (EC 3.4.25.1)
    Language English
    Publishing date 2022-05-12
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2022.05.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Zs.MO 458: Show issues

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  7. Article ; Online: Polymicrobial Infections in the Immunocompromised Host: The COVID-19 Realm and Beyond.

    Higgins, Eibhlin / Gupta, Aanchal / Cummins, Nathan W

    Medical sciences (Basel, Switzerland)

    2022  Volume 10, Issue 4

    Abstract: Immunosuppression changes both susceptibility to and presentation of infection. Infection with one pathogen can also alter host response to a different, unrelated pathogen. These interactions have been seen across multiple infection domains where ... ...

    Abstract Immunosuppression changes both susceptibility to and presentation of infection. Infection with one pathogen can also alter host response to a different, unrelated pathogen. These interactions have been seen across multiple infection domains where bacteria, viruses or fungi act synergistically with a deleterious impact on the host. This phenomenon has been well described with bacterial and fungal infections complicating influenza and is of particular interest in the context of the COVID-19 pandemic. Modulation of the immune system is a crucial part of successful solid organ and hematopoietic stem cell transplantation. Herein, we present three cases of polymicrobial infection in transplant recipients. These case examples highlight complex host-pathogen interactions and the resultant clinical syndromes.
    MeSH term(s) Humans ; Coinfection ; COVID-19 ; Pandemics ; Immunocompromised Host ; Hematopoietic Stem Cell Transplantation/adverse effects
    Language English
    Publishing date 2022-10-20
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2754473-4
    ISSN 2076-3271 ; 2076-3271
    ISSN (online) 2076-3271
    ISSN 2076-3271
    DOI 10.3390/medsci10040060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: CORR Insights: Is synovial C-reactive protein a useful marker for periprosthetic joint infection?

    Cummins, Nathan W

    Clinical orthopaedics and related research

    2014  Volume 472, Issue 12, Page(s) 4004–4005

    MeSH term(s) Arthroplasty, Replacement, Hip/adverse effects ; Arthroplasty, Replacement, Knee/adverse effects ; C-Reactive Protein/analysis ; Female ; Hip Prosthesis/adverse effects ; Humans ; Inflammation Mediators/analysis ; Knee Prosthesis/adverse effects ; Male ; Prosthesis-Related Infections/diagnosis ; Synovial Fluid/chemistry
    Chemical Substances Inflammation Mediators ; C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2014-08-19
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80301-7
    ISSN 1528-1132 ; 0009-921X
    ISSN (online) 1528-1132
    ISSN 0009-921X
    DOI 10.1007/s11999-014-3882-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.188: Show issues Location:
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  9. Article ; Online: Mechanisms of Human Immunodeficiency Virus-Associated Lymphocyte Regulated Cell Death.

    Paim, Ana C / Badley, Andrew D / Cummins, Nathan W

    AIDS research and human retroviruses

    2019  Volume 36, Issue 2, Page(s) 101–115

    Abstract: Human immunodeficiency virus-1 (HIV-1) causes CD4 T cell depletion through a number of mechanisms, including programmed cell death pathways (both apoptotic and nonapoptotic). In the setting of HIV-1 infection, the enhanced lymphocyte cell death occurs as ...

    Abstract Human immunodeficiency virus-1 (HIV-1) causes CD4 T cell depletion through a number of mechanisms, including programmed cell death pathways (both apoptotic and nonapoptotic). In the setting of HIV-1 infection, the enhanced lymphocyte cell death occurs as a consequence of complex interactions between the host immune system and viral factors, which are reviewed herein. On the other hand, the main challenge to HIV-1 eradication is the development of latent infection in a subset of long lived cells, including CD4
    MeSH term(s) Apoptosis/immunology ; Autophagy/immunology ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/virology ; Cell Death/immunology ; HIV Infections/immunology ; HIV-1 ; Host Microbial Interactions/immunology ; Humans ; Lymphocytes/immunology ; Lymphocytes/pathology ; Lymphocytes/virology ; Macrophages/immunology ; Macrophages/virology ; Necroptosis/immunology
    Language English
    Publishing date 2019-12-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 639130-8
    ISSN 1931-8405 ; 0889-2229
    ISSN (online) 1931-8405
    ISSN 0889-2229
    DOI 10.1089/AID.2019.0213
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1928: Show issues Location:
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  10. Article ; Online: The Role of the BCL-2 Family of Proteins in HIV-1 Pathogenesis and Persistence.

    Chandrasekar, Aswath P / Cummins, Nathan W / Badley, Andrew D

    Clinical microbiology reviews

    2019  Volume 33, Issue 1

    Abstract: Advances in HIV-1 therapy have transformed the once fatal infection into a manageable, chronic condition, yet the search for a widely applicable approach to cure remains elusive. The ineffectiveness of antiretroviral therapy (ART) in reducing the size of ...

    Abstract Advances in HIV-1 therapy have transformed the once fatal infection into a manageable, chronic condition, yet the search for a widely applicable approach to cure remains elusive. The ineffectiveness of antiretroviral therapy (ART) in reducing the size of the HIV-1 latent reservoir has prompted investigation into the mechanisms of HIV-1 latency and immune escape. One of the major regulators of apoptosis, the BCL-2 protein, alongside its homologous family members, is a major target of HIV-1-induced change. Recent studies have now demonstrated the association of this protein with cells that support proviral forms in the setting of latency and have helped identify BCL-2 as a novel and promising therapeutic target for HIV-1 therapy directed at possible cure. This review aims to systematically review the interactions of HIV-1 with BCL-2 and its homologs and to examine the possibility of using BCL-2 inhibitors in the study and elimination of the latent reservoir.
    MeSH term(s) Anti-HIV Agents/pharmacology ; Anti-HIV Agents/therapeutic use ; Antiretroviral Therapy, Highly Active ; Disease Susceptibility ; HIV Infections/drug therapy ; HIV Infections/metabolism ; HIV Infections/virology ; HIV-1/drug effects ; HIV-1/physiology ; Host-Pathogen Interactions/genetics ; Humans ; Multigene Family ; Proto-Oncogene Proteins c-bcl-2/antagonists & inhibitors ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Viral Load ; Virus Activation ; Virus Latency
    Chemical Substances Anti-HIV Agents ; BCL2 protein, human ; Proto-Oncogene Proteins c-bcl-2
    Language English
    Publishing date 2019-10-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 645015-5
    ISSN 1098-6618 ; 0893-8512
    ISSN (online) 1098-6618
    ISSN 0893-8512
    DOI 10.1128/CMR.00107-19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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