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Book: Adams and Victor's principles of neurology

Ropper, Allan H. / Samuels, Martin A. / Klein, Joshua P. / Prasad, Sashank / Adams, Raymond D. / Victor, Maurice

2023

Abstract: This edition focuses on the wise application of science, evidence from trials, and is closely coupled to the traditional value of the neurological history and examination-essentially the craft of neurology"-- ...

Title variant	Principles of neurology
Author's details	Allan H. Ropper, MD, Martin A. Samuels, MD, Joshua P. Klein, MD, Sashank Prasad, MD
Abstract	"This edition focuses on the wise application of science, evidence from trials, and is closely coupled to the traditional value of the neurological history and examination-essentially the craft of neurology"--
Keywords	Nervous System Diseases ; Neurologic Manifestations
Language	English
Size	ix, 1605 Seiten, Illustrationen
Edition	Twelfth edition
Publisher	McGraw Hill
Publishing place	New York
Publishing country	United States
Document type	Book
HBZ-ID	HT030334238
ISBN	978-1-264-26452-0 ; 1-264-26452-6 ; 9781264264537 ; 1264264534
Database	Catalogue ZB MED Medicine, Health

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2023 A 948	available for loan (reading room)	Lesesaal EG

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Article ; Online: [¹¹C]-(+)-PHNO PET imaging of dopamine D(2/3) receptors in Parkinson's disease with impulse control disorders.

Payer, Doris E / Guttman, Mark / Kish, Stephen J / Tong, Junchao / Strafella, Antonio / Zack, Martin / Adams, John R / Rusjan, Pablo / Houle, Sylvain / Furukawa, Yoshiaki / Wilson, Alan A / Boileau, Isabelle

Movement disorders : official journal of the Movement Disorder Society

2015 Volume 30, Issue 2, Page(s) 160–166

Abstract: ... positron emission tomography (PET) radioligand imaging with the D3 dopamine receptor preferring agonist [¹¹C]-(+)-propyl ...

Abstract	Dopamine agonist medications with high affinity for the D3 dopamine receptor are commonly used to treat Parkinson's disease, and have been associated with pathological behaviors categorized under the umbrella of impulse control disorders (ICD). The aim of this study was to investigate whether ICD in Parkinson's patients are associated with greater D3 dopamine receptor availability. We used positron emission tomography (PET) radioligand imaging with the D3 dopamine receptor preferring agonist [¹¹C]-(+)-propyl-hexahydro-naphtho-oxazin (PHNO) in Parkinson's patients with (n = 11) and without (n = 21) ICD, and age-, sex-, and education-matched healthy control subjects (n = 18). Contrary to hypotheses, [¹¹C]-(+)-PHNO binding in D3 -rich brain areas was not elevated in Parkinson's patients with ICD compared with those without; instead, [¹¹C]-(+)-PHNO binding in ventral striatum was 20% lower (P = 0.011), correlating with two measures of ICD severity (r = -0.8 and -0.9), which may reflect higher dopamine tone in ventral striatum. In dorsal striatum, where [¹¹C]-(+)-PHNO binding is associated with D2 receptor levels, [¹¹C]-(+)-PHNO binding was elevated across patients compared with controls. We conclude that although D3 dopamine receptors have been linked to the occurrence of ICD in Parkinson's patients. Our findings do not support the hypothesis that D3 receptor levels are elevated in Parkinson's patients with ICD. We also did not find ICD-related abnormalities in D2 receptor levels. Our findings argue against the possibility that differences in D2/3 receptor levels can account for the development of ICD in PD; however, we cannot rule out that differences in dopamine levels (particularly in ventral striatum) may be involved.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Disruptive, Impulse Control, and Conduct Disorders/diagnostic imaging ; Disruptive, Impulse Control, and Conduct Disorders/etiology ; Disruptive, Impulse Control, and Conduct Disorders/metabolism ; Dopamine/metabolism ; Dopamine Agents ; Female ; Humans ; Male ; Middle Aged ; Oxazines ; Parkinson Disease/complications ; Parkinson Disease/diagnostic imaging ; Parkinson Disease/metabolism ; Positron-Emission Tomography/methods ; Receptors, Dopamine D2/metabolism ; Receptors, Dopamine D3/metabolism
Chemical Substances	Dopamine Agents ; Oxazines ; Receptors, Dopamine D2 ; Receptors, Dopamine D3 ; naxagolide (22Z7E0X6OF) ; Dopamine (VTD58H1Z2X)
Language	English
Publishing date	2015-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	607633-6
ISSN	1531-8257 ; 0885-3185
ISSN (online)	1531-8257
ISSN	0885-3185
DOI	10.1002/mds.26135
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Article ; Online: Outcome of Hodgkin Lymphoma Patients With a Posttreatment 18F-Fluoro-2-Deoxy-d-Glucose Positron Emission Tomography (FDG-PET)-Negative Residual Mass: Systematic Review and Meta-analysis.

Adams, Hugo J A / Nievelstein, Rutger A J / Kwee, Thomas C

Pediatric hematology and oncology

2015 Volume 32, Issue 8, Page(s) 515–524

Abstract: ... with a posttreatment (18)F-fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET)-negative residual mass ... with an FDG-PET-negative residual mass after first-line therapy were included. The overall quality of included ... patients with a FDG-PET-negative residual mass after first-line therapy is approximately 6.8%. Considering ...

Abstract	To systematically review and meta-analyze the outcome of Hodgkin lymphoma patients with a posttreatment (18)F-fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET)-negative residual mass. A systematic PubMed/MEDLINE database search was performed. The methodological quality of included studies was assessed. The number of patients with a posttreatment non-FDG-avid residual mass and the number of these patients who developed disease relapse during follow-up were extracted from each included study. Heterogeneity in disease relapse proportions across individual studies was assessed using the I2 test, with heterogeneity defined as I(2) > 50%. Using a Freeman-Tukey transformation, the disease relapse proportions from each individual study were then meta-analyzed with either a fixed-effects model (if I2 ≤ 50 %) or a random-effects model (if I2 > 50 %). A total of 5 studies comprising a total of 727 Hodgkin lymphoma patients with an FDG-PET-negative residual mass after first-line therapy were included. The overall quality of included studies was moderate. The proportion of patients with a posttreatment non-FDG-avid residual mass who experienced disease relapse during follow-up ranged between 0% and 13.8%. There was heterogeneity in disease relapse proportions across individual studies (I2 = 61.4%). Pooled disease relapse proportion (random effects) was 6.8% (95% confidence interval: 2.6%-12.5%). The disease relapse rate in Hodgkin lymphoma patients with a FDG-PET-negative residual mass after first-line therapy is approximately 6.8%. Considering the existing literature, the presence of a non-FDG-avid residual mass has not been proven yet to be associated with a worse outcome than a posttreatment FDG-PET-based complete remission status without a residual mass.
MeSH term(s)	Female ; Glucose-6-Phosphate/analogs & derivatives ; Glucose-6-Phosphate/therapeutic use ; Hodgkin Disease/diagnostic imaging ; Hodgkin Disease/mortality ; Hodgkin Disease/therapy ; Humans ; Male ; Neoplasm, Residual ; Positron-Emission Tomography/methods ; Radiography
Chemical Substances	2-fluoro-2-deoxyglucose-6-phosphate (40871-47-4) ; Glucose-6-Phosphate (56-73-5)
Language	English
Publishing date	2015
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	632914-7
ISSN	1521-0669 ; 0888-0018
ISSN (online)	1521-0669
ISSN	0888-0018
DOI	10.3109/08880018.2015.1085934
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Book: Cellular senescence and tumor suppression

Adams, Peter D.

(Biomedicine)

2010

Author's details	Peter D. Adams ... ed
Series title	Biomedicine
Language	English
Size	XIII, 272 S. : graph. Darst., 229 mm x 152 mm
Publisher	Springer
Publishing place	New York
Publishing country	United States
Document type	Book
HBZ-ID	HT016225203
ISBN	978-1-441-91074-5 ; 9781441910752 ; 1-441-91074-3 ; 1441910751
Database	Catalogue ZB MED Medicine, Health

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2010 A 764	order for loan	Magazin

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Article ; Online: Targeting the epichaperome to combat AML.

Li, Sha / Adams, Peter D

Blood

2023 Volume 142, Issue 12, Page(s) 1031–1032

MeSH term(s)	Humans ; Leukemia, Myeloid, Acute/genetics ; Tumor Suppressor Protein p53
Chemical Substances	TP53 protein, human ; Tumor Suppressor Protein p53
Language	English
Publishing date	2023-09-20
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood.2023021386
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Book ; Online ; E-Book: Pancreatitis

Adams, David B. / Cotton, Peter B. / Zyromski, Nicholas J. / Windsor, John

medical and surgical management

2017

Author's details	edited by David B. Adams, Peter B. Cotton, Nicholas J. Zyromski, John Windsor
Language	English
Size	1 Online-Ressource (x, 326 Seiten), Illustrationen
Publisher	Wiley Blackwell
Publishing place	Chichester, West Sussex
Publishing country	Great Britain
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT019260118
ISBN	978-1-118-92492-1 ; 9781118917121 ; 1-118-92492-4 ; 111891712X
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Is aging a "Retro"spective event?

Dasgupta, Nirmalya / Adams, Peter D

Cell

2023 Volume 186, Issue 2, Page(s) 233–235

Abstract: Reactivation of endogenous retroviruses (ERVs), the relics of ancient infections, has been implicated in a number of disease contexts. In this issue of Cell, Liu et al. show how reactivation of ERVs in old age can induce senescence. This awakening of ... ...

Abstract	Reactivation of endogenous retroviruses (ERVs), the relics of ancient infections, has been implicated in a number of disease contexts. In this issue of Cell, Liu et al. show how reactivation of ERVs in old age can induce senescence. This awakening of ERVs is associated with their epigenetic derepression and contributes to age-associated chronic inflammation.
MeSH term(s)	Endogenous Retroviruses/genetics ; Aging/genetics ; Aging/pathology ; Inflammation
Language	English
Publishing date	2023-01-16
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2022.12.040
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Article ; Online: Hematopoiesis: a BETter understanding.

Dasgupta, Nirmalya / Adams, Peter D

EMBO reports

2023 Volume 24, Issue 10, Page(s) e57927

Abstract: Epigenetic modifications are known to be crucial for hematopoietic stem cell (HSC) differentiation, with the BET family member BRD4 playing a vital role in this as an epigenetic reader. In this issue of EMBO reports, Yang et al (2023) demonstrate that ... ...

Abstract	Epigenetic modifications are known to be crucial for hematopoietic stem cell (HSC) differentiation, with the BET family member BRD4 playing a vital role in this as an epigenetic reader. In this issue of EMBO reports, Yang et al (2023) demonstrate that the absence of BRD4 leads to senescence in HSCs and hematopoietic progenitor cells (HPCs), affecting the expression of crucial genes involved in myeloid and erythroid development. These data suggest that BRD4 has a protective role in preserving histone tails, thereby sustaining normal HSC/HPC functions.
Language	English
Publishing date	2023-08-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2020896-0
ISSN	1469-3178 ; 1469-221X
ISSN (online)	1469-3178
ISSN	1469-221X
DOI	10.15252/embr.202357927
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Article ; Online: Functional imaging of SDHx-related head and neck paragangliomas: comparison of 18F-fluorodihydroxyphenylalanine, 18F-fluorodopamine, 18F-fluoro-2-deoxy-D-glucose PET, 123I-metaiodobenzylguanidine scintigraphy, and 111In-pentetreotide scintigraphy.

King, Kathryn S / Chen, Clara C / Alexopoulos, Dimitrios K / Whatley, Millie A / Reynolds, James C / Patronas, Nicholas / Ling, Alexander / Adams, Karen T / Xekouki, Paraskevi / Lando, Howard / Stratakis, Constantine A / Pacak, Karel

The Journal of clinical endocrinology and metabolism

2011 Volume 96, Issue 9, Page(s) 2779–2785

Abstract: ... 18)F-fluoro-2-deoxy-D-glucose ((18)F-FDG) PET/CT, (123)I-metaiodobenzylguanidine ((123)I-MIBG ... FDOPA) positron emission tomography (PET), (18)F-fluorodopamine ((18)F-FDA) PET/computed tomography (CT ... Results: Prospectively (18)F-FDOPA PET localized 26 of 26 lesions in the 10 patients, CT ...

Abstract	Rationale: Accurate diagnosis of head and neck paragangliomas is often complicated by biochemical silence and lack of catecholamine-associated symptoms, making accurate anatomical and functional imaging techniques essential to the diagnostic process. Methods: Ten patients (seven SDHD, three SDHB), with a total of 26 head and neck paragangliomas, were evaluated with anatomical and functional imaging. This study compares five different functional imaging techniques [(18)F-fluorodihydroxyphenylalanine ((18)F-FDOPA) positron emission tomography (PET), (18)F-fluorodopamine ((18)F-FDA) PET/computed tomography (CT), (18)F-fluoro-2-deoxy-D-glucose ((18)F-FDG) PET/CT, (123)I-metaiodobenzylguanidine ((123)I-MIBG) scintigraphy, and (111)In-pentetreotide scintigraphy] in the localization of head and neck paragangliomas. Results: Prospectively (18)F-FDOPA PET localized 26 of 26 lesions in the 10 patients, CT/magnetic resonance imaging localized 21 of 26 lesions, (18)F-FDG PET/CT localized 20 of 26 lesions, (111)In-pentetreotide scintigraphy localized 16 of 25 lesions, (18)F-FDA PET/CT localized 12 of 26 lesions, and (123)I-MIBG scintigraphy localized eight of 26 lesions. Differences in imaging efficacy related to genetic phenotype, even in the present small sample size, included the negativity of (18)F-FDA PET/CT and (123)I-MIBG scintigraphy in patients with SDHB mutations and the accuracy of (18)F-FDG PET/CT in all patients with SDHD mutations, as compared with the accuracy of (18)F-FDG PET/CT in only one patient with an SDHB mutation. Conclusion: Overall, (18)F-FDOPA PET proved to be the most efficacious functional imaging modality in the localization of SDHx-related head and neck paragangliomas and may be a potential first-line functional imaging agent for the localization of these tumors.
MeSH term(s)	3-Iodobenzylguanidine ; Adult ; Brain Mapping/methods ; Dihydroxyphenylalanine/analogs & derivatives ; Dopamine/analogs & derivatives ; Female ; Fluorodeoxyglucose F18 ; Head and Neck Neoplasms/diagnostic imaging ; Head and Neck Neoplasms/genetics ; Humans ; Male ; Middle Aged ; Paraganglioma/diagnostic imaging ; Paraganglioma/genetics ; Positron-Emission Tomography ; Prospective Studies ; Radiopharmaceuticals ; Somatostatin/analogs & derivatives ; Succinate Dehydrogenase/genetics ; Tomography, Emission-Computed/methods
Chemical Substances	Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; 3-Iodobenzylguanidine (35MRW7B4AD) ; Somatostatin (51110-01-1) ; Dihydroxyphenylalanine (63-84-3) ; Succinate Dehydrogenase (EC 1.3.99.1) ; pentetreotide (G083B71P98) ; Dopamine (VTD58H1Z2X)
Language	English
Publishing date	2011-07-13
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, N.I.H., Intramural
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/jc.2011-0333
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Article: Positron emission tomography with fluoro-2-deoxy-D-glucose (FDG-PET) in the staging of post transplant lymphoproliferative disorder in lung transplant recipients.

Marom, Edith M / McAdams, H Page / Butnor, Kelly J / Coleman, R Edward

Journal of thoracic imaging

2004 Volume 19, Issue 2, Page(s) 74–78

Abstract: ... may affect therapy. Positron emission tomography with fluoro-2-deoxy-D-glucose (FDG-PET) has proven useful ... This study examined our initial experience using FDG-PET imaging to stage lung transplant recipients ...

Abstract	Posttransplantation lymphoproliferative disorder (PTLD) is a histologic heterogeneous disease that complicates 4 to 8% of lung transplant recipients. Disease extent is an important prognostic factor and may affect therapy. Positron emission tomography with fluoro-2-deoxy-D-glucose (FDG-PET) has proven useful for staging high-grade lymphomas but is less accurate for staging low-grade and extranodal lymphoma. This study examined our initial experience using FDG-PET imaging to stage lung transplant recipients with posttransplantation lymphoproliferative disorder. FDG can show foci of uptake, particularly in extrathoracic sites, not seen by conventional imaging, which allows more accurate staging of disease thereby yielding useful prognostic information and guiding therapy.
MeSH term(s)	Fluorodeoxyglucose F18 ; Humans ; Lung Transplantation ; Lymphoproliferative Disorders/diagnostic imaging ; Lymphoproliferative Disorders/pathology ; Male ; Middle Aged ; Radiopharmaceuticals ; Retrospective Studies ; Tomography, Emission-Computed
Chemical Substances	Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2004-01-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	632900-7
ISSN	1536-0237 ; 0883-5993
ISSN (online)	1536-0237
ISSN	0883-5993
DOI	10.1097/00005382-200404000-00002
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