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Article: [Discipline construction of critical care medicine under the guideline of "excellence, high-quality and sustainability" in the First Affiliated Hospital of Zhengzhou University].

Liu, Zhangsuo

Zhonghua wei zhong bing ji jiu yi xue

2019 Volume 31, Issue 2, Page(s) 139–142

Abstract: Objective: Critical care medicine plays an important role in public health emergencies, major disasters and treatments of critically ill patients as an emerging clinical discipline. Our hospital put critical care medicine in an important position and ... ...

Abstract	Objective: Critical care medicine plays an important role in public health emergencies, major disasters and treatments of critically ill patients as an emerging clinical discipline. Our hospital put critical care medicine in an important position and apply multiple measures under the guidance of the spirit of graded diagnosis and national medical system reform combined with our concept of "more detailed, more excellent, high quality and sustainable development". Our hospital promote rapid, high-quality sustainable development of critical care by increasing discipline construction, scientific research, professional training, talent introduction, academic exchange, information construction, and precision medical treatment, etc.
MeSH term(s)	China ; Critical Care ; Education, Medical/standards ; Guidelines as Topic ; Hospitals, University ; Humans
Language	Chinese
Publishing date	2019-03-02
Publishing country	China
Document type	Journal Article
ISSN	2095-4352
ISSN	2095-4352
DOI	10.3760/cma.j.issn.2095-4352.2019.02.003
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Article: Mechanistic Pathogenesis of Endothelial Dysfunction in Diabetic Nephropathy and Retinopathy.

Yang, Jing / Liu, Zhangsuo

Frontiers in endocrinology

2022 Volume 13, Page(s) 816400

Abstract: Diabetic nephropathy (DN) and diabetic retinopathy (DR) are microvascular complications of diabetes. Microvascular endothelial cells are thought to be the major targets of hyperglycemic injury. In diabetic microvasculature, the intracellular ... ...

Abstract	Diabetic nephropathy (DN) and diabetic retinopathy (DR) are microvascular complications of diabetes. Microvascular endothelial cells are thought to be the major targets of hyperglycemic injury. In diabetic microvasculature, the intracellular hyperglycemia causes damages to the vascular endothelium, via multiple pathophysiological process consist of inflammation, endothelial cell crosstalk with podocytes/pericytes and exosomes. In addition, DN and DR diseases development are involved in several critical regulators including the cell adhesion molecules (CAMs), the vascular endothelial growth factor (VEGF) family and the Notch signal. The present review attempts to gain a deeper understanding of the pathogenesis complexities underlying the endothelial dysfunction in diabetes diabetic and retinopathy, contributing to the development of new mechanistic therapeutic strategies against diabetes-induced microvascular endothelial dysfunction.
MeSH term(s)	Diabetes Mellitus/metabolism ; Diabetic Nephropathies/etiology ; Diabetic Nephropathies/metabolism ; Diabetic Retinopathy/metabolism ; Endothelial Cells/metabolism ; Humans ; Hyperglycemia/complications ; Hyperglycemia/metabolism ; Vascular Endothelial Growth Factor A/metabolism
Chemical Substances	Vascular Endothelial Growth Factor A
Language	English
Publishing date	2022-05-25
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2022.816400
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Article ; Online: Sepsis-Associated Acute Kidney Injury

Dong Wang / Tongwen Sun / Zhangsuo Liu

Intensive Care Research, Vol 3, Iss 4, Pp 251-

2023 Volume 258

Abstract: Abstract Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host immune response to infection. The kidneys are one of the first organs to be injured in sepsis. About two-thirds of patients with septic shock develop acute ... ...

Abstract	Abstract Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host immune response to infection. The kidneys are one of the first organs to be injured in sepsis. About two-thirds of patients with septic shock develop acute kidney injury, with a six- to eightfold increase in mortality. Growing evidences elucidate pathophysiological mechanisms, biomarkers, and response to therapy of sepsis-associated acute kidney injury (S-AKI). However, there is still a lack of effective and specific interventions for the treatment of S-AKI. This review summarizes the relevant evidence and provides an overview of the current understanding of S-AKI, focusing on pathophysiology, diagnosis, biomarkers, and therapeutic approaches.
Keywords	Sepsis ; Sepsis-associated acute lung injury ; Epidemiology ; Pathophysiology ; Treatment ; Prevention ; Medical emergencies. Critical care. Intensive care. First aid ; RC86-88.9 ; Medicine ; R
Language	English
Publishing date	2023-08-01T00:00:00Z
Publisher	Springer
Document type	Article ; Online
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Article ; Online: Telitacicept for autoimmune nephropathy.

Cai, Jingjing / Gao, Dan / Liu, Dongwei / Liu, Zhangsuo

Frontiers in immunology

2023 Volume 14, Page(s) 1169084

Abstract: B cells and the humoral immunity are important players in the pathogenesis of autoimmune diseases. BAFF (also known as BLYS) and a proliferation-inducing ligand APRIL are required for the maintenance of the B-cell pool and humoral immunity. BAFF and ... ...

Abstract	B cells and the humoral immunity are important players in the pathogenesis of autoimmune diseases. BAFF (also known as BLYS) and a proliferation-inducing ligand APRIL are required for the maintenance of the B-cell pool and humoral immunity. BAFF and APRIL can promote B-cell differentiation, maturation, and plasma cell antibody secretion. BAFF/APRIL overexpression has been identified in several autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, IgA nephropathy, etc. Telitacicept, a novel fully human TACI-Fc fusion protein that binds both BAFF and APRIL, was approved in China in March 2021 for the treatment of systemic lupus erythematosus at a recommended dose of 160 mg/w subcutaneously and is in clinical trials for the treatment of multiple indications in other autoimmune diseases. In this review, we explored telitacicept's mechanism of action and clinical data. In addition, the immune features of autoimmune nephropathy were discussed, emphasizing lupus nephritis, IgA nephropathy, and membranous nephropathy.
MeSH term(s)	Humans ; Glomerulonephritis, IGA/drug therapy ; B-Cell Activating Factor/metabolism ; Lupus Erythematosus, Systemic ; Lupus Nephritis/drug therapy ; Lupus Nephritis/pathology ; Autoantibodies
Chemical Substances	telitacicept ; B-Cell Activating Factor ; Autoantibodies
Language	English
Publishing date	2023-06-05
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1169084
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Article: Serum Total Bilirubin and Progression of Chronic Kidney Disease and Mortality: A Systematic Review and Meta-Analysis.

Li, Jia / Liu, Dongwei / Liu, Zhangsuo

Frontiers in medicine

2021 Volume 7, Page(s) 549

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2021-01-25
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2020.00549
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Article ; Online: Metabolomic profiling of amino acids study reveals a distinct diagnostic model for diabetic kidney disease.

Wang, Jiao / Zhou, Chunyu / Zhang, Qing / Liu, Zhangsuo

Amino acids

2023 Volume 55, Issue 11, Page(s) 1563–1572

Abstract: Diabetic kidney disease (DKD), a highly prevalent complication of diabetes mellitus, is a major cause of mortality in patients. However, identifying circulatory markers to diagnose DKD requires a thorough understanding of the metabolic mechanisms of DKD. ...

Abstract	Diabetic kidney disease (DKD), a highly prevalent complication of diabetes mellitus, is a major cause of mortality in patients. However, identifying circulatory markers to diagnose DKD requires a thorough understanding of the metabolic mechanisms of DKD. In this study, we performed ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) to reveal altered metabolic profiles of amino acids (AAs) in patients with DKD. We found decreased plasma levels of histidine and valine, increased urine levels of proline, decreased urine levels of histidine and valine, and increased saliva levels of arginine in patients with DKD compared with the levels in patients with type 2 diabetes mellitus (T2DM) and in healthy controls. Our analyses of the key metabolites and metabolic enzymes involved in histidine and valine metabolism indicated that the AAs level alterations may be due to enhanced carnosine hydrolysis, decreased degradation of homocarnosine and anserine, enhanced histidine methylation, and systemic enhancement of valine metabolism in patients with DKD. Notably, we generated a distinct diagnostic model with an AUC of 0.957 and an accuracy up to 92.2% on the basis of the AA profiles in plasma, urine and saliva differing in patients with DKD using logistic regression and receiver operating characteristic analyses. In conclusion, our results suggest that altered AA metabolic profiles are associated with the progression of DKD. Our DKD diagnostic model on the basis of AA levels in plasma, urine, and saliva may provide a theoretical basis for innovative strategies to diagnose DKD that may replace cumbersome kidney biopsies.
MeSH term(s)	Humans ; Diabetic Nephropathies/metabolism ; Amino Acids ; Diabetes Mellitus, Type 2/metabolism ; Histidine ; Chromatography, Liquid ; Tandem Mass Spectrometry ; Amines ; Valine
Chemical Substances	Amino Acids ; Histidine (4QD397987E) ; Amines ; Valine (HG18B9YRS7)
Language	English
Publishing date	2023-09-22
Publishing country	Austria
Document type	Journal Article
ZDB-ID	1121341-3
ISSN	1438-2199 ; 0939-4451
ISSN (online)	1438-2199
ISSN	0939-4451
DOI	10.1007/s00726-023-03330-0
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Zs.A 3490: Show issues

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Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Atrasentan in patients with diabetes and chronic kidney disease.

Liu, Dongwei / Liu, Zhangsuo

Lancet (London, England)

2020 Volume 395, Issue 10220, Page(s) 269–270

MeSH term(s)	Atrasentan ; Diabetes Mellitus, Type 2 ; Double-Blind Method ; Humans ; Kidney ; Renal Insufficiency, Chronic
Chemical Substances	Atrasentan (V6D7VK2215)
Language	English
Publishing date	2020-01-02
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	3306-6
ISSN	1474-547X ; 0023-7507 ; 0140-6736
ISSN (online)	1474-547X
ISSN	0023-7507 ; 0140-6736
DOI	10.1016/S0140-6736(19)33021-1
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Ua VI Zs.5: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: The key mediator of diabetic kidney disease: Potassium channel dysfunction.

Guo, Jia / Zhang, Chaojie / Zhao, Hui / Yan, Yufan / Liu, Zhangsuo

Genes & diseases

2023 Volume 11, Issue 4, Page(s) 101119

Abstract: Diabetic kidney disease is a leading cause of end-stage renal disease, making it a global public health concern. The molecular mechanisms underlying diabetic kidney disease have not been elucidated due to its complex pathogenesis. Thus, exploring these ... ...

Abstract	Diabetic kidney disease is a leading cause of end-stage renal disease, making it a global public health concern. The molecular mechanisms underlying diabetic kidney disease have not been elucidated due to its complex pathogenesis. Thus, exploring these mechanisms from new perspectives is the current focus of research concerning diabetic kidney disease. Ion channels are important proteins that maintain the physiological functions of cells and organs. Among ion channels, potassium channels stand out, because they are the most common and important channels on eukaryotic cell surfaces and function as the basis for cell excitability. Certain potassium channel abnormalities have been found to be closely related to diabetic kidney disease progression and genetic susceptibility, such as K
Language	English
Publishing date	2023-09-22
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2821806-1
ISSN	2352-3042 ; 2352-3042
ISSN (online)	2352-3042
ISSN	2352-3042
DOI	10.1016/j.gendis.2023.101119
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Article ; Online: Novel immune cross-talk between inflammatory bowel disease and IgA nephropathy.

Yan, Qianqian / Zhao, Zihao / Liu, Dongwei / Li, Jia / Pan, Shaokang / Duan, Jiayu / Liu, Zhangsuo

Renal failure

2024 Volume 46, Issue 1, Page(s) 2337288

Abstract: The mechanisms underlying the complex correlation between immunoglobulin A nephropathy (IgAN) and inflammatory bowel disease (IBD) remain unclear. This study aimed to identify the optimal cross-talk genes, potential pathways, and mutual immune- ... ...

Abstract	The mechanisms underlying the complex correlation between immunoglobulin A nephropathy (IgAN) and inflammatory bowel disease (IBD) remain unclear. This study aimed to identify the optimal cross-talk genes, potential pathways, and mutual immune-infiltrating microenvironments between IBD and IgAN to elucidate the linkage between patients with IBD and IgAN. The IgAN and IBD datasets were obtained from the Gene Expression Omnibus (GEO). Three algorithms, CIBERSORTx, ssGSEA, and xCell, were used to evaluate the similarities in the infiltrating microenvironment between the two diseases. Weighted gene co-expression network analysis (WGCNA) was implemented in the IBD dataset to identify the major immune infiltration modules, and the Boruta algorithm, RFE algorithm, and LASSO regression were applied to filter the cross-talk genes. Next, multiple machine learning models were applied to confirm the optimal cross-talk genes. Finally, the relevant findings were validated using histology and immunohistochemistry analysis of IBD mice. Immune infiltration analysis showed no significant differences between IBD and IgAN samples in most immune cells. The three algorithms identified 10 diagnostic genes, MAPK3, NFKB1, FDX1, EPHX2, SYNPO, KDF1, METTL7A, RIDA, HSDL2, and RIPK2; FDX1 and NFKB1 were enhanced in the kidney of IBD mice. Kyoto Encyclopedia of Genes and Genomes analysis showed 15 mutual pathways between the two diseases, with lipid metabolism playing a vital role in the cross-talk. Our findings offer insights into the shared immune mechanisms of IgAN and IBD. These common pathways, diagnostic cross-talk genes, and cell-mediated abnormal immunity may inform further experimental studies.
MeSH term(s)	Humans ; Animals ; Mice ; Glomerulonephritis, IGA/genetics ; Kidney ; Algorithms ; Gene Expression Profiling ; Inflammatory Bowel Diseases/genetics ; Hydroxysteroid Dehydrogenases ; Proteins
Chemical Substances	HSDL2 protein, human (EC 1.1.-) ; Hydroxysteroid Dehydrogenases (EC 1.1.-) ; KDF1 protein, mouse ; Proteins
Language	English
Publishing date	2024-04-17
Publishing country	England
Document type	Journal Article
ZDB-ID	632949-4
ISSN	1525-6049 ; 0886-022X
ISSN (online)	1525-6049
ISSN	0886-022X
DOI	10.1080/0886022X.2024.2337288
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Zs.A 1331: Show issues

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Article ; Online: Hematological features and risk factors of hospitalized COVID-19 patients

Chaoyang Hua / Jia Li / Yanfang Yang / Zhangsuo Liu

European Journal of Inflammation, Vol

A retrospective analysis

2022 Volume 20

Abstract: Background: Coronavirus disease 2019 (COVID-19) became pandemic in 2020 and recently, mutated coronaviruses have emerged in many countries. The aim of this study was to identify the clinical characteristics and risk factors for critical illness in ... ...

Abstract	Background: Coronavirus disease 2019 (COVID-19) became pandemic in 2020 and recently, mutated coronaviruses have emerged in many countries. The aim of this study was to identify the clinical characteristics and risk factors for critical illness in hospitalized COVID-19 patients in Zhengzhou for clinical prevention and management. Materials and methods: A total of 70 patients hospitalized with COVID-19 were enrolled between 21 January and 29 February 2020, in Zhengzhou, China. Clinical characteristics, hematological findings, neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and inflammatory index on admission were obtained from medical records, COVID-19 patients with different outcomes were compared. Results: The median age was 55 years. Forty-three (61.0%) patients were classified as having severe or critical cases. Eighteen (25.7%) patients died in hospital and the remaining 52 were discharged. Patients who died tend to be old with expectoration and chronic obstructive pulmonary disease. Compared to survivor, non-survivor had significantly higher numbers of leucocytes and neutrophils, NLR, aspartate aminotransferase (AST), γ-glutamyl transpeptidase, total bilirubin, direct bilirubin, lactate dehydrogenase (LDH), prothrombin time, D-dimer, C-reactive protein, and decreased platelets, lymphocytes, uric acid, and albumin (ALB). Logistic regression analysis identified leucocytes, platelets, PLR, NLR, AST, and ALB as independent predictive factors for poor outcomes. The area under curve of the combination of leucocytes, PLR, NLR, and AST was 0.87, with a sensitivity of 0.83 and specificity of 0.81. Conclusion: Our results identified risk factors among COVID-19 patients for in-hospital mortality. Leucocytes, PLR, NLR, and AST could have important reference value for predicting prognosis, especially in low-resource countries.
Keywords	Medicine ; R
Subject code	610
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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