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Article ; Online: E-Cigarette-Associated Endothelial Damage: A Potential Mechanism for Erectile Dysfunction.

Pincus, Joshua / Sandoval, Victor / Dick, Brian / Sanekommu, Ganesh / Rajasekaran, Raj / Ramasamy, Ranjith / Raheem, Omer

Sexual medicine reviews

2021 Volume 10, Issue 1, Page(s) 168–173

Abstract: ... Sandoval V, Dick B, et al. E-Cigarette-Associated Endothelial Damage: A Potential Mechanism ... Introduction: Electronic cigarettes (e-cigs) have increased in popularity as a potentially less ... smoking cigarettes and erectile dysfunction (ED), the effect of e-cigs on erectile function has been understudied ...

Abstract	Introduction: Electronic cigarettes (e-cigs) have increased in popularity as a potentially less harmful alternative to tobacco smoking; however, the literature suggests "vaping" can cause endothelial damage, which can adversely affect erectile function. While there is a known link between smoking cigarettes and erectile dysfunction (ED), the effect of e-cigs on erectile function has been understudied. Objectives: To review the evidence for e-cig use causing endothelial dysfunction, to explore endothelial dysfunction as a potential mechanism for ED, and to determine if there is literature to support e-cigs as a cause of ED. Methods: A literature review was performed to identify publications pertaining to e-cig consumption and ED. Publications regarding e-cig consumption and vascular or endothelial damage were also included. The search was conducted through PubMed, MEDLINE database, the Cochrane Library Central Search, Web of Science, and Google Scholar. We identified 40+ publications for review, including 6 clinical trials and 3 basic science studies. Results: The literature suggests that e-cig use induces oxidative stress, including the direct formation of reactive oxygen species and hydroxyl radicals, leading to endothelial damage. Endothelial dysfunction is a potential mechanism for ED, but there is a paucity of studies evaluating the relationship between e-cig use and ED. Conclusion: E-cig use may cause ED in men, but more studies, specifically clinical trials, are needed to establish a relationship between e-cigs and ED. E-cig-induced endothelial dysfunction is a potential mechanism for ED that is worth exploring further. Pincus J, Sandoval V, Dick B, et al. E-Cigarette-Associated Endothelial Damage: A Potential Mechanism for Erectile Dysfunction. Sex Med Rev 2022;10:168-173.
MeSH term(s)	Electronic Nicotine Delivery Systems ; Erectile Dysfunction/etiology ; Humans ; Male ; Vaping
Language	English
Publishing date	2021-04-27
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2722257-3
ISSN	2050-0521 ; 2050-0513
ISSN (online)	2050-0521
ISSN	2050-0513
DOI	10.1016/j.sxmr.2021.01.003
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Article ; Online: Inhibition of angiotensin-induced aortic aneurysm by metformin in apolipoprotein E-deficient mice.

Kunath, Anne / Unosson, Jon / Friederich-Persson, Malou / Bjarnegård, Niclas / Becirovic-Agic, Mediha / Björck, Martin / Mani, Kevin / Wanhainen, Anders / Wågsäter, Dick

JVS-vascular science

2021 Volume 2, Page(s) 33–42

Abstract: ... synergistic effects of metformin and imatinib.: Methods: Angiotensin II was used to induce AAAs in apolipoprotein E ...

Abstract	Objective: Metformin is associated with a reduced incidence and growth of abdominal aortic aneurysms (AAAs). The aim of the present study was to investigate the inhibitory effects of metformin on AAA development and possible underlying mechanisms in experimentally induced AAAs in mice, along with the possible synergistic effects of metformin and imatinib. Methods: Angiotensin II was used to induce AAAs in apolipoprotein E knockout ( Results: Metformin (n = 11) suppressed the formation and progression of AAAs by 50% compared with the vehicle controls (n = 12), with no further effects from imatinib (n = 7). Metformin reduced total cholesterol and mRNA expression of Conclusion: Metformin inhibited aneurysm formation and progression and normalized vascular function in Clinical relevance: Retrospective studies of the effects of metformin in patients with aneurysm have so far only been performed of those with type 2 diabetes. The present study shows that metformin has effects on nondiabetic mice and revealed the mechanistic effects mediated by the drug that could also be important to study as outcomes in humans. Future clinical trials using metformin are warranted in patients without diabetes with abdominal aortic aneurysms.
Language	English
Publishing date	2021-03-03
Publishing country	United States
Document type	Journal Article
ISSN	2666-3503
ISSN (online)	2666-3503
DOI	10.1016/j.jvssci.2020.11.031
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Article ; Online: Effectiveness and cost-effectiveness of a web-based cardiac rehabilitation programme for people with chronic stable angina: protocol for the ACTIVATE (Angina Controlled Trial Investigating the Value of the 'Activate your heart' Therapeutic E-intervention) randomised controlled trial.

Williams, Nefyn H / Collins, Brendan / Comerford, Terence J / Dodd, Susanna / Fisher, Michael / Hardwick, Ben / Hennessy, Sophie / Jolly, Kate / Jones, Ian / Lane, Deirdre / Lip, Gregory Y H / Morgan, Erica / Ralph, Penelope / Thijssen, Dick / Singh, Sally J

BMJ open

2024 Volume 14, Issue 3, Page(s) e084509

Abstract: Introduction: Chronic stable angina is common and disabling. Cardiac rehabilitation is routinely offered to people following myocardial infarction or revascularisation procedures and has the potential to help people with chronic stable angina. However, ... ...

Abstract	Introduction: Chronic stable angina is common and disabling. Cardiac rehabilitation is routinely offered to people following myocardial infarction or revascularisation procedures and has the potential to help people with chronic stable angina. However, there is insufficient evidence of effectiveness and cost-effectiveness for its routine use in this patient group. The objectives of this study are to compare the effectiveness and cost-effectiveness of the 'Activate Your Heart' cardiac rehabilitation programme for people with chronic stable angina compared with usual care. Methods and analysis: ACTIVATE is a multicentre, parallel-group, two-arm, superiority, pragmatic randomised controlled trial, with recruitment from primary and secondary care centres in England and Wales and a target sample size of 518 (1:1 allocation; allocation sequence by minimisation programme with built-in random element). The study uses secure web-based allocation concealment. The two treatments will be optimal usual care (control) and optimal usual care plus the 'Activate Your Heart' web-based cardiac rehabilitation programme (intervention). Outcome assessment and statistical analysis will be performed blinded; participants will be unblinded. Outcomes will be measured at baseline and at 6 and 12 months' follow-up. Primary outcome will be the UK version of Seattle Angina Questionnaire (SAQ-UK), physical limitations domain at 12 months' follow-up. Secondary outcomes will be the remaining two domains of SAQ-UK, dyspnoea, anxiety and depression, health utility, self-efficacy, physical activity and the incremental shuttle walk test. All safety events will be recorded, and serious adverse events assessed to determine whether they are related to the intervention and expected. Concurrent economic evaluation will be cost-utility analysis from health service perspective. An embedded process evaluation will determine the mechanisms and processes that explain the implementation and impacts of the cardiac rehabilitation programme. Ethics and dissemination: North of Scotland National Health Service Research Ethics Committee approval, reference 21/NS/0115. Participants will provide written informed consent. Results will be disseminated by peer-reviewed publication. Trial registration number: ISRCTN10054455.
MeSH term(s)	Humans ; Cardiac Rehabilitation/methods ; Angina, Stable ; Cost-Benefit Analysis ; State Medicine ; Internet ; Quality of Life ; Randomized Controlled Trials as Topic ; Multicenter Studies as Topic
Language	English
Publishing date	2024-03-25
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2024-084509
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Book ; Online: Incorporating Wireless Communication Parameters into the E-Model Algorithm

Rodríguez, Demóstenes Z. / Melgarejo, Dick Carrillo / Ramírez, Miguel A. / Nardelli, Pedro H. J. / Möller, Sebastian

2021

Abstract: ... quality assessment methods. ITU-T Recommendation G.107 describes the E-model algorithm, which is ... However, the NB, WB, and FB E-model algorithms do not consider wireless techniques used in these networks ... into the NB and WB E-model algorithms. To accomplish this goal, MIMO and wireless channel parameters are ...

Abstract	Telecommunication service providers have to guarantee acceptable speech quality during a phone call to avoid a negative impact on the users' quality of experience. Currently, there are different speech quality assessment methods. ITU-T Recommendation G.107 describes the E-model algorithm, which is a computational model developed for network planning purposes focused on narrowband (NB) networks. Later, ITU-T Recommendations G.107.1 and G.107.2 were developed for wideband (WB) and fullband (FB) networks. These algorithms use different impairment factors, each one related to different speech communication steps. However, the NB, WB, and FB E-model algorithms do not consider wireless techniques used in these networks, such as Multiple-Input-Multiple-Output (MIMO) systems, which are used to improve the communication system robustness in the presence of different types of wireless channel degradation. In this context, the main objective of this study is to propose a general methodology to incorporate wireless network parameters into the NB and WB E-model algorithms. To accomplish this goal, MIMO and wireless channel parameters are incorporated into the E-model algorithms, specifically into the $I_{e,eff}$ and $I_{e,eff,WB}$ impairment factors. For performance validation, subjective tests were carried out, and the proposed methodology reached a Pearson correlation coefficient (PCC) and a root mean square error (RMSE) of $0.9732$ and $0.2351$, respectively. It is noteworthy that our proposed methodology does not affect the rest of the E-model input parameters, and it intends to be useful for wireless network planning in speech communication services. Comment: 18 pages
Keywords	Electrical Engineering and Systems Science - Audio and Speech Processing ; Computer Science - Sound
Subject code	600
Publishing date	2021-03-05
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: E-cigarette use is prospectively associated with initiation of cannabis among college students.

Ksinan, Albert J / Spindle, Tory R / Thomas, Nathaniel S / Eissenberg, Thomas / Dick, Danielle M

Addictive behaviors

2020 Volume 106, Page(s) 106312

Abstract: E-cigarettes have dramatically increased in popularity among youth. Coincident with expanded ... associations between e-cigarette and cannabis use in a large, diverse college sample assessed over four ... timepoints (freshman - senior year; N = 4,670). E-cigarette use and cannabis use were modelled in a four-wave ...

Abstract	E-cigarettes have dramatically increased in popularity among youth. Coincident with expanded legalization, young adults' use of cannabis (marijuana) has also steadily increased in recent years. Use of tobacco products can increase the chances of later cannabis initiation among youth. However, most longitudinal investigations of tobacco and cannabis use patterns have focused on tobacco cigarettes, included adolescents as opposed to young adults, and have only employed two timepoints. The current study examined prospective associations between e-cigarette and cannabis use in a large, diverse college sample assessed over four timepoints (freshman - senior year; N = 4,670). E-cigarette use and cannabis use were modelled in a four-wave cross-lagged model. The results showed significant bidirectional associations between both substances, even after controlling for time-varying levels of depressive symptoms, alcohol use, and polysubstance use, sensation seeking, demographic variables, concurrent associations and previous levels of use. Moreover, the significance of the predictive path from e-cigarette use to later cannabis use remained unchanged when we ran the same model, but restricted the sample to e-cigarette-only users (i.e., never cigarette smokers), whereas only one prospective path from cannabis to e-cigarette use was significant in this subsample. The current findings suggest that the association of e-cigarette use and cannabis use is likely bidirectional, with stronger support for the link from e-cigarette use to later cannabis use, above and beyond cigarette use. As e-cigarettes gain further hold of the tobacco product market share and cannabis legalization continues to expand, data such as these will be critical for informing regulatory decisions for e-cigarettes and cannabis, particularly involving their accessibility to youth and young adults.
MeSH term(s)	Adolescent ; Cannabis ; Electronic Nicotine Delivery Systems ; Humans ; Prospective Studies ; Students ; Vaping ; Young Adult
Language	English
Publishing date	2020-01-11
Publishing country	England
Document type	Journal Article
ZDB-ID	197618-7
ISSN	1873-6327 ; 0306-4603
ISSN (online)	1873-6327
ISSN	0306-4603
DOI	10.1016/j.addbeh.2020.106312
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Article: Schulternetzwerk Deutschland e. V.

Egmond, Dick

manuelletherapie

2016 Volume 20, Issue 03, Page(s) 104–106

Language	German
Publishing date	2016-07-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2138834-9
ISSN	1439-2348 ; 1433-2671
ISSN (online)	1439-2348
ISSN	1433-2671
DOI	10.1055/s-0042-108707
Database	Thieme publisher's database

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Article ; Online: Protocol for a randomised trial evaluating a preconception-early childhood telephone-based intervention with tailored e-health resources for women and their partners to optimise growth and development among children in Canada: a Healthy Life Trajectory Initiative (HeLTI Canada).

Dennis, Cindy-Lee / Marini, Flavia / Dick, Jennifer Abbass / Atkinson, Stephanie / Barrett, Jon / Bell, Rhonda / Berard, Anick / Berger, Howard / Brown, Hillary K / Constantin, Evelyn / Da Costa, Deborah / Feller, Andrea / Guttmann, Astrid / Janus, Magdalena / Joseph, K S / Jüni, Peter / Kimmins, Sarah / Letourneau, Nicole / Li, Patricia /

Lye, Stephen / Maguire, Jonathon L / Matthews, Stephen G / Millar, David / Misita, Dragana / Murphy, Kellie / Nuyt, Anne Monique / O'Connor, Deborah L / Parekh, Rulan Savita / Paterson, Andrew / Puts, Martine / Ray, Joel / Roumeliotis, Paul / Scherer, Stephen / Sellen, Daniel / Semenic, Sonia / Shah, Prakesh S / Smith, Graeme N / Stremler, Robyn / Szatmari, Peter / Telnner, Deanna / Thorpe, Kevin / Tremblay, Mark S / Vigod, Simone / Walker, Mark / Birken, Catherine

BMJ open

2021 Volume 11, Issue 2, Page(s) e046311

Abstract: ... controlled trial evaluating a preconception-early childhood telephone-based intervention with tailored e ...

Abstract	Introduction: The 'Developmental Origins of Health and Disease' hypothesis suggests that a healthy trajectory of growth and development in pregnancy and early childhood is necessary for optimal health, development and lifetime well-being. The purpose of this paper is to present the protocol for a randomised controlled trial evaluating a preconception-early childhood telephone-based intervention with tailored e-health resources for women and their partners to optimise growth and development among children in Canada: a Healthy Life Trajectory Initiative (HeLTI Canada). The primary objective of HeLTI Canada is to determine whether a 4-phase 'preconception to early childhood' lifecourse intervention can reduce the rate of child overweight and obesity. Secondary objectives include improved child: (1) growth trajectories; (2) cardiometabolic risk factors; (3) health behaviours, including nutrition, physical activity, sedentary behaviour and sleep; and (4) development and school readiness at age 5 years. Method and analysis: A randomised controlled multicentre trial will be conducted in two of Canada's highly populous provinces-Alberta and Ontario-with 786 nulliparous (15%) and 4444 primiparous (85%) women, their partners and, when possible, the first 'sibling child.' The intervention is telephone-based collaborative care delivered by experienced public health nurses trained in healthy conversation skills that includes detailed risk assessments, individualised structured management plans, scheduled follow-up calls, and access to a web-based app with individualised, evidence-based resources. An 'index child' conceived after randomisation will be followed until age 5 years and assessed for the primary and secondary outcomes. Pregnancy, infancy (age 2 years) and parental outcomes across time will also be assessed. Ethics and dissemination: The study has received approval from Clinical Trials Ontario (CTO 1776). The findings will be published in peer-reviewed journals and disseminated to policymakers at local, national and international agencies. Findings will also be shared with study participants and their communities. Trial registration number: ISRCTN13308752; Pre-results.
MeSH term(s)	Alberta ; Child ; Child, Preschool ; Female ; Growth and Development ; Health Resources ; Humans ; Multicenter Studies as Topic ; Ontario ; Pregnancy ; Randomized Controlled Trials as Topic ; Telephone
Language	English
Publishing date	2021-02-10
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2020-046311
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Article ; Online: Using an e-Health Intervention to Reduce Prolonged Sitting in UK Office Workers: A Randomised Acceptability and Feasibility Study.

Carter, Sophie E / Draijer, Richard / Maxwell, Joseph D / Morris, Abigail S / Pedersen, Scott J / Graves, Lee E F / Thijssen, Dick H J / Hopkins, Nicola D

International journal of environmental research and public health

2020 Volume 17, Issue 23

Abstract: ... of an e-health intervention to reduce prolonged sitting among sedentary UK-based office workers. Secondary ... an e-health intervention. Healthy, university office workers (n = 14) completed this study. An 8 week ... a lack of autonomy and disruption to their workflow when using the e-health intervention, raising ...

Abstract	Low-cost workplace interventions are required to reduce prolonged sitting in office workers as this may improve employees' health and well-being. This study aimed to assess the acceptability and feasibility of an e-health intervention to reduce prolonged sitting among sedentary UK-based office workers. Secondary aims were to describe preliminary changes in employee health, mood and work productivity after using an e-health intervention. Healthy, university office workers (n = 14) completed this study. An 8 week randomised crossover design was used, consisting of two trials: Intervention (computer-based prompts) and Control. Eligibility and retention rates were recorded to assess the feasibility of the trial and interviews were conducted following the intervention to explore its acceptability. Sitting, standing and stepping were objectively assessed prior to and during week 8 of each trial. Before and after each trial, measurements of vascular function, cerebrovascular function, mood and work productivity were obtained. This study had eligibility and retention rates of 54.5% and 77.8%, respectively. Participants expressed a lack of autonomy and disruption to their workflow when using the e-health intervention, raising concerns over its acceptability and long-term implementation. Preliminary data indicate that the intervention may improve the patterning of activity accrued during work hours, with increases in the number of standing and stepping bouts completed, in addition to improving vascular function. This e-health intervention is feasible to deliver in a cohort of university office workers. However, adaptations to its implementation, such as personalised settings, are needed to increase acceptability before larger trials can be conducted.
MeSH term(s)	Feasibility Studies ; Health Promotion ; Humans ; Male ; Occupational Health ; Posture ; Sitting Position ; Telemedicine ; United Kingdom ; Workplace
Language	English
Publishing date	2020-12-01
Publishing country	Switzerland
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ISSN	1660-4601
ISSN (online)	1660-4601
DOI	10.3390/ijerph17238942
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Conference proceedings: Symposium a Tribute to Dr. Frank E. Stinchfield

Stinchfield, Frank E. / Dick, Harold M.

[circa 1994]

1994

Institution	Symposium a Tribute to Dr. Frank E. Stinchfield
Author's details	Harold M. Dick, guest ed
Keywords	Orthopedics / congresses
Language	English
Publishing country	United States
Document type	Book ; Conference proceedings
Note	In: Clinical orthopaedics and related research. - ISSN 0009-921X. - 306 (1994), S. [1] - 109
HBZ-ID	HT006385037
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
Uk I Zs 188 -306-	verfügbar in Königswinter	Königswinter

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Article ; Online: Using an e-Health Intervention to Reduce Prolonged Sitting in UK Office Workers

Sophie E. Carter / Richard Draijer / Joseph D. Maxwell / Abigail S. Morris / Scott J. Pedersen / Lee E. F. Graves / Dick H. J. Thijssen / Nicola D. Hopkins

International Journal of Environmental Research and Public Health, Vol 17, Iss 8942, p

A Randomised Acceptability and Feasibility Study

2020 Volume 8942

Abstract	Low-cost workplace interventions are required to reduce prolonged sitting in office workers as this may improve employees’ health and well-being. This study aimed to assess the acceptability and feasibility of an e-health intervention to reduce prolonged sitting among sedentary UK-based office workers. Secondary aims were to describe preliminary changes in employee health, mood and work productivity after using an e-health intervention. Healthy, university office workers (n = 14) completed this study. An 8 week randomised crossover design was used, consisting of two trials: Intervention (computer-based prompts) and Control. Eligibility and retention rates were recorded to assess the feasibility of the trial and interviews were conducted following the intervention to explore its acceptability. Sitting, standing and stepping were objectively assessed prior to and during week 8 of each trial. Before and after each trial, measurements of vascular function, cerebrovascular function, mood and work productivity were obtained. This study had eligibility and retention rates of 54.5% and 77.8%, respectively. Participants expressed a lack of autonomy and disruption to their workflow when using the e-health intervention, raising concerns over its acceptability and long-term implementation. Preliminary data indicate that the intervention may improve the patterning of activity accrued during work hours, with increases in the number of standing and stepping bouts completed, in addition to improving vascular function. This e-health intervention is feasible to deliver in a cohort of university office workers. However, adaptations to its implementation, such as personalised settings, are needed to increase acceptability before larger trials can be conducted.
Keywords	sedentary behaviour ; workplace ; prompts ; cardiovascular health ; Medicine ; R
Subject code	360 ; 796
Language	English
Publishing date	2020-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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