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Article: A Literature Review of Microscopic Colitis.

Pervez, Ahmed / Siddique, Khurram / Khan, Muhammad Amir Saeed

2024 Volume 16, Issue 1, Page(s) e52862

Abstract: Although the clinical importance of microscopic colitis (MC) is highly increasing, however, the disease is still mysterious due to several challenges. Recent MC data depend mainly on doubts and uncertainties leading to misclassification. This review ... ...

Abstract	Although the clinical importance of microscopic colitis (MC) is highly increasing, however, the disease is still mysterious due to several challenges. Recent MC data depend mainly on doubts and uncertainties leading to misclassification. This review discussed the current knowledge gaps about MC and various controversies regarding its subtypes, pathogenesis, and management. The diagnosis of MC is based mainly on histology and immunohistopathology which can discriminate two subtypes. However, transitional forms are often associated with misclassification. The site and number of the colon biopsies have been agreed upon as at least three from each side of the colon (right and left) with a total of six. There is no credible, clear explanation for the increased incidence. The etiopathogenesis is possibly multifactorial with a high impact on the immunological background. It is proposed that MC would be the initiative of irritable bowel disease, which needs further data clarification. Although budesonide is an effective treatment in most cases, budesonide-refractory MC represents a significant clinical challenge. Therefore, immunomodulators and biologics are now well-thought to be the second-line choice for treatment.
Language	English
Publishing date	2024-01-24
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.52862
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Examination of factors associated with the temporal stability assessment of crash severity by using generalised linear model-A case study.

Alshehri, Abdulaziz H / Pervez, Amjad / Hussain, Muhammad / Farooq, Danish / Hussain, Etikaf

PloS one

2024 Volume 19, Issue 4, Page(s) e0299094

Abstract: Road crashes are a major public safety concern in Pakistan. Prior studies in Pakistan investigated the impact of different factors on road crashes but did not consider the temporal stability of crash data. This means that the recommendations based on ... ...

Abstract	Road crashes are a major public safety concern in Pakistan. Prior studies in Pakistan investigated the impact of different factors on road crashes but did not consider the temporal stability of crash data. This means that the recommendations based on these studies are not fully effective, as the impact of certain factors may change over time. To address this gap in the literature, this study aims to identify the factors contributing to crash severity in road crashes and examine how their impact varies over time. In this comprehensive study, we utilized Generalised Linear Model (GLM) on the crash data between the years 2013 to 2017, encompassing a total sample of 802 road crashes occurred on the N-5 road section in Pakistan, a 429-kilometer stretch connecting two big cities of Pakistan, i.e., Peshawar and Lahore. The purpose of the GLM was to quantify the temporal stability of the factors contributing crash severity in each year from 2013 to 2017. Within this dataset, 60% (n = 471) were fatal crashes, while the remaining 40% (n = 321) were non-fatal. The results revealed that the factors including the day of the week, the location of the crashes, weather conditions, causes of the crashes, and the types of vehicles involved, exhibited the temporal instability over time. In summary, our study provides in-depth insights aimed at reducing crash severity and potentially aiding in the development of effective crash mitigation policies in Pakistan and other nations having similar road safety problems. This research holds great promise in exploring the dynamic safety implications of emerging transportation technologies, particularly in the context of the widespread adoption of connected and autonomous vehicles.
MeSH term(s)	Humans ; Accidents, Traffic ; Linear Models ; Transportation ; Risk Factors ; Autonomous Vehicles ; Wounds and Injuries
Language	English
Publishing date	2024-04-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0299094
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Article: Improved Diagnostic Confidence Imparted by Radiologists in Radiology Reports After Educational Interventions on Reporting Styles.

Zafar, Uffan / Ahmad, Muhammad Nadeem / Nadeem, Naila / Muhammad Zohaib Uddin, Mallick / Khan, Noman / Alam, Muhammad Masood / Hafeez, Anam / Pervez, Hafsa / Zafar, Fariha

Cureus

2024 Volume 16, Issue 2, Page(s) e53926

Abstract: Background Radiology reports are important medico-legal documents facilitating communication between radiologists and referring doctors. Language clarity and precision are crucial for effective communication in these reports. Radiology reporting has ... ...

Abstract	Background Radiology reports are important medico-legal documents facilitating communication between radiologists and referring doctors. Language clarity and precision are crucial for effective communication in these reports. Radiology reporting has changed with the evolution of imaging technology, prompting the adoption of precise terminology. Diagnostic certainty phrases (DCPs) play an important role in communicating diagnostic confidence in radiology reports. Objective The aim of this study was to evaluate the use of DCPs in radiology reports, before and after targeted educational interventions. Materials and methods The study was approved by the Aga Khan University Hospital's Ethical Review Committee and includes cross-sectional radiology reports. It involved three cycles of retrospective evaluation, with educational interventions in between to improve the use of DCPs. Results The study found a dynamic shift in the use of DCPs during the three cycles. Initially, intermediate-certainty phrases prevailed, followed by an increase in high-certainty phrases and a drop in low-certainty phrases. Later cycles showed a significant decline in DCPs and an increase in the use of definitive language. Across all subspecialties, there was a consistent decrease in intermediate- and low-certainty DCPs. Conclusion The study validates the transformative impact of educational interventions on the use of DCPs in radiology reports. The radiology reports frequently used DCPs with intermediate to low diagnostic certainty with improvement in the subsequent cycles of the study after educational interventions. It emphasizes the significance of continuing education to ensure the use of precise nomenclature.
Language	English
Publishing date	2024-02-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.53926
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Article ; Online: Capacitive and Diffusive Contributions in Supercapacitors and Batteries: A Critique of b-Value and the ν-ν

Pervez, Sheharyar / Iqbal, Muhammad Zahir

Small (Weinheim an der Bergstrasse, Germany)

2023 Volume 19, Issue 48, Page(s) e2305059

Abstract: Electrochemical energy storage devices run on two fundamentally different processes: charge storage across the double layer and redox reactions. A satisfactory understanding of the underlying mechanism is only possible once the two contributions are ... ...

Abstract	Electrochemical energy storage devices run on two fundamentally different processes: charge storage across the double layer and redox reactions. A satisfactory understanding of the underlying mechanism is only possible once the two contributions are deconvoluted. The b-value and the ν -ν
Language	English
Publishing date	2023-07-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2168935-0
ISSN	1613-6829 ; 1613-6810
ISSN (online)	1613-6829
ISSN	1613-6810
DOI	10.1002/smll.202305059
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Article: Global geographic and gender disparities in stem cell-related surgical research: bibliometric review of the top 200 most-cited articles.

Martins, Russell Seth / Nasir, Aqsa Muhammad / Charolia, Zobiyah Sajid / Pervez, Alina / Mahmud, Omar / Jehanzeb, Hamzah

JPMA. The Journal of the Pakistan Medical Association

2023 Volume 73Suppl 1, Issue 2, Page(s) S105–S110

Abstract: Objectives: The study aimed to identify geographic and gender disparities in the quality, academic impact, and media attention of the top-cited articles related to stem cell-related surgical research.: Methods: The following data was extracted for ... ...

Abstract	Objectives: The study aimed to identify geographic and gender disparities in the quality, academic impact, and media attention of the top-cited articles related to stem cell-related surgical research. Methods: The following data was extracted for the top 200 most-cited articles (2011-2021): article- (including citation metrics and country of publication), journal- (including impact factor), and author-level (including corresponding author gender) variables. Article Altmetric Attention Score (AAS), a measure of mass mainstream and social media attention, was also recorded. Results: Most articles originated from high-income countries (HICs: 175 [87.5%]), with only 7 (3.5%) from lower-middle-income countries. Articles from non-HIC were published in journals with significantly lower impact factors (6.66 [3.75-9.46] vs. 23.2 [7.3-32.5]; p < 0.001) and AAS (7 [3-14.5] vs. 30 [11-83]; p < 0.001). Only 44 (22%) of articles were authored by a female corresponding author, with these having significantly fewer citations than those authored by a male (289 [250-400] vs. 331.5 [267.25-451.25]; p=0.031). Conclusions: Even amongst the top-cited literature, our results demonstrate worrying disparities in the geographic origins of stem cell-related surgical research. The vast majority originates from HICs, with these articles being published in better journals and receiving greater media attention. We also identified significant gender disparities, with female representation being concerningly low and female-authored articles receiving significantly fewer citations.
MeSH term(s)	Female ; Humans ; Male ; Bibliometrics ; Journal Impact Factor ; Social Media ; Stem Cells
Language	English
Publishing date	2023-02-12
Publishing country	Pakistan
Document type	Journal Article ; Review
ZDB-ID	603873-6
ISSN	0030-9982
ISSN	0030-9982
DOI	10.47391/JPMA.AKUS-17
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Article: Identification, Genome Sequencing, and Characterizations of

Fatima, Anees / Ibrahim, Muhammad / Naseer, Adil / Pervez, Arshid / Asad, Muhammad / Shah, Aamer Ali / Hasan, Fariha / Alonazi, Wadi B / Ferheen, Ifra / Khan, Samiullah

Microorganisms

2023 Volume 11, Issue 11

Abstract: The stomach's colonization ... ...

Abstract	The stomach's colonization by
Language	English
Publishing date	2023-10-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms11112658
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Article ; Online: Association Between All-Cause Mortality and High-Sensitivity Cardiac Troponin Concentrations in Patients With Chest Pain.

Annie, Frank H / Kepfinger, Joshua / Ahmed, Fatima / Pervez, Muhammad Ijaz / Elashery, Ahmad

Angiology

2023 , Page(s) 33197231191433

Abstract: We assessed the association between troponin levels and all-cause mortality in individuals with chest pain who presented to the Charleston Area Medical Center Emergency Department (CAMC). We identified adult patients with chest pain as defined in the ... ...

Abstract	We assessed the association between troponin levels and all-cause mortality in individuals with chest pain who presented to the Charleston Area Medical Center Emergency Department (CAMC). We identified adult patients with chest pain as defined in the International Classification of Diseases 10 (R07) family group from the CAMC data warehouse between June 6, 2020, and June 6, 2021. These cases required a visit to the emergency room. We created 3 different cohorts to assess the endpoints of all-cause mortality at 30 days and 6 months. Patients were divided into the following 3 categories: negative troponin level, defined as high sensitivity troponin I (HSTNI) assay ≤15 pg/mL for women and ≤20 pg/mL for men; weakly positive, 21-88 pg/mL for men and 16-88 pg/mL for women; and strongly positive, >88 pg/mL for men and women. A propensity score matching analysis was also conducted using the negative group as a control; the weakly and strongly positive groups were compared to the control across differing cardiology covariates. This study introduces novel cutoffs for high-sensitivity troponin I (Beckman Coulter assay, Beckman Coulter, Inc., Chaska Campus, 1000 Lake Hazeltine Drive, Chaska, Minnesota 55318).
Language	English
Publishing date	2023-07-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	80040-5
ISSN	1940-1574 ; 0003-3197
ISSN (online)	1940-1574
ISSN	0003-3197
DOI	10.1177/00033197231191433
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Article: Complete versus Subtotal Resection of Paediatric Craniopharyngioma.

Pervez, Wardah / Bakhshi, Saqib Kamran / A Mirza, Farhan / Shamim, Muhammad Shahzad

JPMA. The Journal of the Pakistan Medical Association

2021 Volume 71, Issue 2(A), Page(s) 564–566

Abstract: Optimal management of craniopharyngioma is challenging and requires multidisciplinary efforts for a successful outcome. The debate over radical versus a conservative resection followed by radiotherapy, continues. Current literature reports no difference ... ...

Abstract	Optimal management of craniopharyngioma is challenging and requires multidisciplinary efforts for a successful outcome. The debate over radical versus a conservative resection followed by radiotherapy, continues. Current literature reports no difference in disease freedom and overall survival between the two surgical viewpoints, and favours conservative resection and radiotherapy, leading to lower morbidity and superior functional outcomes.
MeSH term(s)	Child ; Craniopharyngioma/surgery ; Humans ; Pituitary Neoplasms/surgery ; Treatment Outcome
Language	English
Publishing date	2021-04-05
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	603873-6
ISSN	0030-9982
ISSN	0030-9982
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Article ; Online: Safety outcomes of anti-platelet therapy post coronary artery bypass graft surgery: A systematic review and network meta-analysis of randomized control trials.

Hasan, Syed U / Pervez, Alina / Shah, Arshad A / Shah, Syed DA / Aslam, Muhammad / Arshad, Anosha / Rajput, Amna S / Zubair, M Mujeeb

Perfusion

2023 , Page(s) 2676591231159513

Abstract: Background: Antiplatelet therapy is used to decrease the risk of graft failure post coronary artery bypass graft surgery. We aimed to compare dual antiplatelet therapy (DAPT) with monotherapy along with a comparison of Aspirin, Ticagrelor, Aspirin+ ... ...

Abstract	Background: Antiplatelet therapy is used to decrease the risk of graft failure post coronary artery bypass graft surgery. We aimed to compare dual antiplatelet therapy (DAPT) with monotherapy along with a comparison of Aspirin, Ticagrelor, Aspirin+Ticagrelor (A+T) and Aspirin+Clopidogrel (A+C) to determine the major and minor bleeding risk, risk of postoperative myocardial infarction (MI), stroke, and all-cause mortality (ACM). Methods: Randomized Controlled Trials comparing the four groups were included. Odds ratio (OR) and Absolute Risk (AR) were employed to assess the mean and standard deviation (SD) with 95% confidence intervals (CI). The Bayesian random-effects model was used for statistical analysis. Risk difference and Cochran Q tests were used to calculate rank probability (RP) and heterogeneity, respectively. Results: We included 10 trials, consisting of 21 arms and 3926 patients. For the risk of major and minor bleed, A + T and Ticagrelor showed the lowest mean value of 0.040 (0.043) and 0.067 (0.073), respectively, and the highest RP of being the safest group. While a direct comparison between DAPT and monotherapy resulted in an OR of 0.57 [0.34, 0.95] for the risk of minor bleed. A + T was found to have the highest RP and the lowest mean value in terms of ACM, MI, and stroke. Conclusion: No significant difference was found between monotherapy or dual-antiplatelet therapy for the major bleeding risk safety outcome, however DAPT was found to have a significantly higher rate of minor bleeding complications post-CABG. DAPT should be considered as the antiplatelet modality of choice post-CABG.
Language	English
Publishing date	2023-02-20
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	645038-6
ISSN	1477-111X ; 0267-6591
ISSN (online)	1477-111X
ISSN	0267-6591
DOI	10.1177/02676591231159513
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Termination of seizures in the paediatric age group, best benzodiazepine and route of administration: A network meta-analysis.

Hasan, Syed Umar / Pervez, Alina / Bhatty, Shaheen / Shamim, Shifa / Naeem, Aaima / Naseeb, Muhammad Wahdan

The European journal of neuroscience

2022 Volume 56, Issue 3, Page(s) 4234–4245

Abstract: This network meta-analysis aims to compare various benzodiazepines and their route of administration using the data published exclusively in randomized controlled trials (RCTs). Two thousand two hundred sixty-three children presenting with an episode of ... ...

Abstract	This network meta-analysis aims to compare various benzodiazepines and their route of administration using the data published exclusively in randomized controlled trials (RCTs). Two thousand two hundred sixty-three children presenting with an episode of seizure to ER or to a paramedic where they were administered a benzodiazepine as the first-line treatment were included. All the outcomes were measured for their mean with 95% CI and rank probability. The primary outcome was the number of successful seizure cessation. Secondary outcomes were the time interval between drug administration and seizure cessation, the time interval between patient arrival and seizure cessation and the number of episodes of seizure recurrence after drug administration. For the number of successful cessations, intramuscular midazolam showed the highest mean and best rank probability with a value of .881 (.065) and 57.9%, respectively. For the time of cessation, both intravenous lorazepam (IVL) and intravenous diazepam showed a mean of 3.30 (1.30) with IVL having the highest rank probability of 32%. For total time for cessation, intranasal midazolam showed the best mean and rank probability with a value of 4.3 (1.1) and 55%, respectively. Buccal midazolam showed the lowest mean with a value of .106 (.084) for rate of recurrence. Although there was no significant difference between the treatments, but based on the rank probability, IVL shows more promising results for patients who already have an established intravenous line, and for patients presenting in the ER without an intravenous line, the first line of treatment should be INM as it shows the highest rank probability in total time with second-highest successful cessation rate.
MeSH term(s)	Anticonvulsants/therapeutic use ; Benzodiazepines/therapeutic use ; Child ; Diazepam/therapeutic use ; Humans ; Lorazepam ; Midazolam/therapeutic use ; Network Meta-Analysis ; Seizures/drug therapy ; Status Epilepticus
Chemical Substances	Anticonvulsants ; Benzodiazepines (12794-10-4) ; Lorazepam (O26FZP769L) ; Diazepam (Q3JTX2Q7TU) ; Midazolam (R60L0SM5BC)
Language	English
Publishing date	2022-06-17
Publishing country	France
Document type	Journal Article ; Meta-Analysis ; Review
ZDB-ID	645180-9
ISSN	1460-9568 ; 0953-816X
ISSN (online)	1460-9568
ISSN	0953-816X
DOI	10.1111/ejn.15732
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