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  1. Article ; Online: Operative Management of Vocal Fold Avulsion Following Pediatric Laryngotracheal Separation.

    Chang, Michael T / Schoppy, David W / Schoppy, Krista K / Sidell, Douglas R

    Ear, nose, & throat journal

    2019  Volume 100, Issue 4, Page(s) NP185–NP188

    Abstract: Laryngotracheal disruption in children is rare but life-threatening, and endolaryngeal injuries may go overlooked. We present the case of a 10-year-old boy who sustained near-complete laryngotracheal separation, multiple laryngeal fractures, and ... ...

    Abstract Laryngotracheal disruption in children is rare but life-threatening, and endolaryngeal injuries may go overlooked. We present the case of a 10-year-old boy who sustained near-complete laryngotracheal separation, multiple laryngeal fractures, and arytenoid and vocal fold avulsion following blunt cervical trauma. These injuries were not identified radiographically and only became apparent intraoperatively. Following surgical repair, the patient was successfully decannulated, eating a normal diet, and had a serviceable speaking voice within 2 months. In children, the diagnosis of severe endolaryngeal injuries may be elusive and therefore require high degree of clinical suspicion. Surgical success requires accurate diagnosis and prompt intervention.
    MeSH term(s) Child ; Humans ; Laryngeal Nerve Injuries/complications ; Laryngeal Nerve Injuries/surgery ; Laryngoscopy/methods ; Larynx/injuries ; Larynx/surgery ; Male ; Medical Illustration ; Neck Injuries/complications ; Neck Injuries/surgery ; Reconstructive Surgical Procedures ; Trachea/injuries ; Trachea/surgery ; Treatment Outcome ; Vocal Cords/injuries ; Vocal Cords/surgery ; Wounds, Nonpenetrating/complications ; Wounds, Nonpenetrating/surgery
    Language English
    Publishing date 2019-09-26
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 750153-5
    ISSN 1942-7522 ; 0145-5613
    ISSN (online) 1942-7522
    ISSN 0145-5613
    DOI 10.1177/0145561319866821
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  2. Article ; Online: Standardized Margin Assessment Is Needed Before Implementing Negative Margin as a Quality Measure-Reply.

    Schoppy, David W / Divi, Vasu

    JAMA otolaryngology-- head & neck surgery

    2018  Volume 144, Issue 6, Page(s) 542

    MeSH term(s) Humans ; Margins of Excision ; Neck Dissection ; Neoplasm Recurrence, Local
    Language English
    Publishing date 2018-03-28
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2701825-8
    ISSN 2168-619X ; 2168-6181
    ISSN (online) 2168-619X
    ISSN 2168-6181
    DOI 10.1001/jamaoto.2018.0080
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  3. Article ; Online: Immunotherapy for Head and Neck Squamous Cell Carcinoma.

    Schoppy, David W / Sunwoo, John B

    Hematology/oncology clinics of North America

    2015  Volume 29, Issue 6, Page(s) 1033–1043

    Abstract: Although head and neck squamous cell carcinoma has traditionally been considered to be a very immunosuppressive, or at least nonimmunogenic, tumor type, recent results from clinical studies of immune checkpoint blockade strategies have led to resurgence ... ...

    Abstract Although head and neck squamous cell carcinoma has traditionally been considered to be a very immunosuppressive, or at least nonimmunogenic, tumor type, recent results from clinical studies of immune checkpoint blockade strategies have led to resurgence in the enthusiasm for immunotherapeutic approaches. Additional strategies for immunotherapy that are under active investigation include enhancement of cetuximab-mediated antibody-dependent cell-mediated cytotoxicity, tumor vaccines, and engineered T cells for adoptive therapy. All of these studies have early-phase clinical trials under way, and the next several years will be exciting as the results of these studies are reported.
    MeSH term(s) Animals ; Antibodies, Monoclonal/pharmacology ; Antibodies, Monoclonal/therapeutic use ; Antibody-Dependent Cell Cytotoxicity/immunology ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Cancer Vaccines/therapeutic use ; Carcinoma, Squamous Cell/immunology ; Carcinoma, Squamous Cell/metabolism ; Carcinoma, Squamous Cell/therapy ; Cell- and Tissue-Based Therapy/methods ; Cetuximab/therapeutic use ; Head and Neck Neoplasms/immunology ; Head and Neck Neoplasms/metabolism ; Head and Neck Neoplasms/therapy ; Humans ; Immune System/drug effects ; Immune System/immunology ; Immune System/metabolism ; Immunotherapy/methods ; Molecular Targeted Therapy ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell/metabolism ; Recombinant Fusion Proteins ; Squamous Cell Carcinoma of Head and Neck ; T-Lymphocyte Subsets/drug effects ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism
    Chemical Substances Antibodies, Monoclonal ; Antineoplastic Agents ; Cancer Vaccines ; Receptors, Antigen, T-Cell ; Recombinant Fusion Proteins ; Cetuximab (PQX0D8J21J)
    Language English
    Publishing date 2015-10-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 93115-9
    ISSN 1558-1977 ; 0889-8588
    ISSN (online) 1558-1977
    ISSN 0889-8588
    DOI 10.1016/j.hoc.2015.07.009
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  4. Article ; Online: Management of the neck in thyroid cancer.

    Schoppy, David W / Holsinger, F Christopher

    Otolaryngologic clinics of North America

    2014  Volume 47, Issue 4, Page(s) 545–556

    Abstract: The management of regional lymph nodes in thyroid carcinoma is guided by preoperative evaluation, histologic subtype, and often a consideration of data for potential benefit and morbidity of a neck dissection. The goal of lymphadenectomy is complete ... ...

    Abstract The management of regional lymph nodes in thyroid carcinoma is guided by preoperative evaluation, histologic subtype, and often a consideration of data for potential benefit and morbidity of a neck dissection. The goal of lymphadenectomy is complete surgical resection of grossly evident metastatic disease and the removal of regional lymph node groups at highest risk for microscopic disease. Surgery should achieve disease eradication but preserve voice, airway, swallowing, and parathyroid function. This article discusses recommendations for addressing cervical lymph nodes in thyroid carcinoma, discusses current literature regarding the common histologic subtype (papillary carcinoma), and details our operative approach.
    MeSH term(s) Adenocarcinoma, Follicular/pathology ; Adenocarcinoma, Follicular/surgery ; Carcinoma/pathology ; Carcinoma/surgery ; Carcinoma, Papillary ; Carotid Artery Injuries/etiology ; Chyle ; Humans ; Hypocalcemia/etiology ; Hypocalcemia/therapy ; Hypoparathyroidism/etiology ; Hypoparathyroidism/therapy ; Lymph Node Excision/methods ; Lymphatic Metastasis ; Neck Dissection/adverse effects ; Neck Dissection/methods ; Postoperative Care ; Postoperative Complications/therapy ; Thyroid Cancer, Papillary ; Thyroid Neoplasms/pathology ; Thyroid Neoplasms/surgery
    Language English
    Publishing date 2014-07-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 417489-6
    ISSN 1557-8259 ; 0030-6665
    ISSN (online) 1557-8259
    ISSN 0030-6665
    DOI 10.1016/j.otc.2014.04.004
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  5. Article ; Online: Chk'ing p53-deficient breast cancers.

    Schoppy, David W / Brown, Eric J

    The Journal of clinical investigation

    2012  Volume 122, Issue 4, Page(s) 1202–1205

    Abstract: Loss or functional impairment of p53 occurs in many human cancers, and its absence is often associated with a poor response to conventional chemotherapy. Hence, much effort is currently devoted to developing novel treatments for p53-deficient ... ...

    Abstract Loss or functional impairment of p53 occurs in many human cancers, and its absence is often associated with a poor response to conventional chemotherapy. Hence, much effort is currently devoted to developing novel treatments for p53-deficient malignancies. One approach is to target pathways that are selectively required for the survival of p53-deficient cancer cells, thus exploiting a synthetic lethal interaction. Previous studies have demonstrated that inhibition of the ataxia telangiectasia and Rad3-related (ATR) and checkpoint kinase 1 (Chk1) pathway in p53-deficient cells can induce such a synthetic lethal outcome. In this issue of the JCI, Ma et al. take these findings a step closer to the clinic by demonstrating that highly specific inhibitors of Chk1 synergize with chemotherapy to stem progression of p53-deficient triple-negative breast cancers in a xenotransplant model of this disease. Together with other recent studies, this report highlights the promise of ATR and Chk1 inhibitors in targeted cancer treatment.
    MeSH term(s) Animals ; Antineoplastic Agents/therapeutic use ; Breast Neoplasms/drug therapy ; Checkpoint Kinase 1 ; Female ; Humans ; Molecular Targeted Therapy ; Neoplasm Proteins/antagonists & inhibitors ; Protein Kinase Inhibitors/therapeutic use ; Protein Kinases/drug effects ; Staurosporine/analogs & derivatives ; Staurosporine/therapeutic use ; Thiophenes/therapeutic use ; Tumor Suppressor Protein p53/deficiency ; Urea/analogs & derivatives ; Urea/therapeutic use
    Chemical Substances 3-(carbamoylamino)-5-(3-fluorophenyl)-N-(3-piperidyl)thiophene-2-carboxamide ; Antineoplastic Agents ; Neoplasm Proteins ; Protein Kinase Inhibitors ; TP53 protein, human ; Thiophenes ; Tumor Suppressor Protein p53 ; 7-hydroxystaurosporine (7BU5H4V94A) ; Urea (8W8T17847W) ; Protein Kinases (EC 2.7.-) ; CHEK1 protein, human (EC 2.7.11.1) ; Checkpoint Kinase 1 (EC 2.7.11.1) ; Staurosporine (H88EPA0A3N)
    Language English
    Publishing date 2012-03-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI63205
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  6. Article ; Online: Contemporary mandibular reconstruction.

    Divi, Vasu / Schoppy, David W / Williams, Ryan A / Sirjani, Davud B

    Current opinion in otolaryngology & head and neck surgery

    2016  Volume 24, Issue 5, Page(s) 433–439

    Abstract: Purpose of review: Multiple disease processes, including neoplasia, trauma, and medication side-effects, necessitate segmental resection and subsequent reconstruction of the mandible. As surgical techniques have advanced, several technologies have been ... ...

    Abstract Purpose of review: Multiple disease processes, including neoplasia, trauma, and medication side-effects, necessitate segmental resection and subsequent reconstruction of the mandible. As surgical techniques have advanced, several technologies have been developed with the potential to significantly transform a surgeon's approach to the restoration of mandibular continuity. The purpose of this review is to highlight many of these relatively newer tools and discuss their evolving role in mandibular reconstruction.
    Recent findings: Several contemporary studies have documented the application of different approaches and modifications to mandibular reconstruction - including computer-aided design or computer-aided modeling, contemporary plating systems, osseointegrated implants, and various modifications to existing osseocutaneous free tissue transfer options - and have reported relatively high success rates.
    Summary: In discussing these reports, we present a survey of current and developing technologies in the field of mandibular reconstruction and aim to provide sufficient context for the gradual integration of these techniques into practice.
    Language English
    Publishing date 2016-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1232518-1
    ISSN 1531-6998 ; 1068-9508
    ISSN (online) 1531-6998
    ISSN 1068-9508
    DOI 10.1097/MOO.0000000000000284
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  7. Article ; Online: Induction of

    Small, Sara H / Tang, E Jessica / Ragland, Ryan L / Ruzankina, Yaroslava / Schoppy, David W / Mandal, Rahul S / Glineburg, M Rebecca / Ustelenca, Zgjim / Powell, Daniel J / Simpkins, Fiona / Johnson, F Bradley / Brown, Eric J

    Science signaling

    2021  Volume 14, Issue 714, Page(s) eaba2611

    Abstract: Cytokine production is a critical component of cell-extrinsic responses to DNA damage and cellular senescence. Here, we demonstrated that expression of the gene encoding interleukin-19 (IL-19) was enhanced by DNA damage through pathways mediated by c-Jun ...

    Abstract Cytokine production is a critical component of cell-extrinsic responses to DNA damage and cellular senescence. Here, we demonstrated that expression of the gene encoding interleukin-19 (IL-19) was enhanced by DNA damage through pathways mediated by c-Jun amino-terminal kinase (JNK) and cGAS-STING and that
    MeSH term(s) Animals ; Cytokines/genetics ; DNA Damage ; Interleukins/metabolism ; MAP Kinase Signaling System ; Membrane Proteins/genetics ; Mice ; Nucleotidyltransferases/genetics ; Nucleotidyltransferases/metabolism ; Signal Transduction
    Chemical Substances Cytokines ; Il19 protein, mouse ; Interleukins ; Membrane Proteins ; Sting1 protein, mouse ; Nucleotidyltransferases (EC 2.7.7.-)
    Language English
    Publishing date 2021-12-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2417226-1
    ISSN 1937-9145 ; 1945-0877
    ISSN (online) 1937-9145
    ISSN 1945-0877
    DOI 10.1126/scisignal.aba2611
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  8. Article ; Online: Assessing the Impact of Targeting CEACAM1 in Head and Neck Squamous Cell Carcinoma.

    Tam, Kenric / Schoppy, David W / Shin, June Ho / Tay, Joshua K / Moreno-Nieves, Uriel / Mundy, David C / Sunwoo, John B

    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

    2018  Volume 159, Issue 1, Page(s) 76–84

    Abstract: Objective In conjunction with advances made in cytotoxic chemotherapy, radiation, and surgery, immunotherapy has emerged as a fourth modality of treatment for head and neck squamous cell carcinoma (HNSCC). Understanding the mechanisms by which HNSCC ... ...

    Abstract Objective In conjunction with advances made in cytotoxic chemotherapy, radiation, and surgery, immunotherapy has emerged as a fourth modality of treatment for head and neck squamous cell carcinoma (HNSCC). Understanding the mechanisms by which HNSCC evades immune-mediated control will aid in the development of new therapies to augment an antitumor immune response. Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a cell surface receptor that is expressed on malignant cells and lymphocytes such as natural killer (NK) cells. We sought to determine whether tumor-derived CEACAM1 inhibits NK cell cytotoxicity and whether blockade of CEACAM1 restores antitumor immunity. Study Design In vitro HNSCC cell line study. Setting Research laboratory. Subject and Methods We utilized a real-time cell analyzer to assess NK cell cytotoxicity against an oral squamous cell carcinoma cell line after modulating CEACAM1 expression by cytokines and shRNA knockdown of CEACAM1 expression. Results NK cells and HNSCC cells both demonstrated cytokine-inducible expression of CEACAM1. Coincubation of NK cells and HNSCC cells resulted in the upregulation of CEACAM1 on the tumor cells. When compared with CEACAM1
    MeSH term(s) Antigens, CD/physiology ; Cell Adhesion Molecules/physiology ; Cells, Cultured ; Humans ; Immunotherapy/methods ; Killer Cells, Natural/physiology ; Molecular Targeted Therapy ; Squamous Cell Carcinoma of Head and Neck/immunology ; Squamous Cell Carcinoma of Head and Neck/therapy
    Chemical Substances Antigens, CD ; CD66 antigens ; Cell Adhesion Molecules
    Language English
    Publishing date 2018-02-13
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 392085-9
    ISSN 1097-6817 ; 0161-6439 ; 0194-5998
    ISSN (online) 1097-6817
    ISSN 0161-6439 ; 0194-5998
    DOI 10.1177/0194599818756627
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  9. Article ; Online: Predictors of Mortality in HPV-Associated Oropharynx Carcinoma Treated With Surgery Alone.

    Han, Mary / Stanford-Moore, Gaelen B / Larson, Andrew R / Schoppy, David W / Cognetti, David M / Joshi, Arjun S / Houlton, Jeffery J / Ryan, William R

    The Laryngoscope

    2019  Volume 130, Issue 7, Page(s) E423–E435

    Abstract: Objective: Survival outcomes for human papillomavirus-associated oropharynx squamous cell carcinoma (HPV + OPSCC) treated with surgery alone are unclear. To increase understanding, we assessed overall survival (OS) outcomes using the national cancer ... ...

    Abstract Objective: Survival outcomes for human papillomavirus-associated oropharynx squamous cell carcinoma (HPV + OPSCC) treated with surgery alone are unclear. To increase understanding, we assessed overall survival (OS) outcomes using the national cancer database (NCDB).
    Methods: We conducted a retrospective analysis of OS of 736 NCDB HPV + OPSCC patients who underwent surgery alone from 2010 to 2014 using univariate and multivariate analyses and the Kaplan-Meir method.
    Results: Multivariable analysis found the following independent risk factors for death: American Joint Commission on Cancer (AJCC) 8th edition pathologic stage(p)N2 versus pN0 disease (hazard ratio [HR], 5.5; P = 0.000006), macroscopic extranodal extension (ENE) versus non-ENE (HR, 4.9; P < 0.02), a positive lymph nodes (LN) percentage of ≥10% (HR, 4.2; P = 0.0002), and five or more positive LNs (HR, 4.9; P = 0.00004). Three-year OS was significantly worse for AJCC 8th edition pN2 versus pN0 but not for 7th edition pN2 versus pN0 disease. Five-year OS was significantly worse for positive versus negative surgical margins, AJCC 8th edition stage II versus I, and either microscopic or macroscopic ENE versus non-ENE positive LNs. For 523 (71%) AJCC 8th edition stage I patients and for 283 (38%) patients who were pT1-T2, with negative margins, pN0-N1, with ≤4 pathologic LNs, without ENE, and with >20 LNs removed during neck dissection, the 3-year OS rates were 93% and 95%, respectively, and the 5-year OS rates were 91% and 95%, respectively.
    Conclusion: In the context of the lack of detail and possible inaccuracies found in the NCDB, surgery alone for AJCC 8th edition stage I HPV + OPSCC, particularly pT1-T2, pN0-N1 with ≤4 pathologic LNs, without ENE, and with negative surgical margins has a high OS.
    Level of evidence: 4 Laryngoscope, 130:E423-E435, 2020.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Carcinoma, Squamous Cell/mortality ; Carcinoma, Squamous Cell/surgery ; Carcinoma, Squamous Cell/virology ; Female ; Humans ; Male ; Middle Aged ; Multivariate Analysis ; Neck Dissection/mortality ; Neoplasm Staging ; Oropharyngeal Neoplasms/mortality ; Oropharyngeal Neoplasms/surgery ; Oropharyngeal Neoplasms/virology ; Oropharynx/pathology ; Papillomaviridae ; Papillomavirus Infections/complications ; Papillomavirus Infections/mortality ; Papillomavirus Infections/virology ; Prognosis ; Proportional Hazards Models ; Retrospective Studies ; Survival Rate ; Treatment Outcome ; Young Adult
    Language English
    Publishing date 2019-11-01
    Publishing country United States
    Document type Evaluation Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.28344
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  10. Article ; Online: Transoral endoscopic head and neck surgery (eHNS) for minor salivary gland tumors of the oropharynx.

    Schoppy, David W / Kupferman, Michael E / Hessel, Amy C / Bell, Diana M / Garland, Elizabeth M / Damrose, Edward J / Holsinger, F Christopher

    Cancers of the head & neck

    2017  Volume 2, Page(s) 5

    Abstract: Background: Transoral endoscopic head and neck surgery (eHNS), including transoral laser microsurgery (TLM) and transoral robotic surgery (TORS), provides access to subsites in the head and neck that have traditionally been difficult to approach. Minor ... ...

    Abstract Background: Transoral endoscopic head and neck surgery (eHNS), including transoral laser microsurgery (TLM) and transoral robotic surgery (TORS), provides access to subsites in the head and neck that have traditionally been difficult to approach. Minor salivary gland tumors, while relatively uncommon, are frequently malignant and can occur at sites in the oropharynx accessible by transoral eHNS. Presented here is the largest review to date of patients with minor salivary gland tumors of the oropharynx managed with transoral eHNS as primary or salvage therapy.
    Methods: A retrospective chart review was performed, including data from 20 patients with minor salivary gland tumors of the oropharynx managed with transoral eHNS at 2 tertiary, academic medical centers. Details of tumor pathology, margin analysis, adjuvant therapy, and an assessment of oncologic outcome were included.
    Results: The base of tongue was the most common tumor site (75%). Adenoid cystic carcinoma (ACC) accounted for most cases (35%), and negative margins were obtained in most (95%) through an endoscopic-only approach. Overall, 50% of patients received post-operative radiation therapy. Postoperative complications were limited, with one patient (5%) returning to the OR for control of post-operative oropharyngeal bleeding. On average follow-up of 36 months, 90% of patients were alive with no evidence of recurrence.
    Conclusion: In this experience, transoral eHNS provided a safe and consistent surgical approach to management of minor salivary gland malignancies, with low complication rates and good locoregional control. Thus, transoral eHNS may play a valuable role in the multi-disciplinary management of these malignancies.
    Trial registration number: None/not applicable.
    Language English
    Publishing date 2017-05-31
    Publishing country England
    Document type Journal Article
    ISSN 2059-7347
    ISSN (online) 2059-7347
    DOI 10.1186/s41199-017-0024-2
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