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Book ; Online: Remote Sensing of Environmental Changes in Cold Regions

Du, Jinyang / Watts, Jennifer D. / Lu, Hui / Jiang, Lingmei / Tarolli, Paolo

2019

Abstract: This Special Issue gathers papers reporting recent advances in the remote sensing of cold regions. It includes contributions presenting improvements in modeling microwave emissions from snow, assessment of satellite-based sea ice concentration products, ... ...

Abstract	This Special Issue gathers papers reporting recent advances in the remote sensing of cold regions. It includes contributions presenting improvements in modeling microwave emissions from snow, assessment of satellite-based sea ice concentration products, satellite monitoring of ice jam and glacier lake outburst floods, satellite mapping of snow depth and soil freeze/thaw states, near-nadir interferometric imaging of surface water bodies, and remote sensing-based assessment of high arctic lake environment and vegetation recovery from wildfire disturbances in Alaska. A comprehensive review is presented to summarize the achievements, challenges, and opportunities of cold land remote sensing
Keywords	Science (General)
Size	1 electronic resource (210 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Document type	Book ; Online
Note	eng ; Open Access
HBZ-ID	HT020324082
ISBN	9783039215706 ; 9783039215713 ; 3039215701 ; 303921571X
DOI	10.3390/books978-3-03921-571-3
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Hospital-Based Medical-Legal Partnerships for Complex Care Patients: Intersectionality and Ethics Considerations.

Garg, Megha / Oliva, Jennifer / Lu, Alice / Martin, Marlene / Hooper, Sarah

The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics

2024 Volume 51, Issue 4, Page(s) 764–770

Abstract: Health systems are integrating medical-legal partnerships (MLPs) into clinical care and increasingly center "complex care" patients. These patients have intersecting medical and social needs and often face systemic inequities that exacerbate their ... ...

Abstract	Health systems are integrating medical-legal partnerships (MLPs) into clinical care and increasingly center "complex care" patients. These patients have intersecting medical and social needs and often face systemic inequities that exacerbate their chronic health conditions. This paper describes a role for MLPs in hospital quality initiatives; examines the ethics of MLPs assisting with guardianship and institutionalization of hospital patients including marginalized groups; and advocates for MLP interventions designed to address intersectional and ethical concerns.
MeSH term(s)	Humans ; Intersectional Framework ; Hospitals
Language	English
Publishing date	2024-03-13
Publishing country	England
Document type	Journal Article
ZDB-ID	1168812-9
ISSN	1748-720X ; 1073-1105 ; 0277-8459
ISSN (online)	1748-720X
ISSN	1073-1105 ; 0277-8459
DOI	10.1017/jme.2023.154
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Zs.A 2075: Show issues

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Article: Surgical Drain-Related Small Bowel Obstruction After Open Radical Cystoprostatectomy: A Case Report.

Lin, Xin / Lu, Jennifer / Fitzgerald, John

Cureus

2023 Volume 15, Issue 10, Page(s) e46368

Abstract: Surgical drains are commonly used to manage intraperitoneal fluid after major surgeries, but their prophylactic use has been controversial due to potential complications. One rarely reported complication is small bowel obstruction (SBO), primarily seen ... ...

Abstract	Surgical drains are commonly used to manage intraperitoneal fluid after major surgeries, but their prophylactic use has been controversial due to potential complications. One rarely reported complication is small bowel obstruction (SBO), primarily seen in post-colorectal surgeries. We present a case of SBO following open radical cystectomy due to surgical drain placement, a complication not previously reported in urologic surgeries. The case highlights the importance of considering the risks and benefits of prophylactic drain placement. It emphasizes the need for a higher index of suspicion for SBO in patients with surgical drains who develop post-operative nausea and distention. Timely radiological imaging and clinical examination are crucial for accurate diagnosis and proper treatment.
Language	English
Publishing date	2023-10-02
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.46368
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Article ; Online: Is the "Pandemic Diet" Nonlithogenic?

Shkolnik, Brian / Zhao, Kelley / Lu, Jennifer Y / Kothari, Pankti / Herfel, Scott / Schulsinger, Hailey / Schulsinger, David

Journal of endourology

2024

Abstract: Introduction and Objective: ...

Abstract	Introduction and Objective:
Language	English
Publishing date	2024-05-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	356931-7
ISSN	1557-900X ; 0892-7790
ISSN (online)	1557-900X
ISSN	0892-7790
DOI	10.1089/end.2023.0535
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Zs.A 2628: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: The viscoelasticity of high concentration monoclonal antibodies using particle tracking microrheology.

Lewis, Conor M / Heise, Charles T / Harasimiuk, Natalia / Tovey, Jennifer / Lu, Jian R / Waigh, Thomas A

APL bioengineering

2024 Volume 8, Issue 2, Page(s) 26105

Abstract: The viscoelasticity of monoclonal antibodies (mAbs) is important during their production, formulation, and drug delivery. High concentration mAbs can provide higher efficacy therapeutics (e.g., during immunotherapy) and improved efficiency during their ... ...

Abstract	The viscoelasticity of monoclonal antibodies (mAbs) is important during their production, formulation, and drug delivery. High concentration mAbs can provide higher efficacy therapeutics (e.g., during immunotherapy) and improved efficiency during their production (economy of scale during processing). Two humanized mAbs were studied (mAb-1 and mAb-2) with differing isoelectric points. Using high speed particle tracking microrheology, we demonstrated that the mAb solutions have significant viscoelasticities above concentrations of 40 mg/ml. Power law viscoelasticity was observed over the range of time scales (
Language	English
Publishing date	2024-04-24
Publishing country	United States
Document type	Journal Article
ISSN	2473-2877
ISSN (online)	2473-2877
DOI	10.1063/5.0201626
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Article ; Online: Reduction of Teprotumumab-Induced Hearing Loss With Comparable Efficacy Using Half-Dose Therapy.

Phansalkar, Ragini / Lu, Tracy / Alyono, Jennifer / Lee, Jennifer / Dosiou, Chrysoula / Kossler, Andrea Lora

Ophthalmic plastic and reconstructive surgery

2023 Volume 39, Issue 4, Page(s) e101–e104

Abstract: Teprotumumab has been shown to be effective in the treatment of thyroid eye disease, a potentially vision-threatening condition. Adverse events, including sensorineural hearing loss, have been associated with teprotumumab. The authors present the case of ...

Abstract	Teprotumumab has been shown to be effective in the treatment of thyroid eye disease, a potentially vision-threatening condition. Adverse events, including sensorineural hearing loss, have been associated with teprotumumab. The authors present the case of a 64-year-old female who discontinued teprotumumab due to significant sensorineural hearing loss after 4 infusions, along with other adverse events. The patient was unresponsive to a subsequent course of intravenous methylprednisolone and orbital radiation, during which she experienced worsening thyroid eye disease symptoms. Teprotumumab was restarted 1 year later, at a half dose of 10 mg/kg for 8 infusions. Three months post-treatment, she retains resolution of double vision and orbital inflammatory signs, and significant improvement in proptosis. She tolerated all infusions with an overall reduction in the severity of her adverse events and without return of significant sensorineural hearing loss. The authors conclude that a lower dose of teprotumumab can be effective for patients with active moderate-severe thyroid eye disease who experience significant or intolerable adverse events.
MeSH term(s)	Humans ; Female ; Middle Aged ; Graves Ophthalmopathy/drug therapy ; Antibodies, Monoclonal, Humanized/adverse effects ; Exophthalmos ; Hearing Loss, Sensorineural/chemically induced ; Hearing Loss, Sensorineural/diagnosis ; Hearing Loss, Sensorineural/drug therapy
Chemical Substances	teprotumumab (Y64GQ0KC0A) ; Antibodies, Monoclonal, Humanized
Language	English
Publishing date	2023-03-03
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	632830-1
ISSN	1537-2677 ; 0740-9303
ISSN (online)	1537-2677
ISSN	0740-9303
DOI	10.1097/IOP.0000000000002355
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Article: Novel metagenomics analysis of stony coral tissue loss disease.

Heinz, Jakob M / Lu, Jennifer / Huebner, Lindsay K / Salzberg, Steven L / Sommer, Markus / Rosales, Stephanie M

bioRxiv : the preprint server for biology

2024

Abstract: Stony coral tissue loss disease (SCTLD) has devastated coral reefs off the coast of Florida and continues to spread throughout the Caribbean. Although a number of bacterial taxa have consistently been associated with SCTLD, no pathogen has been ... ...

Abstract	Stony coral tissue loss disease (SCTLD) has devastated coral reefs off the coast of Florida and continues to spread throughout the Caribbean. Although a number of bacterial taxa have consistently been associated with SCTLD, no pathogen has been definitively implicated in the etiology of SCTLD. Previous studies have predominantly focused on the prokaryotic community through 16S rRNA sequencing of healthy and affected tissues. Here, we provide a different analytical approach by applying a bioinformatics pipeline to publicly available metagenomic sequencing samples of SCTLD lesions and healthy tissues from four stony coral species. To compensate for the lack of coral reference genomes, we used data from apparently healthy coral samples to approximate a host genome and healthy microbiome reference. These reads were then used as a reference to which we matched and removed reads from diseased lesion tissue samples, and the remaining reads associated only with disease lesions were taxonomically classified at the DNA and protein levels. For DNA classifications, we used a pathogen identification protocol originally designed to identify pathogens in human tissue samples, and for protein classifications, we used a fast protein sequence aligner. To assess the utility of our pipeline, a species-level analysis of a candidate genus,
Language	English
Publishing date	2024-04-02
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.01.02.573916
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Article ; Online: Transcriptomic analysis reveals particulate hexavalent chromium regulates key inflammatory pathways in human lung fibroblasts as a possible mechanism of carcinogenesis.

Kouokam, J Calvin / Speer, Rachel M / Meaza, Idoia / Toyoda, Jennifer H / Lu, Haiyan / Wise, John Pierce

Toxicology and applied pharmacology

2024 Volume 485, Page(s) 116889

Abstract: Hexavalent chromium [Cr(VI)] is considered a major environmental health concern and lung carcinogen. However, the exact mechanism by which Cr(VI) causes lung cancer in humans remains unclear. Since several reports have demonstrated a role for ... ...

Abstract	Hexavalent chromium [Cr(VI)] is considered a major environmental health concern and lung carcinogen. However, the exact mechanism by which Cr(VI) causes lung cancer in humans remains unclear. Since several reports have demonstrated a role for inflammation in Cr(VI) toxicity, the present study aimed to apply transcriptomics to examine the global mRNA expression in human lung fibroblasts after acute (24 h) or prolonged (72 and 120 h) exposure to 0.1, 0.2 and 0.3 μg/cm
MeSH term(s)	Humans ; Chromium/toxicity ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Lung/drug effects ; Lung/metabolism ; Lung/pathology ; Transcriptome/drug effects ; Gene Expression Profiling/methods ; Lung Neoplasms/genetics ; Lung Neoplasms/chemically induced ; Lung Neoplasms/pathology ; Lung Neoplasms/metabolism ; Inflammation/chemically induced ; Inflammation/genetics ; Inflammation/metabolism ; Chromates/toxicity ; Zinc Compounds/pharmacology ; Zinc Compounds/toxicity ; Cell Line ; Carcinogenesis/drug effects ; Carcinogenesis/chemically induced ; Carcinogenesis/genetics ; Signal Transduction/drug effects
Chemical Substances	Chromium (0R0008Q3JB) ; chromium hexavalent ion (18540-29-9) ; zinc chromate (05F2837HUF) ; Chromates ; Zinc Compounds
Language	English
Publishing date	2024-03-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	204477-8
ISSN	1096-0333 ; 0041-008X
ISSN (online)	1096-0333
ISSN	0041-008X
DOI	10.1016/j.taap.2024.116889
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Article ; Online: Healthcare Resource Utilization and Costs in an At-Risk Population With Diabetic Retinopathy.

Rajeswaren, Vivian / Lu, Vivian / Chen, Hongan / Patnaik, Jennifer L / Manoharan, Niranjan

Translational vision science & technology

2024 Volume 13, Issue 2, Page(s) 12

Abstract: Purpose: Several investigators have suggested the cost-effectiveness of earlier screening, management of risk factors, and early treatment for diabetic retinopathy (DR). We aimed to evaluate the extent of health care utilization and cost of delayed care ...

Abstract	Purpose: Several investigators have suggested the cost-effectiveness of earlier screening, management of risk factors, and early treatment for diabetic retinopathy (DR). We aimed to evaluate the extent of health care utilization and cost of delayed care by insurance type in a vulnerable patient population. Methods: A retrospective analysis of patients with DR was conducted using electronic medical record (EMR) data from January 2014 to December 2020 at Denver Health Medical Center, a safety net institution. Patients were classified by disease severity and insurance status. DR-specific costs were assessed via Current Procedural Terminology (CPT) codes over a 24-month follow-up period. Results: Among the 313 patients, a higher proportion of non-English speaking patients were uninsured. Rates of proliferative DR at presentation differed across insurance groups (62% of uninsured, 42% of discount plan, and 33% of Medicare/Medicaid, P = 0.016). There was a significant difference in the total median cost between discount plan patients ($1258, interquartile range [IQR] = $0 - $5901) and both Medicare patients ($751, IQR = $0, $7148, P = 0.037) and Medicaid patients ($593, IQR = $0 - $6299, P = 0.025). Conclusions: There were higher rates of proliferative DR at presentation among the uninsured and discount plan patients and greater total median cost in discount plan patients compared to Medicare or Medicaid. These findings prioritize mitigating gaps in insurance coverage and barriers to preventative care among vulnerable populations. Translational relevance: Advanced diabetic disease and increased downstream health care utilization and cost vary across insurance type, suggesting improved access to preventative care is needed in these specific at-risk populations.
MeSH term(s)	Humans ; Aged ; United States/epidemiology ; Medicare ; Retrospective Studies ; Diabetic Retinopathy/diagnosis ; Diabetic Retinopathy/epidemiology ; Diabetic Retinopathy/therapy ; Risk Factors ; Delivery of Health Care ; Diabetes Mellitus
Language	English
Publishing date	2024-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2674602-5
ISSN	2164-2591 ; 2164-2591
ISSN (online)	2164-2591
ISSN	2164-2591
DOI	10.1167/tvst.13.2.12
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Article ; Online: Practice Patterns Affecting Delays in Care of Testicular Torsion.

Zhao, Kelley / Lu, Jennifer Y / Shkolnik, Brian / Davis, Rachel Bennett

Urology

2023 Volume 184, Page(s) 83–86

Abstract: Objectives: To compare impact of day or on-call team, pediatric or adult attending, and patient age on testicular torsion management and outcomes.: Methods: A retrospective study of patients with testicular torsion between 2012 and 2022 at a single ... ...

Abstract	Objectives: To compare impact of day or on-call team, pediatric or adult attending, and patient age on testicular torsion management and outcomes. Methods: A retrospective study of patients with testicular torsion between 2012 and 2022 at a single institution was conducted. Variables impacting management time were assessed using univariate analyses. Results: One hundred and thirty-four patients were included: 49 underwent orchiectomies and 84 underwent orchiopexies. There was no significant difference between efficiency of on-call vs day team regarding time to ultrasound or time to operating room (OR). There were no significant differences between pediatric vs adult attending surgeons for time to surgery, intraoperative length of surgery, or testicular salvage rates. However, when patients were stratified by age greater or younger than 18years, older patients had significantly longer symptom duration (91.9 vs 20.0 minutes, P = .005), time to receive an ultrasound from emergency room registration (152 vs 87 minutes, P < .001), time to OR from emergency room registration (268 vs 185 minutes, P < .001), and time to OR from ultrasound read (187 vs 123 minutes, P = .03). Older patients also had lower rates of testicular salvage approaching significance (orchiectomy rate 48.8% vs 31.5%, P = .057). Conclusion: While no significant delays in testicular torsion management were detected between management by on-call vs day team nor pediatric vs adult attending, increased age of patient was associated with delays in definitive surgical management. Greater index of suspicion for testicular torsion diagnosis in adult patients may improve the rate of testicular salvage.
MeSH term(s)	Adult ; Male ; Humans ; Child ; Adolescent ; Spermatic Cord Torsion/diagnosis ; Spermatic Cord Torsion/surgery ; Retrospective Studies ; Orchiectomy ; Emergency Service, Hospital ; Health Facilities
Language	English
Publishing date	2023-12-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	192062-5
ISSN	1527-9995 ; 0090-4295
ISSN (online)	1527-9995
ISSN	0090-4295
DOI	10.1016/j.urology.2023.11.007
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