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Article ; Online: Mesenchymal Stem Cell Transplantation for Spinal Cord Injury: Current Status and Prospects.

Hirota, Ryosuke / Sasaki, Masanori / Honmou, Osamu / Yamashita, Toshihiko

Spine surgery and related research

2023 Volume 7, Issue 4, Page(s) 319–326

Abstract: Since the 1990s, our group has been conducting basic research on regenerative medicine using various cell types to treat several central nervous system diseases, including spinal cord injury (SCI). We have reported many positive effects of the ... ...

Abstract	Since the 1990s, our group has been conducting basic research on regenerative medicine using various cell types to treat several central nervous system diseases, including spinal cord injury (SCI). We have reported many positive effects of the intravenous administration of mesenchymal stem cells (MSCs) derived from the bone marrow. In the current study, MSCs were administered intravenously to a rat model of severe SCI (crush injury) during the acute to subacute stages-considerable motor function recovery was observed. Furthermore, MSC transplantation in a chronic-phase SCI model improved motor function. In this review, we discuss recent updates in basic research on the intravenous infusion of MSCs and prospects for SCI research.
Language	English
Publishing date	2023-02-13
Publishing country	Japan
Document type	Journal Article ; Review
ISSN	2432-261X
ISSN (online)	2432-261X
DOI	10.22603/ssrr.2022-0234
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Article ; Online: Carotid web arising in the common carotid artery and adjacent to a transverse process of the cervical spine: A case report.

Naito Gomi, Masanori / Iwasaki, Koichi / Sasaki, Isao

The neuroradiology journal

2023 , Page(s) 19714009231212371

Abstract: Background and importance: A carotid web (CaW) is an intraluminal membrane-like filling defect typically located in the posterior wall of the proximal internal carotid artery and is increasingly recognized as a potential cause of embolic stroke. We ... ...

Abstract	Background and importance: A carotid web (CaW) is an intraluminal membrane-like filling defect typically located in the posterior wall of the proximal internal carotid artery and is increasingly recognized as a potential cause of embolic stroke. We herein reported a case of a CaW that has an unusual location at the CCA; furthermore, an elongated transverse process of the cervical spine was adjacent to the CaW at the CCA. Clinical presentation: An 87-year-old woman with a history of minor stroke underwent thorough radiological examinations of her CCA lesion. Radiological examinations, including duplex ultrasonography, digital subtraction angiography (DSA), computed tomography, and magnetic resonance angiography, revealed that the morphological characteristics of the lesion were compatible with those of a typical CaW except for its location at the CCA. Furthermore, three-dimensional DSA revealed that the lesion was adjacent to the transverse process of the sixth cervical spine (C6), suggesting mechanical damage by the spinal transverse process as a possible pathogenesis of this CaW. Conclusion: This is the rare case of a CaW located in the CCA, far from the carotid bulb. Arterial dissection due to mechanical damage by the spinal transverse process may be a possible causative mechanism of the CaW in the present case.
Language	English
Publishing date	2023-10-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2257770-1
ISSN	2385-1996 ; 1971-4009 ; 1120-9976
ISSN (online)	2385-1996
ISSN	1971-4009 ; 1120-9976
DOI	10.1177/19714009231212371
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Zs.A 2823: Show issues

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Article ; Online: Lysophospholipids transport across blood-brain barrier in an in vitro reconstruction model.

Tsukahara, Tamotsu / Sasaki, Masanori / Haniu, Hisao / Matsuda, Yoshikazu

Biochemical and biophysical research communications

2023 Volume 676, Page(s) 91–96

Abstract: This study builds on our previous study, which highlighted the need for further research on the potential use of lysophospholipid (LPL) supplementation to prevent chronic and age-related diseases. We aimed to evaluate the transmembrane transport of LPL ... ...

Abstract	This study builds on our previous study, which highlighted the need for further research on the potential use of lysophospholipid (LPL) supplementation to prevent chronic and age-related diseases. We aimed to evaluate the transmembrane transport of LPL across rat and monkey blood-brain barrier (BBB) models. An in vitro monkey BBB model is required to elucidate the differences between rat and primate BBB-related data and to measure the permeability of LPLs being researched in relation to the human BBB. Based on our previous experiment, porcine liver decomposition product-derived phospholipids (PEL) strongly inhibit α-synuclein (α-Syn) aggregation. We have identified several candidates potentially relevant for the inhibition of α-Syn aggregation, such as LPC18:1, LPE18:1, and LPI18:0; however, the BBB permeability of these LPLs remains unclear. In the present study, we assessed the ability of these LPLs to pass through the in vitro rat and monkey BBB models. LPC18:1 showed high BBB permeability, LPI18:0 showed medium permeability, and the BBB permeation of LPE18:1 was negligible. Our results suggest that LPC18:1 and LPI18:0 are functional food factors that can cross the BBB.
Language	English
Publishing date	2023-07-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2023.07.044
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Zs.A 116: Show issues

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Article ; Online: Combined Brønsted Base-Promoted CO

Shigeno, Masanori / Tohara, Itsuki / Sasaki, Keita / Nozawa-Kumada, Kanako / Kondo, Yoshinori

Organic letters

2022 Volume 24, Issue 26, Page(s) 4825–4830

Abstract: Interest in developing methods for direct ... ...

Abstract	Interest in developing methods for direct CO
Language	English
Publishing date	2022-06-28
Publishing country	United States
Document type	Journal Article
ISSN	1523-7052
ISSN (online)	1523-7052
DOI	10.1021/acs.orglett.2c01986
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Article ; Online: Operando Li metal plating diagnostics via MHz band electromagnetics.

Ishigaki, Masanori / Ishikawa, Keisuke / Usuki, Tsukasa / Kondo, Hiroki / Komagata, Shogo / Sasaki, Tsuyoshi

Nature communications

2023 Volume 14, Issue 1, Page(s) 7275

Abstract: A nondestructive detection method for internal Li-metal plating in lithium-ion batteries is essential to improve their lifetime. Here, we demonstrate a direct Li-metal detection technology that focuses on electromagnetic behaviour. Through an ... ...

Abstract	A nondestructive detection method for internal Li-metal plating in lithium-ion batteries is essential to improve their lifetime. Here, we demonstrate a direct Li-metal detection technology that focuses on electromagnetic behaviour. Through an interdisciplinary approach combining the ionic behaviour of electrochemical reactions at the negative electrode and the electromagnetic behaviour of electrons based on Maxwell's equations, we find that internal Li-metal plating can be detected by the decrease in real part of the impedance at high-frequency. This finding enables simpler diagnostics when compared to data-driven analysis because we can correlate a direct response from the electronic behaviour to the metallic material property rather changes in the ionic behaviour. We test this response using commercial Li-ion batteries subject to extremely fast charging conditions to induce Li-metal plating. From this, we develop a battery sensor that detects and monitors the cycle-by-cycle growth of Li-metal plating. This work not only contributes to advancing future Li-ion battery development but may also serve as a tool for Li-metal plating monitoring in real-field applications to increase the useable lifetime of Li-ion batteries and to prevent detrimental Li-metal plating.
Language	English
Publishing date	2023-11-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-43138-w
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Article: Erratum to "Crossing double stent retriever technique for refractory terminal internal carotid artery occlusion" [Radiology Case Reports 17 (2022) 1848-1852].

Sasaki, Isao / Imahori, Taichiro / Yano, Tatsuya / Gomi, Masanori / Kuroda, Junko / Kobayashi, Norikata / Sato, Kimitoshi / Niwa, Yoji / IwasaKi, Koichi / Hasegawa, Hiroshi

Radiology case reports

2024 Volume 19, Issue 4, Page(s) 1658

Abstract: This corrects the article DOI: 10.1016/j.radcr.2022.03.023.]. ...

Abstract	[This corrects the article DOI: 10.1016/j.radcr.2022.03.023.].
Language	English
Publishing date	2024-01-12
Publishing country	Netherlands
Document type	Published Erratum
ZDB-ID	2406300-9
ISSN	1930-0433
ISSN	1930-0433
DOI	10.1016/j.radcr.2023.12.036
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Article ; Online: [3. Magnetic Resonance Imaging for Analysis of Neural Plasticity Induced by Neuroregenerative Therapy].

Nagahama, Hiroshi / Sasaki, Masanori / Kiyose, Ryo / Yasuda, Naomi / Honmou, Osamu

Nihon Hoshasen Gijutsu Gakkai zasshi

2021 Volume 77, Issue 10, Page(s) 1238–1244

MeSH term(s)	Magnetic Resonance Imaging ; Nerve Regeneration ; Neuronal Plasticity
Language	Japanese
Publishing date	2021-10-20
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2269092-X
ISSN	1881-4883 ; 0369-4305
ISSN (online)	1881-4883
ISSN	0369-4305
DOI	10.6009/jjrt.2021_JSRT_77.10.1238
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Article ; Online: Impact of comprehensive quality improvement program on outcomes in very-low-birth-weight infants: A cluster-randomized controlled trial in Japan.

Nishida, Toshihiko / Kusuda, Satoshi / Mori, Rintaro / Toyoshima, Katsuaki / Mitsuhashi, Hideko / Sasaki, Hatoko / Yonemoto, Naohiro / Kono, Yumi / Uchiyama, Atsushi / Fujimura, Masanori

Early human development

2024 Volume 190, Page(s) 105947

Abstract: Background: Differences in outcomes among neonatal intensive care units (NICUs) in Japan have been noted, prompting the need for quality improvement.: Aim: To assess a comprehensive quality improvement program on outcomes in very-low-birth-weight ( ... ...

Abstract	Background: Differences in outcomes among neonatal intensive care units (NICUs) in Japan have been noted, prompting the need for quality improvement. Aim: To assess a comprehensive quality improvement program on outcomes in very-low-birth-weight (VLBW) infants. Study design: A cluster-randomized clinical trial. Subjects: Forty hospitals and VLBW infants born in 2012-2014 and admitted to those hospitals were study subjects. Outcome measures: The intervention group (IG) received a comprehensive quality improvement program involving clinical practice guidelines, educational outreach visits, workshops, opinion leader training, audits, and feedback. The control group (CG) was provided only with the guidelines. The primary outcome was survival without neurological impairment at three years of age. Results: IG consisted of 19 hospitals and 1735 infants, while CG included 21 hospitals and 1700 infants. There were no significant differences in gestational weeks, 29.1(26.9-31.3) vs. 29.1(26.7-31.1) or birth weights (g), 1054(789-1298) vs. 1084(810-1309) between the two groups. Both groups showed survival rates without neurological impairment of 67.2 % (1166) and 66.9 % (1137), respectively, without a significant difference. There was no significant difference in mortalities at NICU discharge between the groups, with rates of 4.0 % (70) and 4.2 % (72) respectively. Several clinically relevant improvements were observed in IG, including reduced rates of sepsis, adrenal insufficiency, transfusion for anemia, and a shorter interval to achieve full enteral feeding. However, these did not lead to improvements in the primary outcome. Conclusion: The comprehensive quality improvement program to Japanese NICUs did not result in a significant improvement in survival without neurological impairment in VLBW infants.
MeSH term(s)	Infant, Newborn ; Infant ; Female ; Humans ; Child ; Japan ; Quality Improvement ; Infant, Very Low Birth Weight ; Birth Weight ; Intensive Care Units, Neonatal
Language	English
Publishing date	2024-01-26
Publishing country	Ireland
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	752532-1
ISSN	1872-6232 ; 0378-3782
ISSN (online)	1872-6232
ISSN	0378-3782
DOI	10.1016/j.earlhumdev.2024.105947
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Zs.A 1373: Show issues

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Article ; Online: Protective Effects of Hydrogen Gas Inhalation for Hindlimb Ischaemia-Reperfusion Injury in a Mouse Model.

Hayashi, Masanori / Obara, Hideaki / Matsuda, Sachiko / Homma, Koichiro / Sasaki, Junichi / Matsubara, Kentaro / Higuchi, Makoto / Sano, Motoaki / Masugi, Yohei / Kitagawa, Yuko

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

2024

Abstract: Objective: Ischaemia-reperfusion (I/R) injury is a severe post-operative complication that triggers an inflammatory response and causes severe damage. Hydrogen gas has anti-oxidant and anti-apoptotic properties and has been shown to be safe in humans. ... ...

Abstract	Objective: Ischaemia-reperfusion (I/R) injury is a severe post-operative complication that triggers an inflammatory response and causes severe damage. Hydrogen gas has anti-oxidant and anti-apoptotic properties and has been shown to be safe in humans. The study aimed to investigate whether hydrogen gas protects against skeletal muscle I/R injury. Methods: Experimental basic research using mice. A total of 160 eight to 10 week old albino laboratory bred strain of house mice (25.8 ± 0.68 g) were used in this study. The mice were cable tied to the hindlimb under anaesthesia and then placed in an anaesthesia box filled with air and 2% isoflurane (control group); 80 mice were additionally subjected to 1.3% hydrogen gas in this mix (hydrogen group). After two hours, the cable ties were removed to initiate reperfusion, and hydrogen inhalation lasted for six hours in the hydrogen group. After six hours, the mice were taken out of the box and kept in cages under standard conditions until time for observation at 16 different time points after reperfusion: zero, two, four, six, eight, and 10 hours and one, two, three, four, five, six, seven, 14, 21, and 28 days. Five mice were sacrificed using excess anaesthesia at each time point, and the bilateral hindlimb tissues were harvested. The inflammatory effects of the I/R injury were assessed by evaluating serum interleukin-6 concentrations using enzyme linked immunosorbent assay, as well as histological and immunohistochemical analyses. Untreated mice with I/R injury were used as controls. Results: Hydrogen gas showed protective effects associated with a reduction in inflammatory cell infiltration (neutrophils, macrophages, and lymphocytes), a reduced area of damaged muscle, maintenance of normal muscle cells, and replacement of damaged muscle cells with neoplastic myocytes. Conclusion: Inhalation of hydrogen gas had a protective effect against hindlimb I/R injury in mice, in part by reducing inflammatory cell infiltration and in part by preserving normal muscle cells.
Language	English
Publishing date	2024-01-30
Publishing country	England
Document type	Journal Article
ZDB-ID	1225869-6
ISSN	1532-2165 ; 1078-5884
ISSN (online)	1532-2165
ISSN	1078-5884
DOI	10.1016/j.ejvs.2024.01.081
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Zs.A 2283: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 381: Show issues

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Article ; Online: Investigation of deep learning model for predicting immune checkpoint inhibitor treatment efficacy on contrast-enhanced computed tomography images of hepatocellular carcinoma.

Nakao, Yasuhiko / Nishihara, Takahito / Sasaki, Ryu / Fukushima, Masanori / Miuma, Satoshi / Miyaaki, Hisamitsu / Akazawa, Yuko / Nakao, Kazuhiko

Scientific reports

2024 Volume 14, Issue 1, Page(s) 6576

Abstract: Although the use of immune checkpoint inhibitors (ICIs)-targeted agents for unresectable hepatocellular carcinoma (HCC) is promising, individual response variability exists. Therefore, we developed an artificial intelligence (AI)-based model to predict ... ...

Abstract	Although the use of immune checkpoint inhibitors (ICIs)-targeted agents for unresectable hepatocellular carcinoma (HCC) is promising, individual response variability exists. Therefore, we developed an artificial intelligence (AI)-based model to predict treatment efficacy using pre-ICIs contrast-enhanced computed tomography (CT) imaging characteristics. We evaluated the efficacy of atezolizumab and bevacizumab in 43 patients at the Nagasaki University Hospital from 2020 to 2022 using the modified Response Evaluation Criteria in Solid Tumors. A total of 197 Progressive Disease (PD), 271 Partial Response (PR), and 342 Stable Disease (SD) contrast CT images of HCC were used for training. We used ResNet-18 as the Convolutional Neural Network (CNN) model and YOLOv5, YOLOv7, YOLOv8 as the You Only Look Once (YOLO) model with precision-recall curves and class activation maps (CAMs) for diagnostic performance evaluation and model interpretation, respectively. The 3D t-distributed Stochastic Neighbor Embedding was used for image feature analysis. The YOLOv7 model demonstrated Precision 53.7%, Recall 100%, F1 score 69.8%, mAP@0.5 99.5% for PD, providing accurate and clinically versatile predictions by identifying decisive points. The ResNet-18 model had Precision 100% and Recall 100% for PD. However, the CAMs sites did not align with the tumors, suggesting the CNN model is not predicting that a given CT slice is PD, PR, or SD, but that it accurately predicts Individual Patient's CT slices. Preparing substantial training data for tumor drug effect prediction models is challenging compared to general tumor diagnosis models; hence, large-scale validation using an efficient YOLO model is warranted.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/diagnostic imaging ; Carcinoma, Hepatocellular/drug therapy ; Artificial Intelligence ; Immune Checkpoint Inhibitors/pharmacology ; Immune Checkpoint Inhibitors/therapeutic use ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/drug therapy ; Deep Learning ; Tomography, X-Ray Computed/methods ; Treatment Outcome
Chemical Substances	Immune Checkpoint Inhibitors
Language	English
Publishing date	2024-03-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-57078-y
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