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Article: Eyesight quality and Computer Vision Syndrome.

Bogdănici, Camelia Margareta / Săndulache, Diana Elena / Nechita, Corina Andreea

2018 Volume 61, Issue 2, Page(s) 112–116

Abstract: The aim of the study was to analyze the effects that gadgets have on eyesight quality. A prospective observational study was conducted from January to July 2016, on 60 people who were divided into two groups: Group 1 - 30 middle school pupils with a mean ...

Abstract	The aim of the study was to analyze the effects that gadgets have on eyesight quality. A prospective observational study was conducted from January to July 2016, on 60 people who were divided into two groups: Group 1 - 30 middle school pupils with a mean age of 11.9 ± 1.86 and Group 2 - 30 patients evaluated in the Ophthalmology Clinic, "Sf. Spiridon" Hospital, Iași, with a mean age of 21.36 ± 7.16 years. The clinical parameters observed were the following: visual acuity (VA), objective refraction, binocular vision (BV), fusional amplitude (FA), Schirmer's test. A questionnaire was also distributed, which contained 8 questions that highlighted the gadget's impact on the eyesight. The use of different gadgets, such as computer, laptops, mobile phones or other displays become part of our everyday life and people experience a variety of ocular symptoms or vision problems related to these. Computer Vision Syndrome (CVS) represents a group of visual and extraocular symptoms associated with sustained use of visual display terminals. Headache, blurred vision, and ocular congestion are the most frequent manifestations determined by the long time use of gadgets. Mobile phones and laptops are the most frequently used gadgets. People who use gadgets for a long time have a sustained effort for accommodation. A small amount of refractive errors (especially myopic shift) was objectively recorded by various studies on near work. Dry eye syndrome could also be identified, and an improvement of visual comfort could be observed after the instillation of artificial tears drops. Computer Vision Syndrome is still under-diagnosed, and people should be made aware of the bad effects the prolonged use of gadgets has on eyesight.
MeSH term(s)	Accommodation, Ocular ; Adult ; Female ; Humans ; Male ; Myopia ; Prospective Studies ; User-Computer Interface ; Vision Tests ; Vision, Binocular ; Visual Acuity ; Young Adult
Language	English
Publishing date	2018-01-31
Publishing country	Romania
Document type	Journal Article ; Observational Study
ZDB-ID	2842202-8
ISSN	2501-2533 ; 2457-4325
ISSN (online)	2501-2533
ISSN	2457-4325
DOI	10.22336/rjo.2017.21
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Article: Medical and legal point of view for low-vision patients.

Bogdănici, Camelia-Margareta / Bogdănici, Ştefan Tudor / Săndulache, Diana Elena / Diaconu, Carmen-Mariana

Romanian journal of ophthalmology

2018 Volume 62, Issue 1, Page(s) 48–53

Abstract: The aim of the study was to highlight the medical and legal difficulties in framing low-vision patients for certification. We performed a retrospective observational study conducted from January 2013 to January 2016, on 63 patients with the mean age of ... ...

Abstract	The aim of the study was to highlight the medical and legal difficulties in framing low-vision patients for certification. We performed a retrospective observational study conducted from January 2013 to January 2016, on 63 patients with the mean age of 16.37±3.34 years, evaluated at the Ophthalmology Clinic from "Sf. Spiridon" Hospital, Iași, in order to release a medical certificate required at the Expertise Board. The clinical parameters observed were visual acuity (VA) with correction, objective refraction (in Spherical Equivalent - SEq), intraocular pressure, slit lamp examination of the anterior pole, fundus examination, orthoptic eye exam, and ocular ultrasonography (in selected cases). The main causes for the decreased visual acuity found are
MeSH term(s)	Adolescent ; Adult ; Amblyopia ; Female ; Humans ; Male ; Myopia ; Retrospective Studies ; Vision, Low ; Visual Acuity ; Young Adult
Language	English
Publishing date	2018-01
Publishing country	Romania
Document type	Journal Article
ZDB-ID	2842202-8
ISSN	2457-4325
ISSN	2457-4325
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Book ; Online ; Thesis: Nierenfunktion Kinase-defizienter Mäuse

Sandulache, Diana [Verfasser]

2008

Author's details	von Diana Sandulache
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	English
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article: High-Risk

Sandulache, Vlad C / Michikawa, Chieko / Kataria, Pranav / Gleber-Netto, Frederico O / Bell, Diana / Trivedi, Sanchit / Rao, Xiayu / Wang, Jing / Zhao, Mei / Jasser, Samar / Myers, Jeffrey N / Pickering, Curtis R

Clinical cancer research : an official journal of the American Association for Cancer Research

2018 Volume 24, Issue 7, Page(s) 1727–1733

Abstract: Purpose: ...

Abstract	Purpose:
MeSH term(s)	Carcinoma, Squamous Cell/genetics ; Cohort Studies ; Disease-Free Survival ; Female ; Humans ; Lymph Nodes/pathology ; Lymphatic Metastasis/genetics ; Lymphatic Metastasis/pathology ; Male ; Mouth/pathology ; Mouth Neoplasms/genetics ; Mutation/genetics ; Prognosis ; Retrospective Studies ; Tumor Suppressor Protein p53/genetics
Chemical Substances	TP53 protein, human ; Tumor Suppressor Protein p53
Language	English
Publishing date	2018-01-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1225457-5
ISSN	1557-3265 ; 1078-0432
ISSN (online)	1557-3265
ISSN	1078-0432
DOI	10.1158/1078-0432.CCR-17-0721
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Zs.A 4223: Show issues

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Article ; Online: A High-throughput Approach to Identify Effective Systemic Agents for the Treatment of Anaplastic Thyroid Carcinoma.

Henderson, Ying C / Mohamed, Abdallah S R / Maniakas, Anastasios / Chen, Yunyun / Powell, Reid T / Peng, Shaohua / Cardenas, Maria / Williams, Michelle D / Bell, Diana / Zafereo, Mark E / Wang, Rui Jennifer / Scherer, Steve E / Wheeler, David A / Cabanillas, Maria E / Hofmann, Marie-Claude / Johnson, Faye M / Stephan, Clifford C / Sandulache, Vlad / Lai, Stephen Y

The Journal of clinical endocrinology and metabolism

2021 Volume 106, Issue 10, Page(s) 2962–2978

Abstract: Background: Despite the use of aggressive multimodality treatment, most anaplastic thyroid carcinoma (ATC) patients die within a year of diagnosis. Although the combination of BRAF and MEK inhibitors has recently been approved for use in BRAF-mutated ... ...

Abstract	Background: Despite the use of aggressive multimodality treatment, most anaplastic thyroid carcinoma (ATC) patients die within a year of diagnosis. Although the combination of BRAF and MEK inhibitors has recently been approved for use in BRAF-mutated ATC, they remain effective in a minority of patients who are likely to develop drug resistance. There remains a critical clinical need for effective systemic agents for ATC with a reasonable toxicity profile to allow for rapid translational development. Material and methods: Twelve human thyroid cancer cell lines with comprehensive genomic characterization were used in a high-throughput screening (HTS) of 257 compounds to select agents with maximal growth inhibition. Cell proliferation, colony formation, orthotopic thyroid models, and patient-derived xenograft (PDX) models were used to validate the selected agents. Results: Seventeen compounds were effective, and docetaxel, LBH-589, and pralatrexate were selected for additional in vitro and in vivo analysis as they have been previously approved by the US Food and Drug Administration for other cancers. Significant tumor growth inhibition (TGI) was detected in all tested models treated with LBH-589; pralatrexate demonstrated significant TGI in the orthotopic papillary thyroid carcinoma model and 2 PDX models; and docetaxel demonstrated significant TGI only in the context of mutant TP53. Conclusions: HTS identified classes of systemic agents that demonstrate preferential effectiveness against aggressive thyroid cancers, particularly those with mutant TP53. Preclinical validation in both orthotopic and PDX models, which are accurate in vivo models mimicking tumor microenvironment, may support initiation of early-phase clinical trials in non-BRAF mutated or refractory to BRAF/MEK inhibition ATC.
MeSH term(s)	Animals ; Antineoplastic Agents/pharmacology ; Carcinogenicity Tests ; Cell Line, Tumor ; Disease Models, Animal ; High-Throughput Screening Assays ; Humans ; Protein Kinase Inhibitors/pharmacology ; Proto-Oncogene Proteins B-raf/drug effects ; Thyroid Carcinoma, Anaplastic/drug therapy ; Thyroid Neoplasms/drug therapy ; Tumor Microenvironment/drug effects
Chemical Substances	Antineoplastic Agents ; Protein Kinase Inhibitors ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1)
Language	English
Publishing date	2021-06-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/clinem/dgab424
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Article ; Online: Residual nodal disease in patients with advanced-stage oropharyngeal squamous cell carcinoma treated with definitive radiation therapy and posttreatment neck dissection: Association with locoregional recurrence, distant metastasis, and decreased survival.

Sandulache, Vlad C / Ow, Thomas J / Daram, Shiva P / Hamilton, Jackson / Skinner, Heath / Bell, Diana / Rosenthal, David I / Beadle, Beth M / Ang, K Kian / Kies, Merrill S / Johnson, Faye M / El-Naggar, Adel K / Myers, Jeffrey N

Head & neck

2013 Volume 35, Issue 10, Page(s) 1454–1460

Abstract: Background: Oropharyngeal squamous cell carcinoma (OPSCC) is increasing in frequency. We reviewed patients with advanced-stage OPSCC treated with chemoradiation to assess the impact of residual neck disease on survival.: Methods: We reviewed 202 ... ...

Abstract	Background: Oropharyngeal squamous cell carcinoma (OPSCC) is increasing in frequency. We reviewed patients with advanced-stage OPSCC treated with chemoradiation to assess the impact of residual neck disease on survival. Methods: We reviewed 202 patients with OPSCC between 1990 and 2010 treated with primary chemoradiation followed by neck dissection. Imaging was analyzed using RECIST (Response Evaluation Criteria In Solid Tumors) 1.1 criteria. Survival was evaluated using both univariate and multivariate analyses. Results: Overall survival at 5 years was 89%. Forty-two patients (21%) had residual disease in the neck (pN+). pN+ was associated with greater locoregional recurrence (LRR) and distant metastasis (DM) and decreased survival. No clinicopathologic factors were predictive of pN+. Contrasted posttreatment CT had low sensitivity and specificity. Conclusions: In advanced OPSCC pN+, patients have higher rates of LRR and DM. Neither clinicopathologic factors nor posttreatment imaging was predictive of pN+, although increased use of modern imaging may reduce the rate of negative neck dissections.
MeSH term(s)	Adult ; Aged ; Cancer Care Facilities ; Carcinoma, Squamous Cell/mortality ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/therapy ; Chemoradiotherapy/methods ; Chemoradiotherapy/mortality ; Cohort Studies ; Combined Modality Therapy ; Disease-Free Survival ; Female ; Follow-Up Studies ; Humans ; Kaplan-Meier Estimate ; Lymph Nodes/pathology ; Lymph Nodes/surgery ; Male ; Middle Aged ; Multivariate Analysis ; Neck Dissection/methods ; Neck Dissection/mortality ; Neoplasm Invasiveness/pathology ; Neoplasm Recurrence, Local/mortality ; Neoplasm Recurrence, Local/pathology ; Neoplasm Recurrence, Local/therapy ; Neoplasm Staging ; Neoplasm, Residual/mortality ; Neoplasm, Residual/pathology ; Neoplasm, Residual/therapy ; Oropharyngeal Neoplasms/mortality ; Oropharyngeal Neoplasms/pathology ; Oropharyngeal Neoplasms/therapy ; Proportional Hazards Models ; Retrospective Studies ; Risk Assessment ; Survival Analysis ; Texas ; Treatment Outcome
Language	English
Publishing date	2013-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	645165-2
ISSN	1097-0347 ; 0148-6403 ; 1043-3074
ISSN (online)	1097-0347
ISSN	0148-6403 ; 1043-3074
DOI	10.1002/hed.23173
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Zs.A 1493: Show issues

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Article ; Online: Effects of gum arabic (Acacia senegal) on water and electrolyte balance in healthy mice.

Nasir, Omaima / Artunc, Ferruh / Saeed, Amal / Kambal, M A / Kalbacher, Hubert / Sandulache, Diana / Boini, Krishna M / Jahovic, Nermina / Lang, Florian

Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation

2008 Volume 18, Issue 2, Page(s) 230–238

Abstract: Objective: Gum arabic (GA) is a dietary fiber derived from the dried exudates of Acacia senegal. It is widely used in both the pharmaceutical and food industries as an emulsifier and stabilizer. It is also used in the traditional treatment of patients ... ...

Abstract	Objective: Gum arabic (GA) is a dietary fiber derived from the dried exudates of Acacia senegal. It is widely used in both the pharmaceutical and food industries as an emulsifier and stabilizer. It is also used in the traditional treatment of patients with chronic kidney disease in Middle Eastern countries. However, the effects of GA on renal function remain ill-defined. Design: We explored the effects of GA on the water and electrolyte balance of healthy wild-type 129S1/SvImJ mice (n = 18). Feces and urine were collected in metabolic cages before and after 3 or 14 days of treatment with 10% GA in drinking water. Results: The GA solutions contained particularly high concentrations of Ca2+, Mg2+, and K+. Because of enhanced uptake, treatment with GA significantly increased both the intestinal and renal excretion of Mg2+ and Ca(2+). The latter was accompanied by decreased urinary excretion of inorganic phosphate and decreased plasma concentrations of 1,25-dihydroxy vitamin D. Moreover, GA significantly increased fecal weight and Na+ excretion. Gum arabic increased 24-h creatinine clearance (from 283 +/- 35 to 382 +/- 40 muL/min [SEM]) and urinary antidiuretic hormone excretion, and decreased daily urine output (from 1.8 +/- 0.2 to 1.2 +/- 0.1 mL/24 h) as well as the urinary excretion of Na(+) (from 226 +/- 22 to 196 +/- 19 mumol/24 h). In conclusion, treatment with GA resulted in moderate but significant increases of creatinine clearance and altered electrolyte excretion, i.e., effects favorable in renal insufficiency.
MeSH term(s)	Animals ; Calcium/pharmacokinetics ; Creatinine/metabolism ; Dietary Fiber/pharmacology ; Disease Models, Animal ; Feces/chemistry ; Female ; Glomerular Filtration Rate/drug effects ; Gum Arabic/pharmacology ; Magnesium/pharmacokinetics ; Male ; Mice ; Potassium/pharmacokinetics ; Renal Insufficiency/drug therapy ; Urinalysis ; Water-Electrolyte Balance/drug effects
Chemical Substances	Dietary Fiber ; Gum Arabic (9000-01-5) ; Creatinine (AYI8EX34EU) ; Magnesium (I38ZP9992A) ; Potassium (RWP5GA015D) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2008-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1080003-7
ISSN	1532-8503 ; 1051-2276
ISSN (online)	1532-8503
ISSN	1051-2276
DOI	10.1053/j.jrn.2007.08.004
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Zs.A 3273: Show issues

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Article ; Online: Downregulation of angiogenin transcript levels and inhibition of colonic carcinoma by gum arabic (Acacia senegal).

Nasir, Omaima / Wang, Kan / Föller, Michael / Bhandaru, Madhuri / Sandulache, Diana / Artunc, Ferruh / Ackermann, Teresa F / Ebrahim, Ammar / Palmada, Monica / Klingel, Karin / Saeed, Amal M / Lang, Florian

Nutrition and cancer

2010 Volume 62, Issue 6, Page(s) 802–810

Abstract: Gum Arabic (GA), a nutrient from dried exudate of Acacia senegal, is widely used as emulsifier and stabilizer. It stimulates sodium and water absorption in diarrhea. This study explored the effects of GA in colonic tissue. Mice were treated with GA (10% ... ...

Abstract	Gum Arabic (GA), a nutrient from dried exudate of Acacia senegal, is widely used as emulsifier and stabilizer. It stimulates sodium and water absorption in diarrhea. This study explored the effects of GA in colonic tissue. Mice were treated with GA (10% wt/vol) in drinking water and gene array was performed. As GA modified several tumor-relevant genes, chemical cancerogenesis (intraperitoneal injection of 20 mg/kg 1,2-dimethylhydrazine followed by 3 cycles of 3% dextrane sodium sulphate in drinking water) was induced with or without GA treatment. Within 4 days, GA treatment decreased the colonic transcript levels of the angiogenetic factors angiogenin 1, angiogenin 3, and angiogenin 4 by 78 +/- 18%, 88 +/- 15%, and 92 +/- 13%, respectively (n = 5 each), and of further genes including CD38 antigen, aquaporin4, interleukin18, vav-3-oncogene, gamma(+)-amino acid transporter, sulfatase1, ubiquitinD, and chemokine ligand5. According to Western blotting, GA treatment similarly decreased angiogenin protein expression, and according to immunohistochemistry, it decreased ss-catenin expression. Chemical cancerogenesis resulted in multiple colonic tumors within 12 wk. GA treatment (10% wt/wt) in drinking water significantly decreased the number of tumors by 70%. The observations disclose a powerful anticarcinogenic effect of GA. The nutrient could thus be used for the prophylaxis against colon carcinoma particularly in individuals at enhanced risk.
MeSH term(s)	1,2-Dimethylhydrazine ; Animals ; Anticarcinogenic Agents/pharmacology ; Colonic Neoplasms/prevention & control ; Down-Regulation ; Female ; Gum Arabic/pharmacology ; Male ; Mice ; Mice, Inbred BALB C ; RNA, Messenger/analysis ; Ribonuclease, Pancreatic/analysis ; Ribonuclease, Pancreatic/antagonists & inhibitors ; Ribonuclease, Pancreatic/genetics
Chemical Substances	Anticarcinogenic Agents ; RNA, Messenger ; Gum Arabic (9000-01-5) ; angiogenin (EC 3.1.27.-) ; Ribonuclease, Pancreatic (EC 3.1.27.5) ; 1,2-Dimethylhydrazine (IX068S9745)
Language	English
Publishing date	2010
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	424433-3
ISSN	1532-7914 ; 0163-5581
ISSN (online)	1532-7914
ISSN	0163-5581
DOI	10.1080/01635581003605920
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Article: Downregulation of Angiogenin Transcript Levels and Inhibition of Colonic Carcinoma by Gum Arabic (Acacia senegal)

Nasir, Omaima / Wang, Kan / Foller, Michael / Bhandaru, Madhuri / Sandulache, Diana / Artunc, Ferruh / Ackermann, Teresa F / Ebrahim, Ammar / Palmada, Monica / Klingel, Karin / Saeed, Amal M / Lang, Florian

Nutrition and cancer. 2010 Aug-Sept, v. 62, no. 6

2010

Abstract	Gum Arabic (GA), a nutrient from dried exudate of Acacia senegal, is widely used as emulsifier and stabilizer. It stimulates sodium and water absorption in diarrhea. This study explored the effects of GA in colonic tissue. Mice were treated with GA (10% wt/vol) in drinking water and gene array was performed. As GA modified several tumor-relevant genes, chemical cancerogenesis (intraperitoneal injection of 20 mg/kg 1,2-dimethylhydrazine followed by 3 cycles of 3% dextrane sodium sulphate in drinking water) was induced with or without GA treatment. Within 4 days, GA treatment decreased the colonic transcript levels of the angiogenetic factors angiogenin 1, angiogenin 3, and angiogenin 4 by 78 ± 18%, 88 ± 15%, and 92 ± 13%, respectively (n = 5 each), and of further genes including CD38 antigen, aquaporin4, interleukin18, vav-3-oncogene, γ+-amino acid transporter, sulfatase1, ubiquitinD, and chemokine ligand5. According to Western blotting, GA treatment similarly decreased angiogenin protein expression, and according to immunohistochemistry, it decreased β-catenin expression. Chemical cancerogenesis resulted in multiple colonic tumors within 12 wk. GA treatment (10% wt/wt) in drinking water significantly decreased the number of tumors by 70%. The observations disclose a powerful anticarcinogenic effect of GA. The nutrient could thus be used for the prophylaxis against colon carcinoma particularly in individuals at enhanced risk.
Keywords	gene expression regulation ; mice ; animal models ; angiotensins ; carcinogenesis ; genes ; colorectal neoplasms ; oncogenes ; gum arabic ; anticarcinogenic activity ; Acacia senegal ; drinking water ; functional foods
Language	English
Dates of publication	2010-08
Size	p. 802-810.
Document type	Article
ZDB-ID	424433-3
ISSN	0163-5581
ISSN	0163-5581
Database	NAL-Catalogue (AGRICOLA)

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Article: Lack of the serum and glucocorticoid-inducible kinase SGK1 attenuates the volume retention after treatment with the PPARgamma agonist pioglitazone.

Artunc, Ferruh / Sandulache, Diana / Nasir, Omaima / Boini, Krishna M / Friedrich, Björn / Beier, Norbert / Dicks, Edith / Pötzsch, Sven / Klingel, Karin / Amann, Kerstin / Blazer-Yost, Bonnie L / Scholz, Wolfgang / Risler, Teut / Kuhl, Dietmar / Lang, Florian

Pflugers Archiv : European journal of physiology

2008 Volume 456, Issue 2, Page(s) 425–436

Abstract: PPARgamma-agonists enhance insulin sensitivity and improve glucose utilization in diabetic patients. Adverse effects of PPARgamma-agonists include volume retention and edema formation. Recent observations pointed to the ability of PPARgamma agonists to ... ...

Abstract	PPARgamma-agonists enhance insulin sensitivity and improve glucose utilization in diabetic patients. Adverse effects of PPARgamma-agonists include volume retention and edema formation. Recent observations pointed to the ability of PPARgamma agonists to enhance transcription of the serum and glucocorticoid-inducible kinase SGK1, a kinase that is genomically upregulated by mineralocorticoids and stimulates various renal channels and transporters including the renal epithelial Na+ channel ENaC. SGK1 has been proposed to mediate the volume retention after treatment with PPARgamma agonists. To test this hypothesis, food containing the PPARgamma agonist pioglitazone (0.02%, i.e., approximately 25 mg/kg bw/day) was administered to gene-targeted mice lacking SGK1 (sgk1-/-, n=12) and their wild-type littermates (sgk1+/+), n=12). According to in situ hybridization, quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) and immunofluorescence, treatment with pioglitazone significantly increased renal SGK1 mRNA and protein expression in sgk1+/+ mice. The treatment increased body weight significantly in both, sgk1+/+ mice (+2.2+/-0.3 g) and sgk-/- mice (+1.3+/-0.2 g), and decreased hematocrit significantly in sgk1+/+ mice (-6.5+/-1.0%) and sgk1-/- mice (-3.1+/-0.6%). Both effects were significantly (p<0.05) more pronounced in sgk1+/+ mice. According to Evans Blue distribution, pioglitazone increased plasma volume only in sgk1+/+ mice (from 50.9+/-3.9 to 63.7+/-2.5 microl/g bw) but not in sgk-/- mice (from 46.8+/-3.8 to 48.3+/-5.2 microl/g bw). Pioglitazone decreased aldosterone plasma levels and blood pressure and increased leptin plasma levels in both genotypes. We conclude that SGK1 contributes to but does not fully account for the volume retention during treatment with the PPARgamma agonist pioglitazone.
MeSH term(s)	Animals ; Epithelial Sodium Channels/metabolism ; Hypoglycemic Agents/pharmacology ; Immediate-Early Proteins/genetics ; Immediate-Early Proteins/metabolism ; Kidney/enzymology ; Kidney/physiology ; Mice ; Mice, Knockout ; Mineralocorticoids/metabolism ; PPAR gamma/agonists ; Plasma Volume/drug effects ; Plasma Volume/physiology ; Protein-Serine-Threonine Kinases/genetics ; Protein-Serine-Threonine Kinases/metabolism ; RNA, Messenger/metabolism ; Thiazolidinediones/pharmacology ; Up-Regulation/drug effects
Chemical Substances	Epithelial Sodium Channels ; Hypoglycemic Agents ; Immediate-Early Proteins ; Mineralocorticoids ; PPAR gamma ; RNA, Messenger ; Thiazolidinediones ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; serum-glucocorticoid regulated kinase (EC 2.7.11.1) ; pioglitazone (X4OV71U42S)
Language	English
Publishing date	2008-05
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	6380-0
ISSN	1432-2013 ; 0031-6768
ISSN (online)	1432-2013
ISSN	0031-6768
DOI	10.1007/s00424-007-0401-5
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