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Artikel ; Online: Medication-Associated Diethylene Glycol Mass Poisoning - A Preventable Cause of Illness and Death.

Schier, Joshua / Chang, Arthur / Kapil, Vikas

2023 Band 388, Heft 13, Seite(n) 1156–1157

Mesh-Begriff(e)	Humans ; Acute Kidney Injury/chemically induced ; Acute Kidney Injury/etiology ; Acute Kidney Injury/mortality ; Acute Kidney Injury/prevention & control ; Drug-Related Side Effects and Adverse Reactions/etiology ; Ethylene Glycols/poisoning ; Poisoning/complications ; Poisoning/prevention & control
Chemische Substanzen	diethylene glycol (61BR964293) ; Ethylene Glycols
Sprache	Englisch
Erscheinungsdatum	2023-03-02
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMp2215840
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Selecting patients for interventional procedures to treat hypertension.

Lobo, Melvin D / Rull, Gurvinder / Saxena, Manish / Kapil, Vikas

Blood pressure

2023 Band 32, Heft 1, Seite(n) 2248276

Abstract: Purpose: ...

Abstract	Purpose:
Mesh-Begriff(e)	Humans ; Patient Selection ; Hypertension/therapy ; Kidney ; Baroreflex ; Diuretics
Chemische Substanzen	Diuretics
Sprache	Englisch
Erscheinungsdatum	2023-09-04
Erscheinungsland	England
Dokumenttyp	Journal Article ; Review
ZDB-ID	1170048-8
ISSN	1651-1999 ; 1651-2480 ; 0803-7051 ; 0803-8023
ISSN (online)	1651-1999 ; 1651-2480
ISSN	0803-7051 ; 0803-8023
DOI	10.1080/08037051.2023.2248276
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Use of Genomics to Develop Novel Therapeutics and Personalize Hypertension Therapy.

Magavern, Emma F / Kapil, Vikas / Saxena, Manish / Gupta, Ajay / Caulfield, Mark J

Arteriosclerosis, thrombosis, and vascular biology

2024 Band 44, Heft 4, Seite(n) 784–793

Abstract: Hypertension is a prevalent public health problem, contributing to >10 million deaths annually. Though multiple therapeutics exist, many patients suffer from treatment-resistant hypertension or try several medications before achieving blood pressure ... ...

Abstract	Hypertension is a prevalent public health problem, contributing to >10 million deaths annually. Though multiple therapeutics exist, many patients suffer from treatment-resistant hypertension or try several medications before achieving blood pressure control. Genomic advances offer mechanistic understanding of blood pressure variability, therapeutic targets, therapeutic response, and promise a stratified approach to treatment of primary hypertension. Cyclic guanosine monophosphate augmentation, aldosterone synthase inhibitors, and angiotensinogen blockade with silencing RNA and antisense therapies are among the promising novel approaches. Pharmacogenomic studies have also been done to explore the genetic bases underpinning interindividual variability in response to existing therapeutics. A polygenic approach using risk scores is likely to be the next frontier in stratifying responses to existing therapeutics.
Mesh-Begriff(e)	Humans ; Hypertension/drug therapy ; Hypertension/genetics ; Blood Pressure/genetics ; Multifactorial Inheritance ; Genomics ; Pharmacogenetics
Sprache	Englisch
Erscheinungsdatum	2024-02-22
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Review
ZDB-ID	1221433-4
ISSN	1524-4636 ; 1079-5642
ISSN (online)	1524-4636
ISSN	1079-5642
DOI	10.1161/ATVBAHA.123.319220
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Solar UV Radiation: A Potential Modifiable Risk Factor for Hypertension.

Kapil, Vikas / Gupta, Ajay K

Journal of the American Heart Association

2020 Band 9, Heft 5, Seite(n) e015627

Mesh-Begriff(e)	Blood Pressure ; Humans ; Hypertension/epidemiology ; Hypertension/etiology ; Risk Factors ; Sunlight ; Ultraviolet Rays/adverse effects
Sprache	Englisch
Erscheinungsdatum	2020-02-28
Erscheinungsland	England
Dokumenttyp	Editorial ; Comment
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.120.015627
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Artikel ; Online: Adult hypertension referral pathway and therapeutic management: British and Irish Hypertension Society position statement.

Lewis, Philip / George, Jacob / Kapil, Vikas / Poulter, Neil R / Partridge, Sarah / Goodman, James / Faconti, Luca / McCormack, Terry / Wilkinson, Ian B

Journal of human hypertension

2024 Band 38, Heft 1, Seite(n) 3–7

Abstract: In the UK, most adults with hypertension are managed in Primary Care. Referrals to Secondary Care Hypertension Specialists are targeted to patients in whom further investigations are likely to change management decisions. In this position statement the ... ...

Abstract	In the UK, most adults with hypertension are managed in Primary Care. Referrals to Secondary Care Hypertension Specialists are targeted to patients in whom further investigations are likely to change management decisions. In this position statement the British and Irish Hypertension Society provide clinicians with a framework for referring patients to Hypertension Specialists. Additional therapeutic advice is provided to optimise patient management whilst awaiting specialist review. Our aim is to ensure that referral criteria to Hypertension Specialists are consistent across the UK and Ireland to ensure equitable access for all patients.
Mesh-Begriff(e)	Adult ; Humans ; Hypertension/diagnosis ; Hypertension/therapy ; Ireland ; Referral and Consultation ; White People ; United Kingdom
Sprache	Englisch
Erscheinungsdatum	2024-01-09
Erscheinungsland	England
Dokumenttyp	Journal Article ; Review
ZDB-ID	639472-3
ISSN	1476-5527 ; 0950-9240
ISSN (online)	1476-5527
ISSN	0950-9240
DOI	10.1038/s41371-023-00882-2
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Non-pharmacological factors for hypertension management: a systematic review of international guidelines.

Maniero, Carmela / Lopuszko, Aleksandra / Papalois, Kyriaki-Barbara / Gupta, Ajay / Kapil, Vikas / Khanji, Mohammed Y

European journal of preventive cardiology

2022 Band 30, Heft 1, Seite(n) 17–33

Abstract: Lifestyle modifications are one of the cornerstones of hypertension prevention and treatment. We aimed to systematically review hypertension guidelines on their recommendations on non-pharmacological factors including lifestyle interventions, to ... ...

Abstract	Lifestyle modifications are one of the cornerstones of hypertension prevention and treatment. We aimed to systematically review hypertension guidelines on their recommendations on non-pharmacological factors including lifestyle interventions, to highlight strength of evidence, similarities, and differences. This systematic review was registered with the international Prospective Register of Systematic Reviews (CRD42021288815). Publications in MEDLINE and EMBASE databases over 10 years since January 2010 to June 2020 were identified. We also included the search from websites of organizations responsible for guidelines development. Two reviewers screened the titles and abstracts to identify relevant guidelines. Two reviewers independently assessed rigour of guideline development using the AGREE II instrument, and one reviewer extracted recommendations. Of the identified guidelines, 10 showed good rigour of development (AGREE II ≥ 60%) and were included in the systematic review. The guidelines were consistent in most recommendations (reduced salt intake, weight, dietary patterns, increased physical activity and smoking cessation, and limiting alcohol intake). Some areas of disagreement were identified, regarding recommendations on novel psychological and environmental factors such as stress or air pollution, alcohol intake thresholds, meat, coffee and tea consumption and refined sugars. Current guidelines agree on the importance of lifestyle in the treatment and prevention of hypertension. Consensus on smoking cessation, limited salt intake, increased physical activity support their integration in management of hypertensive patients and in public health measurements in general population as preventative measurements. Further research into the role of environmental and psychological factors may help clarify future recommendations.
Mesh-Begriff(e)	Humans ; Hypertension/etiology ; Hypertension/therapy ; Public Health ; Sodium Chloride, Dietary/adverse effects ; Healthy Lifestyle ; Health Behavior
Chemische Substanzen	Sodium Chloride, Dietary
Sprache	Englisch
Erscheinungsdatum	2022-08-08
Erscheinungsland	England
Dokumenttyp	Journal Article ; Systematic Review
ZDB-ID	2626011-6
ISSN	2047-4881 ; 2047-4873
ISSN (online)	2047-4881
ISSN	2047-4873
DOI	10.1093/eurjpc/zwac163
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Diagnosis and management of primary hyperaldosteronism in patients with hypertension: a practical approach endorsed by the British and Irish Hypertension Society.

Faconti, Luca / Kulkarni, Spoorthy / Delles, Christian / Kapil, Vikas / Lewis, Philip / Glover, Mark / MacDonald, Thomas M / Wilkinson, Ian B

Journal of human hypertension

2023 Band 38, Heft 1, Seite(n) 8–18

Abstract: Alongside the lack of homogeneity among international guidelines and consensus documents on primary hyperaldosteronism, the National UK guidelines on hypertension do not provide extensive recommendations regarding the diagnosis and management of this ... ...

Abstract	Alongside the lack of homogeneity among international guidelines and consensus documents on primary hyperaldosteronism, the National UK guidelines on hypertension do not provide extensive recommendations regarding the diagnosis and management of this condition. Local guidelines vary from area to area, and this is reflected in the current clinical practice in the UK. In an attempt to provide support to the clinicians involved in the screening of subjects with hypertension and clinical management of suspected cases of primary hyperaldosteronism the following document has been prepared on the behalf of the BIHS Guidelines and Information Service Standing Committee. Through remote video conferences, the authors of this document reviewed an initial draft which was then circulated among the BIHS Executive members for feedback. A survey among members of the BIHS was carried out in 2022 to assess screening strategies and clinical management of primary hyperaldosteronism in the different regions of the UK. Feedback and results of the survey were then discussed and incorporated in the final document which was approved by the panel after consensus was achieved considering critical review of existing literature and expert opinions. Grading of recommendations was not performed in light of the limited available data from properly designed randomized controlled trials.
Mesh-Begriff(e)	Humans ; Hypertension/diagnosis ; Hypertension/therapy ; Consensus ; Hyperaldosteronism/complications ; Hyperaldosteronism/diagnosis ; Hyperaldosteronism/therapy
Sprache	Englisch
Erscheinungsdatum	2023-11-14
Erscheinungsland	England
Dokumenttyp	Journal Article ; Review
ZDB-ID	639472-3
ISSN	1476-5527 ; 0950-9240
ISSN (online)	1476-5527
ISSN	0950-9240
DOI	10.1038/s41371-023-00875-1
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Improved lifestyle is associated with improved depression, anxiety and well-being over time in UK healthcare professionals during the COVID-19 pandemic: insights from the CoPE-HCP cohort study.

Khanji, Mohammed Y / Collett, George / Godec, Thomas / Maniero, Carmela / Ng, Sher May / Siddiqui, Imrana / Gupta, Jaya / Kapil, Vikas / Gupta, Ajay

General psychiatry

2023 Band 36, Heft 1, Seite(n) e100908

Abstract: Background: One potential modifiable factor to improve the mental health of healthcare professionals (HCPs) during the pandemic is lifestyle.: Aims: This study aimed to assess whether an improved lifestyle during the pandemic is associated with ... ...

Abstract	Background: One potential modifiable factor to improve the mental health of healthcare professionals (HCPs) during the pandemic is lifestyle. Aims: This study aimed to assess whether an improved lifestyle during the pandemic is associated with improved mental health symptoms and mental well-being in HCPs over time. Methods: This was a cohort study involving an online survey distributed at two separate time points during the pandemic (baseline (July-September 2020) and follow-up (December 2020-March 2021)) to HCPs working in primary or secondary care in the UK. Both surveys assessed for major depressive disorder (MDD) (Patient Health Questionnaire-9 (PHQ-9)), generalised anxiety disorder (GAD) (Generalised Anxiety Disorder-7 (GAD-7)), mental well-being (Short Warwick-Edinburgh Mental Well-being Score (SWEMWBS)) and self-reported lifestyle change (compared with the start of the pandemic) on multiple domains. Cumulative scores were calculated to estimate overall lifestyle change compared with that before the pandemic (at both baseline and follow-up). At each time point, separate logistic regression models were constructed to relate the lifestyle change score with the presence of MDD, GAD and low mental well-being. Linear regression models were also developed relating the change in lifestyle scores from baseline to follow-up to changes in PHQ-9, GAD-7 and SWEMWBS scores. Results: 613 HCPs completed both baseline assessment and follow-up assessment. Consistent significant cross-sectional associations between increased lifestyle change scores and a reduced risk of MDD, GAD and low mental well-being were observed at both baseline and follow-up. Over the study period, a whole unit increase in the change in novel scores (ie, improved overall lifestyle) over 4 months was inversely associated with changes in PHQ-9 (adjusted coefficient: -0.51, 95% confidence interval (CI): -0.73 to -0.30, p<0.001) and GAD-7 scores (adjusted coefficient: -0.32, 95% CI: -0.53 to -0.10, p=0.004) and positively associated with the change in SWEMWBS scores (adjusted coefficient: 0.37, 95% CI: 0.18 to 0.55, p<0.001). Conclusions: Improved lifestyle over time is associated with improved mental health and mental well-being in HCPs during the pandemic. Improving lifestyle could be a recommended intervention for HCPs to help mitigate the mental health impact during the current and future pandemics. Trial registration number: NCT04433260.
Sprache	Englisch
Erscheinungsdatum	2023-01-20
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	2941976-1
ISSN	2517-729X ; 2517-729X ; 2096-5923
ISSN (online)	2517-729X
ISSN	2517-729X ; 2096-5923
DOI	10.1136/gpsych-2022-100908
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Rapid Decline of SARS-CoV-2 Viral Load in Single vs. Double-Dose (Short-Interval <6 Weeks) ChAdOx nCoV-19 Vaccinated Health-Care Workers.

Ghosh, Arnab / Kanta, Poonam / Ramola, Manisha / Mohindra, Ritin / Goyal, Kapil / Kishore, Roop / Suri, Vikas / Lakshmi, P V M / Chauhan, Chanderkanta / Sharma, Manisha / Rakshit, Partha / Ponnusamy, Kalaiarasan / Dikid, Tanzin / Singh, Mini P

Current microbiology

2024 Band 81, Heft 4, Seite(n) 95

Abstract: The present work was carried out during the emergence of Delta Variant of Concern (VoC) and aimed to study the change in SARS CoV-2 viral load in Covishield vaccinated asymptomatic/mildly symptomatic health-care workers (HCWs) to find out the optimum ... ...

Abstract	The present work was carried out during the emergence of Delta Variant of Concern (VoC) and aimed to study the change in SARS CoV-2 viral load in Covishield vaccinated asymptomatic/mildly symptomatic health-care workers (HCWs) to find out the optimum isolation period. The SARS CoV-2 viral load was carried out in sequential samples of 55 eligible HCWs which included unvaccinated (UnV; n = 11), single-dose vaccinated (SDV, n = 20) and double-dose vaccinated [DDV, n = 24; short-interval (<6 weeks)] subjects. The mean load of envelope (E) gene on day 5 in SDV [0.42 × 10
Mesh-Begriff(e)	Humans ; ChAdOx1 nCoV-19 ; SARS-CoV-2/genetics ; Viral Load ; COVID-19/prevention & control
Chemische Substanzen	ChAdOx1 nCoV-19 (B5S3K2V0G8)
Sprache	Englisch
Erscheinungsdatum	2024-02-14
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	134238-1
ISSN	1432-0991 ; 0343-8651
ISSN (online)	1432-0991
ISSN	0343-8651
DOI	10.1007/s00284-023-03603-7
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Effect of iron-fortified rice on the hemoglobin level of the individuals aged more than six months: A meta-analysis of controlled trials.

Ramaswamy, Gomathi / Yadav, Kapil / Goel, Akhil Dhanesh / Yadav, Vikas / Arora, Srishti / Vohra, Kashish / Khanam, Areeba / Kant, Shashi

Journal of family medicine and primary care

2023 Band 11, Heft 12, Seite(n) 7527–7536

Abstract: Fortification of staple food items with iron is a potential strategy to address anemia for a larger population. We reviewed studies to assess the impact of iron-fortified rice (IFR) on hemoglobin levels of individuals more than six months of age. We ... ...

Abstract	Fortification of staple food items with iron is a potential strategy to address anemia for a larger population. We reviewed studies to assess the impact of iron-fortified rice (IFR) on hemoglobin levels of individuals more than six months of age. We included studies assessing the effectiveness of IFR (with or without other micronutrients) conducted in any part of the world available in PubMed, Embase, Web of Science, Cochrane Library, Google Scholar, clinicaltrials.gov, International database of prospectively registered systematic reviews in health and social care (PROSPERO), unicef.org, and who.int databases and published from January 1, 1990 to April 1, 2019 (PROSPERO registration number: RD42020139895). We extracted the changes in hemoglobin, serum ferritin, and serum transferrin levels among the participants. Finally, data from 15 trials and their 21 subsets were analyzed. Mean difference in hemoglobin was 0.53 g/dl (95% CI: 0.26, 0.80, P < 0.001, I2 = 84%) in the IFR group compared to the control group. In the subgroup analysis after removing studies with small sample size and high risk for bias, a mean difference of 0.44 g/dl (95% CI: 0.20, 0.69, P < 0.001, I2 = 82%) was observed. No significant effect on serum ferritin or transferrin levels was observed. From this review it can be concluded that fortification of rice with iron can be adopted as an intervention to improve hemoglobin levels, especially in countries where rice is the major part food of staple diet. Research is needed on an optimal iron compound for fortification and the acceptance of IFR.
Sprache	Englisch
Erscheinungsdatum	2023-01-17
Erscheinungsland	India
Dokumenttyp	Journal Article ; Review
ZDB-ID	2735275-4
ISSN	2278-7135 ; 2249-4863
ISSN (online)	2278-7135
ISSN	2249-4863
DOI	10.4103/jfmpc.jfmpc_409_22
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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