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Book ; Online ; E-Book: Symptomatic

Francomano, Clair A. / Hakim, Alan J. / Henderson, Lansdale G. S. / Henderson Sr., Fraser C.

the symptom-based handbook for Ehlers-Danlos syndromes and hypermobility spectrum disorders

2023

Title variant	Symptom-based handbook for Ehlers-Danlos syndromes and hypermobility spectrum disorders
Author's details	edited by Clair A. Francomano [and more]
MeSH term(s)	Ehlers-Danlos Syndrome ; Joint Instability
Keywords	Ehlers-Danlos syndrome ; Joints/Hypermobility
Subject code	616.77
Language	English
Size	1 online resource (662 pages)
Edition	1st ed.
Publisher	Elsevier
Publishing place	San Diego
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	0-323-95083-3 ; 9780323950824 ; 978-0-323-95083-1 ; 0323950825
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Do risk scores improve use of faecal immunochemical testing for haemoglobin in symptomatic patients in primary care?

Digby, Jayne / Fraser, Callum G / Clark, Gavin / Mowat, Craig / Strachan, Judith A / Steele, Robert J C

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

2024

Abstract: ... of colonoscopies as a f-Hb threshold of ≥10 μg Hb/g gave improved sensitivity for CRC in both cohorts. A RSM ... which excluded f-Hb was used to investigate the effect of raising the f-Hb threshold from ≥10 to ≥20 μg Hb/g ...

Abstract	Aim: Faecal immunochemical testing (FIT) is used in the detection of colorectal cancer (CRC). FIT is invariably used at a single faecal haemoglobin (f-Hb) concentration threshold. The aim of this observational study was to explore risk scoring models (RSMs) with f-Hb and other risk factors for CRC in symptomatic patients attending primary care, potentially speeding diagnosis and saving endoscopy resources. Method: Records of patients completing FIT were linked with The Scottish Cancer Registry and with other databases with symptoms, full blood count and demographic variables, and randomized into derivation and validation cohorts. Stepwise multivariable logistic regression created RSMs assessed in the validation cohort. Results: Of 18 805 unique patients, 9374 and 9431 were in the derivation and validation cohorts, respectively: f-Hb, male sex, increasing age, iron deficiency anaemia and raised systemic immune inflammation index created the final RSM. A risk score threshold of ≥2.363, generating the same number of colonoscopies as a f-Hb threshold of ≥10 μg Hb/g gave improved sensitivity for CRC in both cohorts. A RSM which excluded f-Hb was used to investigate the effect of raising the f-Hb threshold from ≥10 to ≥20 μg Hb/g in those with a low risk score. This approach would have generated 234 fewer colonoscopies but missed four CRCs. Conclusion: The RSM conferred no significant benefit to patients with very low f-Hb and CRC. Alternative strategies combining FIT with other variables may be more appropriate for safety-netting of symptomatic patients. Further work to develop and investigate the value of RSM for significant bowel disease other than CRC may also be beneficial.
Language	English
Publishing date	2024-02-29
Publishing country	England
Document type	Journal Article
ZDB-ID	1440017-0
ISSN	1463-1318 ; 1462-8910
ISSN (online)	1463-1318
ISSN	1462-8910
DOI	10.1111/codi.16925
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 5799: Show issues

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Article ; Online: Cancer researchers' experiences with and perceptions of research data sharing: Results of a cross-sectional survey.

Hamilton, Daniel G / Page, Matthew J / Everitt, Sarah / Fraser, Hannah / Fidler, Fiona

Accountability in research

2024 , Page(s) 1–28

Abstract: Background: Despite wide recognition of the benefits of sharing research data, public availability rates have not increased substantially in oncology or medicine more broadly over the last decade.: Methods: We surveyed 285 cancer researchers to ... ...

Abstract	Background: Despite wide recognition of the benefits of sharing research data, public availability rates have not increased substantially in oncology or medicine more broadly over the last decade. Methods: We surveyed 285 cancer researchers to determine their prior experience with sharing data and views on known drivers and inhibitors. Results: We found that 45% of respondents had shared some data from their most recent empirical publication, with respondents who typically studied non-human research participants, or routinely worked with human genomic data, more likely to share than those who did not. A third of respondents added that they had previously shared data privately, with 74% indicating that doing so had also led to authorship opportunities or future collaborations for them. Journal and funder policies were reported to be the biggest general drivers toward sharing, whereas commercial interests, agreements with industrial sponsors and institutional policies were the biggest prohibitors. We show that researchers' decisions about whether to share data are also likely to be influenced by participants' desires. Conclusions: Our survey suggests that increased promotion and support by research institutions, alongside greater championing of data sharing by journals and funders, may motivate more researchers in oncology to share their data.
Language	English
Publishing date	2024-02-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2069334-5
ISSN	1545-5815 ; 0898-9621
ISSN (online)	1545-5815
ISSN	0898-9621
DOI	10.1080/08989621.2024.2308606
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Redefining both iron deficiency and anaemia in cardiovascular disease.

Cleland, John G F / Pellicori, Pierpaolo / Graham, Fraser J

European heart journal

2023 Volume 44, Issue 22, Page(s) 1992–1994

MeSH term(s)	Humans ; Cardiovascular Diseases/complications ; Cardiovascular Diseases/epidemiology ; Iron Deficiencies ; Anemia, Iron-Deficiency/complications ; Anemia/etiology ; Vascular Diseases
Language	English
Publishing date	2023-03-07
Publishing country	England
Document type	Editorial ; Comment
ZDB-ID	603098-1
ISSN	1522-9645 ; 0195-668X
ISSN (online)	1522-9645
ISSN	0195-668X
DOI	10.1093/eurheartj/ehad154
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Zs.A 1563: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: The acceptability and utility of Indigenous youth health assessments: a narrative systematic review.

Fraser, Jed / Askew, Deborah / Mahoney, Ray / Spurling, Geoffrey

Australian journal of primary health

2023 Volume 29, Issue 4, Page(s) 296–305

Abstract: Background: Indigenous youth are navigating the transition from childhood to adulthood while contending with challenges of ongoing colonisation and everyday lived experiences of racism. A comprehensive assessment of Indigenous youth's health could ... ...

Abstract	Background: Indigenous youth are navigating the transition from childhood to adulthood while contending with challenges of ongoing colonisation and everyday lived experiences of racism. A comprehensive assessment of Indigenous youth's health could enable early diagnosis and respond to health concerns. This narrative systematic review synthesises evidence about the acceptability and utility of primary health care-based health assessments for improving the health and wellbeing of Indigenous youth. Methods: A systematic search strategy was conducted using 20 electronic databases. Studies were included if they reported on health assessments conducted in primary health care with youth aged 12-24years who were Indigenous to Australia, New Zealand, Canada, the USA, Taiwan, and the arctic regions of Scandinavia and Russia. A narrative synthesis was undertaken. Results: Of 3061 unique studies identified, seven met the eligibility criteria. Included studies showed that youth health assessments were useful for making new diagnoses, detecting social and emotional wellbeing concerns, and biomedical parameters. Co-created health assessments with Indigenous youth conducted by clinicians familiar to the community were well accepted. Digital health assessments administered using an electronic tablet provide advantages. No health outcomes were reported. Additionally, no health assessments addressed the impacts of colonisation and racism. Conclusion: There is insufficient evidence to make firm conclusions about the benefits of health assessments; however, health assessments can be useful for detecting new diagnoses and concerns regarding social determinants of health, and social and emotional wellbeing. Future development of Indigenous youth health assessments needs to involve Indigenous youth's perspectives and interpretations of health.
MeSH term(s)	Humans ; Adolescent ; Child ; Young Adult ; Canada ; Narration ; Australia ; New Zealand
Language	English
Publishing date	2023-01-25
Publishing country	Australia
Document type	Systematic Review ; Journal Article
ZDB-ID	2566332-X
ISSN	1836-7399 ; 1448-7527
ISSN (online)	1836-7399
ISSN	1448-7527
DOI	10.1071/PY22128
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effects of bovine whey protein on exercise-induced gut permeability in healthy adults: a randomised controlled trial.

Ulluwishewa, Dulantha / Nicholls, Grayson / Henderson, Harold / Bernstein, Daniel / Fraser, Karl / Barnett, Matthew P G / Barnes, Matthew J

European journal of applied physiology

2024

Abstract: ... the treatment (2 g/day of milk powder containing 200 mg of whey protein) or placebo (2 g/day of milk powder ...

Abstract	Purpose: Intestinal permeability is a critical component of gut barrier function. Barrier dysfunction can be triggered by certain stressors such as exercise, and if left unmanaged can lead to local and systemic disorders. The aim of this study was to investigate the effects of a specific whey protein fraction in alleviating exercise-induced gut permeability as assessed by recovery of lactulose/rhamnose (L/R) and lactulose/mannitol (L/M) urinary probes. Methods: Eight males and eight females (aged 18-50) completed two arms of a double-blind, placebo-controlled, crossover study. For each arm participants performed two baseline intestinal permeability assessments, following which they consumed the treatment (2 g/day of milk powder containing 200 mg of whey protein) or placebo (2 g/day of milk powder) for 14 days, before performing a post-exercise permeability assessment. The exercise protocol involved a 20-min run at 80% of maximal oxygen uptake on a 1% incline. Results: Mixed model analysis revealed an increase in L/R (23%; P < 0.001) and L/M (20%; P < 0.01) recovery following exercise. However, there was no treatment or treatment × exercise effect. Conclusion: The exercise protocol utilised in our study induces gut permeability. However, consuming whey protein, at the dose and timing prescribed, is not able to mitigate this effect.
Language	English
Publishing date	2024-02-22
Publishing country	Germany
Document type	Journal Article
ZDB-ID	124793-1
ISSN	1439-6327 ; 1432-1025 ; 0301-5548 ; 1439-6319
ISSN (online)	1439-6327 ; 1432-1025
ISSN	0301-5548 ; 1439-6319
DOI	10.1007/s00421-024-05423-4
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Article ; Online: Early-Life Initiation of Primary Prevention Strategies to Reduce Atherosclerosis Risk-Reply.

Armstrong, Matthew K / Fraser, Brooklyn J / Magnussen, Costan G

JAMA cardiology

2021 Volume 6, Issue 12, Page(s) 1467–1468

MeSH term(s)	Atherosclerosis/prevention & control ; Cognition ; Humans ; Primary Prevention
Language	English
Publishing date	2021-10-05
Publishing country	United States
Document type	Letter ; Comment
ISSN	2380-6591
ISSN (online)	2380-6591
DOI	10.1001/jamacardio.2021.3951
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Recruitment dynamics of juvenile salmonids: Comparisons among populations and with classic case studies.

Matte, Jean-Michel O / Fraser, Dylan J / Grant, James W A

Journal of fish biology

2024

Abstract: ... a Beverton-Holt model. Although environmental variables (e.g., temperature, pH, depth, substrate) correlated ...

Abstract	Understanding recruitment, the process by which individuals are added to a population or to a fishery, is critical for understanding population dynamics and facilitating sustainable fisheries management. Important variation in recruitment dynamics is observed among populations, wherein some populations exhibit asymptotic productivity and others exhibit overcompensation (i.e., compensatory density-dependence in recruitment). Our ability to understand this interpopulation variability in recruitment patterns is limited by a poor understanding of the underlying mechanisms, such as the complex interactions between density dependence, recruitment, and environment. Furthermore, most studies on recruitment are conducted using an observational design with long time series that are seldom replicated across populations in an experimentally controlled fashion. Without proper replication, extrapolations between populations are tenuous, and the underlying environmental trends are challenging to quantify. To address these issues, we conducted a field experiment manipulating stocking densities of juvenile brook trout Salvelinus fontinalis in three wild populations to show that these neighboring populations-which exhibit divergent patterns of density dependence due to environmental conditions-also have important differences in recruitment dynamics. Testing against four stock-recruitment models (density independent, linear, Beverton-Holt, and Ricker), populations exhibited ~twofold variation in asymptotic productivity, with no overcompensation following a Beverton-Holt model. Although environmental variables (e.g., temperature, pH, depth, substrate) correlated with population differences in recruitment, they did not improve the predictive power in individual populations. Comparing our patterns of recruitment with classic salmonid case studies revealed that despite differences in the shape and parameters of the curves (i.e., Ricker vs. Beverton-Holt), a maximum stocking density of about five YOY fish/m
Language	English
Publishing date	2024-04-10
Publishing country	England
Document type	Journal Article
ZDB-ID	410564-3
ISSN	1095-8649 ; 0022-1112
ISSN (online)	1095-8649
ISSN	0022-1112
DOI	10.1111/jfb.15748
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Estimating the numbers of aquatic birds affected by oil spills: pre-planning, response, and post-incident considerations

Fraser, G.S. / Robertson, G.J. / Stenhouse, I.J. / Ellis, J.I.

Environmental reviews. 2022, v. 30, no. 2

2022

Abstract: Oil spills most visibly affect waterbirds and often the number of birds affected, a key measure of environmental damage from an incident, is required for public communication, population management, and legal reasons. We review and outline steps that can ...

Abstract	Oil spills most visibly affect waterbirds and often the number of birds affected, a key measure of environmental damage from an incident, is required for public communication, population management, and legal reasons. We review and outline steps that can be taken to improve accuracy in the estimation of the number of birds affected in each of three phases: (1) pre-planning; (2) during a response; and (3) post-response. The more pre-planning undertaken, the more robust the estimates will be. Personnel involved in damage assessment efforts must have training in quantitative biology and need support during all three phases. The main approaches currently used to estimate the number of birds affected include probability exposure models and carcass sampling — both onshore and on the water. Probability exposure models can be used in the post-incident phase, particularly in offshore scenarios where beached bird surveys are not possible, and requires three datasets: (1) at-sea bird densities; (2) bird mortality; and (3) the spill trajectory. Carcass sampling using beached bird surveys is appropriate if trajectories indicate affected birds will reach shore. Carcass sampling can also occur via on-water transects and may overlap with risk assessment efforts. Damage assessment efforts should include a measure of sublethal effects following the post-acute phase of spills, yet this area has significant knowledge gaps. We urge jurisdictions worldwide to improve pre-incident planning. We provide guidance on how, in the absence of pre-incident data, quality data can be obtained during or after an incident. These recommendations are relevant for areas with aquatic-based industrial activities which can result in a spill of substances that could injure or kill waterbirds.
Keywords	data collection ; human resources ; mortality ; oils ; probability ; water birds
Language	English
Size	p. 323-341.
Publishing place	Canadian Science Publishing
Document type	Article
ZDB-ID	2027518-3
ISSN	1208-6053 ; 1181-8700
ISSN (online)	1208-6053
ISSN	1181-8700
DOI	10.1139/er-2021-0121
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Temperate woody species across the angiosperm phylogeny acquire tolerance to water deficit stress during the growing season.

Grossman, Jake J / Coe, Henry B / Fey, Olivia / Fraser, Natalie / Salaam, Musa / Semper, Chelsea / Williamson, Ceci G

The New phytologist

2024

Abstract: Understanding the capacity of temperate trees to acclimate to limited soil water has become essential in the face of increasing drought risk due to climate change. We documented seasonal - or phenological - patterns in acclimation to water deficit stress ...

Abstract	Understanding the capacity of temperate trees to acclimate to limited soil water has become essential in the face of increasing drought risk due to climate change. We documented seasonal - or phenological - patterns in acclimation to water deficit stress in stems and leaves of tree species spanning the angiosperm phylogeny. Over 3 yr of field observations carried out in two US arboreta, we measured stem vulnerability to embolism (36 individuals of 7 Species) and turgor loss point (119 individuals of 27 species) over the growing season. We also conducted a growth chamber experiment on 20 individuals of one species to assess the mechanistic relationship between soil water restriction and acclimation. In three-quarters of species measured, plants became less vulnerable to embolism and/or loss of turgor over the growing season. We were able to stimulate this acclimatory effect by withholding water in the growth chamber experiment. Temperate angiosperms are capable of acclimation to soil water deficit stress, showing maximum vulnerability to soil water deficits following budbreak and becoming more resilient to damage over the course of the growing season or in response to simulated drought. The species-specific tempo and extent of this acclimatory potential constitutes preadaptive climate change resilience.
Language	English
Publishing date	2024-03-21
Publishing country	England
Document type	Journal Article
ZDB-ID	208885-x
ISSN	1469-8137 ; 0028-646X
ISSN (online)	1469-8137
ISSN	0028-646X
DOI	10.1111/nph.19692
Database	MEDical Literature Analysis and Retrieval System OnLINE

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