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Article: Progression of renal disease: current concepts and therapeutic approaches.

Bourgoignie, J J

1992 Volume 36, Page(s) S61–5

Abstract: The pathogenesis of progressive renal disease includes systemic hypertension and intrarenal factors that may be hemodynamic or metabolic in origin and involve mediators of inflammation. Most current information derives from experiments in rodents. In ... ...

Abstract	The pathogenesis of progressive renal disease includes systemic hypertension and intrarenal factors that may be hemodynamic or metabolic in origin and involve mediators of inflammation. Most current information derives from experiments in rodents. In other species (rabbit, dog, baboon) subjected to renal mass reduction, a greater variety of pathologic changes is apparent than in rats. Clinical trials at controlling progression of renal disease are compounded by numerous factors; and it is not evident that extrapolation can safely be made from results of animal studies to human disease. The mechanism(s) of renal disease progression in humans, therefore, remain largely unknown. Current therapeutic recommendations in patients with chronic renal disease include limitation of phosphorus absorption, correction of lipid abnormalities and control of systemic blood pressure. The latter can be achieved with a variety of agents some of which, like angiotensin converting enzyme inhibitors and calcium antagonists, may be preferred because of specific intrarenal effects.
MeSH term(s)	Animals ; Antihypertensive Agents/therapeutic use ; Calcium Channel Blockers/therapeutic use ; Dietary Proteins/administration & dosage ; Humans ; Kidney Failure, Chronic/etiology ; Kidney Failure, Chronic/physiopathology ; Kidney Failure, Chronic/therapy ; Nephrons/injuries ; Phosphorus, Dietary/administration & dosage ; Renal Circulation
Chemical Substances	Antihypertensive Agents ; Calcium Channel Blockers ; Dietary Proteins ; Phosphorus, Dietary
Language	English
Publishing date	1992-05
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Review
ZDB-ID	193442-9
ISSN	2157-1716 ; 0098-6577 ; 2157-1724
ISSN (online)	2157-1716
ISSN	0098-6577 ; 2157-1724
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Renal complications of human immunodeficiency virus type 1.

Bourgoignie, J J

Kidney international

1990 Volume 37, Issue 6, Page(s) 1571–1584

MeSH term(s)	AIDS-Related Complex/complications ; Acid-Base Imbalance/complications ; Acquired Immunodeficiency Syndrome/complications ; Acute Kidney Injury/complications ; Adult ; HIV-1 ; Humans ; Kidney/pathology ; Kidney Diseases/complications ; Kidney Diseases/pathology ; Male
Language	English
Publishing date	1990-06
Publishing country	United States
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	120573-0
ISSN	1523-1755 ; 0085-2538
ISSN (online)	1523-1755
ISSN	0085-2538
DOI	10.1038/ki.1990.151
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Article: Acquired immunodeficiency syndrome (AIDS)--related renal disease.

Bourgoignie, J J

Klinische Wochenschrift

1989 Volume 67, Issue 17, Page(s) 889–894

Abstract: More than 87,000 patients with acquired immunodeficiency syndrome (AIDS) were reported to the Centers for Disease Control in the United States, of whom more than half died through January 1989. When the AIDS epidemic is considered worldwide, these ... ...

Abstract	More than 87,000 patients with acquired immunodeficiency syndrome (AIDS) were reported to the Centers for Disease Control in the United States, of whom more than half died through January 1989. When the AIDS epidemic is considered worldwide, these numbers should be doubled at least [27]. Whereas electrolyte disorders and acute renal complications were recognized early on in the AIDS epidemic, it was not until 1984 that a nephropathy was described in patients with human immunodeficiency virus-Type 1 (HIV-1) (formerly called LAV/HTLV-III) infection [18, 30, 36]. This nephropathy was characterized, clinically, by heavy proteinuria or the nephrotic syndrome and a rapid progression to end-stage chronic renal failure and, pathologically, by an aggressive form of focal segmental glomerulosclerosis. The existence of an AIDS-related nephropathy was not readily accepted because of its uneven geographic distribution amongst areas severely affected by the AIDS epidemic [24, 48]. This brief review summarizes the clinical and pathologic features of AIDS-related nephropathy.
MeSH term(s)	Acquired Immunodeficiency Syndrome/complications ; Acquired Immunodeficiency Syndrome/pathology ; HIV-1/pathogenicity ; Humans ; Kidney/pathology ; Kidney Diseases/complications ; Kidney Diseases/pathology ; Opportunistic Infections/complications ; Opportunistic Infections/pathology ; Prospective Studies
Language	English
Publishing date	1989-09-01
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	200457-4
ISSN	0023-2173
ISSN	0023-2173
DOI	10.1007/bf01717345
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Article: Natriuretic hormones: comparison of renal effects.

Bourgoignie, J J

Klinische Wochenschrift

1987 Volume 65 Suppl 8, Page(s) 14–20

Abstract: The natriuretic properties of two small molecular weight endogenous compounds are reviewed. One may originate from the hypothalamus (natriuretic factor-NF) and the other from the cardiac atria (atrial natriuretic peptide-ANP). Differences in the ... ...

Abstract	The natriuretic properties of two small molecular weight endogenous compounds are reviewed. One may originate from the hypothalamus (natriuretic factor-NF) and the other from the cardiac atria (atrial natriuretic peptide-ANP). Differences in the intrarenal mechanisms of action of NF and ANP should be anticipated in view of the fundamentally different cellular effects of NF and ANP. NF is an inhibitor of (NaK) ATPase and inhibits active sodium transport across the isolated frog skin or toad bladder while ANP has no effect on NaK ATPase and sodium transport in vitro across the isolated anuran membrane. NF may have vasoconstrictive properties. In contrast ANP has vasorelaxing properties in some vascular beds and decreases blood pressure. Both compounds are diuretic, natriuretic and phosphaturic in intact kidneys and in kidneys with a decreased functional mass. Effects on potassium excretion are variable. For both, the increases in water and solute excretion are associated with several sites of action within the nephron. Whereas NF has little effect on glomerular filtration rate (GFR) and filtration fraction, ANP may induce impressive changes in kidney and in superficial nephron GFR, increasing the filtered load of water and solutes. ANP also increases filtration fraction changing, thereby, the peritubular physical forces of filtrate reabsorption. Both NF and ANP inhibit water and solute reabsorption in the proximal tubule. With NF, a direct tubular effect has been demonstrated in recollection micropuncture studies. In contrast, a direct epithelial effect has not been elicited with ANP in the proximal tubule.(ABSTRACT TRUNCATED AT 250 WORDS)
MeSH term(s)	Animals ; Atrial Natriuretic Factor/pharmacology ; Dogs ; Glomerular Filtration Rate/drug effects ; Hemodynamics/drug effects ; Humans ; Kidney/drug effects ; Kidney Tubules/drug effects ; Natriuretic Agents/pharmacology ; Renal Circulation/drug effects
Chemical Substances	Natriuretic Agents ; Atrial Natriuretic Factor (85637-73-6)
Language	English
Publishing date	1987
Publishing country	Germany
Document type	Comparative Study ; Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	200457-4
ISSN	0023-2173
ISSN	0023-2173
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Article ; Online: Renal mucormycosis in the HIV patient.

Guardia, J A / Bourgoignie, J / Diego, J

American journal of kidney diseases : the official journal of the National Kidney Foundation

2000 Volume 35, Issue 5, Page(s) E24

Abstract: Mucormycosis is an increasingly recognized opportunistic infection. It usually affects patients with debilitating conditions such as cancer, diabetes mellitus, renal failure, and extensive burns. Mucor infection has also been described in human ... ...

Abstract	Mucormycosis is an increasingly recognized opportunistic infection. It usually affects patients with debilitating conditions such as cancer, diabetes mellitus, renal failure, and extensive burns. Mucor infection has also been described in human immunodeficiency virus (HIV) patients. The most common clinical presentations are the cerebral, cutaneous, and renal forms. We describe a unique case of bilateral renal mucormycosis presenting with renal failure in an HIV-infected patient. In the immunosuppressed host, a history of intravenous (IV) drug abuse associated with symptoms of pyelonephritis should alert the clinician to the possibility of mucor infection. Blood and urine culture are often negative. The diagnosis is made histologically in most cases. The treatment of HIV patients with mucormycosis and renal failure includes hemodialysis, nephrectomy, and intravenous amphotericin in addition to antiretroviral therapy. Bilateral renal involvement with Mucor carries a poor prognosis.
MeSH term(s)	AIDS-Related Opportunistic Infections/diagnosis ; Adult ; Fatal Outcome ; HIV Infections/complications ; Humans ; Kidney/diagnostic imaging ; Kidney/pathology ; Kidney Diseases/diagnosis ; Kidney Diseases/etiology ; Male ; Mucorales/isolation & purification ; Mucormycosis/diagnosis ; Mucormycosis/etiology ; Tomography, X-Ray Computed
Language	English
Publishing date	2000-05
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	604539-x
ISSN	1523-6838 ; 0272-6386
ISSN (online)	1523-6838
ISSN	0272-6386
DOI	10.1016/s0272-6386(00)70289-7
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Zs.A 1669: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Régulations hormonales du métabolisme phospho-calcique au niveau du rein.

Bourgoignie, J J

Schweizerische medizinische Wochenschrift

1982 Volume 112, Issue 49, Page(s) 1759–1763

Abstract: The effects of hormones in the renal handling of calcium and phosphate are reviewed in the context of transport events occurring in different segments of the nephron. Hormones that influence the renal handling of calcium include parathyroid hormone, ... ...

Title translation	Hormonal regulation of phosphorus and calcium metabolism at the kidney level.
Abstract	The effects of hormones in the renal handling of calcium and phosphate are reviewed in the context of transport events occurring in different segments of the nephron. Hormones that influence the renal handling of calcium include parathyroid hormone, calcitonin and vitamin D. However, the kidney plays only a minor role in the maintenance of calcium balance. Hormones that modify the renal handling of phosphate are parathyroid hormone, thyroid hormone, growth hormone, glucocorticoids and vitamin D. In contrast to calcium, the kidney plays an important role in the maintenance of phosphate balance. In this endocrine context the contribution of the kidney is reviewed in clinical conditions of hypo- and hyperphosphatemia.
MeSH term(s)	Absorption ; Calcitonin/physiology ; Calcium/metabolism ; Homeostasis ; Hormones/physiology ; Humans ; Kidney/metabolism ; Kidney Tubules/metabolism ; Parathyroid Hormone/physiology ; Phosphates/metabolism ; Receptors, Cell Surface/metabolism ; Receptors, Parathyroid Hormone ; Vitamin D/physiology
Chemical Substances	Hormones ; Parathyroid Hormone ; Phosphates ; Receptors, Cell Surface ; Receptors, Parathyroid Hormone ; Vitamin D (1406-16-2) ; Calcitonin (9007-12-9) ; Calcium (SY7Q814VUP)
Language	French
Publishing date	1982-12-04
Publishing country	Switzerland
Document type	English Abstract ; Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Review
ZDB-ID	200461-6
ISSN	0036-7672
ISSN	0036-7672
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Ua VI Zs.152: Show issues

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Article: HIV-associated nephropathies.

Bourgoignie, J J / Pardo, V

The New England journal of medicine

1992 Volume 327, Issue 10, Page(s) 729–730

MeSH term(s)	AIDS-Associated Nephropathy/immunology ; Antigen-Antibody Complex/analysis ; Glomerulonephritis/immunology ; Glomerulonephritis, IGA/immunology ; HIV Infections/immunology ; Humans ; Male
Chemical Substances	Antigen-Antibody Complex
Language	English
Publishing date	1992-09-03
Publishing country	United States
Document type	Comment ; Editorial
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJM199209033271012
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Article: Acute rhabdomyolysis associated with cocaine intoxication

Bourgoignie, J. J.

New England J. Medicine

1988 Volume 319, Issue 11, Page(s) 673–677

Institution	P.O. Box 016960, USA Miami, FL 33101 University of Miami School of Medicine, Division of Nephrology (R-126)
Keywords	Cocain ; Komplikation ; Muskulatur ; Niereninsuffizienz ; Mortalitaet ; Inzidenz
Language	English
Document type	Article
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
Database	Social Medicine (SOMED)

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Article: The nephropathology in human immunodeficiency virus (HIV-1) infection.

Bourgoignie, J J / Pardo, V

Kidney international. Supplement

1991 Volume 35, Page(s) S19–23

Abstract: The nephropathology observed in patients with HIV infection is reviewed. A characteristic, though not specific, nephropathy associated with HIV infection can be encountered in HIV carriers, in patients with AIDS-related complex and in patients with AIDS. ...

Abstract	The nephropathology observed in patients with HIV infection is reviewed. A characteristic, though not specific, nephropathy associated with HIV infection can be encountered in HIV carriers, in patients with AIDS-related complex and in patients with AIDS. HIV-associated nephropathy typically exhibits the features of an aggressive form of focal and segmental glomerulosclerosis. Distinctive pathologic features include: 1) the "collapsing" and predominantly global pattern of glomerulosclerosis; 2) the severity of visceral epithelial cell hypertrophy and droplet formation; 3) the prominent tubular microcysts and cast formation; 4) the focal tubular degenerative features; and 5) the numerous tubuloreticular inclusions.
MeSH term(s)	AIDS-Associated Nephropathy/pathology ; Acquired Immunodeficiency Syndrome/pathology ; HIV Infections/pathology ; HIV-1 ; Humans ; Kidney/pathology
Language	English
Publishing date	1991-12
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Review
ZDB-ID	193442-9
ISSN	2157-1716 ; 0098-6577 ; 2157-1724
ISSN (online)	2157-1716
ISSN	0098-6577 ; 2157-1724
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Article: Renographic diagnosis of renovascular hypertension with angiotensin converting enzyme inhibition and furosemide.

Sfakianakis, G N / Bourgoignie, J J

American journal of hypertension

1991 Volume 4, Issue 12 Pt 2, Page(s) 706S–710S

Abstract: Captopril renography is a powerful tool for evaluating renovascular hypertension. In this article we examine four different protocols: 99mTc-DTPA, [131I]hippuran with captopril, [131I]hippuran with enalaprilat, and 99mTc-mercaptoacetyltriglycine (MAG3). ... ...

Abstract	Captopril renography is a powerful tool for evaluating renovascular hypertension. In this article we examine four different protocols: 99mTc-DTPA, [131I]hippuran with captopril, [131I]hippuran with enalaprilat, and 99mTc-mercaptoacetyltriglycine (MAG3). In our experience, [131I]hippuran renograms are a reliable and reproducible test in patients both with and without azotemia. Although our experience with the new 99mTc-MAG3 technique is somewhat limited, it appears that this will also be a valuable test, which additionally has several advantages over hippuran, namely, a smaller turnaround time between test and baseline study, a smaller dose of radioactivity, better images, and more accurate counts. We look forward to the future development of this technique.
MeSH term(s)	Angioplasty, Balloon ; Angiotensin-Converting Enzyme Inhibitors ; Clinical Protocols ; Furosemide ; Humans ; Hypertension, Renovascular/diagnostic imaging ; Hypertension, Renovascular/therapy ; Iodine Radioisotopes ; Iodohippuric Acid ; Oligopeptides ; Organotechnetium Compounds ; Radiography ; Radioisotope Renography/methods ; Renal Artery/diagnostic imaging ; Technetium Tc 99m Mertiatide
Chemical Substances	Angiotensin-Converting Enzyme Inhibitors ; Iodine Radioisotopes ; Oligopeptides ; Organotechnetium Compounds ; Iodohippuric Acid (147-58-0) ; Technetium Tc 99m Mertiatide (36ITO9SKQJ) ; Furosemide (7LXU5N7ZO5)
Language	English
Publishing date	1991-12
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639383-4
ISSN	1879-1905 ; 0895-7061
ISSN (online)	1879-1905
ISSN	0895-7061
DOI	10.1093/ajh/4.12.706s
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