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Article: Rdj2, a J protein family member, interacts with cellular prion PrP(C).

Beck, Katy E / Kay, Jason G / Braun, Janice E A

Biochemical and biophysical research communications

2006 Volume 346, Issue 3, Page(s) 866–871

Abstract: ... inquiry. Here we demonstrate a novel interaction between PrP(C) and the J protein family member, Rdj2 ... dependent. Other J proteins such as CSPalpha and auxilin did not associate with PrP(C) in the absence of ATP ... demonstrating the specificity of the PrP(C)/J protein interaction. These findings suggest that the J protein ...

Abstract	PrP(C) is a glycosylphosphatidylinositol (GPI) anchored glycoprotein of unknown function. Misfolding of normal cellular PrP(C) to the pathogenic PrP(Sc) is the hallmark of prion diseases (transmissible spongiform encephalopathies). Prion diseases are characterized by extensive neurodegeneration and early death. Understanding how PrP(C) maintains its correct conformation is a major endeavor of current inquiry. Here we demonstrate a novel interaction between PrP(C) and the J protein family member, Rdj2 (DjA2; Dj3, Dnj3, Cpr3, and Hirip4). The importance of the J protein family in the cellular folding machinery has been recognized for many years. The PrP(C)/Rdj2 association was direct and concentration-dependent. Other J proteins such as CSPalpha and auxilin did not associate with PrP(C) in the absence of ATP, demonstrating the specificity of the PrP(C)/J protein interaction. These findings suggest that the J protein family serves as a 'folding catalyst' for PrP(C) and implicates Rdj2 as a factor in the protection against prion diseases.
MeSH term(s)	Adenosine Triphosphate/pharmacology ; Animals ; HSP40 Heat-Shock Proteins/classification ; HSP40 Heat-Shock Proteins/genetics ; HSP40 Heat-Shock Proteins/metabolism ; PrPC Proteins/metabolism ; Protein Binding ; Rats ; Temperature
Chemical Substances	Dnaja2 protein, rat ; HSP40 Heat-Shock Proteins ; PrPC Proteins ; Adenosine Triphosphate (8L70Q75FXE)
Language	English
Publishing date	2006-08-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205723-2
ISSN	0006-291X ; 0006-291X
ISSN (online)	0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2006.05.185
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Zs.A 116: Show issues

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Book ; Online: Collaborative study to establish a World Health Organization international Hepatitis B virus genotype panel for HBsAG Assays / by Michael Chudy, Kay-Matin Hanschmann, Heiner Scheiblauer, Ulrike C. Wend, Christian G. Schüttler, Wolfram H. Gerlich, Sigrid Nick, J. Kress, and C. Micha Nübling

Chudy, Michael / Hanschmann, Kay-Martin O / Scheiblauer, Heiner / Wend, Ulrike C / Schüttler, Christian G / Gerlich, W. H / Nick, Sigrid / Kress, J / Nübling, Micha C / World Health Organization. Biologicals Unit / WHO Expert Committee on Biological Standardization (2011 : Geneva, Switzerland)

2011

Abstract: WHO/BS/2011.2180 ... English only ... 60 p. ...

Abstract	WHO/BS/2011.2180 English only 60 p.
Keywords	Genotype ; Hepatitis B surface antigens ; Pharmaceuticals and Biologicals
Language	English
Publisher	Geneva : World Health Organization
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Geospatial analysis of groundwater depth for manual well drilling suitability in the Zinder Region, Niger, supplementary data to: Thomas, SA; McGwire, Kenneth C; Thomas, J; Kratt, C; Lutz, A; McKay, WA; Trammell, E Jamie (2012): Geospatial and regression tree analysis to map groundwater depth for manual well drilling suitability in the Zinder Region of Niger. Journal of Hydrology, 446-447, 35-47

Thomas, SA / Kratt, C / Lutz, A / McGwire, Kenneth C / McKay, WA / Thomas, J / Trammell, E Jamie

2012

Abstract: Manual and low-tech well drilling techniques have potential to assist in reaching the United Nations' millennium development goal for water in sub-Saharan Africa. This study used publicly available geospatial data in a regression tree analysis to predict ...

Abstract	Manual and low-tech well drilling techniques have potential to assist in reaching the United Nations' millennium development goal for water in sub-Saharan Africa. This study used publicly available geospatial data in a regression tree analysis to predict groundwater depth in the Zinder region of Niger to identify suitable areas for manual well drilling. Regression trees were developed and tested on a database for 3681 wells in the Zinder region. A tree with 17 terminal leaves provided a range of ground water depth estimates that were appropriate for manual drilling, though much of the tree's complexity was associated with depths that were beyond manual methods. A natural log transformation of groundwater depth was tested to see if rescaling dataset variance would result in finer distinctions for regions of shallow groundwater. The RMSE for a log-transformed tree with only 10 terminal leaves was almost half that of the untransformed 17 leaf tree for groundwater depths less than 10 m. This analysis indicated important groundwater relationships for commonly available maps of geology, soils, elevation, and enhanced vegetation index from the MODIS satellite imaging system.
Language	English
Dates of publication	2012-9999
Size	Online-Ressource
Publisher	PANGAEA - Data Publisher for Earth & Environmental Science
Publishing place	Bremen/Bremerhaven
Document type	Book ; Online
Note	This dataset is supplement to doi:10.1016/j.jhydrol.2012.04.023
DOI	10.1594/PANGAEA.778418
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article: Studies on the structure of complement C3 and the stability of C3 derived phagocytic ligands C3b/iC3b in SJL/J and BALB/c mice.

Lynch, D M / Kay, P H / Papadimitriou, J M / Grounds, M D

European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics

1993 Volume 20, Issue 1, Page(s) 1–9

Abstract: ... in humans, quantitative and qualitative studies of complement C3 were undertaken in SJL/J and BALB/c mice ... serum C3 concentrations than SJL/J females and both sexes of BALB/c mice suggesting that serum C3 ... Female SJL/J mice are more susceptible to development of experimental autoimmune myositis than most ...

Abstract	Female SJL/J mice are more susceptible to development of experimental autoimmune myositis than most other mouse strains. Since complement has been implicated in the pathogenesis of inflammatory muscle disease in humans, quantitative and qualitative studies of complement C3 were undertaken in SJL/J and BALB/c mice to determine whether complement may influence disease susceptibility in SJL/J mice. In accordance with previous studies, mature male and female BALB/c mice were shown to have similar serum C3 concentrations. However, differences were found between mature male and female SJL/J mice. Male SJL/J mice have significantly higher serum C3 concentrations than SJL/J females and both sexes of BALB/c mice suggesting that serum C3 concentration may be variably influenced by sex in some mouse strains. Qualitatively, SJL/J mice were shown to have a different allotypic form of C3 (C3F) compared to the common electrophoretically slow form (C3S) found in BALB/c mice and most other mouse strains. Furthermore, studies on the decay rate of C3 revealed that C3b/iC3b fragments are converted to C3c/d at a faster rate in sera from female SJL/J mice compared to female BALB/c mice. Because removal and solubility of immune complexes is influenced by complement C3, it is possible that the more rapid decay of the phagocytic ligands C3b/iC3b may account for the increased susceptibility to development of autoimmune disease in female SJL/J mice.
MeSH term(s)	Animals ; Autoimmune Diseases/genetics ; Autoimmune Diseases/immunology ; Complement Activation ; Complement C3/chemistry ; Complement C3/genetics ; Complement C3/metabolism ; Complement C3b/metabolism ; Female ; Immunogenetics ; Male ; Mice ; Mice, Inbred BALB C ; Molecular Structure ; Myositis/genetics ; Myositis/immunology ; Phagocytosis ; Polymorphism, Genetic ; Species Specificity
Chemical Substances	Complement C3 ; Complement C3b (80295-43-8)
Language	English
Publishing date	1993-02
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1069883-8
ISSN	1365-2370 ; 0960-7420 ; 1367-3661
ISSN (online)	1365-2370
ISSN	0960-7420 ; 1367-3661
DOI	10.1111/j.1744-313x.1993.tb00090.x
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Book ; Online: (Table 3) Interannual variability of total mass flux at the deep sediment trap site CBmeso between 1988 and 2006, supplementary data to: Fischer, Gerhard; Reuter, C; Karakas, G?kay; Nowald, Nicolas; Wefer, Gerold (2009): Offshore advection of particles within the Cape Blanc filament, Mauritania: Results from observational and modelling studies. In: Freon, P; Barange, M; Aristegui, J (eds.) Eastern Boundary Upwelling systems: Integrative and Comparative Approaches. Special Edition, Progress in Oceanography, 83(1-4), 322-330

Fischer, Gerhard / Karakas, G?kay / Nowald, Nicolas / Reuter, C / Wefer, Gerold

2009

Abstract: This article will review major features of the 'giant' Cape Blanc filament off Mauritania with regard to the transport of chlorophyll and organic carbon from the shelf to the open ocean. Within the filament, chlorophyll is transported about 400 km ... ...

Abstract	This article will review major features of the 'giant' Cape Blanc filament off Mauritania with regard to the transport of chlorophyll and organic carbon from the shelf to the open ocean. Within the filament, chlorophyll is transported about 400 km offshore. Modelled particle distributions along a zonal transect at 21?N showed that particles with a sinking velocity of 5 m d-1 are advected offshore by up to 600 km in subsurface particle clouds generally located between 400 m and 800 m water depth, forming an Intermediate Nepheloid Layer (INL). It corresponds to the depth of the oxygen minimum zone. Heavier particles with a sinking velocity of 30 m d-1 are transported from the shelf within the Bottom Layer (BL) of more than 1000 m thickness, largely following the topography of the bottom slope. The particles advected within the BL contribute to the enhanced winter-spring mass fluxes collected at the open-ocean mesotrophic sediment trap site CB-13 (200 nm offshore), due to a long distance advection in deeper waters. The lateral contribution to the deep sediment trap in winter-spring is estimated to be 63% and 72% for organic carbon and total mass, respectively, whereas the lateral input for both components on an annual basis is estimated to be in the order of 15%. Biogenic opal increases almost fivefold from the upper to the lower mesotrophic CB-13 trap, also pointing to an additional source for biogenic silica from eutrophic coastal waters. Blooms obviously sink in smaller, probably mesoscale-sized patches with variable settling rates, depending on the type of aggregated particles and their ballast content. Generally, particle sinking rates are exceptionally high off NW Africa. Very high chlorophyll values and a large size of the Cape Blanc filament in 1998-1999 are also documented in enhanced total mass and organic carbon fluxes. An increasing trend in satellite chlorophyll concentrations and the size of the Cape Blanc filament between 1997 and 2008 as observed for other coastal upwelling areas is not documented.
Language	English
Dates of publication	2009-9999
Size	Online-Ressource
Publisher	PANGAEA - Data Publisher for Earth & Environmental Science
Publishing place	Bremen/Bremerhaven
Document type	Book ; Online
Note	This dataset is supplement to doi:10.1016/j.pocean.2009.07.023
DOI	10.1594/PANGAEA.760041
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: Cross-Education Effects of Isokinetic Eccentric Plantarflexor Training on Flexibility, Strength, and Muscle-Tendon Mechanics.

Kay, Anthony D / Blazevich, Anthony J / Tysoe, Jessica C / Baxter, Brett A

Medicine and science in sports and exercise

2024

Abstract: Introduction: Large increases in joint range of motion (ROM) have been reported after eccentric resistance training, however limited data exist describing the associated mechanisms or potential cross-education effects in the contralateral limb. ... ...

Abstract	Introduction: Large increases in joint range of motion (ROM) have been reported after eccentric resistance training, however limited data exist describing the associated mechanisms or potential cross-education effects in the contralateral limb. Therefore, the effects of a 6-week isokinetic eccentric plantarflexor training program were examined in 26 participants. Methods: Before and after the training program, dorsiflexion ROM, plantarflexor strength, and muscle-tendon unit (MTU) morphology and mechanics were measured in control (n = 13) and experimental (n = 13) young adult groups. Training consisted of 5 sets of 12 maximal isokinetic eccentric plantarflexor contractions twice weekly on the right limb. Results: Significant (P < 0.05) increases in dorsiflexion ROM (4.0-9.5°), stretch tolerance (40.3-95.9%), passive elastic energy storage (47.5-161.3%), and isometric (38.1-40.6%) and eccentric (46.7-67.0%) peak plantarflexor torques were detected in both trained and contralateral limbs in the experimental group. Significant increases in gastrocnemius medialis (GM) and soleus thickness (5.4-6.1%), GM fascicle length (7.6 ± 8.5%), passive plantarflexor MTU stiffness (30.1 ± 35.5%) and Achilles tendon stiffness (5.3 ± 4.9%) were observed in the trained limb only. Significant correlations were detected between the changes in trained and contralateral limbs for dorsiflexion ROM (r = 0.59) and both isometric (r = 0.79) and eccentric (r = 0.73) peak torques. No significant changes in any metric were detected in the control group. Conclusions: Large ROM increases in the trained limb were associated with neurological, mechanical, and structural adaptations, with evidence of a cross-education effect in the contralateral limb being primarily driven by neurological adaptation (stretch tolerance). The large improvements in ROM, muscle size, and strength confirm that isokinetic eccentric training is a highly effective training tool, with potential for use in athletic and clinical populations where MTU function is impaired and current therapies are ineffective.
Language	English
Publishing date	2024-03-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	603994-7
ISSN	1530-0315 ; 0195-9131 ; 0025-7990
ISSN (online)	1530-0315
ISSN	0195-9131 ; 0025-7990
DOI	10.1249/MSS.0000000000003418
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Zs.A 869: Show issues

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Article ; Online: Concurrent use of two dual-combination drenches containing monepantel/abamectin and oxfendazole/levamisole in sheep: effect on marker residues 21 and 28 days after administration.

McKay, C H / Baker, K E / VanHoff, K J / Smith, C / George, S D

New Zealand veterinary journal

2024 Volume 72, Issue 3, Page(s) 133–140

Abstract: Aims: To determine the concentration, in comparison with the maximum residue limit (MRL), of anthelmintic marker residues in the target tissues (liver and fat) of sheep treated concurrently with two oral drenches, one containing monepantel and abamectin ...

Abstract	Aims: To determine the concentration, in comparison with the maximum residue limit (MRL), of anthelmintic marker residues in the target tissues (liver and fat) of sheep treated concurrently with two oral drenches, one containing monepantel and abamectin and the other oxfendazole and levamisole. Methods: On day 0 of the study, 12 sheep (six male and six female; 8-9-months old) were dosed according to individual body weight determined the day prior. Zolvix Plus (dual-active oral drench containing 25 g/L monepantel and 2 g/L abamectin) was administered to all animals prior to administration of Scanda (dual-active oral drench containing 80 g/L levamisole hydrochloride and 45.3 g/L oxfendazole). Six sheep (three male and three female) were slaughtered 21 and 28 days after treatment and renal fat and liver samples were collected.Using validated methods, analyses for monepantel sulfone, abamectin, levamisole and oxfendazole (expressed as total fenbendazole sulfone following conversion of the combined concentrations of oxfendazole, fenbendazole and fenbendazole sulfone) were performed on liver samples while renal fat specimens were analysed for monepantel sulfone and abamectin residues only. Detected concentrations were compared to the established MRL in sheep for each analyte determined by the Ministry for Primary Industries. Results: All residues detected in samples of liver and fat collected 21 and 28 days after treatment were below the MRL for each analyte. All liver samples collected on day 21 had detectable monepantel sulfone (mean 232 (min 110, max 388) μg/kg) and oxfendazole (mean 98.7 (min 51.3, max 165) μg/kg) residues below the MRL (5,000 and 500 μg/kg, respectively). Monepantel sulfone (mean 644 (min 242, max 1,119) μg/kg; MRL 7,000 μg/kg) residues were detected in 6/6 renal fat samples. Levamisole residues were detected in 3/6 livers (mean 40.0 (min 14.3, max 78.3) μg/kg; MRL 100 μg/kg), and abamectin residues in 1/6 livers (0.795 μg/kg; MRL 25 μg/kg) and 2/6 fat samples, (mean 0.987 (min 0.514, max 1.46) μg/kg; MRL 50 μg/kg) 21 days after treatment. Conclusion and clinical relevance: These results suggest that concurrent administration of Zolvix Plus and Scanda to sheep is unlikely to result in an extended residue profile for any of the active ingredients, with all analytes measured being under the approved New Zealand MRL 21 days after treatment. This work was not completed in line with guidance for establishing official residue profiles, nor is it sufficient to propose a new withholding period.
MeSH term(s)	Animals ; Male ; Female ; Sheep ; Levamisole/therapeutic use ; Fenbendazole/therapeutic use ; Anthelmintics/therapeutic use ; Sulfones/therapeutic use ; Sheep Diseases/drug therapy ; Aminoacetonitrile/analogs & derivatives ; Benzimidazoles ; Ivermectin/analogs & derivatives
Chemical Substances	abamectin (5U8924T11H) ; Levamisole (2880D3468G) ; monepantel sulfone ; oxfendazole (OMP2H17F9E) ; Fenbendazole (621BVT9M36) ; monepantel (82MA79VJ33) ; Anthelmintics ; Sulfones ; Aminoacetonitrile (3739OQ10IJ) ; Benzimidazoles ; Ivermectin (70288-86-7)
Language	English
Publishing date	2024-02-18
Publishing country	England
Document type	Journal Article
ZDB-ID	415642-0
ISSN	1176-0710 ; 0048-0169
ISSN (online)	1176-0710
ISSN	0048-0169
DOI	10.1080/00480169.2024.2314494
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Zs.B 588: Show issues

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Article ; Online: Evaluation of post-operative surveillance strategies and surgeon perceptions and beliefs of surveillance for pancreatic ductal adenocarcinoma in the UK.

McKay, Siobhan C / Pathak, Samir / Roberts, Keith J

HPB : the official journal of the International Hepato Pancreato Biliary Association

2023 Volume 25, Issue 10, Page(s) 1247–1254

Abstract: Background: Despite high rates of recurrence after surgery for pancreatic ductal adenocarcinoma (PDAC) there is lack of standardised surveillance practices. We aimed to identify UK surveillance practice and interrogate surgeon beliefs around ... ...

Abstract	Background: Despite high rates of recurrence after surgery for pancreatic ductal adenocarcinoma (PDAC) there is lack of standardised surveillance practices. We aimed to identify UK surveillance practice and interrogate surgeon beliefs around surveillance. Methods: A web-based survey was sent to all UK pancreatic units to assess surveillance practice for resected PDAC, factors influencing surveillance protocols, and perceptions and beliefs surrounding on current postoperative surveillance. Results: There was wide variation in reported practice between 40 consultant surgeons from 28 pancreatic units (100% unit response rate). 26% had standardised surveillance compared to 18% with no standardised practice. 16% individualised surveillance to the patient, and 40% reported differing practices between surgeons within units despite local surveillance protocols. 66% felt surveillance should be tailored to patient factors, and 58% to patient preference. There was a broad belief regarding a lack of robust evidence supporting surveillance making a trial necessary. Thematic analysis identified surveillance barriers, considerations for trial design, necessity for patient engagement and potential benefits of surveillance. Discussion: Wide variation in surveillance practice exists within and between units. A surveillance trial was deemed beneficial, however identified barriers potentially preclude a trial. Future work should assess acceptability for patients including impact on anxiety and quality-of-life.
MeSH term(s)	Humans ; Pancreatic Neoplasms/diagnosis ; Pancreatic Neoplasms/surgery ; Pancreatic Neoplasms/pathology ; Carcinoma, Pancreatic Ductal/diagnosis ; Carcinoma, Pancreatic Ductal/surgery ; Carcinoma, Pancreatic Ductal/pathology ; Surgeons ; United Kingdom/epidemiology ; Pancreatic Neoplasms
Language	English
Publishing date	2023-06-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2131251-5
ISSN	1477-2574 ; 1365-182X
ISSN (online)	1477-2574
ISSN	1365-182X
DOI	10.1016/j.hpb.2023.06.007
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Article ; Online: Art and science: complementary in medicine?

MacKay, Graham J / Winter, Des C

The British journal of surgery

2022 Volume 109, Issue 6, Page(s) 480

MeSH term(s)	Humans ; Medicine
Language	English
Publishing date	2022-03-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2985-3
ISSN	1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
ISSN (online)	1365-2168
ISSN	0263-1202 ; 0007-1323 ; 1355-7688
DOI	10.1093/bjs/znac047
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Article ; Online: Updated Markov Model to Determine the Optimal Management Strategy for Patients with Paraesophageal Hernia with Symptoms, Cameron Ulcer, or Comorbid Conditions.

DeMeester, Steven R / Bernard, Lisa / Schoppmann, Sebastian F / McKay, Sarah C / Roth, J Scott

Journal of the American College of Surgeons

2024

Abstract: Background: The current paradigm of watchful waiting (WW) in people 65 years or older with an asymptomatic paraesophageal hernia (PEH) is based on a now 20-year old Markov analysis. Recently we have shown that elective laparoscopic PEH repair (ELHR) ... ...

Abstract	Background: The current paradigm of watchful waiting (WW) in people 65 years or older with an asymptomatic paraesophageal hernia (PEH) is based on a now 20-year old Markov analysis. Recently we have shown that elective laparoscopic PEH repair (ELHR) provides an increase in life-years compared to watchful waiting (WW) in most healthy patients aged 40-90. However, elderly patients often have comorbid conditions and may have complications from their PEH such as Cameron lesions. The aim of this study was to determine the optimal strategy, ELHR or WW, in these patients. Study design: A Markov model with updated variables was used to compare life-years (LYs) gained with ELHR vs WW in hypothetical people with any type of PEH and symptoms, Cameron lesions and / or comorbid conditions. Results: In men and women aged 40-90 years-old with PEH-related symptoms and /or Cameron lesions, ELHR led to an increase in L-Ys over WW. The presence of comorbid conditions impacted life expectancy overall, but ELHR remained the preferred approach in all but 90 year-olds with symptoms but no Cameron lesions. Conclusions: Using a Markov model with updated values for key variables associated with management options for patients with a PEH we showed that life expectancy was improved with ELHR in most men and women aged 40-90, particularly in the presence of symptoms and / or Cameron lesions. Comorbid conditions increase the risk for surgery, but ELHR remained the preferred strategy in the majority of symptomatic patients. This model can be used to provide individualized management guidance for patients with a PEH.
Language	English
Publishing date	2024-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	1181115-8
ISSN	1879-1190 ; 1072-7515
ISSN (online)	1879-1190
ISSN	1072-7515
DOI	10.1097/XCS.0000000000001040
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