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Article: Effect of dentin roughening and type of composite material on the restoration of non-carious cervical lesions: an

Verma, Sanjana / Singla, Rakesh / Gill, Gurdeep Singh / Jain, Namita

2023 Volume 48, Issue 4, Page(s) e35

Abstract: Objectives: The purpose of this study was to evaluate the impact of dentin roughening and the type of composite resin used (either bulk-fill flowable or nanohybrid) on the restoration of non-carious cervical lesions (NCCLs) with an 18-month follow-up ... ...

Abstract	Objectives: The purpose of this study was to evaluate the impact of dentin roughening and the type of composite resin used (either bulk-fill flowable or nanohybrid) on the restoration of non-carious cervical lesions (NCCLs) with an 18-month follow-up period. Materials and methods: This prospective split-mouth study included 36 patients, each with a minimum of 4 NCCLs. For each patient, 4 types of restorations were performed: unroughened dentin with nanohybrid composite, unroughened dentin with bulk-fill flowable composite, roughened dentin with nanohybrid composite, and roughened dentin with bulk-fill flowable composite. A universal bonding agent (Tetric N Bond Universal) was applied in self-etch mode for all groups. The restorations were subsequently evaluated at 6, 12, and 18 months in accordance with the criteria set by the FDI World Dental Federation. Inferential statistics were computed using the Friedman test, with the level of statistical significance established at 0.05. Results: The 4 groups exhibited no significant differences in relation to fracture and retention, marginal staining, marginal adaptation, postoperative hypersensitivity, or the recurrence of caries at any follow-up point. Conclusions: Within the limitations of the present study, over an 18-month follow-up period, no significant difference was present in the clinical performance of bulk-fill flowable and nanohybrid composite restorations of non-carious cervical lesions. This held true regardless of whether dentin roughening was performed.
Language	English
Publishing date	2023-10-17
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2715357-5
ISSN	2234-7666 ; 2234-7658
ISSN (online)	2234-7666
ISSN	2234-7658
DOI	10.5395/rde.2023.48.e35
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Article: Comparative assessment of the outcome of complete pulpotomy using mineral trioxide aggregate and Biodentine in mature permanent mandibular molars with symptomatic irreversible pulpitis: A randomized clinical trial with 18 months of follow-up.

Singla, Rakesh / Laller, Vipula / Gill, Gurdeep Singh / Jain, Namita / Kumar, Tarun / Dhillon, Jaidev Singh

Journal of conservative dentistry and endodontics

2023 Volume 26, Issue 4, Page(s) 402–408

Abstract: Background: Mature permanent teeth with irreversible pulpitis have traditionally been managed with pulpectomy. With advancements in pulp biology and dental materials, many clinicians are using vital pulp therapies like pulpotomy to manage such teeth. ... ...

Abstract	Background: Mature permanent teeth with irreversible pulpitis have traditionally been managed with pulpectomy. With advancements in pulp biology and dental materials, many clinicians are using vital pulp therapies like pulpotomy to manage such teeth. The current study was conducted to help clinicians in making decisions about case selection and choice of material for such cases. Aim: This randomized clinical trial evaluated the outcome of complete pulpotomy, using mineral trioxide aggregate (MTA) and Biodentine, in permanent mandibular molars with symptomatic irreversible pulpitis (SIP). Materials and methods: Fifty patients with moderate-to-severe pain in mandibular molars with SIP were included in this prospective, parallel, single-blind clinical trial. Coronal pulp was completely removed and hemostasis was achieved with a cotton pellet moistened with 2.5% sodium hypochlorite. Subsequently, the radicular orifices were randomly covered with MTA or Biodentine. All teeth were permanently restored with composite restoration at the same appointment. Clinical evaluation was performed at 1 week, 3 months, 6 months, 12 months, and 18 months and radiographic evaluation was done after 6 months, 12 months, and 18 months. Mann-Whitney Results: Success rates of MTA and Biodentine pulpotomy were 63.6% and 69.6%, respectively, with no significant difference between the two groups at any follow-up period ( Conclusion: There were no significant differences in complete pulpotomy success rates between MTA and Biodentine over 18 months in mandibular molars with SIP.
Language	English
Publishing date	2023-07-28
Publishing country	India
Document type	Journal Article
ISSN	2950-4716
ISSN	2950-4716
DOI	10.4103/jcd.jcd_170_23
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Article ; Online: Clonidine as an Adjuvant to Local Anaesthetic in Infraclavicular Brachial Plexus Block

Anupama Gill / Namita Saraswat / Jyoti Singh / Nitin Choudhary / Preeti S Govind

Journal of Clinical and Diagnostic Research, Vol 17, Iss 4, Pp UC35-UC

A Randomised Clinical Trial

2023 Volume 38

Abstract: Introduction: Brachial plexus blocks are routinely performed to provide anaesthesia and analgesia for upper limb orthopaedic surgeries. Various adjuvants are being added to local anaesthetic solution to prolong the duration of sensory and motor blockade ... ...

Abstract	Introduction: Brachial plexus blocks are routinely performed to provide anaesthesia and analgesia for upper limb orthopaedic surgeries. Various adjuvants are being added to local anaesthetic solution to prolong the duration of sensory and motor blockade to ensure successful completion of long duration surgeries with adequate postoperative analgesia. Clonidine is used in varying dosages as adjuvant for peripheral nerve block. Aim: To study different dosages of clonidine when used as an adjuvant in infraclavicular approach to brachial plexus block. Materials and Methods: The randomised double-blind clinical study enrolled 60 American Society of Anaesthesiologists (ASA) I and II patients, between ages of 18-60 years, undergoing elective forearm orthopaedic surgery, lasting more than one hour. Based on the dose of clonidine added, the patients were distributed to group I (75 μg); group II (100 μg) and group III (150 μg). They were compared with regard to onset and duration of sensory and motor blockade, haemodynamic parameters, quality of sedation and side-effects. The results were analysed using Statistical Package for the Social Sciences (SPSS) version 21.0. Results: Demographic profile was comparable between the study groups. The onset of sensory and motor duration was faster in group III (5.8±1.65 minutes; 10.08±0.98 minutes). Also, the duration of sensory and motor blockade was highest in group III (11.02±2.33 hours; 10.44±1.45 hours). Patients in group III had significantly higher level of sedation in comparison to other groups. Conclusion: Clonidine in a dose of 150 μg provides significantly longer duration of sensory and motor blockade without any adverse haemodynamic outcomes.
Keywords	infraclavicular approach ; peripheral nerve block ; sensory block ; Medicine ; R
Subject code	796
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	JCDR Research and Publications Private Limited
Document type	Article ; Online
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Article ; Online: Comparison of Ultrasound Examination and Fiberoptic Laryngoscopy for Confirmation of Laryngeal Mask Airway Placement.

Malik, Priti / Arora, Namita / Kakkar, Aanchal / Sharma, Anupama Gill / Kaur, Mohandeep

Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine

2023 Volume 42, Issue 8, Page(s) 1819–1827

Abstract: Objectives: 1) To compare ultrasound (US) examination and fiberoptic laryngoscopy (FOL) for confirmation of laryngeal mask airway (LMA) placement. 2) To evaluate the necessity for reinsertion of LMA based on FOL.: Methods: This prospective ... ...

Abstract	Objectives: 1) To compare ultrasound (US) examination and fiberoptic laryngoscopy (FOL) for confirmation of laryngeal mask airway (LMA) placement. 2) To evaluate the necessity for reinsertion of LMA based on FOL. Methods: This prospective observational study included 100 adult patients of American Society of Anesthesiologists (ASA) Grade I and II, undergoing elective surgery under General Anesthesia requiring Proseal LMA™ placement as an airway device. LMA placement was first confirmed by clinical tests. Clinically acceptable patients were further assessed by US and categorized as acceptable (US-A) or unacceptable (US-U) and again by FOL as (FOL-A and FOL-U). Categorical variables presented in number, percentage (%), and continuous variables presented as mean ± SD and median. Inter-rater kappa agreement was used to find out the strength of agreement of acceptability between FOL and US. Results: The LMA placement was clinically acceptable in 82% of patients on first attempt. FOL had 63% (FOL-A) acceptable LMA placement as compared with US examination which had 56% (US-A). In 85% of patients, US and FOL findings were in good agreement with each other for LMA placement (κ = 0.690 and P < .05). In all patients of FOL of unacceptable (FOL-U) category (37%), LMA was replaced with endotracheal tube. Conclusion: US provides a safe, non-invasive, and real-time dynamic assessment with 85% diagnostic accuracy for confirmation of LMA placement as compared with FOL.
MeSH term(s)	Adult ; Humans ; Laryngeal Masks ; Laryngoscopy ; Intubation, Intratracheal ; Anesthesia, General ; Ultrasonography
Language	English
Publishing date	2023-02-27
Publishing country	England
Document type	Observational Study ; Journal Article
ZDB-ID	604829-8
ISSN	1550-9613 ; 0278-4297
ISSN (online)	1550-9613
ISSN	0278-4297
DOI	10.1002/jum.16203
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Article ; Online: Evaluating Combined Effect of Oral Premedication with Ibuprofen and Dexamethasone on Success of Inferior Alveolar Nerve Block in Mandibular Molars with Symptomatic Irreversible Pulpitis: A Prospective, Double-blind, Randomized Clinical Trial.

Kumar, Mohit / Singla, Rakesh / Gill, Gurdeep Singh / Kalra, Tarun / Jain, Namita

Journal of endodontics

2021 Volume 47, Issue 5, Page(s) 705–710

Abstract: Introduction: The success rate of inferior alveolar nerve block decreases exorbitantly in teeth with symptomatic irreversible pulpitis. The purpose of this prospective, double-blind, randomized clinical trial was to evaluate the combined effect of oral ... ...

Abstract	Introduction: The success rate of inferior alveolar nerve block decreases exorbitantly in teeth with symptomatic irreversible pulpitis. The purpose of this prospective, double-blind, randomized clinical trial was to evaluate the combined effect of oral premedication with ibuprofen and dexamethasone on the success rate of inferior alveolar nerve block in mandibular molars with symptomatic irreversible pulpitis. Methods: Ninety-four adult patients actively experiencing pain and diagnosed with symptomatic irreversible pulpitis willingly participated in this study. Preoperative pain was recorded on the Heft-Parker visual analog scale. Patients were randomly allocated to 4 different groups and received placebo, 0.5 mg dexamethasone, 800 mg ibuprofen, or a combination of 0.5 mg dexamethasone and 800 mg ibuprofen. One hour after oral premedication, all patients received standard inferior alveolar nerve block containing 2% lignocaine with 1:200,000 adrenaline. Access cavity preparation was initiated 15 minutes after the administration of anesthesia. Pain scores were recorded on VAS after anesthesia, at dentin penetration to pulp chamber opening, and on file placement. Success was defined as no or mild pain (0-54 mm) throughout the procedure. Results: The chi-square test was used for qualitative data comparison. The 1-way analysis of variance test and post hoc Bonferroni test showed a statistically significant difference between the combination of 0.5 mg dexamethasone and 800 mg ibuprofen group and the other 3 groups (P < .001). Conclusions: Preoperative administration of a combination of dexamethasone and ibuprofen improved the success rate of inferior alveolar nerve block in mandibular molars with symptomatic irreversible pulpitis.
MeSH term(s)	Adult ; Anesthesia, Dental ; Anesthetics, Local/therapeutic use ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Dexamethasone/therapeutic use ; Double-Blind Method ; Humans ; Ibuprofen/therapeutic use ; Lidocaine ; Mandibular Nerve ; Molar/surgery ; Nerve Block ; Premedication ; Prospective Studies ; Pulpitis/surgery
Chemical Substances	Anesthetics, Local ; Anti-Inflammatory Agents, Non-Steroidal ; Dexamethasone (7S5I7G3JQL) ; Lidocaine (98PI200987) ; Ibuprofen (WK2XYI10QM)
Language	English
Publishing date	2021-02-04
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	752412-2
ISSN	1878-3554 ; 0099-2399
ISSN (online)	1878-3554
ISSN	0099-2399
DOI	10.1016/j.joen.2021.01.005
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Article: 'Pleomorphic adenoma of the tongue: A common entity at the uncommon location'.

Chhabra, Sonia / Bhutani, Namita / Jain, Promil / Gill, Meenu / Nishisth, Nilay / Sen, Rajeev

Annals of medicine and surgery (2012)

2018 Volume 38, Page(s) 34–36

Abstract: The salivary gland tumors comprise of 3% of head and neck tumors. Pleomorphic adenoma, also known as mixed tumor, is the most common benign neoplasm of the major and minor salivary glands. The occurrence of pleomorphic adenoma of the tongue is very rare, ...

Abstract	The salivary gland tumors comprise of 3% of head and neck tumors. Pleomorphic adenoma, also known as mixed tumor, is the most common benign neoplasm of the major and minor salivary glands. The occurrence of pleomorphic adenoma of the tongue is very rare, and very few cases have been reported in the literature. A 41-year-old male presented with swelling on tongue. Cytological and histological examination revealed pleomorphic adenoma. Complete excision of the mass was done transorally under general anaesthesia. High index of suspicion and an adequate clearance of the tumor with a cuff of surrounding dispensable normal tissues is the key to successful treatment of such tumors. The authors consider the rarity of this case and present a rare case of pleomorphic adenoma of the tongue.
Language	English
Publishing date	2018-12-23
Publishing country	England
Document type	Case Reports
ZDB-ID	2745440-X
ISSN	2049-0801
ISSN	2049-0801
DOI	10.1016/j.amsu.2018.12.004
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Article: Effect of local anesthesia containing vasoconstrictor on sealing ability of dentin with two adhesive systems: Dye leakage and scanning electron microscopy study.

Singla, Rakesh / Tewari, Sanjay / Duhan, Jigyasa / Kumar, Sudhir / Gill, Gurdeep Singh / Jain, Namita

Journal of conservative dentistry : JCD

2018 Volume 21, Issue 3, Page(s) 339–343

Abstract: Objectives: To evaluate the effect of 2% lignocaine containing 1:80,000 adrenaline on the microleakage and ultrastructure of resin tooth interface using an acetone based total etch adhesive (Prime and Bond NT) and an ethanol water based self etch ... ...

Abstract	Objectives: To evaluate the effect of 2% lignocaine containing 1:80,000 adrenaline on the microleakage and ultrastructure of resin tooth interface using an acetone based total etch adhesive (Prime and Bond NT) and an ethanol water based self etch adhesive system (Xeno III). Materials and method: Class V cavities were prepared on buccal surfaces of 72 maxillary first premolars scheduled for orthodontic extraction. In 36 premolars procedure was performed under local anaesthesia (LA) and in other 36 teeth without LA. Restorations were done with hybrid composite Spectrum TPH using either Prime and Bond NT or Xeno III bonding agents. Results: Administration of 2% lignocaine with 1:80,000 adrenaline significantly reduced microleakage and improved quality of hybrid layer and tubular penetration in Prime and Bond NT specimens; but no significant effect was observed in Xeno III specimens. Conclusion: Under clinical conditions, administration of LA reduced microleakage and improved quality of hybrid layer and tubular penetration in total etch adhesive systems.
Language	English
Publishing date	2018-06-01
Publishing country	India
Document type	Journal Article
ZDB-ID	2064481-4
ISSN	0972-0707
ISSN	0972-0707
DOI	10.4103/JCD.JCD_409_16
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Article ; Online: Use of low dose e-beam irradiation to reduce E. coli O157:H7, non-O157 (VTEC) E. coli and Salmonella viability on meat surfaces.

Kundu, Devapriya / Gill, Alexander / Lui, Chenyuan / Goswami, Namita / Holley, Richard

Meat science

2014 Volume 96, Issue 1, Page(s) 413–418

Abstract: This study determined the extent that irradiation of fresh beef surfaces with an absorbed dose of 1 kGy electron (e-) beam irradiation might reduce the viability of mixtures of O157 and non-O157 verotoxigenic Escherichia coli (VTEC) and Salmonella. These ...

Abstract	This study determined the extent that irradiation of fresh beef surfaces with an absorbed dose of 1 kGy electron (e-) beam irradiation might reduce the viability of mixtures of O157 and non-O157 verotoxigenic Escherichia coli (VTEC) and Salmonella. These were grouped together based on similar resistances to irradiation and inoculated on beef surfaces (outside flat and inside round, top and bottom muscle cuts), and then e-beam irradiated. Salmonella serovars were most resistant to 1 kGy treatment, showing a reduction of ≤1.9 log CFU/g. This treatment reduced the viability of two groups of non-O157 E. coli mixtures by ≤4.5 and ≤3.9 log CFU/g. Log reductions of ≤4.0 log CFU/g were observed for E. coli O157:H7 cocktails. Since under normal processing conditions the levels of these pathogens on beef carcasses would be lower than the lethality caused by the treatment used, irradiation at 1 kGy would be expected to eliminate the hazard represented by VTEC E. coli.
MeSH term(s)	Adipose Tissue/chemistry ; Animals ; Cattle ; Colony Count, Microbial ; Consumer Product Safety ; Dose-Response Relationship, Radiation ; Escherichia coli O157/growth & development ; Escherichia coli O157/radiation effects ; Food Contamination/prevention & control ; Food Irradiation/methods ; Food Microbiology ; Meat/microbiology ; Microbial Viability/radiation effects ; Muscle, Skeletal/chemistry ; Salmonella/growth & development ; Salmonella/radiation effects ; Shiga-Toxigenic Escherichia coli/growth & development ; Shiga-Toxigenic Escherichia coli/radiation effects
Language	English
Publishing date	2014-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	753319-6
ISSN	1873-4138 ; 0309-1740
ISSN (online)	1873-4138
ISSN	0309-1740
DOI	10.1016/j.meatsci.2013.07.034
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Article ; Online: Time from definitive therapy to onset of metastatic disease predicts outcomes in men with metastatic hormone sensitive prostate cancer.

Hahn, Andrew W / Stenehjem, David D / Alex, Anitha B / Gill, David M / Cheng, Heather H / Kessler, Elizabeth R / Chittoria, Namita / Twardowski, Przemyslaw / Vaishampayan, Ulka / Agarwal, Neeraj

Urologic oncology

2019 Volume 37, Issue 6, Page(s) 352.e19–352.e24

Abstract: Purpose: Contemporary treatment for metastatic hormone sensitive prostate cancer (mHSPC) includes androgen deprivation therapy (ADT) plus abiraterone or docetaxel. While these intensified regimens have improved efficacy, they are also associated with ... ...

Abstract	Purpose: Contemporary treatment for metastatic hormone sensitive prostate cancer (mHSPC) includes androgen deprivation therapy (ADT) plus abiraterone or docetaxel. While these intensified regimens have improved efficacy, they are also associated with increased cost and toxicities. Not all men with mHSPC may be candidates for these intensified regimens, yet there are no clinical models or biomarkers used to optimize treatment selection. Herein, we hypothesized that longer time from prior definitive therapy (DT), either radical prostatectomy, definitive radiotherapy, or both, to onset of metastatic disease is associated with improved survival outcomes in men with newly diagnosed mHSPC. Methods: This multicenter retrospective study included men initiating systemic therapy with ADT for new mHSPC. Kaplan-Meier and COX proportional hazard models assessed time to metastatic castration-resistant prostate cancer (mCRPC) and overall survival (OS) by receipt of prior DT. Results: Of the 253 men with new mHSPC, 115 (45%) had received prior DT. In a multivariate analysis, increasing years from DT to the start of ADT was an independent predictor of time to mCRPC (per year: hazard ratio 0.91 95% confidence interval 0.84-0.99, P = 0.020) and improved OS (per year: hazard ratio 0.87, 95% confidence interval 0.74-0.99, P = 0.0025) in patients with new mHSPC, and may assist with risk stratification in these patients at time of mHSPC. Conclusion: Time from DT to start of ADT is an independent predictor of time to mCRPC and OS in men with new mHSPC, and may assist with risk stratification of these patients for systemic therapy selection.
MeSH term(s)	Aged ; Androgen Antagonists/therapeutic use ; Humans ; Male ; Middle Aged ; Neoplasm Metastasis ; Prognosis ; Prostatic Neoplasms/mortality ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/therapy ; Retrospective Studies ; Survival Rate ; Time Factors ; Treatment Outcome
Chemical Substances	Androgen Antagonists
Language	English
Publishing date	2019-02-13
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	1336505-8
ISSN	1873-2496 ; 1078-1439
ISSN (online)	1873-2496
ISSN	1078-1439
DOI	10.1016/j.urolonc.2019.01.029
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Article: Antimicrobial Resistance: Its Surveillance, Impact, and Alternative Management Strategies in Dairy Animals.

Sharma, Chetan / Rokana, Namita / Chandra, Mudit / Singh, Brij Pal / Gulhane, Rohini Devidas / Gill, Jatinder Paul Singh / Ray, Pallab / Puniya, Anil Kumar / Panwar, Harsh

Frontiers in veterinary science

2018 Volume 4, Page(s) 237

Abstract: Antimicrobial resistance (AMR), one among the most common priority areas identified by both national and international agencies, is mushrooming as a silent pandemic. The advancement in public health care through introduction of antibiotics against ... ...

Abstract	Antimicrobial resistance (AMR), one among the most common priority areas identified by both national and international agencies, is mushrooming as a silent pandemic. The advancement in public health care through introduction of antibiotics against infectious agents is now being threatened by global development of multidrug-resistant strains. These strains are product of both continuous evolution and un-checked antimicrobial usage (AMU). Though antibiotic application in livestock has largely contributed toward health and productivity, it has also played significant role in evolution of resistant strains. Although, a significant emphasis has been given to AMR in humans, trends in animals, on other hand, are not much emphasized. Dairy farming involves surplus use of antibiotics as prophylactic and growth promoting agents. This non-therapeutic application of antibiotics, their dosage, and withdrawal period needs to be re-evaluated and rationally defined. A dairy animal also poses a serious risk of transmission of resistant strains to humans and environment. Outlining the scope of the problem is necessary for formulating and monitoring an active response to AMR. Effective and commendably connected surveillance programs at multidisciplinary level can contribute to better understand and minimize the emergence of resistance. Besides, it requires a renewed emphasis on investments into research for finding alternate, safe, cost effective, and innovative strategies, parallel to discovery of new antibiotics. Nevertheless, numerous direct or indirect novel approaches based on host-microbial interaction and molecular mechanisms of pathogens are also being developed and corroborated by researchers to combat the threat of resistance. This review places a concerted effort to club the current outline of AMU and AMR in dairy animals; ongoing global surveillance and monitoring programs; its impact at animal human interface; and strategies for combating resistance with an extensive overview on possible alternates to current day antibiotics that could be implemented in livestock sector.
Language	English
Publishing date	2018-01-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2834243-4
ISSN	2297-1769
ISSN	2297-1769
DOI	10.3389/fvets.2017.00237
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