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Article: Genetic Ablation of the Mitochondrial Calcium Uniporter (MCU) Does not Impair T Cell-Mediated Immunity

Wu, Hao / Brand, Benjamin / Eckstein, Miriam / Hochrein, Sophia M / Shumanska, Magdalena / Dudek, Jan / Nickel, Alexander / Maack, Christoph / Bogeski, Ivan / Vaeth, Martin

Frontiers in pharmacology

2021 Volume 12, Page(s) 734078

Abstract: T cell activation and differentiation is associated with metabolic reprogramming to cope ...

Abstract	T cell activation and differentiation is associated with metabolic reprogramming to cope with the increased bioenergetic demand and to provide metabolic intermediates for the biosynthesis of building blocks. Antigen receptor stimulation not only promotes the metabolic switch of lymphocytes but also triggers the uptake of calcium (Ca
Language	English
Publishing date	2021-12-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.734078
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Article: Conversion of T-kinin to bradykinin by the rat kidney.

Vieira, M A / Moreira, M F / Maack, T / Guimarães, J A

Biochemical pharmacology

1994 Volume 47, Issue 9, Page(s) 1693–1699

Abstract: Isolated rat kidneys were perfused with T-kinin (TK, Ile-Ser-BK) and bradykinin (BK). HPLC analysis ...

Abstract	Isolated rat kidneys were perfused with T-kinin (TK, Ile-Ser-BK) and bradykinin (BK). HPLC analysis of perfusate samples taken at 2-10 min during the TK perfusion (0.5 nmol/mL initial concentration) showed two peptide peaks, the first one eluting at 14.42 min, the same retention time for standard BK, and the second at 16.20 min, corresponding to that of TK. When BK (0.5 nmol/mL) was perfused, only its corresponding peak was obtained although total BK recovery was reduced quickly, as expected. Using both HPLC analysis and a kinin bioassay on the isolated guinea pig ileum, it was found that 12% of the added TK was converted to BK during the first perfusion cycle (2 min). While the BK recovered (12-14% from the initial TK concentration) was maintained at a similar proportion between the 2nd and the 10th min of perfusion, the rate of TK disappearance, as well as its full recovery from the perfusate, indicated further fragmentation of peptides during kinin perfusion. In the presence of 5 microM DL-mercaptomethyl-3-guanidino-ethylthiopropanoic acid (Mergetpa), an inhibitor of plasma carboxypeptidase N (EC 3.4.17.3), the rate of conversion of TK to BK was not affected. On the other hand, the kinase II inhibitor bradykinin potentiating peptide 9a (BPP9a) increased both the proportion of TK converted to BK and the disappearance rate of TK from the perfusate. In the presence of BPP9a, the rate of BK production increased from 1.5 +/- 0.2 to 7.6 +/- 0.9 nmol/min. Furthermore, the recovery of BK was reduced during the first 2 min of perfusion to 7.6% and the conversion rate to 0.9 nmol/min when TK was perfused into the kidney in the presence of 10 microM bestatin, a known inhibitor of aminopeptidases. These data indicate that in the kidney TK is converted to BK, probably by aminopeptidase M, thus suggesting that BK is, in fact, an additional and functional kinin, inducing physiological and/or pathophysiological effects in the rat kidney in which TK is the main kinin released.
MeSH term(s)	3-Mercaptopropionic Acid/analogs & derivatives ; 3-Mercaptopropionic Acid/pharmacology ; Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Animals ; Bradykinin/analogs & derivatives ; Bradykinin/metabolism ; Carboxypeptidases/antagonists & inhibitors ; Kidney/metabolism ; Leucine/analogs & derivatives ; Leucine/pharmacology ; Male ; Perfusion ; Rats ; Rats, Wistar
Chemical Substances	Angiotensin-Converting Enzyme Inhibitors ; 2-mercaptomethyl-3-guanidinoethylthiopropionic acid (77102-28-4) ; T-kinin (86030-63-9) ; 3-Mercaptopropionic Acid (B03TJ3QU9M) ; Carboxypeptidases (EC 3.4.-) ; Leucine (GMW67QNF9C) ; ubenimex (I0J33N5627) ; Bradykinin (S8TIM42R2W)
Language	English
Publishing date	1994-04-29
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	208787-x
ISSN	1873-2968 ; 0006-2952
ISSN (online)	1873-2968
ISSN	0006-2952
DOI	10.1016/0006-2952(94)90549-5
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Article ; Online: X-Ray Dark-Field Signal Reduction Due to Hardening of the Visibility Spectrum.

De Marco, Fabio / Andrejewski, Jana / Urban, Theresa / Willer, Konstantin / Gromann, Lukas / Koehler, Thomas / Maack, Hanns-Ingo / Herzen, Julia / Pfeiffer, Franz

IEEE transactions on medical imaging

2024 Volume 43, Issue 4, Page(s) 1422–1433

Abstract: X-ray dark-field imaging enables a spatially-resolved visualization of ultra-small-angle X-ray scattering. Using phantom measurements, we demonstrate that a material's effective dark-field signal may be reduced by modification of the visibility spectrum ... ...

Abstract	X-ray dark-field imaging enables a spatially-resolved visualization of ultra-small-angle X-ray scattering. Using phantom measurements, we demonstrate that a material's effective dark-field signal may be reduced by modification of the visibility spectrum by other dark-field-active objects in the beam. This is the dark-field equivalent of conventional beam-hardening, and is distinct from related, known effects, where the dark-field signal is modified by attenuation or phase shifts. We present a theoretical model for this group of effects and verify it by comparison to the measurements. These findings have significant implications for the interpretation of dark-field signal strength in polychromatic measurements.
MeSH term(s)	X-Rays ; Tomography, X-Ray Computed/methods ; Radiography ; Models, Theoretical ; Phantoms, Imaging
Language	English
Publishing date	2024-04-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	622531-7
ISSN	1558-254X ; 0278-0062
ISSN (online)	1558-254X
ISSN	0278-0062
DOI	10.1109/TMI.2023.3337994
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Zs.A 2546: Show issues

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Article ; Online: Experimental analysis of the acoustic field of an ultrasonic pulse induced by a fluidic switch.

Bühling, Benjamin / Strangfeld, Christoph / Maack, Stefan / Schweitzer, Thorge

The Journal of the Acoustical Society of America

2021 Volume 149, Issue 4, Page(s) 2150

Abstract: Ultrasonic inspection is a common tool for non-destructive testing in civil engineering (NDT-CE). Currently, transducers are coupled directly to the specimen surface, which makes the inspection time-consuming. Air-coupled ultrasound (ACU) transducers are ...

Abstract	Ultrasonic inspection is a common tool for non-destructive testing in civil engineering (NDT-CE). Currently, transducers are coupled directly to the specimen surface, which makes the inspection time-consuming. Air-coupled ultrasound (ACU) transducers are more time-efficient but need a high pressure amplitude as the impedance mismatch between the air and the concrete is high and large penetration depth is needed for the inspection. Current approaches aim at eliminating the impedance mismatch between the transducer and the air to gain amplitude; however, they hardly fulfill the NDT-CE requirements. In this study, an alternative approach for ultrasound generation is presented: the signal is generated by a fluidic switch that rapidly injects a mass flow into the ambience. The acoustic field, the flow field, and their interaction are investigated. It is shown that the signal has dominant frequencies in the range of 35-60 kHz, and the amplitude is comparable to that of a commercial ACU transducer.
Language	English
Publishing date	2021-05-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	219231-7
ISSN	1520-8524 ; 0001-4966
ISSN (online)	1520-8524
ISSN	0001-4966
DOI	10.1121/10.0003937
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Zs.B 591: Show issues

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Article ; Online: A pathophysiological compass to personalize antianginal drug treatment.

Bertero, Edoardo / Heusch, Gerd / Münzel, Thomas / Maack, Christoph

Nature reviews. Cardiology

2021 Volume 18, Issue 12, Page(s) 838–852

Abstract: Myocardial ischaemia results from coronary macrovascular or microvascular dysfunction compromising the supply of oxygen and nutrients to the myocardium. The underlying pathophysiological processes are manifold and encompass atherosclerosis of epicardial ... ...

Abstract	Myocardial ischaemia results from coronary macrovascular or microvascular dysfunction compromising the supply of oxygen and nutrients to the myocardium. The underlying pathophysiological processes are manifold and encompass atherosclerosis of epicardial coronary arteries, vasospasm of large or small vessels and microvascular dysfunction - the clinical relevance of which is increasingly being appreciated. Myocardial ischaemia can have a broad spectrum of clinical manifestations, together denoted as chronic coronary syndromes. The most common antianginal medications relieve symptoms by eliciting coronary vasodilatation and modulating the determinants of myocardial oxygen consumption, that is, heart rate, myocardial wall stress and ventricular contractility. In addition, cardiac substrate metabolism can be altered to alleviate ischaemia by modulating the efficiency of myocardial oxygen use. Although a universal agreement exists on the prognostic importance of lifestyle interventions and event prevention with aspirin and statin therapy, the optimal antianginal treatment for patients with chronic coronary syndromes is less well defined. The 2019 guidelines of the ESC recommend a personalized approach, in which antianginal medications are tailored towards an individual patient's comorbidities and haemodynamic profile. Although no antianginal medication improves survival, their efficacy for reducing symptoms profoundly depends on the underlying mechanism of the angina. In this Review, we provide clinicians with a rationale for when to use which compound or combination of drugs on the basis of the pathophysiology of the angina and the mode of action of antianginal medications.
MeSH term(s)	Angina Pectoris/drug therapy ; Angina Pectoris/physiopathology ; Cardiovascular Agents/therapeutic use ; Humans ; Precision Medicine
Chemical Substances	Cardiovascular Agents
Language	English
Publishing date	2021-07-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2490375-9
ISSN	1759-5010 ; 1759-5002
ISSN (online)	1759-5010
ISSN	1759-5002
DOI	10.1038/s41569-021-00573-w
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Zs.A 6019: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Enhancing the spectral signatures of ultrasonic fluidic transducer pulses for improved time-of-flight measurements.

Bühling, Benjamin / Maack, Stefan / Schweitzer, Thorge / Strangfeld, Christoph

Ultrasonics

2021 Volume 119, Page(s) 106612

Abstract: Air-coupled ultrasonic (ACU) testing has proven to be a valuable method for increasing the speed in non-destructive ultrasonic testing and the investigation of sensitive specimens. A major obstacle to implementing ACU methods is the significant signal ... ...

Abstract	Air-coupled ultrasonic (ACU) testing has proven to be a valuable method for increasing the speed in non-destructive ultrasonic testing and the investigation of sensitive specimens. A major obstacle to implementing ACU methods is the significant signal power loss at the air-specimen and transducer-air interfaces. The loss between transducer and air can be eliminated by using recently developed fluidic transducers. These transducers use pressurized air and a natural flow instability to generate high sound power signals. Due to this self-excited flow instability, the individual pulses are dissimilar in length, amplitude, and phase. These amplitude and angle modulated pulses offer the great opportunity to further increase the signal-to-noise ratio with pulse compression methods. In practice, multi-input multi-output (MIMO) setups reduce the time required to scan the specimen surface, but demand high pulse discriminability. By applying envelope removal techniques to the individual pulses, the pulse discriminability is increased allowing only the remaining phase information to be targeted for analysis. Finally, semi-synthetic experiments are presented to verify the applicability of the envelope removal method and highlight the suitability of the fluidic transducer for MIMO setups.
Language	English
Publishing date	2021-10-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	200839-7
ISSN	1874-9968 ; 0041-624X
ISSN (online)	1874-9968
ISSN	0041-624X
DOI	10.1016/j.ultras.2021.106612
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Article ; Online: Pharmacological inhibition of GLUT1 as a new immunotherapeutic approach after myocardial infarction.

Chen, Ziyi / Dudek, Jan / Maack, Christoph / Hofmann, Ulrich

Biochemical pharmacology

2021 Volume 190, Page(s) 114597

Abstract: ... on macrophages and T cells) and non-leukocytes, including cardiomyocytes, endothelial cells and fibroblasts ...

Abstract	Myocardial infarction (MI) is one of the major contributors to cardiovascular morbidity and mortality. Excess inflammation significantly contributes to cardiac remodeling and heart failure after MI. Accumulating evidence has shown the central role of cellular metabolism in regulating the differentiation and function of cells. Metabolic rewiring is particularly relevant for proinflammatory responses induced by ischemia. Hypoxia reduces mitochondrial oxidative phosphorylation (OXPHOS) and induces increased reliance on glycolysis. Moreover, activation of a proinflammatory transcriptional program is associated with preferential glucose metabolism in leukocytes. An improved understanding of the mechanisms that regulate metabolic adaptations holds the potential to identify new metabolic targets and strategies to reduce ischemic cardiac damage, attenuate excess local inflammation and ultimately prevent the development of heart failure. Among possible drug targets, glucose transporter 1 (GLUT1) gained considerable interest considering its pivotal role in regulating glucose availability in activated leukocytes and the availability of small molecules that selectively inhibit it. Therefore, we summarize current evidence on the role of GLUT1 in leukocytes (focusing on macrophages and T cells) and non-leukocytes, including cardiomyocytes, endothelial cells and fibroblasts regarding ischemic heart disease. Beyond myocardial infarction, we can foresee the role of GLUT1 blockers as a possible pharmacological approach to limit pathogenic inflammation in other conditions driven by excess sterile inflammation.
MeSH term(s)	Animals ; Cardiovascular Agents/pharmacology ; Cardiovascular Agents/therapeutic use ; Endothelial Cells/drug effects ; Endothelial Cells/immunology ; Endothelial Cells/metabolism ; Glucose Transporter Type 1/antagonists & inhibitors ; Glucose Transporter Type 1/immunology ; Glucose Transporter Type 1/metabolism ; Humans ; Immunotherapy/methods ; Immunotherapy/trends ; Macrophages/drug effects ; Macrophages/immunology ; Macrophages/metabolism ; Myocardial Infarction/drug therapy ; Myocardial Infarction/immunology ; Myocardial Infarction/metabolism ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/immunology ; Myocytes, Cardiac/metabolism ; Oxidative Phosphorylation/drug effects
Chemical Substances	Cardiovascular Agents ; Glucose Transporter Type 1 ; SLC2A1 protein, human
Language	English
Publishing date	2021-05-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	208787-x
ISSN	1873-2968 ; 0006-2952
ISSN (online)	1873-2968
ISSN	0006-2952
DOI	10.1016/j.bcp.2021.114597
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Zs.A 19: Show issues

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Article ; Online: A new approach to characterize cardiac sodium storage by combining fluorescence photometry and magnetic resonance imaging in small animal research.

Christa, Martin / Dithmar, Franziska / Weinaus, Tobias / Kohlhaas, Michael / Arias-Loza, Anahi-Paula / Hofmann, Michelle / Elabyad, Ibrahim A / Gutjahr, Fabian T / Maack, Christoph / Bauer, Wolfgang R

Scientific reports

2024 Volume 14, Issue 1, Page(s) 2426

Abstract: Cardiac myocyte sodium ( ... ...

Abstract	Cardiac myocyte sodium (Na
MeSH term(s)	Mice ; Animals ; Sodium/metabolism ; Animal Experimentation ; Heart Failure/metabolism ; Myocytes, Cardiac/metabolism ; Myocardial Infarction/metabolism ; Magnetic Resonance Imaging/methods
Chemical Substances	Sodium (9NEZ333N27)
Language	English
Publishing date	2024-01-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-52377-w
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Article ; Online: Acoustic and flow data of fluidic and piezoelectric ultrasonic transducers.

Bühling, Benjamin / Maack, Stefan / Schönsee, Eric / Schweitzer, Thorge / Strangfeld, Christoph

Data in brief

2021 Volume 38, Page(s) 107280

Abstract: This data article presents characteristic acoustic and flow data of a fluidic ultrasonic transducer as well as acoustic data of a commercial piezoelectric ultrasonic transducer used in non-destructive testing for civil engineering. The flow data has been ...

Abstract	This data article presents characteristic acoustic and flow data of a fluidic ultrasonic transducer as well as acoustic data of a commercial piezoelectric ultrasonic transducer used in non-destructive testing for civil engineering. The flow data has been acquired using hot-wire anemometry and a Pitot tube. The three-dimensional acoustic data of both devices has been acquired using a calibrated microphone. The distribution of characteristic acoustic properties of both transducers are extracted and given in addition to the raw data. The data presented in the article will be a valuable source for reference and validation, both for developing fluidic and alternate ultrasound generation technologies. Furthermore, they will give additional insight into the acoustic-flow interaction phenomena of high speed switching devices. This article is accompanying the paper Experimental Analysis of the Acoustic Field of an Ultrasonic Pulse Induced by a Fluidic Switch (Bühling et al., 2021) published in The Journal of the Acoustical Society of America, where the data is interpreted in detail and the rationale for characteristic sound properties of the fluidic transducer are given.
Language	English
Publishing date	2021-08-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2786545-9
ISSN	2352-3409 ; 2352-3409
ISSN (online)	2352-3409
ISSN	2352-3409
DOI	10.1016/j.dib.2021.107280
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Article ; Online: Detection of humpback whale (Megaptera novaeangliae) non-song vocalizations around the Vema Seamount, southeast Atlantic Ocean.

Ross-Marsh, E C / Elwen, S H / Fearey, J / Thompson, K F / Maack, T / Gridley, T

JASA express letters

2022 Volume 2, Issue 4, Page(s) 41201

Abstract: Humpback whales are a cosmopolitan, highly vocal species. Investigated here are their vocalizations recorded at the Vema Seamount (31°38'S, 08°20'E) from moored hydrophones in the austral spring of 2019. During the 11-d recording period over 600 non-song ...

Abstract	Humpback whales are a cosmopolitan, highly vocal species. Investigated here are their vocalizations recorded at the Vema Seamount (31°38'S, 08°20'E) from moored hydrophones in the austral spring of 2019. During the 11-d recording period over 600 non-song calls were detected. Calls were predominantly detected at night over three consecutive days. The most common calls were low, frequency-modulated sounds (whups). An impulsive sound (gunshot) previously unknown in humpback whales was also detected. The location and timing of the calls suggests that humpback whales may be using the Vema Seamount as a temporary stop on their migration to their polar feeding grounds.
MeSH term(s)	Animals ; Atlantic Ocean ; Humpback Whale ; Mollusca ; Seasons ; Vocalization, Animal
Language	English
Publishing date	2022-09-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2691-1191
ISSN (online)	2691-1191
DOI	10.1121/10.0010072
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