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  1. Article ; Online: The Enigma of Heart-kidney Transplantation.

    Barten, Markus J / Grahammer, Florian

    Transplantation

    2023  Volume 107, Issue 9, Page(s) 1877–1879

    MeSH term(s) Kidney Transplantation/adverse effects ; Kidney/metabolism ; Adaptor Proteins, Signal Transducing ; Heart ; Heart Transplantation/adverse effects
    Chemical Substances Adaptor Proteins, Signal Transducing
    Language English
    Publishing date 2023-08-21
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000004662
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 488: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 509: Show issues

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  2. Article ; Online: The Dual-specificity Phosphatase 3 (DUSP3): A Potential Target Against Renal Ischemia/Reperfusion Injury.

    Khbouz, Badr / Musumeci, Lucia / Grahammer, Florian / Jouret, François

    Transplantation

    2024  

    Abstract: Renal ischemia/reperfusion (I/R) injury is a common clinical challenge faced by clinicians in kidney transplantation. I/R is the leading cause of acute kidney injury, and it occurs when blood flow to the kidney is interrupted and subsequently restored. I/ ...

    Abstract Renal ischemia/reperfusion (I/R) injury is a common clinical challenge faced by clinicians in kidney transplantation. I/R is the leading cause of acute kidney injury, and it occurs when blood flow to the kidney is interrupted and subsequently restored. I/R impairs renal function in both short and long terms. Renal ischemic preconditioning refers to all maneuvers intended to prevent or attenuate ischemic damage. In this context, the present review focuses on the dual-specificity phosphatase 3 (DUSP3), also known as vaccinia H1-related phosphatase, an uncommon regulator of mitogen-activated protein kinase (MAPK) phosphorylation. DUSP3 has different biological functions: (1) it acts as a tumor modulator and (2) it is involved in the regulation of immune response, thrombosis, hemostasis, angiogenesis, and genomic stability. These functions occur either through MAPK-dependent or MAPK-independent mechanisms. DUSP3 genetic deletion dampens kidney damage and inflammation caused by I/R in mice, suggesting DUSP3 as a potential target for preventing renal I/R injury. Here, we discuss the putative role of DUSP3 in ischemic preconditioning and the potential mechanisms of such an attenuated inflammatory response via improved kidney perfusion and adequate innate immune response.
    Language English
    Publishing date 2024-04-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000005009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 488: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Zs.MO 509: Show issues

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  3. Article ; Online: New structural insights into podocyte biology.

    Grahammer, Florian

    Cell and tissue research

    2017  Volume 369, Issue 1, Page(s) 5–10

    Abstract: The last 5 years have witnessed tremendous advances in both light- and electron-microscopic techniques in the biomedical sciences. Application of these new cutting-edge methods to glomerular biology has advanced considerably and, in part, completed our ... ...

    Abstract The last 5 years have witnessed tremendous advances in both light- and electron-microscopic techniques in the biomedical sciences. Application of these new cutting-edge methods to glomerular biology has advanced considerably and, in part, completed our endeavor to draw a detailed map of the glomerular tuft. The scope of this review is to illustrate these new insights within both the morphometry of podocyte cells and the architecture of the glomerular filtration barrier and to assess whether these findings have indeed had an impact on our biological understanding of glomerular function.
    Language English
    Publishing date 2017-07
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 125067-x
    ISSN 1432-0878 ; 0302-766X
    ISSN (online) 1432-0878
    ISSN 0302-766X
    DOI 10.1007/s00441-017-2590-3
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  4. Article ; Online: Halting renal fibrosis: an unexpected role for mTORC2 signaling.

    Grahammer, Florian

    Kidney international

    2015  Volume 88, Issue 3, Page(s) 437–439

    Abstract: Slowly progressive renal fibrosis is the hallmark of chronic kidney disease, independent of its etiology. Transforming growth factor-β (TGF-β) has been found to be the main profibrotic renal cytokine. Li et al. identify mTORC2 as an important mediator of ...

    Abstract Slowly progressive renal fibrosis is the hallmark of chronic kidney disease, independent of its etiology. Transforming growth factor-β (TGF-β) has been found to be the main profibrotic renal cytokine. Li et al. identify mTORC2 as an important mediator of TGF-β signaling. Being upstream of the previously described profibrotic kinases AKT, SGK1, and PKC-α, mTORC2 represents a potentially interesting drug target. Yet, although the mouse genetic approach yielded convincing results, transition from bench to bedside will remain challenging.
    MeSH term(s) Animals ; Carrier Proteins/metabolism ; Fibroblasts/drug effects ; Kidney/drug effects ; Kidney Diseases/enzymology ; Male ; Multiprotein Complexes/metabolism ; Signal Transduction/drug effects ; TOR Serine-Threonine Kinases/metabolism ; Transforming Growth Factor beta1/pharmacology
    Chemical Substances Carrier Proteins ; Multiprotein Complexes ; Transforming Growth Factor beta1 ; TOR Serine-Threonine Kinases (EC 2.7.1.1)
    Language English
    Publishing date 2015-09
    Publishing country United States
    Document type Comment ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1038/ki.2015.137
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 797: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  5. Article: New structural insights into podocyte biology

    Grahammer, Florian

    Cell and tissue research. 2017 July, v. 369, no. 1

    2017  

    Abstract: The last 5 years have witnessed tremendous advances in both light- and electron-microscopic techniques in the biomedical sciences. Application of these new cutting-edge methods to glomerular biology has advanced considerably and, in part, completed our ... ...

    Abstract The last 5 years have witnessed tremendous advances in both light- and electron-microscopic techniques in the biomedical sciences. Application of these new cutting-edge methods to glomerular biology has advanced considerably and, in part, completed our endeavor to draw a detailed map of the glomerular tuft. The scope of this review is to illustrate these new insights within both the morphometry of podocyte cells and the architecture of the glomerular filtration barrier and to assess whether these findings have indeed had an impact on our biological understanding of glomerular function.
    Keywords biomedical research ; glomerular filtration rate ; morphometry
    Language English
    Dates of publication 2017-07
    Size p. 5-10.
    Publishing place Springer Berlin Heidelberg
    Document type Article
    Note Review
    ZDB-ID 125067-x
    ISSN 1432-0878 ; 0302-766X
    ISSN (online) 1432-0878
    ISSN 0302-766X
    DOI 10.1007/s00441-017-2590-3
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 46/352: Show issues

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  6. Article ; Online: Rodent models to study sodium retention in experimental nephrotic syndrome.

    Xiao, Mengyun / Bohnert, Bernhard N / Grahammer, Florian / Artunc, Ferruh

    Acta physiologica (Oxford, England)

    2022  Volume 235, Issue 3, Page(s) e13844

    Abstract: Sodium retention and edema are hallmarks of nephrotic syndrome (NS). Different experimental rodent models have been established for simulating NS, however, not all of them feature sodium retention which requires proteinuria to exceed a certain threshold. ...

    Abstract Sodium retention and edema are hallmarks of nephrotic syndrome (NS). Different experimental rodent models have been established for simulating NS, however, not all of them feature sodium retention which requires proteinuria to exceed a certain threshold. In rats, puromycin aminonucleoside nephrosis (PAN) is a classic NS model introduced in 1955 that was adopted as doxorubicin-induced nephropathy (DIN) in 129S1/SvImJ mice. In recent years, mice with inducible podocin deletion (Nphs2
    MeSH term(s) Animals ; Doxorubicin ; Epithelial Sodium Channels/genetics ; Humans ; Mice ; Nephrotic Syndrome/chemically induced ; Proteinuria ; Rats ; Rodentia/metabolism ; Serine Proteases/adverse effects ; Sodium/metabolism
    Chemical Substances Epithelial Sodium Channels ; Doxorubicin (80168379AG) ; Sodium (9NEZ333N27) ; Serine Proteases (EC 3.4.-)
    Language English
    Publishing date 2022-05-26
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2218636-0
    ISSN 1748-1716 ; 1748-1708
    ISSN (online) 1748-1716
    ISSN 1748-1708
    DOI 10.1111/apha.13844
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs 229: Show issues Location:
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  7. Article ; Online: Role of mTOR Signaling for Tubular Function and Disease.

    Grahammer, Florian / Huber, Tobias B / Artunc, Ferruh

    Physiology (Bethesda, Md.)

    2021  Volume 36, Issue 6, Page(s) 350–358

    Abstract: The mechanistic target of rapamycin (mTOR) forms two distinct intracellular multiprotein complexes that control a multitude of intracellular processes linked to metabolism, proliferation, actin cytoskeleton, and survival. Recent studies have identified ... ...

    Abstract The mechanistic target of rapamycin (mTOR) forms two distinct intracellular multiprotein complexes that control a multitude of intracellular processes linked to metabolism, proliferation, actin cytoskeleton, and survival. Recent studies have identified the importance of these complexes for transport regulation of ions and nutrients along the entire nephron. First reports could link altered activity of these complexes to certain disease entities, i.e. diabetic nephropathy, acute kidney injury or hyperkalemia.
    MeSH term(s) Humans ; Mechanistic Target of Rapamycin Complex 1 ; Mechanistic Target of Rapamycin Complex 2 ; Multiprotein Complexes ; Sirolimus ; TOR Serine-Threonine Kinases
    Chemical Substances Multiprotein Complexes ; MTOR protein, human (EC 2.7.1.1) ; Mechanistic Target of Rapamycin Complex 1 (EC 2.7.11.1) ; Mechanistic Target of Rapamycin Complex 2 (EC 2.7.11.1) ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Sirolimus (W36ZG6FT64)
    Language English
    Publishing date 2021-09-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2158667-6
    ISSN 1548-9221 ; 1548-9213
    ISSN (online) 1548-9221
    ISSN 1548-9213
    DOI 10.1152/physiol.00021.2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2164: Show issues Location:
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  8. Article ; Online: Early Manifestation of Post-Transplantation Leukemia Due to an Initial EBV Infection in a Kidney Transplant Recipient.

    Grahammer, Florian / Mahmud, Maida / Kluger, Malte A

    Deutsches Arzteblatt international

    2020  Volume 117, Issue 13, Page(s) 223

    MeSH term(s) Adult ; Epstein-Barr Virus Infections/complications ; Humans ; Kidney Transplantation/adverse effects ; Leukemia/diagnosis ; Leukemia/virology ; Male
    Language English
    Publishing date 2020-05-29
    Publishing country Germany
    Document type Case Reports
    ZDB-ID 2406159-1
    ISSN 1866-0452 ; 1866-0452
    ISSN (online) 1866-0452
    ISSN 1866-0452
    DOI 10.3238/arztebl.2020.0223
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Parietal epithelial cell dysfunction in crescentic glomerulonephritis.

    Wong, Milagros N / Tharaux, Pierre-Louis / Grahammer, Florian / Puelles, Victor G

    Cell and tissue research

    2021  Volume 385, Issue 2, Page(s) 345–354

    Abstract: Crescentic glomerulonephritis represents a group of kidney diseases characterized by rapid loss of kidney function and the formation of glomerular crescents. While the role of the immune system has been extensively studied in relation to the development ... ...

    Abstract Crescentic glomerulonephritis represents a group of kidney diseases characterized by rapid loss of kidney function and the formation of glomerular crescents. While the role of the immune system has been extensively studied in relation to the development of crescents, recent findings show that parietal epithelial cells play a key role in the pathophysiology of crescent formation, even in the absence of immune modulation. This review highlights our current understanding of parietal epithelial cell biology and the reported physiological and pathological roles that these cells play in glomerular lesion formation, especially in the context of crescentic glomerulonephritis.
    MeSH term(s) Animals ; Epithelial Cells/pathology ; Glomerulonephritis/pathology ; Humans ; Kidney Glomerulus/pathology
    Language English
    Publishing date 2021-08-28
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 125067-x
    ISSN 1432-0878 ; 0302-766X
    ISSN (online) 1432-0878
    ISSN 0302-766X
    DOI 10.1007/s00441-021-03513-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: A high-throughput drug discovery pipeline to optimize kidney normothermic machine perfusion.

    Hofmann, Smilla / Grahammer, Florian / Edenhofer, Ilka / Puelles, Victor G / Huber, Tobias B / Czogalla, Jan

    Frontiers in physiology

    2022  Volume 13, Page(s) 974615

    Abstract: Kidney transplantation is the only definitive therapy for end-stage kidney disease. The shortage of organs for transplantation is the main limitation of this life-saving treatment. Normothermic machine perfusion (NMP) is a novel preservation technique ... ...

    Abstract Kidney transplantation is the only definitive therapy for end-stage kidney disease. The shortage of organs for transplantation is the main limitation of this life-saving treatment. Normothermic machine perfusion (NMP) is a novel preservation technique with the potential to increase the number of transplantable kidneys through reducing delayed graft function and organ evaluation under physiological conditions. To date, the cellular effects and possible pharmacological interventions during machine perfusion are incompletely understood. A major limitation is the technically complex, time-consuming, and small-scale replication of NMP in rodent models. To overcome this, we developed a 3D-printed, high throughput
    Language English
    Publishing date 2022-09-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.974615
    Database MEDical Literature Analysis and Retrieval System OnLINE

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