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Article ; Online: Exploring the role of apolipoprotein E gene promoter polymorphisms in susceptibility to normal-tension glaucoma in a Korean population.

Park, Young Jun / Shin, Hye-Young / Kim, Jong-Il

2024 Volume 14, Issue 1, Page(s) 8972

Abstract: Glaucoma, particularly primary open-angle glaucoma (POAG), poses a significant global health concern. Distinguished by intraocular pressure (IOP), POAG encompasses high-tension glaucoma (HTG) and normal-tension glaucoma (NTG). Apolipoprotein E (APOE) is ... ...

Abstract	Glaucoma, particularly primary open-angle glaucoma (POAG), poses a significant global health concern. Distinguished by intraocular pressure (IOP), POAG encompasses high-tension glaucoma (HTG) and normal-tension glaucoma (NTG). Apolipoprotein E (APOE) is a multifaceted protein with roles in lipid metabolism, neurobiology, and neurodegenerative diseases. However, controversies persist regarding the impact of APOE single-nucleotide polymorphisms (SNPs) on open-angle glaucoma and NTG. This study aimed to identify APOE-specific SNPs influencing NTG risk. A cohort of 178 patients with NTG recruited from Uijeongbu St. Mary's Hospital and 32,858 individuals from the Korean Genome and Epidemiology Study (KoGES) cohort were included in the analysis. Genotype and haplotype analyses were performed on three promoter SNPs (rs449647, rs769446, and rs405509) and two exonic SNPs (rs429358 and rs7412) located on chromosome 19. Among the five SNPs, rs769446 genotypes exhibited significant differences between cases and controls. The minor allele C of rs769446 emerged as a protective factor against NTG. Furthermore, haplotype analysis of the five SNPs revealed that the A-T-G-T-T haplotype was a statistically significant risk factor for NTG. This study indicated an association between APOE promoter SNPs and NTG in the Korean population. Further studies are required to understand how APOE promoter SNPs contribute to NTG pathogenesis.
MeSH term(s)	Humans ; Apolipoproteins E/genetics ; Genotype ; Glaucoma, Open-Angle/genetics ; Intraocular Pressure ; Low Tension Glaucoma/genetics ; Polymorphism, Single Nucleotide ; Republic of Korea/epidemiology
Chemical Substances	Apolipoproteins E ; ApoE protein, human
Language	English
Publishing date	2024-04-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-58442-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Smartphone Use Type, Fear of Missing Out, Social Support, and Smartphone Screen Time Among Adolescents in Korea: Interactive Effects.

Song, Hye-Young / Kim, Ji-Hye

Frontiers in public health

2022 Volume 10, Page(s) 822741

Abstract: This study aims to examine the relationship between intrapersonal factors, interpersonal factors, smartphone screen time, and the moderating roles of interpersonal factors, on the basis of the ecological model. This study is a cross-sectional and ... ...

Abstract	This study aims to examine the relationship between intrapersonal factors, interpersonal factors, smartphone screen time, and the moderating roles of interpersonal factors, on the basis of the ecological model. This study is a cross-sectional and descriptive study. A total of 428 participants from four public middle schools were selected through convenience sampling (55.1% female; Mean age 13.0 ± 0.78). Data were collected through self-report questionnaires that contained questions about sociodemographic characteristics, intrapersonal factors (types of smartphone use, Fear of missing out-FoMO), interpersonal factors (support from parents, teachers, and peers), and smartphone screen time. The collected data were analysed using descriptive statistics,
MeSH term(s)	Adolescent ; Child ; Cross-Sectional Studies ; Fear ; Female ; Humans ; Male ; Republic of Korea ; Screen Time ; Smartphone ; Social Support
Language	English
Publishing date	2022-03-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2022.822741
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Antioxidant and anti-hepatitis A virus activities of

Kim, Ye-Sol / Kim, Ki An / Seo, Hye-Young / Kim, Sung Hyun / Lee, Hee Min

Heliyon

2024 Volume 10, Issue 3, Page(s) e25600

Abstract: ... Ecklonia ... ...

Abstract	Ecklonia cava
Language	English
Publishing date	2024-02-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e25600
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Article ; Online: Ir(tri-N-heterocyclic carbene)-catalyzed upgrading of glycerol: C-C bond formation for the synthesis of α-hydroxy acids.

Byeon, Heemin / Kim, Jaeho / Lee, Mi-Hyun / Jang, Hye-Young

Organic & biomolecular chemistry

2024 Volume 22, Issue 8, Page(s) 1613–1618

Abstract: Ir(triNHC) complexes catalyzed glycerol and alcohol dehydrogenative coupling, yielding diverse α-hydroxy acids. Unlike conventional conditions, Ir(triNHC) facilitated additional C-C bond formation after lactic acid production from glycerol, exhibiting ... ...

Abstract	Ir(triNHC) complexes catalyzed glycerol and alcohol dehydrogenative coupling, yielding diverse α-hydroxy acids. Unlike conventional conditions, Ir(triNHC) facilitated additional C-C bond formation after lactic acid production from glycerol, exhibiting high TOFs. This protocol successfully converted 1,2-propanediol and sorbitol into α-hydroxy acids, highlighting biomass-derived sources' potential as valuable platform chemicals.
Language	English
Publishing date	2024-02-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2097583-1
ISSN	1477-0539 ; 1477-0520
ISSN (online)	1477-0539
ISSN	1477-0520
DOI	10.1039/d3ob02035e
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Article ; Online: Effects of the coronavirus disease outbreak on the development of neurological disorders in children

Ah-Young Kim / Ji-Hoon Na / Hye-Young Kang / Hankil Lee / Young-Mock Lee

Journal of Infection and Public Health, Vol 17, Iss 1, Pp 102-

A comparison of the incidence of febrile seizure and epilepsy using an interrupted time-series approach

2024 Volume 108

Abstract: Background: With the outbreak of COVID-19, school closures and quarantines following social distancing have brought significant changes to children's lifestyles. Therefore, we aimed to compare the population-adjusted incidence of febrile seizures(FS) and ...

Abstract	Background: With the outbreak of COVID-19, school closures and quarantines following social distancing have brought significant changes to children's lifestyles. Therefore, we aimed to compare the population-adjusted incidence of febrile seizures(FS) and epilepsy before and after the COVID-19 outbreak in Korea and to assess the effects of the COVID-19 outbreak on the incidence by region and age group. Methods: A retrospective cohort study was conducted using nationwide claims data and covid data from January 2019 to December 2020. The incidence of diseases and difference in incidence before (Jan 20 to Dec 30, 2019) and after (Jan 20 to Dec 30, 2020) the COVID-19 outbreak was measured using rate ratio. An Interrupted time series analysis was used to identify the effect of COVID-19 on trends of FS and epilepsy. Subgroup analysis by age, sex, insurance, and risk of coronavirus by area were conducted. Results: Following the onset of the pandemic, the number of newly diagnosed FS cases decreased sharply by 69 % (24,182 to 7238), whereas the incidence of epilepsy, increased to 1.02 times (30,286−29,312), when adjusted in proportion to the population. Notably, a greater decrease in the incidence of FS were found in the regions with high-risk of coronavirus. A result of segmented regression analysis proved the decrease was significant and made immediately after the pandemic started(p < 0.001). In contrast to the incidence of FS, that of epilepsy did not exhibit a significant month-to-month change during the baseline period, immediately after the pandemic started, and during the pandemic. Conclusions: The COVID-19 outbreak and resulting social distancing measures reduced the incidence of febrile seizure immediately rather than gradually. Unlike in the case of acute febrile seizure, the COVID-19 pandemic had no effect on the incidence of chronic epilepsy.
Keywords	COVID-19 ; Infection control ; Epilepsy ; Seizure ; Interrupted time series analysis ; Infectious and parasitic diseases ; RC109-216 ; Public aspects of medicine ; RA1-1270
Subject code	616
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Factors Associated with Frailty According to Gender of Older Adults Living Alone.

Jang, Hye-Young / Kim, Ji-Hye

Healthcare (Basel, Switzerland)

2021 Volume 9, Issue 4

Abstract: This study was conducted to identify the factors associated with frailty according to gender of older adults living alone in Korea. Data from the National Survey of the Living Conditions of Korean Elderly in 2017 were used. Participants were 2340 older ... ...

Abstract	This study was conducted to identify the factors associated with frailty according to gender of older adults living alone in Korea. Data from the National Survey of the Living Conditions of Korean Elderly in 2017 were used. Participants were 2340 older adults who live alone. Frailty was determined based on the frailty criteria developed by van Kan et al. that consist of fatigue, resistance, ambulation, and illness. The collected data were analyzed using descriptive statistics, chi-squared test,
Language	English
Publishing date	2021-04-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare9040475
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Article ; Online: Association between serum creatinine levels and pulmonary function of Korean adults: the 2016-2019 Korea National Health and Nutrition Examination Survey.

Yeun, Young-Ran / Kwak, Yi Sub / Kim, Hye-Young

Physical activity and nutrition

2023 Volume 27, Issue 1, Page(s) 60–65

Abstract: Purpose: Research on the interaction between renal and lung functions has been conducted; however, studies on the general adult population are limited. This study aimed to investigate the association between serum creatinine levels and pulmonary ... ...

Abstract	Purpose: Research on the interaction between renal and lung functions has been conducted; however, studies on the general adult population are limited. This study aimed to investigate the association between serum creatinine levels and pulmonary function in Korean adults. Methods: From the 2016-2019 Korean National Health and Nutrition Examination Survey, we recruited 11,380 participants who were 40 years or older for this study. Serum creatinine levels were divided into three groups: low, normal, and high. Pulmonary function was divided into three groups: normal, restrictive, and obstructive. The odds ratios for abnormal pulmonary function patterns were calculated using weighted multinomial logistic regression analysis. Results: The odds ratios were 0.97 for low vs. normal (0.40-2.33) and 2.00 for high vs. normal (1.18-3.38) for the restrictive pattern, and 0.12 for low vs. normal (0.02-0.49) and 1.74 for high vs. normal (0.90-3.35) for the obstructive pattern after being adjusted for age, sex, smoking status, alcohol consumption, regular exercise, body mass index, diabetes mellitus, hypertension, cardiovascular disease, total energy, and total proteins. Conclusion: High serum creatinine levels were associated with an increased odds ratio for restrictive and obstructive pulmonary function patterns. The odds ratio of the restrictive pattern was higher than that of the obstructive pattern. Screening for abnormal pulmonary function in individuals with high serum creatinine levels may be useful to ensure that there is no abnormal pulmonary function before the onset of potential pulmonary problems. Thus, this study highlights the relationship between renal and pulmonary function using serum creatine levels, which can be easily tested in the primary medical environment of the general population.
Language	English
Publishing date	2023-03-31
Publishing country	Korea (South)
Document type	Journal Article
ISSN	2733-7545
ISSN (online)	2733-7545
DOI	10.20463/pan.2023.0008
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Article ; Online: Effect of fatty acid chain length on physicochemical properties of starch nanocomposites obtained via nanoprecipitation.

Shin, Hye-Young / Kim, Jong Hun / Kim, Jong-Yea

International journal of biological macromolecules

2023 Volume 230, Page(s) 123415

Abstract: To evaluate the effect of elaborate difference in the hydrophobicity of core material on encapsulation process and physicochemical properties of the composites, composites of starch and FA with various chain lengths (C:12-22) were prepared via ... ...

Abstract	To evaluate the effect of elaborate difference in the hydrophobicity of core material on encapsulation process and physicochemical properties of the composites, composites of starch and FA with various chain lengths (C:12-22) were prepared via nanoprecipitation. X-ray diffraction analyses revealed that all composites had a V
MeSH term(s)	Starch/chemistry ; Fatty Acids ; Amylose/chemistry ; Crystallography, X-Ray ; Nanocomposites/chemistry ; X-Ray Diffraction
Chemical Substances	Starch (9005-25-8) ; Fatty Acids ; Amylose (9005-82-7)
Language	English
Publishing date	2023-01-26
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.123415
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Article ; Online: Smartphone Use Type, Fear of Missing Out, Social Support, and Smartphone Screen Time Among Adolescents in Korea

Hye-Young Song / Ji-Hye Kim

Frontiers in Public Health, Vol

Interactive Effects

2022 Volume 10

Abstract	This study aims to examine the relationship between intrapersonal factors, interpersonal factors, smartphone screen time, and the moderating roles of interpersonal factors, on the basis of the ecological model. This study is a cross-sectional and descriptive study. A total of 428 participants from four public middle schools were selected through convenience sampling (55.1% female; Mean age 13.0 ± 0.78). Data were collected through self-report questionnaires that contained questions about sociodemographic characteristics, intrapersonal factors (types of smartphone use, Fear of missing out—FoMO), interpersonal factors (support from parents, teachers, and peers), and smartphone screen time. The collected data were analysed using descriptive statistics, t-test, ANOVA, Pearson's correlation coefficients, and hierarchical regression. The daily smartphone screen time was 4.05 ± 2.16 h. Results showed that social media (β = 0.155), games (β = 0.140), and FoMO (β = 0.227) were positively associated with smartphone screen time, while educational videos (β = −0.130) and parental support (β = −0.212) were negatively associated with smartphone screen time. Peers support moderated the association between games and smartphone screen time. Parental support moderated the association between educational videos, videos/movies/TV, and smartphone screen time. The findings highlight the direct and interactive roles of intrapersonal and interpersonal factors in predicting adolescents' smartphone screen time. Based on this study, the intrapersonal and interpersonal factors of adolescents should be comprehensively considered to intervene in their proper smartphone use.
Keywords	adolescent ; smartphone ; ecological model ; fear of missing out ; social support ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Introduction of managed entry agreements in Korea: Problem, policy, and politics.

Kim, Hyungmin / Godman, Brian / Kwon, Hye-Young / Hong, Song Hee

Frontiers in pharmacology

2023 Volume 14, Page(s) 999220

Abstract: Objectives: ...

Abstract	Objectives:
Language	English
Publishing date	2023-04-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.999220
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