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Book: Qian Yi

Flohr, Carsten

der Begründer der chinesischen Kinderheilkunde?

(Würzburger medizinhistorische Forschungen ; 72)

2001

Author's details	Carsten Flohr
Series title	Würzburger medizinhistorische Forschungen ; 72
Collection
Keywords	China ; Kinderheilkunde ; Geschichte 200 v. Chr.-1278 ; Qian, Yi
Subject	Pädiatrie ; Kinder- und Jugendheilkunde ; Kinder- und Jugendmedizin ; Kindermedizin ; Pediatrics
Language	German
Size	87 S. : Ill., graph. Darst., 21 cm
Publisher	Königshausen und Neumann
Publishing place	Würzburg
Publishing country	Germany
Document type	Book
Note	Literaturverz. S. 61 - 64
HBZ-ID	HT013255401
ISBN	3-8260-2039-1 ; 978-3-8260-2039-1
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Chemical Profiling of Shen-Wu-Yi-Shen Tablets Using UPLC-Q-TOF-MS/MS and Its Quality Evaluation Based on UPLC-DAD Combined with Multivariate Statistical Analysis.

Mei, Yudan / Hu, Yumei / Tao, Xiaoqian / Shang, Jing / Qian, Mengyu / Suo, Fengtai / Li, Jifeng / Cao, Liang / Wang, Zhenzhong / Xiao, Wei

Journal of chromatographic science

2024

Abstract: Shen-Wu-Yi-Shen tablets (SWYST) is a traditional Chinese medicine prescription used for treating ...

Abstract	Shen-Wu-Yi-Shen tablets (SWYST) is a traditional Chinese medicine prescription used for treating chronic kidney disease (CKD). This study aims to characterize the constituents in SWYST and evaluate the quality based on the quantification of multiple bioactive components. SWYST samples were analyzed with ultra-high-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) and a data-processing strategy. As a result, 215 compounds in SWYST were unambiguously identified or tentatively characterized, including 14 potential new compounds. Meanwhile, strategies based on characteristic fragments for rapid identification were summarized, indicating that the qualitative method is accurate and feasible. Notably, the glucose esters of laccaic acid D-type anthraquinone were first found and their fragmentation patterns were described by comparing that of O-glycoside isomers. Besides, based on comparisons of the cleavage ways of mono-acyl glucose with different acyl groups or acylation sites, differences in fragmentation pathways between 1,2-di-O-acyl glucose and 1,6-di-O-acyl glucose were proposed for the first time and verified by reference substances. In addition, a validated UPLC-DAD was established for the determination of 11 major bioactive components related to treatment of CKD (albiflorin, paeoniflorin, 2,3,5,4'-tetrahydroxy-stilbene-2-O-β-d-glucoside (TSG), 1-O-galloyl-2-O-cinnamoyl-β-d-glucose, emodin-8-O-β-d-glucoside, chrysophanol-O-β-d-glucoside, aloe-emodin, rhein, emodin, chrysophanol and physcion). Moreover, TSG and 1-O-galloyl-2-O-cinnamoyl-β-d-glucose were found as the quality markers related to the origins of SWYST based on multivariate statistical analysis. Conclusively, the findings in this work provide a feasible reference for further studies on quality research and mechanisms of action in treating CKD.
Language	English
Publishing date	2024-01-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	80141-0
ISSN	1945-239X ; 0021-9665
ISSN (online)	1945-239X
ISSN	0021-9665
DOI	10.1093/chromsci/bmae001
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Article ; Online: Yi-Qi-Jian-Pi formula ameliorates immune function in acute-on-chronic liver failure by upregulating autophagy and mitochondrial biogenesis in CD8

Tang, Li / Wang, Xi / Zhao, Rong / Chen, Xiaomei / Wang, Feixia / Xia, Siwei / Xiao, Qian / Zhao, Qiang / Yang, Shiyan / Tan, Shanzhong

Journal of ethnopharmacology

2023 Volume 308, Page(s) 116276

Abstract: ... contributes to poor prognosis. The Yi-Qi-Jian-Pi formula (YQJPF) may improve T lymphocyte immune function ...

Abstract	Ethnopharmacological relevance: A key event in the pathogenesis of acute-on-chronic liver failure (ACLF) is the imbalance in the systemic immune response; immunosuppression in patients with ACLF contributes to poor prognosis. The Yi-Qi-Jian-Pi formula (YQJPF) may improve T lymphocyte immune function in patients with ACLF. Aim of the study: To investigate the immune mechanism of YQJPF in vivo and in vitro. Materials and methods: An ACLF rat model was established by injection of CCl Results: YQJPF improved the peripheral blood lymphocyte count and proportion of CD8 Conclusions: Our results suggest that YQJPF could improve immune function in a rat model of ACLF, possibly via affecting the homeostasis of lymphatic mitochondria in CD8
MeSH term(s)	Rats ; Animals ; Acute-On-Chronic Liver Failure/pathology ; Organelle Biogenesis ; CD8-Positive T-Lymphocytes ; Autophagy ; Immunity
Language	English
Publishing date	2023-02-17
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116276
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Article ; Online: Yi-Qi-Jian-Pi formula inhibits hepatocyte pyroptosis through the IDH2-driven tricarboxylic acid cycle to reduce liver injury in acute-on-chronic liver failure.

Zhao, Rong / Zhao, Qiang / Wang, Xi / Chen, Xiaomei / Liang, Chongfeng / Xiao, Qian / Yang, Shiyan / Tan, Shanzhong

Journal of ethnopharmacology

2023 Volume 317, Page(s) 116683

Abstract: Ethnopharmacological relevance: Yi-Qi-Jian-Pi formula (YQJPF) is a commonly used ...

Abstract	Ethnopharmacological relevance: Yi-Qi-Jian-Pi formula (YQJPF) is a commonly used traditional Chinese medicine (TCM) compound used to treat acute-on-chronic liver failure (ACLF) in China, but its specific mechanism of action has not been fully clarified. Aim of the study: The aim of this study was to determine the effect of YQJPF on liver injury and hepatocyte pyroptosis in rats and further explore its molecular mechanism of action. Materials and methods: This study established carbon tetrachloride (CCl Results: YQJPF significantly improved liver injury in vivo and in vitro, which depended on the regulation of hepatocyte NLRP3/GSDMD-induced pyroptosis. In addition, we found that mitochondrial membrane potential and ATP production decreased after LPS treatment of hepatocytes, which suggested that YQJPF may improve mitochondrial energy metabolism disorders in hepatocytes. We administered a hepatocyte mitochondrial uncoupling agent, FCCP, to determine whether mitochondrial metabolic disorders affected cell pyroptosis. The results showed that the expression of IL-18, IL-1β, and NLRP3 proteins increased significantly, indicating that the effect of this drug on hepatocyte pyroptosis may be related to mitochondrial metabolism disorders. We found that YQJPF significantly restored the tricarboxylic acid (TCA) cycle rate-limiting enzyme activity and affected the content of TCA metabolites. Furthermore, we revealed that the IDH2 gene, which plays a unique role in ACLF, is a key factor in the regulation of the mitochondrial TCA cycle and can be upregulated under the action of YQJPF. Conclusions: YQJPF can inhibit classical pyroptosis in hepatocytes by regulating TCA cycle metabolism, thus alleviating liver injury, and IDH2 may be a potential upstream regulatory target of YQJPF.
MeSH term(s)	Rats ; Animals ; Acute-On-Chronic Liver Failure/drug therapy ; Acute-On-Chronic Liver Failure/metabolism ; Acute-On-Chronic Liver Failure/pathology ; Pyroptosis ; Citric Acid Cycle ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Lipopolysaccharides/pharmacology ; Hepatocytes
Chemical Substances	NLR Family, Pyrin Domain-Containing 3 Protein ; Lipopolysaccharides
Language	English
Publishing date	2023-06-13
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116683
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Article: RNA-Seq Expression Analysis of Chronic Asthmatic Mice with Bu-Shen-Yi-Qi Formula Treatment and Prediction of Regulated Gene Targets of Anti-Airway Remodeling.

Cui, Jie / Lv, Zexi / Teng, Fangzhou / Yi, La / Tang, Weifeng / Wang, WenQian / Tulake, Wuniqiemu / Qin, Jingjing / Zhu, Xueyi / Wei, Ying / Dong, Jingcheng

Evidence-based complementary and alternative medicine : eCAM

2021 Volume 2021, Page(s) 3524571

Abstract: ... therapy. Our previous study had shown that Bu-Shen-Yi-Qi formula (BSYQF) could ameliorate ...

Abstract	Airway remodeling is one of the typical pathological characteristics of asthma, while the structural changes of the airways in asthma are complex, which impedes the development of novel asthma targeted therapy. Our previous study had shown that Bu-Shen-Yi-Qi formula (BSYQF) could ameliorate airway remodeling in chronic asthmatic mice by modulating airway inflammation and oxidative stress in the lung. In this study, we analysed the lung transcriptome of control mice and asthmatic mouse model with/without BSYQF treatment. Using RNA-sequencing (RNA-seq) analysis, we found that 264/1746 (15.1%) of transcripts showing abnormal expression in asthmatic mice were reverted back to completely or partially normal levels by BSYQF treatment. Additionally, based on previous results, we identified 21 differential expression genes (DEGs) with fold changes (FC) > (±) 2.0 related to inflammatory, oxidative stress, mitochondria, PI3K/AKT, and MAPK signal pathways which may play important roles in the mechanism of the anti-remodeling effect of BSYQF treatment. Through inputting 21 DEGs into the IPA database to construct a gene network, we inferred Adipoq, SPP1, and TNC which were located at critical nodes in the network may be key regulators of BSYQF's anti-remodeling effect. In addition, the quantitative real-time polymerase chain reaction (qRT-PCR) result for the selected four DEGs matched those of the RNA-seq analysis. Our results provide a preliminary clue to the molecular mechanism of the anti-remodeling effect of BSYQF in asthma.
Language	English
Publishing date	2021-01-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2021/3524571
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Article: The TCM Prescription Yi-Fei-Jie-Du-Tang Inhibit Invasive Migration and EMT of Lung Cancer Cells by Activating Autophagy.

Wang, Shanshan / Wang, Zaichuan / Wu, Yinqiu / Hou, Chao / Dai, Xiaojun / Wang, Qingyin / Wu, Yongjian / Qian, Chao / Zhang, Xiaochun

Evidence-based complementary and alternative medicine : eCAM

2022 Volume 2022, Page(s) 9160616

Abstract: Yi-Fei-Jie-Du-Tang (YFJDT) is a traditional Chinese medicine formulation. Our previous studies have ...

Abstract	Yi-Fei-Jie-Du-Tang (YFJDT) is a traditional Chinese medicine formulation. Our previous studies have demonstrated that YFJDT can be used to treat non-small-cell lung cancer (NSCLC), but its protective effect against NSCLC and its mechanisms remain unclear. In the present study, we evaluated the protective effects and potential mechanisms of YFJDT on a tumor-bearing mouse lung cancer model and A549 cell model. Tumor-bearing mice and A549 cells were treated with YFJDT, tumors were measured during the experiment, and tumor tissues and cell supernatants were collected at the end of the experiment to assess the levels of autophagy and epithelial-mesenchymal transition (EMT)-related proteins. The results showed that YFJDT treatment reduced tumor volume and mass, increased the expression of the autophagy marker LC3, and inhibited EMT-related proteins compared with the model group. Cell survival was reduced in the YFJDT-treated groups compared with the model group, and YFJDT also reduced the migration and invasion ability of A549 cells in a dose-dependent manner. Western blotting detected that YFJDT also upregulated FAT4 in the tumor tissue and A549 cells and downregulated the expression of vimentin. Meanwhile, apoptosis in both tissues and cells was greatly increased with treatment of YFJDT. We further interfered with FAT4 expression in cells and found that the inhibitory effect of YFJDT on EMT was reversed, indicating that YFJDT affects EMT by regulating FAT4 expression. Taken together, results of this study suggested that the inhibitory effect of YFJDT on EMT in lung cancer tumors is through upregulating FAT4, promoting autophagy, and thus inhibiting EMT in cancer cells.
Language	English
Publishing date	2022-01-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2022/9160616
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Article ; Online: Integrated UHPLC-QE/MS, transcriptomics and network pharmacology reveal the mechanisms via which Liang-Yan-Yi-Zhen-San promotes the browning of white adipose tissue.

Yao, Dong / Xing, Bo / Li, Xiang / Xu, Zi-Hua / Liu, Qian / Liu, Xin / Wu, Qiong / Cui, Ya-Ling / Fan, Ying / Zhao, Qing-Chun

Biomedical chromatography : BMC

2023 Volume 37, Issue 12, Page(s) e5734

Abstract: We have previously shown that Liang-Yan-Yi-Zhen-San (LYYZS), an ancient Chinese herbal formula ...

Abstract	We have previously shown that Liang-Yan-Yi-Zhen-San (LYYZS), an ancient Chinese herbal formula, can promote the browning of white adipose tissue. In this study, we sought to determine which active ingredients of LYYZS mediated its effects on the browning of white adipose tissue. Employing ultra-high performance liquid chromatography-Q-Exactive HF mass spectrometry, a total of 52 LYYZS ingredients were identified. On this basis, 1,560 ingredient-related targets of LYYZS were screened using the HERB databases. Meanwhile, RNA sequencing analysis of the inguinal white adipose tissue of mice produced a total of 3148 genes that were significantly differentially expressed following LYYZS treatment and differentially expressed genes regarded as browning-related targets. Through the network pharmacological analysis, a total of 136 intersection targets were obtained and an ingredient-target-pathway network was established. According to network pharmacology analysis, 10 ingredients containing trans-cinnamaldehyde, genistein, daidzein, calycosin, arginine, coumarin, oleic acid, isoleucine, palmitic acid and tyrosine were regarded as active ingredients of browning of white adipose tissue. Integrated evaluation using chemical analysis, transcriptomics and network pharmacology provides an efficient strategy for discovering the active ingredients involved in how LYYZS promotes the browning of white adipose tissue.
MeSH term(s)	Animals ; Mice ; Network Pharmacology ; Chromatography, High Pressure Liquid ; Transcriptome ; Adipose Tissue, Brown ; Gas Chromatography-Mass Spectrometry ; Adipose Tissue, White ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/chemistry
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2023-10-11
Publishing country	England
Document type	Journal Article
ZDB-ID	632848-9
ISSN	1099-0801 ; 0269-3879
ISSN (online)	1099-0801
ISSN	0269-3879
DOI	10.1002/bmc.5734
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Genetic structure and forensic characterization of 36 Y-chromosomal STR loci in Tibeto-Burman-speaking Yi population.

Song, Zhengyang / Wang, Qian / Zhang, Han / Tang, Jing / Wang, Qiyan / Zhang, Hongling / Yang, Meiqing / Ji, Jingyan / Ren, Zheng / Wu, Yan / Huang, Jiang

publication RETRACTED

Molecular genetics & genomic medicine

2021 Volume 9, Issue 2, Page(s) e1572

Abstract: ... Tibeto-Burman-speaking Yi male individuals from Guizhou using Goldeneye: Results: A total of 389 ... DYS645) to 0.9601 (DYS385a/b). Our newly genotyped Yi samples show a close affinity with other Tibeto ...

Abstract	Background: Male-specifically inherited Y-STRs have been widely used in population genetics and forensic investigations. Methods: We genotyped and analyzed Y chromosome haplotypes of 408 unrelated Tibeto-Burman-speaking Yi male individuals from Guizhou using Goldeneye Results: A total of 389 alleles and 396 haplotypes could be detected, and the allelic frequencies ranged from 0.0025 to 0.9875. The haplotype diversity, random match probability, and discrimination capacity values were 0.9999, 0.0026, and 0.9900, respectively. The gene diversity (GD) of 36 Y-STR loci in the studied group ranged from 0.0248 (DYS645) to 0.9601 (DYS385a/b). Our newly genotyped Yi samples show a close affinity with other Tibeto-Burman speaking groups in China and Southeast Asia. Conclusions: The population stratification was almost consistent with the geographic distribution and language-family, both among Chinese and worldwide ethnic groups. Our data may provide useful information for paternal lineage in the forensic application and population genetics, as well as evidence for archaeological and historical research.
MeSH term(s)	China ; Chromosomes, Human, Y/genetics ; Ethnicity/genetics ; Forensic Genetics/methods ; Haplotypes ; Humans ; Male ; Microsatellite Repeats ; Polymorphism, Genetic ; Tibet
Language	English
Publishing date	2021-01-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Retracted Publication
ZDB-ID	2734884-2
ISSN	2324-9269 ; 2324-9269
ISSN (online)	2324-9269
ISSN	2324-9269
DOI	10.1002/mgg3.1572
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Article ; Online: Rapidly mutating Y-STRs study in Chinese Yi population.

Wang, Qian / Jin, Bo / An, Gang / Zhong, Qian / Chen, Meijun / Luo, Xiaoying / Li, Zhilong / Jiang, Youjing / Liang, Weibo / Zhang, Lin

International journal of legal medicine

2018 Volume 133, Issue 1, Page(s) 45–50

Abstract: Y-chromosomal short tandem repeats (Y-STRs) have been widely used in forensic analysis and population genetics. With low to moderate mutation rates, conventional Y-STR panels, including commercially available Y-STR kits, enable the identification of male ...

Abstract	Y-chromosomal short tandem repeats (Y-STRs) have been widely used in forensic analysis and population genetics. With low to moderate mutation rates, conventional Y-STR panels, including commercially available Y-STR kits, enable the identification of male pedigrees but typically fail to differentiate related male individuals. The introduction of rapidly mutating Y-chromosomal short tandem repeats (RM Y-STRs) with higher mutation rates (μ > 10
MeSH term(s)	China ; Chromosomes, Human, Y ; DNA Fingerprinting ; Ethnic Groups/genetics ; Genetics, Population ; Genotype ; Humans ; Male ; Microsatellite Repeats ; Multiplex Polymerase Chain Reaction ; Mutation ; Mutation Rate
Language	English
Publishing date	2018-07-30
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1055109-8
ISSN	1437-1596 ; 0937-9827
ISSN (online)	1437-1596
ISSN	0937-9827
DOI	10.1007/s00414-018-1894-5
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Article ; Online: RNA-Seq Expression Analysis of Chronic Asthmatic Mice with Bu-Shen-Yi-Qi Formula Treatment and Prediction of Regulated Gene Targets of Anti-Airway Remodeling

Jie Cui / Zexi Lv / Fangzhou Teng / La Yi / Weifeng Tang / WenQian Wang / Wuniqiemu Tulake / Jingjing Qin / Xueyi Zhu / Ying Wei / Jingcheng Dong

Evidence-Based Complementary and Alternative Medicine, Vol

2021 Volume 2021

Abstract: ... therapy. Our previous study had shown that Bu-Shen-Yi-Qi formula (BSYQF) could ameliorate ...

Abstract	Airway remodeling is one of the typical pathological characteristics of asthma, while the structural changes of the airways in asthma are complex, which impedes the development of novel asthma targeted therapy. Our previous study had shown that Bu-Shen-Yi-Qi formula (BSYQF) could ameliorate airway remodeling in chronic asthmatic mice by modulating airway inflammation and oxidative stress in the lung. In this study, we analysed the lung transcriptome of control mice and asthmatic mouse model with/without BSYQF treatment. Using RNA-sequencing (RNA-seq) analysis, we found that 264/1746 (15.1%) of transcripts showing abnormal expression in asthmatic mice were reverted back to completely or partially normal levels by BSYQF treatment. Additionally, based on previous results, we identified 21 differential expression genes (DEGs) with fold changes (FC) > (±) 2.0 related to inflammatory, oxidative stress, mitochondria, PI3K/AKT, and MAPK signal pathways which may play important roles in the mechanism of the anti-remodeling effect of BSYQF treatment. Through inputting 21 DEGs into the IPA database to construct a gene network, we inferred Adipoq, SPP1, and TNC which were located at critical nodes in the network may be key regulators of BSYQF's anti-remodeling effect. In addition, the quantitative real-time polymerase chain reaction (qRT-PCR) result for the selected four DEGs matched those of the RNA-seq analysis. Our results provide a preliminary clue to the molecular mechanism of the anti-remodeling effect of BSYQF in asthma.
Keywords	Other systems of medicine ; RZ201-999
Subject code	572
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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