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Article ; Online: Lineage tracing analysis defines erythropoietin-producing cells as a distinct subpopulation of resident fibroblasts with unique behaviors.

Kaneko, Keiichi / Sato, Yuki / Uchino, Eiichiro / Toriu, Naoya / Shigeta, Mayo / Kiyonari, Hiroshi / Endo, Shuichiro / Fukuma, Shingo / Yanagita, Motoko

Kidney international

2022 Volume 102, Issue 2, Page(s) 280–292

Abstract: Erythropoietin (Epo) is produced by a subpopulation of resident fibroblasts in the healthy kidney. We have previously demonstrated that, during kidney fibrosis, kidney fibroblasts including Epo-producing cells transdifferentiate into myofibroblasts and ... ...

Abstract	Erythropoietin (Epo) is produced by a subpopulation of resident fibroblasts in the healthy kidney. We have previously demonstrated that, during kidney fibrosis, kidney fibroblasts including Epo-producing cells transdifferentiate into myofibroblasts and lose their Epo-producing ability. However, it remains unclear whether Epo-producing cells survive and transform into myofibroblasts during fibrosis because previous studies did not specifically label Epo-producing cells in pathophysiological conditions. Here, we generated Epo
MeSH term(s)	Animals ; Erythropoietin/genetics ; Fibroblasts/pathology ; Fibrosis ; Kidney/pathology ; Mice ; Ureteral Obstruction/pathology
Chemical Substances	Erythropoietin (11096-26-7)
Language	English
Publishing date	2022-05-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120573-0
ISSN	1523-1755 ; 0085-2538
ISSN (online)	1523-1755
ISSN	0085-2538
DOI	10.1016/j.kint.2022.04.026
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Article ; Online: Tertiary Lymphoid Tissues Are Microenvironments with Intensive Interactions between Immune Cells and Proinflammatory Parenchymal Cells in Aged Kidneys.

Yoshikawa, Takahisa / Oguchi, Akiko / Toriu, Naoya / Sato, Yuki / Kobayashi, Takashi / Ogawa, Osamu / Haga, Hironori / Sakurai, Satoko / Yamamoto, Takuya / Murakawa, Yasuhiro / Yanagita, Motoko

Journal of the American Society of Nephrology : JASN

2023 Volume 34, Issue 10, Page(s) 1687–1708

Abstract: Significance statement: Ectopic lymphoid structures called tertiary lymphoid tissues (TLTs) develop in several kidney diseases and are associated with poor renal prognosis. However, the mechanisms underlying TLT expansion and their effect on renal ... ...

Abstract	Significance statement: Ectopic lymphoid structures called tertiary lymphoid tissues (TLTs) develop in several kidney diseases and are associated with poor renal prognosis. However, the mechanisms underlying TLT expansion and their effect on renal regeneration remain unclear. The authors report that single-nucleus RNA sequencing and validation experiments demonstrate that TLTs potentially amplify inflammation in aged injured kidneys. Lymphocytes within TLTs promote proinflammatory phenotypes of the surrounding proximal tubules and fibroblasts within the TLTs via proinflammatory cytokine production. These proinflammatory parenchymal cells then interact with immune cells by chemokine or cytokine production. Such cell-cell interactions potentially increase inflammation, expand TLTs, and exacerbate kidney injury. These findings help illuminate renal TLT pathology and suggest potential therapeutic targets. Background: Ectopic lymphoid structures called tertiary lymphoid tissues (TLTs) develop in several kidney diseases and are associated with poor renal prognosis. However, the mechanisms that expand TLTs and underlie exacerbation of kidney injury remain unclear. Methods: We performed single-nucleus RNA sequencing (snRNA-seq) on aged mouse kidneys with TLTs after ischemia-reperfusion injury. The results were validated using immunostaining, in situ hybridization of murine and human kidneys, and in vitro experiments. Results: Using snRNA-seq, we identified proinflammatory and profibrotic Vcam1+ injured proximal tubules (PTs) with NF κ B and IFN-inducible transcription factor activation. VCAM1 + PTs were preferentially localized around TLTs and drove inflammation and fibrosis via the production of multiple chemokines or cytokines. Lymphocytes within TLTs expressed Tnf and Ifng at high levels, which synergistically upregulated VCAM1 and chemokine expression in cultured PT cells. In addition, snRNA-seq also identified proinflammatory and profibrotic fibroblasts, which resided within and outside TLTs, respectively. Proinflammatory fibroblasts exhibited STAT1 activation and various chemokine or cytokine production, including CXCL9/CXCL10 and B cell-activating factor, contributing to lymphocyte recruitment and survival. IFN γ upregulated the expression of these molecules in cultured fibroblasts in a STAT1-dependent manner, indicating potential bidirectional interactions between IFN γ -producing CXCR3 + T cells and proinflammatory fibroblasts within TLTs. The cellular and molecular components described in this study were confirmed in human kidneys with TLTs. Conclusions: These findings suggest that TLTs potentially amplify inflammation by providing a microenvironment that allows intense interactions between renal parenchymal and immune cells. These interactions may serve as novel therapeutic targets in kidney diseases involving TLT formation.
MeSH term(s)	Humans ; Mice ; Animals ; Lymphoid Tissue/metabolism ; Cytokines ; Chemokines/metabolism ; Interferon-gamma ; Kidney/metabolism ; Chemokine CXCL9 ; Inflammation ; Chemokine CXCL10 ; Receptors, CXCR3
Chemical Substances	Cytokines ; Chemokines ; Interferon-gamma (82115-62-6) ; Chemokine CXCL9 ; Chemokine CXCL10 ; Receptors, CXCR3
Language	English
Publishing date	2023-08-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1085942-1
ISSN	1533-3450 ; 1046-6673
ISSN (online)	1533-3450
ISSN	1046-6673
DOI	10.1681/ASN.0000000000000202
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Article ; Online: Amino acid catabolite markers for early prognostication of pneumonia in patients with COVID-19.

Maeda, Rae / Seki, Natsumi / Uwamino, Yoshifumi / Wakui, Masatoshi / Nakagama, Yu / Kido, Yasutoshi / Sasai, Miwa / Taira, Shu / Toriu, Naoya / Yamamoto, Masahiro / Matsuura, Yoshiharu / Uchiyama, Jun / Yamaguchi, Genki / Hirakawa, Makoto / Kim, Yun-Gi / Mishima, Masayo / Yanagita, Motoko / Suematsu, Makoto / Sugiura, Yuki

Nature communications

2023 Volume 14, Issue 1, Page(s) 8469

Abstract: Effective early-stage markers for predicting which patients are at risk of developing SARS-CoV-2 infection have not been fully investigated. Here, we performed comprehensive serum metabolome analysis of a total of 83 patients from two cohorts to ... ...

Abstract	Effective early-stage markers for predicting which patients are at risk of developing SARS-CoV-2 infection have not been fully investigated. Here, we performed comprehensive serum metabolome analysis of a total of 83 patients from two cohorts to determine that the acceleration of amino acid catabolism within 5 days from disease onset correlated with future disease severity. Increased levels of de-aminated amino acid catabolites involved in the de novo nucleotide synthesis pathway were identified as early prognostic markers that correlated with the initial viral load. We further employed mice models of SARS-CoV2-MA10 and influenza infection to demonstrate that such de-amination of amino acids and de novo synthesis of nucleotides were associated with the abnormal proliferation of airway and vascular tissue cells in the lungs during the early stages of infection. Consequently, it can be concluded that lung parenchymal tissue remodeling in the early stages of respiratory viral infections induces systemic metabolic remodeling and that the associated key amino acid catabolites are valid predictors for excessive inflammatory response in later disease stages.
MeSH term(s)	Humans ; Animals ; Mice ; COVID-19 ; SARS-CoV-2 ; RNA, Viral ; Pneumonia ; Amino Acids
Chemical Substances	RNA, Viral ; Amino Acids
Language	English
Publishing date	2023-12-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-44266-z
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Article ; Online: A case of nephrotic syndrome showing contemporary presence of apolipoprotein E2 homozygote glomerulopathy and membranous nephropathy-like findings modified by apolipoprotein E Toyonaka.

Hirashima, Hisako / Komiya, Toshiyuki / Toriu, Naoya / Hara, Shigeo / Matsunaga, Akira / Saito, Takao / Muso, Eri

Clinical nephrology. Case studies

2018 Volume 6, Page(s) 45–51

Abstract: A 79-year-old man was admitted to our hospital for proteinuria due to nephrotic syndrome. Renal biopsy revealed focal sclerosis and foam cell infiltration in the glomerulus. In addition, electron microscopic findings (EM) revealed peculiar electron-dense ...

Abstract	A 79-year-old man was admitted to our hospital for proteinuria due to nephrotic syndrome. Renal biopsy revealed focal sclerosis and foam cell infiltration in the glomerulus. In addition, electron microscopic findings (EM) revealed peculiar electron-dense deposits (EDDs) in both sides of the glomerular basement membrane. Although subepithelial deposits had spike formation highly resembling those seen in membranous nephropathy (MN), immunoglobulins and complements were not identified by immunofluorescence study, and microbubbles appeared in high magnification of EM different from the immune disease. The analysis of apolipoprotein (Apo) E showed an elevated concentration of plasma ApoE. The phenotype, genotype, and DNA sequence studies revealed homozygous ApoE2/2 and a novel missense mutation called ApoE Toyonaka (Ser197Cys). This case may confirm the independent responsibility of ApoE2/2 and ApoE Toyonaka for ApoE2 homozygote glomerulopathy and MN-like EDD findings, respectively.
Language	English
Publishing date	2018-11-30
Publishing country	Germany
Document type	Case Reports
ISSN	2196-5293
ISSN (online)	2196-5293
DOI	10.5414/CNCS109509
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Article ; Online: CD153/CD30 signaling promotes age-dependent tertiary lymphoid tissue expansion and kidney injury.

Sato, Yuki / Oguchi, Akiko / Fukushima, Yuji / Masuda, Kyoko / Toriu, Naoya / Taniguchi, Keisuke / Yoshikawa, Takahisa / Cui, Xiaotong / Kondo, Makiko / Hosoi, Takeshi / Komidori, Shota / Shimizu, Yoko / Fujita, Harumi / Jiang, Li / Kong, Yingyi / Yamanashi, Takashi / Seita, Jun / Yamamoto, Takuya / Toyokuni, Shinya /

Hamazaki, Yoko / Hattori, Masakazu / Yoshikai, Yasunobu / Boor, Peter / Floege, Jürgen / Kawamoto, Hiroshi / Murakawa, Yasuhiro / Minato, Nagahiro / Yanagita, Motoko

The Journal of clinical investigation

2022 Volume 132, Issue 2

Abstract: Tertiary lymphoid tissues (TLTs) facilitate local T and B cell interactions in chronically inflamed organs. However, the cells and molecular pathways that govern TLT formation are poorly defined. Here, we identified TNF superfamily CD153/CD30 signaling ... ...

Abstract	Tertiary lymphoid tissues (TLTs) facilitate local T and B cell interactions in chronically inflamed organs. However, the cells and molecular pathways that govern TLT formation are poorly defined. Here, we identified TNF superfamily CD153/CD30 signaling between 2 unique age-dependent lymphocyte subpopulations, CD153+PD-1+CD4+ senescence-associated T (SAT) cells and CD30+T-bet+ age-associated B cells (ABCs), as a driver for TLT expansion. SAT cells, which produced ABC-inducing factors IL-21 and IFN-γ, and ABCs progressively accumulated within TLTs in aged kidneys after injury. Notably, in kidney injury models, CD153 or CD30 deficiency impaired functional SAT cell induction, which resulted in reduced ABC numbers and attenuated TLT formation with improved inflammation, fibrosis, and renal function. Attenuated TLT formation after transplantation of CD153-deficient bone marrow further supported the importance of CD153 in immune cells. Clonal analysis revealed that SAT cells and ABCs in the kidneys arose from both local differentiation and recruitment from the spleen. In the synovium of aged rheumatoid arthritis patients, T peripheral helper/T follicular helper cells and ABCs also expressed CD153 and CD30, respectively. Together, our data reveal a previously unappreciated function of CD153/CD30 signaling in TLT formation and propose targeting the CD153/CD30 signaling pathway as a therapeutic target for slowing kidney disease progression.
MeSH term(s)	Acute Kidney Injury/genetics ; Acute Kidney Injury/immunology ; Aging/genetics ; Aging/immunology ; Animals ; CD30 Ligand/genetics ; CD30 Ligand/immunology ; CD4-Positive T-Lymphocytes/immunology ; Ki-1 Antigen/genetics ; Ki-1 Antigen/immunology ; Lymphoid Tissue/immunology ; Male ; Mice ; Mice, Knockout ; Signal Transduction/genetics ; Signal Transduction/immunology
Chemical Substances	CD30 Ligand ; Ki-1 Antigen ; Tnfsf8 protein, mouse
Language	English
Publishing date	2022-07-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Video-Audio Media
ZDB-ID	3067-3
ISSN	1558-8238 ; 0021-9738
ISSN (online)	1558-8238
ISSN	0021-9738
DOI	10.1172/JCI146071
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Article ; Online: Rapidly progressive glomerulonephritis caused by tegafur/gimeracil/oteracil resulted in diabetes nephropathy, in a patient with minor risk of diabetes nephropathy: a case report.

Toriu, Naoya / Sawa, Naoki / Imafuku, Aya / Hasegawa, Eiko / Sekine, Akinari / Mizuno, Hiroki / Yamanouchi, Masayuki / Hiramatsu, Rikako / Hayami, Noriko / Hoshino, Junichi / Kawada, Masahiro / Suwabe, Tatsuya / Ohashi, Kenichi / Fujii, Takeshi / Ubara, Yoshifumi

CEN case reports

2020 Volume 9, Issue 4, Page(s) 347–353

Abstract: A 79-year-old Japanese male with a history of type 2 diabetes mellitus (T2DM) for 16 years was admitted to evaluate possible renal disease. The T2DM was well controlled in this patient using nutrition therapy without the need for any diabetes medication, ...

Abstract	A 79-year-old Japanese male with a history of type 2 diabetes mellitus (T2DM) for 16 years was admitted to evaluate possible renal disease. The T2DM was well controlled in this patient using nutrition therapy without the need for any diabetes medication, and both diabetes retinopathy and proteinuria were negative. At the age of 78 advanced colorectal cancer (stage IIIa) was diagnosed and laparoscopic-assisted colectomy was performed. Following this procedure, the patient began treatment with tegafur/gimeracil/oteracil (S-1), 80 mg twice daily for 28 days of 42-day cycle. The patient received S-1 for 6 months, during which time, serum albumin decreased from 3.0 g/dL to 1.1 g/dL, urinary protein increased from negative to 3.0 g/day, and serum creatinine increased from 0.9 mg/dL to 2.1 mg/dL. Treatment with S-1 was discontinued, and furosemide 180 mg and prednisolone 30 mg treatment was initiated; however, serum creatinine levels continued to increase to 7.2 mg/dL and proteinuria continued to increase reaching a nephrotic range. A disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) activity was decreased to 27.0%. Renal biopsy showed Kimmelstiel-Wilson nodules, while immunofluorescence intensity of IgG subclass was IgG1 dominant, which was not compatible with diabetic nephropathy (DN). Plasma exchange was not affected. However, hemodialysis was initiated.The results of this investigation suggest that when S-1 monotherapy is performed in the case with DN, rapidly progressive glomerulonephritis (RPGN) may develop due to a condition similar to thrombotic microangiopathy, even in patients with a minor risk factor of DN.
MeSH term(s)	Aged ; Asian Continental Ancestry Group/ethnology ; Biopsy ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/surgery ; Creatinine/blood ; Diabetic Nephropathies/diagnosis ; Diabetic Nephropathies/etiology ; Diabetic Nephropathies/therapy ; Disease Progression ; Drug Combinations ; Glomerulonephritis/chemically induced ; Glomerulonephritis/complications ; Humans ; Kidney/pathology ; Male ; Neoplasm Staging ; Oxonic Acid/adverse effects ; Oxonic Acid/therapeutic use ; Proteinuria/diagnosis ; Pyridines/adverse effects ; Pyridines/therapeutic use ; Renal Dialysis/methods ; Risk Assessment ; Serum Albumin/analysis ; Tegafur/adverse effects ; Tegafur/therapeutic use ; Withholding Treatment
Chemical Substances	Drug Combinations ; Pyridines ; Serum Albumin ; tegafur-gimeracil-oteracil ; S 1 (combination) (150863-82-4) ; Tegafur (1548R74NSZ) ; Oxonic Acid (5VT6420TIG) ; Creatinine (AYI8EX34EU)
Language	English
Publishing date	2020-05-07
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	2660492-9
ISSN	2192-4449 ; 2192-4449
ISSN (online)	2192-4449
ISSN	2192-4449
DOI	10.1007/s13730-020-00485-7
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Article ; Online: CD153/CD30 signaling promotes age-dependent tertiary lymphoid tissue expansion and kidney injury

Yuki Sato / Akiko Oguchi / Yuji Fukushima / Kyoko Masuda / Naoya Toriu / Keisuke Taniguchi / Takahisa Yoshikawa / Xiaotong Cui / Makiko Kondo / Takeshi Hosoi / Shota Komidori / Yoko Shimizu / Harumi Fujita / Li Jiang / Yingyi Kong / Takashi Yamanashi / Jun Seita / Takuya Yamamoto / Shinya Toyokuni /

Yoko Hamazaki / Masakazu Hattori / Yasunobu Yoshikai / Peter Boor / Jürgen Floege / Hiroshi Kawamoto / Yasuhiro Murakawa / Nagahiro Minato / Motoko Yanagita

The Journal of Clinical Investigation, Vol 132, Iss

2022 Volume 2

Abstract	Tertiary lymphoid tissues (TLTs) facilitate local T and B cell interactions in chronically inflamed organs. However, the cells and molecular pathways that govern TLT formation are poorly defined. Here, we identified TNF superfamily CD153/CD30 signaling between 2 unique age-dependent lymphocyte subpopulations, CD153+PD-1+CD4+ senescence-associated T (SAT) cells and CD30+T-bet+ age-associated B cells (ABCs), as a driver for TLT expansion. SAT cells, which produced ABC-inducing factors IL-21 and IFN-γ, and ABCs progressively accumulated within TLTs in aged kidneys after injury. Notably, in kidney injury models, CD153 or CD30 deficiency impaired functional SAT cell induction, which resulted in reduced ABC numbers and attenuated TLT formation with improved inflammation, fibrosis, and renal function. Attenuated TLT formation after transplantation of CD153-deficient bone marrow further supported the importance of CD153 in immune cells. Clonal analysis revealed that SAT cells and ABCs in the kidneys arose from both local differentiation and recruitment from the spleen. In the synovium of aged rheumatoid arthritis patients, T peripheral helper/T follicular helper cells and ABCs also expressed CD153 and CD30, respectively. Together, our data reveal a previously unappreciated function of CD153/CD30 signaling in TLT formation and propose targeting the CD153/CD30 signaling pathway as a therapeutic target for slowing kidney disease progression.
Keywords	Inflammation ; Nephrology ; Medicine ; R
Subject code	570
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	American Society for Clinical Investigation
Document type	Article ; Online
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Article ; Online: Regression of renal amyloid deposits by VAD therapy plus autologous stem cell transplantation in a patient with primary AL amyloidosis.

Toriu, Naoya / Sawa, Naoki / Hiramatsu, Rikako / Mizuno, Hiroki / Ikuma, Daisuke / Sekine, Akinari / Hayami, Noriko / Sumida, Keiichi / Yamanouchi, Masayuki / Hasegawa, Eiko / Hoshino, Junichi / Takaichi, Kenmei / Wake, Atsushi / Ohashi, Kenichi / Fujii, Takeshi / Ubara, Yoshifumi

CEN case reports

2019 Volume 9, Issue 1, Page(s) 6–10

Abstract: We report a 58-year-old Japanese woman who presented with nephrotic syndrome. Steroid therapy and cyclosporine A administration were initiated, but hematological remission and renal response were not achieved. Renal biopsy revealed amyloid deposits in ... ...

Abstract	We report a 58-year-old Japanese woman who presented with nephrotic syndrome. Steroid therapy and cyclosporine A administration were initiated, but hematological remission and renal response were not achieved. Renal biopsy revealed amyloid deposits in the mesangial region and the small arteries. Proteomic analysis based on laser microdissection and mass spectrometry showed that the amyloid deposits were composed of the constant region of the lambda light chain. She received vincristine, adriamycin, and dexamethasone therapy followed by high-dose melphalan and autologous stem cell transplantation, resulting in hematological complete remission and renal response with negative urinary Bence-Jones protein and proteinuria. Renal biopsy was performed four times during follow-up, demonstrating that amyloid deposits decreased gradually, while glomeruli showing global sclerosis increased from 3 to 62%. This case suggests that glomerular amyloid deposits can be cleared via tissue remodeling, if stem cells producing amyloid precursors are completely replaced by unrelated cells after stem cell transplantation.
MeSH term(s)	Antibiotics, Antineoplastic/therapeutic use ; Antineoplastic Agents, Hormonal/therapeutic use ; Antineoplastic Agents, Phytogenic/therapeutic use ; Asian Continental Ancestry Group ; Combined Modality Therapy ; Dexamethasone/therapeutic use ; Doxorubicin/therapeutic use ; Female ; Hematopoietic Stem Cell Transplantation/methods ; Humans ; Immunoglobulin Light-chain Amyloidosis/pathology ; Immunoglobulin Light-chain Amyloidosis/therapy ; Immunoglobulin lambda-Chains/drug effects ; Immunoglobulin lambda-Chains/metabolism ; Kidney/pathology ; Kidney/physiopathology ; Melphalan/therapeutic use ; Middle Aged ; Myeloablative Agonists/therapeutic use ; Nephrotic Syndrome/drug therapy ; Plaque, Amyloid/drug therapy ; Plaque, Amyloid/metabolism ; Plaque, Amyloid/pathology ; Proteomics ; Remission Induction ; Transplantation, Autologous/methods ; Vincristine/therapeutic use
Chemical Substances	Antibiotics, Antineoplastic ; Antineoplastic Agents, Hormonal ; Antineoplastic Agents, Phytogenic ; Immunoglobulin lambda-Chains ; Myeloablative Agonists ; Vincristine (5J49Q6B70F) ; Dexamethasone (7S5I7G3JQL) ; Doxorubicin (80168379AG) ; Melphalan (Q41OR9510P)
Language	English
Publishing date	2019-09-14
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	2660492-9
ISSN	2192-4449 ; 2192-4449
ISSN (online)	2192-4449
ISSN	2192-4449
DOI	10.1007/s13730-019-00416-1
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Article: Everolimus Reduces the Size of Tuberous Sclerosis Complex-Related Huge Renal Angiomyolipomas Exceeding 20 cm in the Longest Diameter.

Toriu, Naoya / Mizuno, Hiroki / Sawa, Naoki / Sumida, Keiichi / Suwabe, Tatsuya / Hayami, Noriko / Sekine, Akinari / Yamanouchi, Masayuki / Hoshino, Junichi / Takaichi, Kenmei / Yanagita, Motoko / Fujimaru, Takuya / Mori, Takayasu / Sohara, Eisei / Uchida, Shinichi / Ubara, Yoshifumi

Case reports in oncology

2018 Volume 11, Issue 2, Page(s) 258–267

Abstract: We evaluated the efficacy of everolimus in 3 patients who had huge renal angiomyolipomas associated with tuberous sclerosis complex. Two patients with large lipid-rich angiomyolipomas had a history of renal transarterial embolization for renal bleeding, ... ...

Abstract	We evaluated the efficacy of everolimus in 3 patients who had huge renal angiomyolipomas associated with tuberous sclerosis complex. Two patients with large lipid-rich angiomyolipomas had a history of renal transarterial embolization for renal bleeding, but the effect had only been temporary and the embolized kidneys had continued to enlarge. In case 1, case 2, and case 3, total renal volume was respectively 3,891, 4,035, and 1,179 cm
Language	English
Publishing date	2018-05-02
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2458961-5
ISSN	1662-6575
ISSN	1662-6575
DOI	10.1159/000488704
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Article: Renal-Limited Thrombotic Microangiopathy due to Bevacizumab Therapy for Metastatic Colorectal Cancer: A Case Report.

Toriu, Naoya / Sekine, Akinari / Mizuno, Hiroki / Hasegawa, Eiko / Yamanouchi, Masayuki / Hiramatsu, Rikako / Hayami, Noriko / Hoshino, Junichi / Kawada, Masahiro / Suwabe, Tatsuya / Sumida, Keiichi / Sawa, Naoki / Takaichi, Kenmei / Ohashi, Kenichi / Fujii, Takeshi / Matoba, Shuichiro / Ubara, Yoshifumi

Case reports in oncology

2019 Volume 12, Issue 2, Page(s) 391–400

Abstract: An 88-year-old Japanese man received bevacizumab for colorectal cancer with liver and peritoneal metastasis, during which nephrotic range proteinuria occurred (7.66 g/day). Renal biopsy showed endothelial damage with subendothelial swelling and a double ... ...

Abstract	An 88-year-old Japanese man received bevacizumab for colorectal cancer with liver and peritoneal metastasis, during which nephrotic range proteinuria occurred (7.66 g/day). Renal biopsy showed endothelial damage with subendothelial swelling and a double contour of the glomerular basement membrane, which indicated a diagnosis of thrombotic microangiopathy (TMA). After bevacizumab was stopped, proteinuria decreased to 1 g/day. During the clinical course, this patient had no extrarenal manifestations. This case suggests that renal injury induced by bevacizumab is characterized by nephrotic range proteinuria and histological TMA, and is a renal-limited condition that differs from systemic TMA related to thrombotic thrombocytopenic purpura.
Language	English
Publishing date	2019-06-04
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2458961-5
ISSN	1662-6575
ISSN	1662-6575
DOI	10.1159/000500716
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