LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 36

Search options

  1. Article ; Online: Anti-oxidative treatment with vitamin E improves peripheral vascular function in patients with diabetes mellitus and Haptoglobin 2-2 genotype: A double-blinded cross-over study.

    Alshiek, Jonia Amer / Dayan, Lior / Asleh, Rabea / Blum, Shany / Levy, Andrew P / Jacob, Giris

    Diabetes research and clinical practice

    2017  Volume 131, Page(s) 200–207

    Abstract: Vascular dysfunction in both conduit arteries and small vessels is a major contributor to the development of cardiovascular disease (CVD) in diabetes mellitus (DM). In diabetes there is a process of systemic chronic inflammation accompanied by high ... ...

    Abstract Vascular dysfunction in both conduit arteries and small vessels is a major contributor to the development of cardiovascular disease (CVD) in diabetes mellitus (DM). In diabetes there is a process of systemic chronic inflammation accompanied by high oxidative stress causing a subsequent decrease in vascular reactivity and negatively affect the metabolic processes responsible for functioning of the microvasculature. Vitamin E is classified as an antioxidant due to its ability to scavenge lipid radicals and terminate oxidative chain reactions. We conducted a double-blinded cross-over study with vitamin E versus placebo in individuals with type 2DM and the Hp2-2 genotype and assessed different aspects of peripheral vascular function in these patients. Twenty patients completed the study with 10 individuals in each study cohort. We were able to show significant improvement of indirect indices of vascular function following 8weeks of treatment with vitamin E. This improvement was consistent for weeks even after stopping the vitamin E treatment. We concluded that a pharmacogenomic rationale utilizing the Hp genotype might potentially provide cardiovascular benefit with vitamin E.
    Language English
    Publishing date 2017-09
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 632523-3
    ISSN 1872-8227 ; 0168-8227
    ISSN (online) 1872-8227
    ISSN 0168-8227
    DOI 10.1016/j.diabres.2017.06.026
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2047: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Cholesterol efflux capacity and atherosclerosis.

    Asleh, Rabea / Levy, Andrew P / Blum, Shany

    The New England journal of medicine

    2011  Volume 364, Issue 15, Page(s) 1473; author reply 1474–5

    MeSH term(s) Cholesterol/metabolism ; Coronary Artery Disease/genetics ; Coronary Artery Disease/metabolism ; Genotype ; Haptoglobins/genetics ; Haptoglobins/metabolism ; Hemoglobins/metabolism ; Humans ; Lipoproteins, HDL/metabolism
    Chemical Substances Haptoglobins ; Hemoglobins ; Lipoproteins, HDL ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2011-04-13
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1101853
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.34: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Haptoglobin genotype and cardiovascular outcomes in diabetes mellitus - natural history of the disease and the effect of vitamin E treatment. Meta-analysis of the medical literature.

    Vardi, Moshe / Blum, Shany / Levy, Andrew P

    European journal of internal medicine

    2012  Volume 23, Issue 7, Page(s) 628–632

    Abstract: Background: Diabetes mellitus carries a high risk for vascular events. Diabetics with different haptoglobin (Hp) types may carry different risk profiles, and may respond differently to vitamin E treatment. We aim to summarize the evidence about ... ...

    Abstract Background: Diabetes mellitus carries a high risk for vascular events. Diabetics with different haptoglobin (Hp) types may carry different risk profiles, and may respond differently to vitamin E treatment. We aim to summarize the evidence about cardiovascular risk in diabetic patients, according to their Hp type, and the effect of vitamin E treatment on these sub-groups.
    Methods: We searched MEDLINE and on-going trials' databases until February 2011; gray literature; reference lists of identified articles; and experts. Two investigators screened and selected studies that prospectively followed cardiovascular outcomes in diabetic patients with different Hp types (natural history analysis), and randomized controlled trials reporting the effect of vitamin E on cardiovascular outcomes in diabetics, in which Hp typing was performed (interventional analysis).
    Results: Five and three studies, comprising 1829 and 2110 patients, were eligible for the natural history and the interventional analyses, respectively. The percentage of diabetic patients experiencing non-fatal MI, stroke, or cardiovascular death was significantly higher in the Hp 2-2 population (odds ratio (OR) 2.03 (95% confidence interval (CI) 1.46 to 2.81)). In patients with Hp 2-2 genotype, the OR for a combined endpoint was 0.66 in favor of the vitamin E treated group (95% CI 0.48 to 0.9). This effect was not shown in other Hp types.
    Conclusion: Hp type 2-2 carries a high risk of cardiovascular events in diabetic patients. A pharmacogenomic approach towards treatment of diabetic patients with vitamin E may be warranted.
    MeSH term(s) Antioxidants/therapeutic use ; Cardiovascular Diseases/genetics ; Cardiovascular Diseases/prevention & control ; Diabetes Complications/genetics ; Diabetes Complications/prevention & control ; Diabetes Mellitus/genetics ; Genotype ; Haptoglobins/genetics ; Humans ; Myocardial Infarction/genetics ; Myocardial Infarction/prevention & control ; Pharmacogenetics ; Risk Factors ; Stroke/genetics ; Stroke/prevention & control ; Vitamin E/therapeutic use
    Chemical Substances Antioxidants ; Haptoglobins ; Vitamin E (1406-18-4)
    Language English
    Publishing date 2012-05-14
    Publishing country Netherlands
    Document type Journal Article ; Meta-Analysis ; Review
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2012.04.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2608: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Pharmacogenomics in prevention of diabetic cardiovascular disease: utilization of the haptoglobin genotype in determining benefit from vitamin E.

    Levy, Andrew P / Blum, Shany

    Expert review of cardiovascular therapy

    2007  Volume 5, Issue 6, Page(s) 1105–1111

    Abstract: Numerous large clinical trials have been carried out over the past several years testing the ability of the antioxidant vitamin E to prevent diabetic cardiovascular disease. Meta-analysis of these studies has demonstrated that vitamin E does not provide ... ...

    Abstract Numerous large clinical trials have been carried out over the past several years testing the ability of the antioxidant vitamin E to prevent diabetic cardiovascular disease. Meta-analysis of these studies has demonstrated that vitamin E does not provide any cardiovascular protection and may be associated with an increase in mortality. However, these studies did not address possible benefit to subgroups with increased oxidative stress. In this review we provide supporting clinical evidence and a mechanistic basis for utilizing a genetic marker, the haptoglobin genotype, in determining whether vitamin E therapy may or may not be beneficial for a given patient with diabetes.
    MeSH term(s) Antioxidants/therapeutic use ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/genetics ; Cardiovascular Diseases/prevention & control ; Diabetic Angiopathies/drug therapy ; Diabetic Angiopathies/genetics ; Diabetic Angiopathies/mortality ; Diabetic Angiopathies/prevention & control ; Female ; Haptoglobins/drug effects ; Haptoglobins/genetics ; Humans ; Male ; Oxidative Stress/drug effects ; Oxidative Stress/genetics ; Pharmacogenetics ; Randomized Controlled Trials as Topic ; Risk Factors ; Sensitivity and Specificity ; Severity of Illness Index ; Survival Rate ; Treatment Outcome ; Vitamin E/therapeutic use
    Chemical Substances Antioxidants ; Haptoglobins ; Vitamin E (1406-18-4)
    Language English
    Publishing date 2007-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2192343-7
    ISSN 1744-8344 ; 1477-9072
    ISSN (online) 1744-8344
    ISSN 1477-9072
    DOI 10.1586/14779072.5.6.1105
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6107: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: TARGT Gene Therapy Platform for Correction of Anemia in End-Stage Renal Disease.

    Blum, Shany / Shapir, Nir / Miari, Reem / Lerner, Benny / Koren, Belly / Doenyas-Barak, Keren / Efrati, Shai / Pergola, Pablo E / Schwartz, Doron / Chernin, Gil / Yagil, Yoram / Guzy, Serge / Nyska, Abraham / Neil, Garry A

    The New England journal of medicine

    2017  Volume 376, Issue 2, Page(s) 189–191

    MeSH term(s) Anemia/etiology ; Anemia/therapy ; Animals ; Drug Implants ; Erythropoietin/blood ; Erythropoietin/secretion ; Genetic Therapy/methods ; Hemoglobins/analysis ; Humans ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/therapy ; Mice ; Renal Dialysis
    Chemical Substances Drug Implants ; Hemoglobins ; Erythropoietin (11096-26-7)
    Language English
    Publishing date 2017--12
    Publishing country United States
    Document type Letter
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1606202
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.34: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Antioxidants in the prevention of atherosclerosis: the importance of proper patient selection.

    Levy, Yishai / Blum, Shany / Levy, Andrew P

    Clinical nutrition (Edinburgh, Scotland)

    2009  Volume 28, Issue 5, Page(s) 581–582

    Abstract: We wish to comment on the recent publication by Katiski and Manes. We absolutely agree with the reviewers that there has been no consistent protective effect of any single antioxidant or combination against cardiovascular morbidity and mortality. However, ...

    Abstract We wish to comment on the recent publication by Katiski and Manes. We absolutely agree with the reviewers that there has been no consistent protective effect of any single antioxidant or combination against cardiovascular morbidity and mortality. However, one reason why antioxidant trials may have failed to show clinical benefit in these studies may be related to inappropriate patient selection. Thus, we would like to present a recent prospective double blind placebo controlled study (ICARE), which assessed potential cardiovascular benefit from vitamin E in a subgroup of patients with both Diabetes Mellitus (DM) and the Haptoglobin (Hp) 2-2 genotype-agroup with very high oxidative stress. We believe that groups with evidence of a significant pro-oxidative and pro-inflammatory milieu such as the diabetic patients with the Hp 2-2 genotype, may benefit from antioxidants. Thus, better identification of such sub-groups, which will respond favorably to treatment with antioxidants is worthy of investigation.
    MeSH term(s) Antioxidants/administration & dosage ; Cardiovascular Diseases/prevention & control ; Diabetes Mellitus ; Dietary Supplements ; Genetic Predisposition to Disease ; Haptoglobins/genetics ; Humans ; Oxidative Stress ; Patient Selection ; Randomized Controlled Trials as Topic ; Vitamin E/administration & dosage
    Chemical Substances Antioxidants ; Haptoglobins ; Vitamin E (1406-18-4)
    Language English
    Publishing date 2009-10
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 604812-2
    ISSN 1532-1983 ; 0261-5614
    ISSN (online) 1532-1983
    ISSN 0261-5614
    DOI 10.1016/j.clnu.2009.04.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1774: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Does Haptoglobin Phenotype Influence Postnatal Morbidity in Preterm Neonates?

    Kessel, Irena / Leib, Maayan / Levy, Andrew / Miller-Lotan, Rachel / Waisman, Dan / Jacobson, Eyal / Rotschild, Avi / Blum, Shany

    American journal of perinatology

    2016  Volume 33, Issue 2, Page(s) 130–135

    Abstract: Background: Haptoglobin (Hp) is an acute phase protein with antioxidant, bacteriostatic, and anti-inflammatory activities. Hp proteins associated with the three major phenotypes differ in their proinflammatory and anti-inflammatory action. Inflammation ... ...

    Abstract Background: Haptoglobin (Hp) is an acute phase protein with antioxidant, bacteriostatic, and anti-inflammatory activities. Hp proteins associated with the three major phenotypes differ in their proinflammatory and anti-inflammatory action. Inflammation and oxidative stress are both involved in most pathophysiological processes in premature infants. The objective of this study was to determine whether Hp phenotype influences clinical manifestations and sepsis incidence in the premature infants.
    Objective: Infants born before 35 weeks gestational age were prospectively evaluated for Hp phenotype and clinical events, including sepsis, necrotizing enterocolitis, bronchopulmonary dysplasia, intraventricular hemorrhage, and retinopathy of prematurity. The participants were observed until discharge.
    Methods: A total of 122 preterm infants were enrolled in the study. Clinical events were not affected by the Hp phenotype. The expression of Hp protein was extremely low in the study population. More septic episodes were found in infants with a birth weight greater than 1,500 g, although, the difference was not statistically significant.
    Results: Extremely low expression of Hp may explain the lack of a correlation between Hp phenotype and sepsis in preterm infants. Further research involving a larger neonatal population is required to better understand the role of the Hp phenotype in morbidity of premature infants.
    MeSH term(s) Bronchopulmonary Dysplasia/epidemiology ; Bronchopulmonary Dysplasia/genetics ; Bronchopulmonary Dysplasia/metabolism ; Cerebral Hemorrhage/epidemiology ; Cerebral Hemorrhage/genetics ; Cerebral Hemorrhage/metabolism ; Cohort Studies ; Electrophoresis, Polyacrylamide Gel ; Enterocolitis, Necrotizing/epidemiology ; Enterocolitis, Necrotizing/genetics ; Enterocolitis, Necrotizing/metabolism ; Female ; Haptoglobins/genetics ; Haptoglobins/metabolism ; Humans ; Infant, Newborn ; Infant, Premature ; Infant, Premature, Diseases/epidemiology ; Infant, Premature, Diseases/genetics ; Infant, Premature, Diseases/metabolism ; Israel/epidemiology ; Male ; Phenotype ; Polymerase Chain Reaction ; Prospective Studies ; Protective Factors ; Retinopathy of Prematurity/epidemiology ; Retinopathy of Prematurity/genetics ; Retinopathy of Prematurity/metabolism ; Risk Factors ; Sepsis/epidemiology ; Sepsis/genetics ; Sepsis/metabolism
    Chemical Substances Haptoglobins
    Language English
    Publishing date 2016-01
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 605671-4
    ISSN 1098-8785 ; 0735-1631
    ISSN (online) 1098-8785
    ISSN 0735-1631
    DOI 10.1055/s-0035-1560042
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1929: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Haptoglobin Genotype as a Determinant of Benefit or Harm From Niacin for Participants With Diabetes.

    Asleh, Rabea / Levy, Nina S / Doros, Gheorge / Costacou, Tina / Robinson, Jennifer G / Blum, Shany / Goldenstein, Hagit / Boden, William E / Simmons, Debra L / Lacy, Megan A / Grunberger, George / Anderson, Todd J / Levy, Andrew P

    Journal of the American College of Cardiology

    2016  Volume 67, Issue 21, Page(s) 2553–2554

    MeSH term(s) Diabetes Mellitus/genetics ; Diabetes Mellitus/metabolism ; Genotype ; Haptoglobins/genetics ; Humans ; Hypolipidemic Agents/therapeutic use ; Lipoproteins, HDL/metabolism ; Niacin/therapeutic use
    Chemical Substances Haptoglobins ; Hypolipidemic Agents ; Lipoproteins, HDL ; Niacin (2679MF687A)
    Language English
    Publishing date 2016--31
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2016.03.533
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1846: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 196: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Pharmacogenomic application of the haptoglobin genotype in the prevention of diabetic cardiovascular disease.

    Blum, Shany / Milman, Uzi / Shapira, Chen / Levy, Andrew P

    Pharmacogenomics

    2008  Volume 9, Issue 8, Page(s) 989–991

    MeSH term(s) Cardiovascular Diseases/complications ; Cardiovascular Diseases/genetics ; Cardiovascular Diseases/prevention & control ; Diabetes Complications/genetics ; Diabetes Complications/prevention & control ; Diabetes Mellitus/genetics ; Diabetes Mellitus/prevention & control ; Genotype ; Haptoglobins/genetics ; Humans ; Pharmacogenetics/trends
    Chemical Substances Haptoglobins
    Language English
    Publishing date 2008-08
    Publishing country England
    Document type Editorial
    ZDB-ID 2019513-8
    ISSN 1744-8042 ; 1462-2416
    ISSN (online) 1744-8042
    ISSN 1462-2416
    DOI 10.2217/14622416.9.8.989
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5247: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: The effect of vitamin E supplementation on cardiovascular risk in diabetic individuals with different haptoglobin phenotypes.

    Blum, Shany / Vardi, Moshe / Levy, Nina S / Miller-Lotan, Rachel / Levy, Andrew P

    Atherosclerosis

    2010  Volume 211, Issue 1, Page(s) 25–27

    MeSH term(s) Cardiovascular Diseases/prevention & control ; Diabetes Mellitus/genetics ; Diabetic Angiopathies/prevention & control ; Haptoglobins/genetics ; Humans ; Phenotype ; Vitamin E/adverse effects ; Vitamin E/therapeutic use
    Chemical Substances Haptoglobins ; Vitamin E (1406-18-4)
    Language English
    Publishing date 2010-07
    Publishing country Ireland
    Document type Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 80061-2
    ISSN 1879-1484 ; 0021-9150
    ISSN (online) 1879-1484
    ISSN 0021-9150
    DOI 10.1016/j.atherosclerosis.2010.02.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 226: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top