LIVIVO - Search results -

Search results

Result 1 - 10 of total 11755

Search options

Article ; Online: Revision of Cytomegalovirus Immunoglobulin M Antibody Titer Cutoff in a Maternal Antibody Screening Program in Japan: A Cohort Comparison Involving a Total of 32,000 Pregnant Women.

Kitamura, Asa / Toriyabe, Kuniaki / Hagimoto-Akasaka, Miki / Hamasaki-Shimada, Kyoko / Ikejiri, Makoto / Minematsu, Toshio / Suga, Shigeru / Kondo, Eiji / Kihira, Masamichi / Morikawa, Fumihiro / Ikeda, Tomoaki

Viruses

2023 Volume 15, Issue 4

Abstract: ... CMV immunoglobulin (Ig) M titer cutoff for IgG avidity measurements as a reflex test in maternal ...

Abstract	Cytomegalovirus (CMV) is associated with congenital infections. We aimed to validate the revised CMV immunoglobulin (Ig) M titer cutoff for IgG avidity measurements as a reflex test in maternal screening to identify women with primary CMV infection and newborn congenital cytomegalovirus (cCMV). We screened maternal CMV antibodies (the Denka assay) in Japan, from 2017 to 2019, using a revised IgM cutoff (≥4.00 index). Participants were tested for IgG and IgM antibodies, and for IgG avidity if IgM levels exceeded the cutoff. We compared these with corresponding results from 2013 to 2017 based on the original cutoff (≥1.21) and recalculated using the revised cutoff. Newborn urine CMV DNA tests were performed for women with low avidity (≤35.0%). Among 12,832 women screened in 2017-2019, 127 (1.0%) had IgM above the revised cutoff. Thirty-five exhibited low avidity, and seven infants developed cCMV. Of 19,435 women screened in 2013-2017, 184 (1.0%) had IgM above the revised cutoff, 67 had low avidity, and 1 had cCMV. The 2017-2019 results were not significantly different from the 2013-2017 results. The revised IgM cutoff improves maternal screening in identifying primary infection and newborn cCMV; however, further study related to other assays than Denka is required.
MeSH term(s)	Infant, Newborn ; Female ; Humans ; Pregnancy ; Cytomegalovirus/genetics ; Pregnant Women ; Pregnancy Complications, Infectious/diagnosis ; Pregnancy Complications, Infectious/epidemiology ; Japan/epidemiology ; Immunoglobulin G ; Cytomegalovirus Infections/diagnosis ; Cytomegalovirus Infections/epidemiology ; Antibodies, Viral ; Immunoglobulin M ; Antibody Affinity
Chemical Substances	Immunoglobulin G ; Antibodies, Viral ; Immunoglobulin M
Language	English
Publishing date	2023-04-13
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15040962
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Development of a simple multiple mutation detection system using seed-coat flavonoid pigments in irradiated Arabidopsis M

Kitamura, Satoshi / Hirata, Shoya / Satoh, Katsuya / Inamura, Rie / Narumi, Issay / Oono, Yutaka

Scientific reports

2022 Volume 12, Issue 1, Page(s) 22467

Abstract: ... using irradiated M ...

Abstract	Ionizing radiation induces genetic variations in plants, which makes it useful for plant breeding. A theory that the induced mutations occur randomly in the genome has long been accepted, but is now controversial. Nevertheless, a comparative analysis of the mutations at multiple loci has not been conducted using irradiated M
MeSH term(s)	Arabidopsis/metabolism ; Flavonoids ; Anthocyanins/genetics ; Plant Breeding ; Mutation ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Seeds/genetics ; Seeds/metabolism ; Gene Expression Regulation, Plant
Chemical Substances	Flavonoids ; Anthocyanins ; Arabidopsis Proteins
Language	English
Publishing date	2022-12-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-26989-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Tubulointerstitial nephritis and uveitis syndrome following meningitis and systemic lymphadenopathy with persistent Toxoplasma immunoglobulin M: a case report.

Oya, Yoshihiro / Futami, Hidekazu / Nakazawa, Takuya / Ishijima, Kazuyuki / Umemiya, Keiko / Takizawa, Fumiyoshi / Imai, Naoki / Kitamura, Hiroshi / Matsumura, Ryutaro

Journal of medical case reports

2021 Volume 15, Issue 1, Page(s) 482

Abstract: ... in immunocompromised or in some immunocompetent individuals. If the immunoglobulin M of Toxoplasma is positive ... on screening, the interpretation of the result is not simple, especially when immunoglobulin M stays positive ... syndrome was made. Toxoplasma gondii-specific immunoglobulin G and immunoglobulin M titers were ...

Abstract	Background: Tubulointerstitial nephritis and uveitis syndrome is a rare lymphocyte-related oculorenal inflammatory disease presumed to be associated with drug use and infectious agents. Toxoplasma gondii is one of such pathogens that could exhibit encephalitis, meningitis, and uveitis in immunocompromised or in some immunocompetent individuals. If the immunoglobulin M of Toxoplasma is positive on screening, the interpretation of the result is not simple, especially when immunoglobulin M stays positive persistently. Case presentation: A 34-year-old Asian male developed fever, headache, and lymphadenopathy with tenderness, which was initially diagnosed as meningitis. Antibiotics were started, and diclofenac sodium was used for the fever. Although his symptoms were alleviated in a week by the treatment, gradual decline in renal function was noted, prompting a renal biopsy that indicated acute granulomatous interstitial nephritis. A week later, tenderness in both eyes with blurred vision appeared and revealed iritis and keratic precipitations in both eyes; hence, the diagnosis of acute tubulointerstitial nephritis and bilateral uveitis syndrome was made. Toxoplasma gondii-specific immunoglobulin G and immunoglobulin M titers were both positive. Although we could not rule out recent infection of Toxoplasma gondii, which may cause uveitis initially, Toxoplasma immunoglobulin G avidity test indicated a distant infection, which allowed us to rule out meningitis and uveitis as responsible for the complication of recent Toxoplasma gondii infection. Drug-induced lymphocyte stimulation test, or lymphocyte transformation test of diclofenac sodium, was solely positive among the tested drugs. Uveitis was alleviated only with ophthalmic steroid, and renal function returned to normal without administration of systemic steroid. Conclusions: We experienced a case of diclofenac-induced tubulointerstitial nephritis and uveitis syndrome. In ruling out infections, Toxoplasma immunoglobulin M was persistently positive, and Toxoplasma immunoglobulin G avidity test indicated a "distant" infection. From these two results, we ruled out recent infection. However, it should be noted that "distant" infection indicated by commercial immunoglobulin G avidity is still a multiplex profile consisting of reinfection, reactivation, and latent infection. Narrowing down the infection profile of Toxoplasma is challenging in some cases. Therefore, careful diagnosis and extended follow-up of such patients are needed.
MeSH term(s)	Adult ; Humans ; Immunoglobulin M ; Lymphadenopathy ; Male ; Meningitis/diagnosis ; Nephritis, Interstitial/diagnosis ; Nephritis, Interstitial/drug therapy ; Toxoplasma ; Uveitis/diagnosis ; Uveitis/drug therapy
Chemical Substances	Immunoglobulin M
Language	English
Publishing date	2021-09-23
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2269805-X
ISSN	1752-1947 ; 1752-1947
ISSN (online)	1752-1947
ISSN	1752-1947
DOI	10.1186/s13256-021-02909-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Discovery of dihydroquinazolinone derivatives as potent, selective, and CNS-penetrant M(1) and M(4) muscarinic acetylcholine receptors agonists.

Uruno, Yoshiharu / Konishi, Yasuko / Suwa, Atsushi / Takai, Kentaro / Tojo, Kengo / Nakako, Tomokazu / Sakai, Mutsuko / Enomoto, Takeshi / Matsuda, Harumi / Kitamura, Atsushi / Sumiyoshi, Takaaki

Bioorganic & medicinal chemistry letters

2015 Volume 25, Issue 22, Page(s) 5357–5361

Abstract: We designed and synthesized a series of dihydroquinazolinone derivatives as selective M1 and M4 muscarinic acetylcholine receptors agonists. Introduction of the N-carbethoxy piperidine unit into a HTS hit compound followed by optimization of the amine ... ...

Abstract	We designed and synthesized a series of dihydroquinazolinone derivatives as selective M1 and M4 muscarinic acetylcholine receptors agonists. Introduction of the N-carbethoxy piperidine unit into a HTS hit compound followed by optimization of the amine linker and the carbamoyl moiety led to the identification of compound 1 as a potential candidate. The identified compound 1 showed high selectivity for M1 and M4 muscarinic acetylcholine receptors with M4 partial agonistic activity. In addition, compound 1 showed good brain penetration and reversed methamphetamine-induced hyperlocomotion in rats (ED50=3.0 mg/kg, sc).
MeSH term(s)	Animals ; Antipsychotic Agents/chemical synthesis ; Antipsychotic Agents/chemistry ; Antipsychotic Agents/pharmacokinetics ; Antipsychotic Agents/pharmacology ; Brain/drug effects ; Drug Discovery ; Molecular Structure ; Muscarinic Agonists/chemical synthesis ; Muscarinic Agonists/pharmacokinetics ; Muscarinic Agonists/pharmacology ; Protein Binding/drug effects ; Rats ; Receptor, Muscarinic M1/agonists ; Receptor, Muscarinic M4/agonists
Chemical Substances	Antipsychotic Agents ; Muscarinic Agonists ; Receptor, Muscarinic M1 ; Receptor, Muscarinic M4
Language	English
Publishing date	2015-11-15
Publishing country	England
Document type	Journal Article
ZDB-ID	1063195-1
ISSN	1464-3405 ; 0960-894X
ISSN (online)	1464-3405
ISSN	0960-894X
DOI	10.1016/j.bmcl.2015.09.032
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3203: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Structure and inhibition of the SARS-CoV-2 main protease reveals strategy for developing dual inhibitors against M

Sacco, Michael Dominic / Ma, Chunlong / Lagarias, Panagiotis / Gao, Ang / Townsend, Julia Alma / Meng, Xiangzhi / Dube, Peter / Zhang, Xiujun / Hu, Yanmei / Kitamura, Naoya / Hurst, Brett / Tarbet, Bart / Marty, Michael Thomas / Kolocouris, Antonios / Xiang, Yan / Chen, Yu / Wang, Jun

bioRxiv : the preprint server for biology

2020

Abstract: The main protease (M ...

Abstract	The main protease (M
Keywords	covid19
Language	English
Publishing date	2020-07-27
Publishing country	United States
Document type	Preprint
DOI	10.1101/2020.07.27.223727
Database	MEDical Literature Analysis and Retrieval System OnLINE

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against M

Science advances

2020 Volume 6, Issue 50

Abstract: The main protease (M ...

Abstract	The main protease (M
MeSH term(s)	Animals ; Caco-2 Cells ; Cathepsin L/antagonists & inhibitors ; Cathepsin L/chemistry ; Cathepsin L/metabolism ; Cell Line ; Cell Line, Tumor ; Chlorocebus aethiops ; Coronavirus 3C Proteases/antagonists & inhibitors ; Coronavirus 3C Proteases/chemistry ; Coronavirus 3C Proteases/metabolism ; Crystallography, X-Ray ; Dogs ; Drug Design ; Humans ; Kinetics ; Madin Darby Canine Kidney Cells ; Models, Chemical ; Molecular Dynamics Simulation ; Molecular Structure ; Protease Inhibitors/chemistry ; Protease Inhibitors/metabolism ; Protease Inhibitors/pharmacology ; Protein Domains ; Vero Cells
Chemical Substances	Protease Inhibitors ; Cathepsin L (EC 3.4.22.15) ; Coronavirus 3C Proteases (EC 3.4.22.28)
Keywords	covid19
Language	English
Publishing date	2020-12-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.abe0751
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Relationships between immunoglobulin M and immunoglobulin G or A in colostrum of Japanese black multiparous cows.

Taniguchi, Saya / Wang, Mengdong / Ikeda, Shuntaro / Yoshioka, Hidetugu / Nagase, Hiroshi / Kitamura, Shoko / Itoyama, Erina / Murakami, Hiroaki / Sugimoto, Miki / Kume, Shinichi

Animal science journal = Nihon chikusan Gakkaiho

2016 Volume 87, Issue 4, Page(s) 536–540

Abstract: This study was conducted to clarify the relationships among immunoglobulin (Ig)M, IgG, IgA, β ...

Abstract	This study was conducted to clarify the relationships among immunoglobulin (Ig)M, IgG, IgA, β-carotene, vitamin A and α-tocopherol contents in colostrum of 24 Japanese Black multiparous cows in order to evaluate the role of IgM on colostral IgG and IgA production. Compared with colostral IgG, colostral IgM and IgA were very low but varied widely. There was positive correlation between colostral IgM and IgG, but colostral IgM was not related with colostral IgA. There was no relationship between colostral IgM and age of cows, although colostral IgG was increased with aging. There were positive correlations among colostral β-carotene, vitamin A and α-tocopherol and these vitamins were positively correlated with colostral IgM and IgG. These results indicate that fat-soluble vitamins may affect colostral IgG and IgM in cows and colostral IgG increases with the increase of colostral IgM.
MeSH term(s)	Aging/metabolism ; Animals ; Cattle ; Colostrum/chemistry ; Female ; Immunoglobulin A/metabolism ; Immunoglobulin G/metabolism ; Immunoglobulin M/metabolism ; Vitamin A/metabolism ; alpha-Tocopherol/metabolism ; beta Carotene/metabolism
Chemical Substances	Immunoglobulin A ; Immunoglobulin G ; Immunoglobulin M ; beta Carotene (01YAE03M7J) ; Vitamin A (11103-57-4) ; alpha-Tocopherol (H4N855PNZ1)
Language	English
Publishing date	2016-04
Publishing country	Australia
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2095161-9
ISSN	1740-0929 ; 1344-3941
ISSN (online)	1740-0929
ISSN	1344-3941
DOI	10.1111/asj.12455
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article: Structure and inhibition of the SARS-CoV-2 main protease reveals strategy for developing dual inhibitors against M(pro) and cathepsin L

Sacco, M. D. / Ma, C. / Lagarias, P. / Gao, A. / Townsend, J. A. / Meng, X. / Dube, P. / Zhang, X. / Hu, Y. / Kitamura, N. / Hurst, B. / Tarbet, B. / Marty, M. T. / Kolocouris, A. / Xiang, Y. / Chen, Y. / Wang, J.

Sci Adv

Abstract: The main protease (M(pro)) of SARS-CoV-2 is a key antiviral drug target While most M(pro ... inhibitors have a γ-lactam glutamine surrogate at the P1 position, we recently discovered several M(pro ... we solved X-ray crystal structures of M(pro) in complex with calpain inhibitors II and XII, and three ...

Abstract	The main protease (M(pro)) of SARS-CoV-2 is a key antiviral drug target While most M(pro) inhibitors have a γ-lactam glutamine surrogate at the P1 position, we recently discovered several M(pro) inhibitors have hydrophobic moieties at the P1 site, including calpain inhibitors II and XII, which are also active against human cathepsin L, a host-protease that is important for viral entry In this study, we solved X-ray crystal structures of M(pro) in complex with calpain inhibitors II and XII, and three analogs of GC-376 The structure of M(pro) with calpain inhibitor II confirmed the S1 pocket can accommodate a hydrophobic methionine side chain, challenging the idea that a hydrophilic residue is necessary at this position Interestingly, the structure of calpain inhibitor XII revealed an unexpected, inverted binding pose Taken together, the biochemical, computational, structural, and cellular data presented herein provide new directions for the development of dual inhibitors as SARS-CoV-2 antivirals
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #913665
Database	COVID19

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Identification of N-substituted 8-azatetrahydroquinolone derivatives as selective and orally active M(1) and M(4) muscarinic acetylcholine receptors agonists.

Takai, Kentaro / Inoue, Yasunao / Konishi, Yasuko / Suwa, Atsushi / Uruno, Yoshiharu / Matsuda, Harumi / Nakako, Tomokazu / Sakai, Mutsuko / Nishikawa, Hiroyuki / Hashimoto, Gakuji / Enomoto, Takeshi / Kitamura, Atsushi / Uematsu, Yasuaki / Kiyoshi, Akihiko / Sumiyoshi, Takaaki

Bioorganic & medicinal chemistry letters

2013 Volume 23, Issue 16, Page(s) 4644–4647

Abstract: We designed and synthesized N-substituted 8-azatetrahydroquinolone derivatives as selective M1 and M4 muscarinic acetylcholine receptors agonists. Optimization of selected derivatives led to the discovery of compound 7 as a highly potent M1 and M4 ... ...

Abstract	We designed and synthesized N-substituted 8-azatetrahydroquinolone derivatives as selective M1 and M4 muscarinic acetylcholine receptors agonists. Optimization of selected derivatives led to the discovery of compound 7 as a highly potent M1 and M4 agonist with weak hERG inhibition. Oral administration of compound 7 improved psychosis-like behavior in rats.
MeSH term(s)	Administration, Oral ; Animals ; Antipsychotic Agents/chemical synthesis ; Antipsychotic Agents/chemistry ; Antipsychotic Agents/pharmacology ; Aza Compounds/chemical synthesis ; Aza Compounds/chemistry ; Aza Compounds/pharmacology ; Behavior, Animal/drug effects ; Hydroquinones/chemical synthesis ; Hydroquinones/chemistry ; Hydroquinones/pharmacology ; Molecular Structure ; Rats ; Receptor, Muscarinic M1/agonists ; Receptor, Muscarinic M4/agonists ; Structure-Activity Relationship
Chemical Substances	Antipsychotic Agents ; Aza Compounds ; Hydroquinones ; Receptor, Muscarinic M1 ; Receptor, Muscarinic M4 ; hydroquinone (XV74C1N1AE)
Language	English
Publishing date	2013-08-15
Publishing country	England
Document type	Journal Article
ZDB-ID	1063195-1
ISSN	1464-3405 ; 0960-894X
ISSN (online)	1464-3405
ISSN	0960-894X
DOI	10.1016/j.bmcl.2013.06.013
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3203: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Tubulointerstitial nephritis and uveitis syndrome following meningitis and systemic lymphadenopathy with persistent Toxoplasma immunoglobulin M

Yoshihiro Oya / Hidekazu Futami / Takuya Nakazawa / Kazuyuki Ishijima / Keiko Umemiya / Fumiyoshi Takizawa / Naoki Imai / Hiroshi Kitamura / Ryutaro Matsumura

Journal of Medical Case Reports, Vol 15, Iss 1, Pp 1-

a case report

2021 Volume 15

Abstract	Abstract Background Tubulointerstitial nephritis and uveitis syndrome is a rare lymphocyte-related oculorenal inflammatory disease presumed to be associated with drug use and infectious agents. Toxoplasma gondii is one of such pathogens that could exhibit encephalitis, meningitis, and uveitis in immunocompromised or in some immunocompetent individuals. If the immunoglobulin M of Toxoplasma is positive on screening, the interpretation of the result is not simple, especially when immunoglobulin M stays positive persistently. Case presentation A 34-year-old Asian male developed fever, headache, and lymphadenopathy with tenderness, which was initially diagnosed as meningitis. Antibiotics were started, and diclofenac sodium was used for the fever. Although his symptoms were alleviated in a week by the treatment, gradual decline in renal function was noted, prompting a renal biopsy that indicated acute granulomatous interstitial nephritis. A week later, tenderness in both eyes with blurred vision appeared and revealed iritis and keratic precipitations in both eyes; hence, the diagnosis of acute tubulointerstitial nephritis and bilateral uveitis syndrome was made. Toxoplasma gondii-specific immunoglobulin G and immunoglobulin M titers were both positive. Although we could not rule out recent infection of Toxoplasma gondii, which may cause uveitis initially, Toxoplasma immunoglobulin G avidity test indicated a distant infection, which allowed us to rule out meningitis and uveitis as responsible for the complication of recent Toxoplasma gondii infection. Drug-induced lymphocyte stimulation test, or lymphocyte transformation test of diclofenac sodium, was solely positive among the tested drugs. Uveitis was alleviated only with ophthalmic steroid, and renal function returned to normal without administration of systemic steroid. Conclusions We experienced a case of diclofenac-induced tubulointerstitial nephritis and uveitis syndrome. In ruling out infections, Toxoplasma immunoglobulin M was persistently positive, and ...
Keywords	Persistent immunoglobulin M (IgM) ; Drug-induced lymphocyte stimulation test (DLST) ; Lymphocyte transformation test (LTT) ; Tubulointerstitial nephritis and uveitis (TINU) syndrome ; Toxoplasma gondii ; IgG avidity test ; Medicine ; R
Subject code	150
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Order via subito

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED