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Article ; Online: Propuesta de posicionamiento sobre las recomendaciones para el uso de mascarillas en los centros sanitarios tras el cese de la obligatoriedad de su uso en España.

Gras Valenti, Paula / Sánchez Payá, José / Rodríguez Díaz, Juan Carlos / Llorens Soriano, Pere / Merino Lucas, Esperanza / Chico Sánchez, Pablo

Revista espanola de salud publica

2024 Volume 98

Abstract: Since the beginning of the COVID-19 pandemic in March 2020, the use of masks has been a fundamental pillar for controlling the transmission of SARS-CoV-2 in different areas. Its mandatory nature has been regulated by different regulations, and its ... ...

Title translation	Positioning proposal on the recommendations for the use of masks in health centers after the cessation of the mandatory use in Spain.
Abstract	Since the beginning of the COVID-19 pandemic in March 2020, the use of masks has been a fundamental pillar for controlling the transmission of SARS-CoV-2 in different areas. Its mandatory nature has been regulated by different regulations, and its effectiveness in reducing the transmission of SARS-CoV-2 and other respiratory viruses has been strongly proven. In this regard, the beneficial impact stands out in healthcare centers where it has been shown to reduce the transmission of respiratory infections, both in patients and healthcare professionals. This document proposes recommendations for the use of masks in health centers at the current time when we find ourselves with an end to the mandatory use of masks in Spain. They are aimed at healthcare professionals, patients and companions/visitors and aim to protect them from acquiring acute respiratory infections as a result of the complex relationships established in the healthcare field.
MeSH term(s)	Humans ; Spain ; Pandemics/prevention & control ; COVID-19/prevention & control ; SARS-CoV-2 ; Respiratory Tract Infections
Language	Spanish
Publishing date	2024-02-01
Publishing country	Spain
Document type	English Abstract ; Journal Article
ZDB-ID	1288657-9
ISSN	2173-9110 ; 0034-8899 ; 1135-5727
ISSN (online)	2173-9110
ISSN	0034-8899 ; 1135-5727
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Article ; Online: Transformation of agricultural wastes into functional oligosaccharides using enzymes and emerging technologies.

Cano-Gonzalez, Carlos N / Contreras-Esquivel, Juan Carlos / Rodríguez-Herrera, Raúl / Aguirre-Loredo, Rocio Yaneli / Soriano-Melgar, Lluvia de Abril Alexandra

Phytochemical analysis : PCA

2024

Abstract: Introduction: Pectin-oligosaccharides (POS) serve diverse purposes as a food ingredient, antimicrobial and biostimulant in plants, and their functionality is linked to the degree of esterification. Grape and broccoli wastes emerge as environmentally ... ...

Abstract	Introduction: Pectin-oligosaccharides (POS) serve diverse purposes as a food ingredient, antimicrobial and biostimulant in plants, and their functionality is linked to the degree of esterification. Grape and broccoli wastes emerge as environmentally friendly alternatives to obtaining pectin, serving as a sustainable source to producing POS. For example, microwaves have proven to be an effective and sustainable method to extract polysaccharides from plant matrices. Objective: This work aims to use grape and broccoli wastes as alternative sources for obtaining pectin by microwave-assisted extraction and biotransformation into POS, which possess biological properties. Material and methods: The extraction conditions were identified at a power of 400 W, 300 s for the extraction of pectin from grape pomace and broccoli waste. Biotransformation of pectins into POS, using commercial enzyme preparations (Viscozyme L and Pectinase). Characterisation was carried out by Fourier-transform infrared spectroscopy, thermogravimetric analysis, and scanning electron microscopy. Results: Physicochemical analysis indicated grape pomace and broccoli waste pectins had galacturonic acid content of 63.81 ± 1.67 and 40.83 ± 2.85 mg 100 mg Conclusion: Production of POS from agro-industrial wastes by emerging technologies, such as the combined use of microwave-assisted extraction and enzymatic processes, represents an alternative method for the generation of bioactive compounds with distinctive properties suitable for different applications of interest.
Language	English
Publishing date	2024-05-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1073576-8
ISSN	1099-1565 ; 0958-0344
ISSN (online)	1099-1565
ISSN	0958-0344
DOI	10.1002/pca.3365
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Article ; Online: Prevalence of HTLV-1/2 infection in pregnant women in Central and South America and the Caribbean: a systematic review and meta-analysis.

Sánchez-Núñez, Juan-Pablo / de-Miguel-Balsa, Eva / Soriano, Vicente / Lorenzo-Garrido, Edurado / Giménez-Richarte, Angel / Otero-Rodriguez, Silvia / Celis-Salinas, Juan-Carlos / de-Mendoza, Carmen / Casapia-Morales, Martin / Ramos-Rincón, José Manuel

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

2024 Volume 143, Page(s) 107018

Abstract: Background: Human T-lymphotropic viruses (HTLV)-1 infection is endemic in many countries of Central and South America and Caribbean (CSA&C). Neither screening nor surveillance programs exist for HTLV-1/2 infection among pregnant women in this region. ... ...

Abstract	Background: Human T-lymphotropic viruses (HTLV)-1 infection is endemic in many countries of Central and South America and Caribbean (CSA&C). Neither screening nor surveillance programs exist for HTLV-1/2 infection among pregnant women in this region. Neither in Western nations with large migrant flows from HTLV-1/2 endemic regions. Methods: Systematic review and meta-analysis of the prevalence of HTLV-1/2 infection among CSA&C pregnant women. We included studies searching EMBASE, PubMed/MEDLINE, Scopus, and Web of Science from inception to February 15, 2023. This systematic review followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses reporting guidelines. Results: We identified a total of 620 studies. Only 41 were finally included in the meta-analysis. Most studies (61.0%) were from Brazil and Peru (14.6%). The total number of participants was 343,707. The pooled prevalence of HTLV-1/2 infection among CSA&C pregnant women was 1.30% (95% CI: 0.96-1.69) using anti-HTLV-1/2 antibody screening tests. There was a high heterogeneity (I Conclusions: The prevalence of HTLV-1/2 infection among CSA&C pregnant women is 1.3%, most cases being HTLV-1. This rate is greater than for other microbial agents regularly checked as part of antenatal screening (such as HIV, hepatitis B, or syphilis). Thus, HTLV-1/2 antenatal testing should be mandatory among CSA&C pregnant women everywhere.
Language	English
Publishing date	2024-03-22
Publishing country	Canada
Document type	Journal Article
ZDB-ID	1331197-9
ISSN	1878-3511 ; 1201-9712
ISSN (online)	1878-3511
ISSN	1201-9712
DOI	10.1016/j.ijid.2024.107018
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Article ; Online: Antiperistaltic Transverse Coloplasty: A Salvage Procedure in Extensive Bowel and Colorectal Resections to Avoid Intestinal Failure.

Segura-Sampedro, Juan José / Morales-Soriano, Rafael / Rodríguez-Pino, José Carlos / Pineño Flores, Cristina / Craus-Miguel, Andrea

Annals of surgical oncology

2023 Volume 30, Issue 12, Page(s) 7236–7239

Abstract: Introduction: After extensive small and colon resections, quality of life can be affected. We propose the antiperistaltic transverse coloplasty as a solution that allows for preservation of the transverse colon after both right and left colectomies ... ...

Abstract	Introduction: After extensive small and colon resections, quality of life can be affected. We propose the antiperistaltic transverse coloplasty as a solution that allows for preservation of the transverse colon after both right and left colectomies while achieving a tension-free colorectal anastomosis slowing the transit and increasing the absorption time, resulting in better stool consistency and quality of life compared with an ileorectal anastomosis. Methods: This technique was performed in a 41-year-old woman with Goblet cell adenocarcinoma of the appendix with peritoneal metastasis. The transverse colon is rotated anticlockwise over the axis of the middle colic vessels toward the left parietocolic flank and relocated to the usual position of the descending colon. Results: After 1 year of follow-up, the patient led a normal life without parenteral nutrition with five bowel movements per day and a weight gain of 15%. Conclusions: The use of an antiperistaltic transverse coloplasty may be worthwhile to perform in cases of extensive bowel resections during cytoreductive surgery leading to short-bowel syndrome to avoid a permanent stoma or intestinal failure and improve patient outcomes.
MeSH term(s)	Female ; Humans ; Adult ; Colon/surgery ; Antidiarrheals ; Quality of Life ; Intestinal Failure ; Colectomy/methods ; Anastomosis, Surgical/methods ; Colorectal Neoplasms/surgery ; Treatment Outcome
Chemical Substances	Antidiarrheals
Language	English
Publishing date	2023-08-26
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-023-14165-0
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Article ; Online: Targeting ribosomal G-quadruplexes with naphthalene-diimides as RNA polymerase I inhibitors for colorectal cancer treatment.

Sanchez-Martin, Victoria / Schneider, David A / Ortiz-Gonzalez, Matilde / Soriano-Lerma, Ana / Linde-Rodriguez, Angel / Perez-Carrasco, Virginia / Gutierrez-Fernandez, Jose / Cuadros, Marta / Morales, Juan C / González, Carlos / Soriano, Miguel / Garcia-Salcedo, Jose A

Cell chemical biology

2022 Volume 28, Issue 12, Page(s) 1807

Language	English
Publishing date	2022-11-08
Publishing country	United States
Document type	Published Erratum
ISSN	2451-9448
ISSN (online)	2451-9448
DOI	10.1016/j.chembiol.2021.12.007
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Article ; Online: Uremic Toxins Induce THP-1 Monocyte Endothelial Adhesion and Migration through Specific miRNA Expression.

Carmona, Andres / Guerrero, Fatima / Muñoz-Castañeda, Juan R / Jimenez, Maria Jose / Rodriguez, Mariano / Soriano, Sagrario / Martin-Malo, Alejandro

International journal of molecular sciences

2023 Volume 24, Issue 16

Abstract: Atherosclerosis is initiated by the activation of endothelial cells that allows monocyte adhesion and transmigration through the vascular wall. The accumulation of uremic toxins such as indoxyl sulphate (IS) and p-cresol (PC) has been associated with ... ...

Abstract	Atherosclerosis is initiated by the activation of endothelial cells that allows monocyte adhesion and transmigration through the vascular wall. The accumulation of uremic toxins such as indoxyl sulphate (IS) and p-cresol (PC) has been associated with atherosclerosis. Currently, miRNAs play a crucial role in the regulation of monocyte activation, adhesion, and trans-endothelial migration. The aim of the present study is to evaluate the effect of IS and PC on monocyte adhesion and migration processes in monocytes co-cultured with endothelial cells as well as to determine the underlying mechanisms. The incubation of HUVECs and THP-1 cells with both IS and PC toxins resulted in an increased migratory capacity of THP-1 cells. Furthermore, the exposure of THP-1 cells to both uremic toxins resulted in the upregulation of BMP-2 and miRNAs-126-3p, -146b-5p, and -223-3p, as well as the activation of nuclear factor kappa B (NF-κB) and a decrease in its inhibitor IĸB. Uremic toxins, such as IS and PC, enhance the migratory and adhesion capacity of THP-1 cells to the vascular endothelium. These toxins, particularly PC, contribute significantly to uremia-associated vascular disease by increasing in THP-1 cells the expression of BMP-2, NF-κB, and key miRNAs associated with the development of atherosclerotic vascular diseases.
MeSH term(s)	Humans ; Uremic Toxins ; Endothelial Cells ; Monocytes ; NF-kappa B ; Atherosclerosis/genetics ; Indican/toxicity ; MicroRNAs/genetics ; Tissue Adhesions
Chemical Substances	Uremic Toxins ; NF-kappa B ; 4-cresol (1MXY2UM8NV) ; Indican (N187WK1Y1J) ; MicroRNAs
Language	English
Publishing date	2023-08-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241612938
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Article ; Online: Horizontal versus vertical force application: association with the change of direction performance in soccer players.

Robles-Ruiz, Juan / Baena-Raya, Andrés / Jiménez-Reyes, Pedro / Soriano-Maldonado, Alberto / Rodríguez-Pérez, Manuel A

European journal of sport science

2022 Volume 23, Issue 1, Page(s) 28–35

Abstract: This study examined which mechanical variables derived from a vertical jump (i.e. concentric peak force [ConcPF] and eccentric peak force [EccPF], flight time [FT]: contraction time [CT], eccentric deceleration rate of force development [EccDecRFD]) and ... ...

Abstract	This study examined which mechanical variables derived from a vertical jump (i.e. concentric peak force [ConcPF] and eccentric peak force [EccPF], flight time [FT]: contraction time [CT], eccentric deceleration rate of force development [EccDecRFD]) and linear sprint (i.e. theoretical maximal force [F
MeSH term(s)	Humans ; Male ; Adolescent ; Young Adult ; Adult ; Soccer ; Athletic Performance ; Running ; Acceleration ; Menopause
Language	English
Publishing date	2022-01-20
Publishing country	England
Document type	Journal Article
ISSN	1536-7290
ISSN (online)	1536-7290
DOI	10.1080/17461391.2021.2013953
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Article: Effectiveness of Omega-3 Fatty Acid Supplementation in Improving the Metabolic and Inflammatory Profiles of Mexican Adults Hospitalized with COVID-19.

Rodríguez-Vera, Diana / Salazar, Juan Rodrigo / Soriano-Ursúa, Marvin A / Guzmán-Pérez, Jessica / Vergara-Castañeda, Arely / Muñoz-Durán, Horacio / Ramírez-Velez, Gabriela L / Vivar-Sierra, Alonso / Naranjo-Navarro, Carlos Rogelio / Meza-Meneses, Patricia A / Loza-Mejía, Marco A / Pinto-Almazán, Rodolfo

Diseases (Basel, Switzerland)

2024 Volume 12, Issue 1

Abstract: Background and objectives: The development of severe COVID-19 is related to the preexistence of comorbidities and an inadequate nutritional status. The latter is a critical factor for the development of infection and the progression of the disease. ... ...

Abstract	Background and objectives: The development of severe COVID-19 is related to the preexistence of comorbidities and an inadequate nutritional status. The latter is a critical factor for the development of infection and the progression of the disease. Notably, optimal nutrition impacts immune system function, as malnutrition is related to high cytokine levels in the late phase of the disease, correlating with a poor prognosis. In this sense, omega-3 fatty acids (O3FAs) have anti-inflammatory properties that may reduce morbidity and mortality from COVID-19 infection. O3FAs are linked to a better prognosis in COVID-19 patients. Materials and methods: In this randomized, double-blind clinical trial, we evaluate the administration of O3FAs to unvaccinated Mexican patients for two weeks starting after the first two hours of hospitalization. Results: The findings support the notion that O3FAs (in a dose high enough to satisfy human physiological requirements in a short time, one capsule of 1.4 g O3FAs daily) exert a comprehensive multi-systemic modulatory influence, affecting inflammatory and metabolic pathways. Significant perturbations in biomarkers, including absolute neutrophil count, hematocrit, and platelet indices, underscore the compound's anti-inflammatory effect. Concurrently, the intervention modulates pivotal metabolic and hepatic parameters, attenuating cardiovascular risk profiles and expediting patient convalescence. These multifarious effects are likely orchestrated through intricate biochemical mechanisms and are subject to individual variations predicated on metabolic factors. Conclusions: The results of this trial support the notion that O3FA supplementation has beneficial effects on COVID-19 patients with moderate presentation by regulating metabolism and limiting inflammation.
Language	English
Publishing date	2024-01-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720869-2
ISSN	2079-9721
ISSN	2079-9721
DOI	10.3390/diseases12010028
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Article: Nonlinear Stabilization Controller for the Boost Converter with a Constant Power Load in Both Continuous and Discontinuous Conduction Modes.

Parada Salado, Juan Gerardo / Herrera Ramírez, Carlos Alonso / Soriano Sánchez, Allan Giovanni / Rodríguez Licea, Martín Antonio

Micromachines

2021 Volume 12, Issue 5

Abstract: The operation of Boost converters in discontinuous conduction mode (DCM) is suitable for many applications due to the, among other advantages, inductor volume reduction, high efficiency, paralleling, and low cost. Uses in biomedicine, nano/ ... ...

Abstract	The operation of Boost converters in discontinuous conduction mode (DCM) is suitable for many applications due to the, among other advantages, inductor volume reduction, high efficiency, paralleling, and low cost. Uses in biomedicine, nano/microelectromechanical, and higher power systems, where wide ranges of input/output voltage and a constant power load (CPL) can coexist, are well-known examples. Under extremely wide operating ranges, it is not difficult to change to a continuous conduction mode (CCM) operation, and instability, chaos, or bifurcations phenomena can occur regardless of the conduction mode. Unfortunately, existing control strategies consider a single conduction mode or linearized models because only slight resistive/CPL power level or input/output voltage variations (and no conduction mode changes) were expected. In this paper, new mathematical models for the Boost converter (with resistive or CPL) that are conduction mode independent are presented and validated. Since the open-loop dynamics of the proposed CPL model is unstable, a nonlinear control law capable of stabilizing the boost converter regardless of the conduction mode is proposed. A stability analysis based on a common-Lyapunov function is provided, and numerical and experimental tests are presented to show the proposal's effectiveness.
Language	English
Publishing date	2021-05-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2620864-7
ISSN	2072-666X
ISSN	2072-666X
DOI	10.3390/mi12050522
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Article: Gallic Acid: A Natural Phenolic Compound Exerting Antitumoral Activities in Colorectal Cancer via Interaction with G-Quadruplexes.

Sanchez-Martin, Victoria / Plaza-Calonge, María Del Carmen / Soriano-Lerma, Ana / Ortiz-Gonzalez, Matilde / Linde-Rodriguez, Angel / Perez-Carrasco, Virginia / Ramirez-Macias, Inmaculada / Cuadros, Marta / Gutierrez-Fernandez, Jose / Murciano-Calles, Javier / Rodríguez-Manzaneque, Juan Carlos / Soriano, Miguel / Garcia-Salcedo, Jose Antonio

Cancers

2022 Volume 14, Issue 11

Abstract: Natural phenolic compounds have gained momentum for the prevention and treatment of cancer, but their antitumoral mechanism of action is not yet well understood. In the present study, we screened the antitumoral potential of several phenolic compounds in ...

Abstract	Natural phenolic compounds have gained momentum for the prevention and treatment of cancer, but their antitumoral mechanism of action is not yet well understood. In the present study, we screened the antitumoral potential of several phenolic compounds in a cellular model of colorectal cancer (CRC). We selected gallic acid (GA) as a candidate in terms of potency and selectivity and extensively evaluated its biological activity. We report on the role of GA as a ligand of DNA G-quadruplexes (G4s), explaining several of its antitumoral effects, including the transcriptional inhibition of ribosomal and
Language	English
Publishing date	2022-05-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14112648
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