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  1. Article ; Online: The fourth wave in chronic kidney disease (CKD) classification: taking into account the aging kidney.

    Musso, Carlos G / Ricardo, Ana C / Aroca-Martinez, Gustavo

    International urology and nephrology

    2023  Volume 56, Issue 2, Page(s) 805–806

    MeSH term(s) Humans ; Kidney/diagnostic imaging ; Renal Insufficiency, Chronic ; Aging
    Language English
    Publishing date 2023-05-26
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 204048-7
    ISSN 1573-2584 ; 0301-1623 ; 0042-1162
    ISSN (online) 1573-2584
    ISSN 0301-1623 ; 0042-1162
    DOI 10.1007/s11255-023-03642-w
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  2. Article ; Online: COVID-19-induced acute kidney injury and chronic kidney disease: correspondence response.

    Musso, Carlos G / Aroca-Martinez, Gustavo

    Jornal brasileiro de nefrologia

    2022  Volume 45, Issue 2, Page(s) 263

    Language Portuguese
    Publishing date 2022-12-22
    Publishing country Brazil
    Document type Letter
    ZDB-ID 2057873-8
    ISSN 2175-8239 ; 2175-8239
    ISSN (online) 2175-8239
    ISSN 2175-8239
    DOI 10.1590/2175-8239-JBN-2022-0115rep-en
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  3. Article ; Online: Population Kidney Health. A New Paradigm for Chronic Kidney Disease Management.

    Burgos-Calderón, Rafael / Depine, Santos Ángel / Aroca-Martínez, Gustavo

    International journal of environmental research and public health

    2021  Volume 18, Issue 13

    Abstract: Statistical data extracted from national databases demonstrate a continuous growth in the incidence and prevalence of chronic kidney disease (CKD) and the ineffectiveness of current policies and strategies based on individual risk factors to reduce them, ...

    Abstract Statistical data extracted from national databases demonstrate a continuous growth in the incidence and prevalence of chronic kidney disease (CKD) and the ineffectiveness of current policies and strategies based on individual risk factors to reduce them, as well as their mortality and costs. Some innovative programs, telemedicine and government interest in the prevention of CKD did not facilitate timely access to care, continuing the increased demand for dialysis and transplants, high morbidity and long-term disability. In contrast, new forms of kidney disease of unknown etiology affected populations in developing countries and underrepresented minorities, who face socioeconomic and cultural disadvantages. With this background, our objective was to analyze in the existing literature the effects of social determinants in CKD, concluding that it is necessary to strengthen current kidney health strategies, designing in a transdisciplinary way, a model that considers demographic characteristics integrated into individual risk factors and risk factors population, incorporating the population health perspective in public health policies to improve results in kidney health care, since CKD continues to be an important and growing contributor to chronic diseases.
    MeSH term(s) Humans ; Kidney ; Population Health ; Prevalence ; Renal Dialysis ; Renal Insufficiency, Chronic/epidemiology ; Renal Insufficiency, Chronic/therapy
    Language English
    Publishing date 2021-06-24
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph18136786
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  4. Article: Pregnancy-Associated Atypical Hemolytic Uremic Syndrome: A Case Report with

    Domínguez-Vargas, Alex / Ariño, Fanny / Silva, Diana / González-Tórres, Henry J / Aroca-Martinez, Gustavo / Egea, Eduardo / Musso, Carlos G

    AJP reports

    2024  Volume 14, Issue 1, Page(s) e96–e100

    Abstract: Pregnancy-associated atypical hemolytic uremic syndrome (P-aHUS) is a rare condition characterized by microangiopathic hemolytic anemia and kidney injury from thrombotic microangiopathy. P-aHUS occurs in approximately 1 in 25,000 pregnancies and is ... ...

    Abstract Pregnancy-associated atypical hemolytic uremic syndrome (P-aHUS) is a rare condition characterized by microangiopathic hemolytic anemia and kidney injury from thrombotic microangiopathy. P-aHUS occurs in approximately 1 in 25,000 pregnancies and is strongly related to complement dysregulation and pregnancy-related disorders, such as preeclampsia, eclampsia, and hemolysis, elevated liver enzymes, low platelet (HELLP) syndrome, resulting in adverse perinatal and fetal outcomes. Complement dysregulation in P-aHUS is commonly attributed to genetic mutations or autoantibodies affecting complement factors, including
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2628074-7
    ISSN 2157-7005 ; 2157-6998
    ISSN (online) 2157-7005
    ISSN 2157-6998
    DOI 10.1055/a-2164-8438
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  5. Article ; Online: Alactic base excess (ABE): a novel internal milieu parameter-its concept and clinical importance.

    Hoque, Md / Nagourney, Jason / Pawlowski, Thomas / Cantos, Joaquin / Aroca-Martinez, Gustavo / Huespe, Ivan / Musso, Carlos G

    International urology and nephrology

    2024  

    Abstract: Inspired by the Stewart-Figge acid-base approach, Gattinoni et al. recently introduced a new internal milieu parameter known as alactic base excess (ABE). The authors defined ABE as the sum of lactate and standard base excess. In the context of sepsis, ... ...

    Abstract Inspired by the Stewart-Figge acid-base approach, Gattinoni et al. recently introduced a new internal milieu parameter known as alactic base excess (ABE). The authors defined ABE as the sum of lactate and standard base excess. In the context of sepsis, ABE has been proposed as a valuable marker to discern between metabolic acidosis resulting from the accumulation of lactate and the retention of fixed acids, which can occur in cases of renal failure. Multiple studies have demonstrated that a negative ABE value (<-3 mmol/L) represents an early marker of renal dysfunction, and significantly correlates with higher mortality rates in septic patients. In conclusion, ABE is a simple and useful parameter that can be used to better interpret a patient's acid-base status, assess renal function, and general prognosis in sepsis. By incorporating ABE into clinical practice, healthcare professionals can enhance their understanding of the complex acid-base imbalances in their patients and tailor more individualized, effective treatment plans.
    Language English
    Publishing date 2024-02-10
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 204048-7
    ISSN 1573-2584 ; 0301-1623 ; 0042-1162
    ISSN (online) 1573-2584
    ISSN 0301-1623 ; 0042-1162
    DOI 10.1007/s11255-024-03949-2
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  6. Article ; Online: Urinary metabolomic profiling of a cohort of Colombian patients with systemic lupus erythematosus.

    Rojo-Sánchez, Alejandra / Carmona-Martes, Ada / Díaz-Olmos, Yirys / Santamaría-Torres, Mary / Cala, Mónica P / Orozco-Acosta, Erick / Aroca-Martínez, Gustavo / Pacheco-Londoño, Leonardo / Navarro-Quiroz, Elkin / Pacheco-Lugo, Lisandro A

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 9555

    Abstract: Systemic lupus erythematosus (SLE) is an autoimmune and multisystem disease with a high public health impact. Lupus nephritis (LN), commonly known as renal involvement in SLE, is associated with a poorer prognosis and increased rates of morbidity and ... ...

    Abstract Systemic lupus erythematosus (SLE) is an autoimmune and multisystem disease with a high public health impact. Lupus nephritis (LN), commonly known as renal involvement in SLE, is associated with a poorer prognosis and increased rates of morbidity and mortality in patients with SLE. Identifying new urinary biomarkers that can be used for LN prognosis or diagnosis is essential and is part of current active research. In this study, we applied an untargeted metabolomics approach involving liquid and gas chromatography coupled with mass spectrometry to urine samples collected from 17 individuals with SLE and no kidney damage, 23 individuals with LN, and 10 clinically healthy controls (HCs) to identify differential metabolic profiles for SLE and LN. The data analysis revealed a differentially abundant metabolite expression profile for each study group, and those metabolites may act as potential differential biomarkers of SLE and LN. The differential metabolic pathways found between the LN and SLE patients with no kidney involvement included primary bile acid biosynthesis, branched-chain amino acid synthesis and degradation, pantothenate and coenzyme A biosynthesis, lysine degradation, and tryptophan metabolism. Receiver operating characteristic curve analysis revealed that monopalmitin, glycolic acid, and glutamic acid allowed for the differentiation of individuals with SLE and no kidney involvement and individuals with LN considering high confidence levels. While the results offer promise, it is important to recognize the significant influence of medications and other external factors on metabolomics studies. This impact has the potential to obscure differences in metabolic profiles, presenting a considerable challenge in the identification of disease biomarkers. Therefore, experimental validation should be conducted with a larger sample size to explore the diagnostic potential of the metabolites found as well as to examine how treatment and disease activity influence the identified chemical compounds. This will be crucial for refining the accuracy and effectiveness of using urine metabolomics for diagnosing and monitoring lupus and lupus nephritis.
    MeSH term(s) Humans ; Female ; Lupus Erythematosus, Systemic/urine ; Lupus Erythematosus, Systemic/metabolism ; Adult ; Metabolomics/methods ; Biomarkers/urine ; Male ; Colombia ; Lupus Nephritis/urine ; Lupus Nephritis/diagnosis ; Lupus Nephritis/metabolism ; Metabolome ; Middle Aged ; Cohort Studies ; Case-Control Studies ; Gas Chromatography-Mass Spectrometry ; Young Adult
    Chemical Substances Biomarkers
    Language English
    Publishing date 2024-04-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-60217-0
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  7. Article ; Online: Population Kidney Health. A New Paradigm for Chronic Kidney Disease Management

    Rafael Burgos-Calderón / Santos Ángel Depine / Gustavo Aroca-Martínez

    International Journal of Environmental Research and Public Health, Vol 18, Iss 6786, p

    2021  Volume 6786

    Abstract: Statistical data extracted from national databases demonstrate a continuous growth in the incidence and prevalence of chronic kidney disease (CKD) and the ineffectiveness of current policies and strategies based on individual risk factors to reduce them, ...

    Abstract Statistical data extracted from national databases demonstrate a continuous growth in the incidence and prevalence of chronic kidney disease (CKD) and the ineffectiveness of current policies and strategies based on individual risk factors to reduce them, as well as their mortality and costs. Some innovative programs, telemedicine and government interest in the prevention of CKD did not facilitate timely access to care, continuing the increased demand for dialysis and transplants, high morbidity and long-term disability. In contrast, new forms of kidney disease of unknown etiology affected populations in developing countries and underrepresented minorities, who face socioeconomic and cultural disadvantages. With this background, our objective was to analyze in the existing literature the effects of social determinants in CKD, concluding that it is necessary to strengthen current kidney health strategies, designing in a transdisciplinary way, a model that considers demographic characteristics integrated into individual risk factors and risk factors population, incorporating the population health perspective in public health policies to improve results in kidney health care, since CKD continues to be an important and growing contributor to chronic diseases.
    Keywords kidney health ; population health ; social determinants ; sociopolitical context ; environment ; advocacy ; Medicine ; R
    Subject code 360
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Renal tubular dysfunction in COVID-19 patients.

    Aroca-Martínez, Gustavo / Avendaño-Echavez, Lil / Garcia, Carlos / Ripoll, Daniela / Dianda, Daniela / Cadena-Bonfanti, Andrés / Musso, Carlos G

    Irish journal of medical science

    2022  Volume 192, Issue 2, Page(s) 923–927

    Abstract: Introduction: SARS-CoV-2 infection can affect other organs aside from those of respiratory system, particularly the kidney, heart, blood, digestive tract, and nervous system. COVID-19 renal compromise consists of different syndromes since proteinuria, ... ...

    Abstract Introduction: SARS-CoV-2 infection can affect other organs aside from those of respiratory system, particularly the kidney, heart, blood, digestive tract, and nervous system. COVID-19 renal compromise consists of different syndromes since proteinuria, hematuria, and acute kidney injury (AKI), until chronic kidney disease. Since COVID-19-induced renal tubular damage has been described as a potential antecedent condition to AKI installation, it was decided to evaluate how COVID-19 affects tubular function.
    Materials and method: Serum inflammatory parameters, urinalysis, and classical urinary indexes in COVID-19 admitted patients who had neither AKI nor chronic kidney disease (CKD) were evaluated. Statistical analysis was performed by applying Student t test.
    Results: Renal tubular function was evaluated in 41 COVID-19 admitted patients who had neither AKI nor CKD. Patients' mean age was 56 years, males (79%), and with normal creatininemia (0.8 ± 0.2 mg/dL) and eGFR (105.7 ± 6.5 mL/min) values. It was found mild hypocalcemia and a relative increased fractional excretion (FE) of sodium, FE of calcium, FE of phosphorus, calcium-creatinine index, urinary osmolarity, and relative alkaline urine pH values.
    Conclusion: Tubular dysfunction was documented in COVID-19 patients.
    MeSH term(s) Male ; Humans ; Middle Aged ; COVID-19/complications ; Calcium ; SARS-CoV-2 ; Acute Kidney Injury ; Renal Insufficiency, Chronic
    Chemical Substances Calcium (SY7Q814VUP)
    Language English
    Publishing date 2022-04-14
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 390895-1
    ISSN 1863-4362 ; 0021-1265
    ISSN (online) 1863-4362
    ISSN 0021-1265
    DOI 10.1007/s11845-022-02993-0
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  9. Article ; Online: Hyponatremia and malnutrition: a comprehensive review.

    Baez, German / Chirio, Martin / Pisula, Pedro / Seminario, Enrique / Carasa, Natalia / Philippi, Romina / Aroca-Martinez, Gustavo / Musso, Carlos G

    Irish journal of medical science

    2023  Volume 193, Issue 2, Page(s) 1043–1046

    Abstract: Background: Hyponatremia (serum sodium lower than 135 mmol/L) is the most frequent electrolyte alteration diagnosed in medical practice. It has deleterious clinical effects, being an independent predictor of mortality. Malnutrition encompasses ... ...

    Abstract Background: Hyponatremia (serum sodium lower than 135 mmol/L) is the most frequent electrolyte alteration diagnosed in medical practice. It has deleterious clinical effects, being an independent predictor of mortality. Malnutrition encompasses pathological states caused by both nutrients excess and deficiency, being frequently documented in chronic kidney disease patients. In addition, chronic hyponatremia promotes adiposity loss and sarcopenia, while malnutrition can induce hyponatremia. This pathological interaction is mediated by four main mechanisms: altered electrolyte body composition (low sodium, low potassium, low phosphorus, or high-water body content), systemic inflammation (cytokines increase), hormonal mechanisms (renin-angiotensin-aldosterone system activation, vasopressin release), and anorexia (primary or secondary).
    Conclusion: Malnutrition can induce hyponatremia through hydro-electrolytic, hormonal, inflammatory, or nutritional behavior changes; while hyponatremia per se can induce malnutrition, so there is a pathophysiological feedback between both conditions.
    MeSH term(s) Humans ; Hyponatremia/etiology ; Chronic Disease ; Sodium ; Malnutrition/complications ; Electrolytes
    Chemical Substances Sodium (9NEZ333N27) ; Electrolytes
    Language English
    Publishing date 2023-09-13
    Publishing country Ireland
    Document type Journal Article ; Review
    ZDB-ID 390895-1
    ISSN 1863-4362 ; 0021-1265
    ISSN (online) 1863-4362
    ISSN 0021-1265
    DOI 10.1007/s11845-023-03490-8
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  10. Article ; Online: Obesity and glomerular filtration rate.

    Schwartz, Paula / Capotondo, Maria M / Quaintenne, Miranda / Musso-Enz, Guido M / Aroca-Martinez, Gustavo / Musso, Carlos G

    International urology and nephrology

    2023  Volume 56, Issue 5, Page(s) 1663–1668

    Abstract: Obesity has received considerable attention in general medicine and nephrology over the last few years. This condition increases the risk of metabolic syndrome, diabetes mellitus, hypertension, and dyslipidemia, which are the main risk factors for ... ...

    Abstract Obesity has received considerable attention in general medicine and nephrology over the last few years. This condition increases the risk of metabolic syndrome, diabetes mellitus, hypertension, and dyslipidemia, which are the main risk factors for developing chronic kidney disease (CKD). Kidney damage caused by obesity can be explained by many mechanisms, such as sympathetic nervous and renin-angiotensin-aldosterone systems activation, mechanical stress, hormonal unbalance, as well as inflammatory cytokines production. Even though creatinine-based glomerular filtration rate (GFR) equations in obese individuals have been validated (Salazar-Corcoran and CKD-MCQ), changes in body weight after bariatric surgery (BS) leads to changes in creatininemia, affecting its reliability. Thus, an average between creatine and cystatin-based GFR equations would be more appropriate in this setting. Bariatric surgery can reverse diabetes mellitus and improve hypertension, which are the main causes of CKD. Conclusion: GFR can be affected by obesity and BS, and its value should be cautiously evaluated in this setting.
    MeSH term(s) Humans ; Glomerular Filtration Rate/physiology ; Reproducibility of Results ; Obesity/complications ; Renal Insufficiency, Chronic/etiology ; Diabetes Mellitus ; Hypertension/etiology ; Creatinine
    Chemical Substances Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2023-11-10
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 204048-7
    ISSN 1573-2584 ; 0301-1623 ; 0042-1162
    ISSN (online) 1573-2584
    ISSN 0301-1623 ; 0042-1162
    DOI 10.1007/s11255-023-03862-0
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