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  1. Article ; Online: Renin-Angiotensin-Aldosterone System Inhibitors in Covid-19.

    Birnbaum, Ron A

    The New England journal of medicine

    2020  Volume 382, Issue 24, Page(s) e92

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; Renin-Angiotensin System ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-19
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2013707
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  2. Article ; Online: Reconstruction of lateral root formation through single-cell RNA sequencing reveals order of tissue initiation.

    Serrano-Ron, Laura / Perez-Garcia, Pablo / Sanchez-Corrionero, Alvaro / Gude, Inmaculada / Cabrera, Javier / Ip, Pui-Leng / Birnbaum, Kenneth D / Moreno-Risueno, Miguel A

    Molecular plant

    2021  Volume 14, Issue 8, Page(s) 1362–1378

    Abstract: Postembryonic organogenesis is critical for plant development. Underground, lateral roots (LRs) form the bulk of mature root systems, yet the ontogeny of the LR primordium (LRP) is not clear. In this study, we performed the single-cell RNA sequencing ... ...

    Abstract Postembryonic organogenesis is critical for plant development. Underground, lateral roots (LRs) form the bulk of mature root systems, yet the ontogeny of the LR primordium (LRP) is not clear. In this study, we performed the single-cell RNA sequencing through the first four stages of LR formation in Arabidopsis. Our analysis led to a model in which a single group of precursor cells, with a cell identity different from their pericycle origins, rapidly reprograms and splits into a mixed ground tissue/stem cell niche fate and a vascular precursor fate. The ground tissue and stem cell niche fates soon separate and a subset of more specialized vascular cells form sucrose transporting phloem cells that appear to connect to the primary root. We did not detect cells resembling epidermis or root cap, suggesting that outer tissues may form later, preceding LR emergence. At this stage, some remaining initial precursor cells form the primordium flanks, while the rest create a reservoir of pluripotent cells that are able to replace the LR if damaged. Laser ablation of the central and lateral LRP regions showed that remaining cells restart the sequence of tissue initiation to form a LR. Collectively, our study reveals an ontological hierarchy for LR formation with an early and sequential split of main root tissues and stem cells.
    MeSH term(s) Arabidopsis/cytology ; Arabidopsis/growth & development ; Organogenesis, Plant/genetics ; Plant Development/genetics ; Plant Roots/cytology ; Plant Roots/growth & development ; Sequence Analysis, RNA ; Stem Cells/cytology
    Language English
    Publishing date 2021-05-29
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2393618-6
    ISSN 1752-9867 ; 1674-2052
    ISSN (online) 1752-9867
    ISSN 1674-2052
    DOI 10.1016/j.molp.2021.05.028
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  3. Article: Reconstruction of lateral root formation through single-cell RNA sequencing reveals order of tissue initiation

    Serrano-Ron, Laura / Perez-Garcia, Pablo / Sanchez-Corrionero, Alvaro / Gude, Inmaculada / Cabrera, Javier / Ip, Pui-Leng / Birnbaum, Kenneth D / Moreno-Risueno, Miguel A

    Molecular plant. 2021 May 26,

    2021  

    Abstract: Postembryonic organogenesis is critical for plant development. Underground, lateral roots (LRs) form the bulk of mature root systems, yet the ontogeny of the LR primordium (LRP) is not clear. In this study, we perform single-cell RNA sequencing through ... ...

    Abstract Postembryonic organogenesis is critical for plant development. Underground, lateral roots (LRs) form the bulk of mature root systems, yet the ontogeny of the LR primordium (LRP) is not clear. In this study, we perform single-cell RNA sequencing through the first four stages of LR formation in Arabidopsis. Our analysis leads to a model in which a single group of precursor cells, with a cell identity different from their pericycle origins, rapidly reprograms and splits into a mixed ground tissue/stem cell niche fate and a vascular precursor fate. The ground tissue and stem cell niche fates soon separate and a subset of more specialized vascular cells form sucrose transporting phloem cells that appear to connect to the primary root. We did not detect cells resembling epidermis or root cap, suggesting that outer tissues may form later, preceding LR emergence. At this stage, some remaining initial precursor cells form the primordium flanks, while the rest create a reservoir of pluripotent cells that are able to replace the LR if damaged. Laser ablation of the central and lateral LRP regions shows that remaining cells restart the sequence of tissue initiation to form an LR. Collectively, our study reveals an ontological hierarchy for LR formation with an early and sequential split of main root tissues and stem cells.
    Keywords Arabidopsis ; lateral roots ; models ; ontogeny ; organogenesis ; phloem ; plant development ; root cap ; sequence analysis ; stem cells ; sucrose
    Language English
    Dates of publication 2021-0526
    Publishing place Elsevier Inc.
    Document type Article
    Note Pre-press version
    ZDB-ID 2393618-6
    ISSN 1752-9867 ; 1674-2052
    ISSN (online) 1752-9867
    ISSN 1674-2052
    DOI 10.1016/j.molp.2021.05.028
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  4. Article ; Online: In-Flight Medical Emergencies Management by Anesthetist-Intensivists and Emergency Physicians.

    Diop, Sylvain / Birnbaum, Ron / Cook, Fabrice / Mounier, Roman

    Aerospace medicine and human performance

    2022  Volume 93, Issue 8, Page(s) 633–636

    Abstract: BACKGROUND: ...

    Abstract BACKGROUND:
    MeSH term(s) Aerospace Medicine ; Aircraft ; Anesthetists ; Emergencies ; Humans ; Physicians
    Language English
    Publishing date 2022-09-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2809085-8
    ISSN 2375-6322 ; 2375-6314
    ISSN (online) 2375-6322
    ISSN 2375-6314
    DOI 10.3357/AMHP.6055.2022
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  5. Article: Clinical pearl: Expanding knowledge of emergency contraception among dermatologists.

    Wu, Jessica / Qaseem, Yasmin / Birnbaum, Ron / Smogorzewski, Jan

    International journal of women's dermatology

    2020  Volume 6, Issue 5, Page(s) 450–451

    Abstract: Dermatologists prescribe teratogenic or potentially teratogenic medications to treat a variety of skin diseases, including spironolactone for hormonal dysregulation in hidradenitis suppurativa or isotretinoin for severe acne. Although contraceptive ... ...

    Abstract Dermatologists prescribe teratogenic or potentially teratogenic medications to treat a variety of skin diseases, including spironolactone for hormonal dysregulation in hidradenitis suppurativa or isotretinoin for severe acne. Although contraceptive options are regularly discussed, dermatologists must also be familiar with emergency contraceptive methods in the case that patients receiving teratogenic medications engage in unprotected sexual intercourse and do not desire pregnancy. A lack of knowledge regarding emergency contraceptive options may represent a practice gap for dermatologists.
    Language English
    Publishing date 2020-06-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2832233-2
    ISSN 2352-6475
    ISSN 2352-6475
    DOI 10.1016/j.ijwd.2020.06.010
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  6. Article ; Online: Terror in Paris: Incidence and risk factors for infections related to high-energy ammunition injuries.

    Birnbaum, Ron / Bitton, Rudy / Pirracchio, Romain / Féral-Pierssens, Anne-Laure / Constant, Anne-Laure / Dubost, Clément / Chousterman, Benjamin / Lescot, Thomas / Lortat-Jacob, Brice / Harrois, Anatole / Abback, Paer-Selim / Belbachir, Anissa / Basto, Emmanuel / Castier, Yves / Laitselart, Philippe / Carli, Pierre / Lapostolle, Frédéric / Tourtier, Jean Pierre / Langlois, Matthieu /
    Raux, Mathieu / Mounier, Roman

    Anaesthesia, critical care & pain medicine

    2021  Volume 40, Issue 4, Page(s) 100908

    Abstract: Background: We aimed to assess the incidence and the risk factors for secondary wound infections associated to high-energy ammunition injuries (HEAI) in the cohort of civilian casualties from the 2015 terrorist attacks in Paris.: Methods: This ... ...

    Abstract Background: We aimed to assess the incidence and the risk factors for secondary wound infections associated to high-energy ammunition injuries (HEAI) in the cohort of civilian casualties from the 2015 terrorist attacks in Paris.
    Methods: This retrospective multi-centric study included casualties presenting at least one HEAI who underwent surgery during the first 48 h following hospital admission. HEAI-associated infection was defined as a wound infection occurring within the initial 30 days following trauma. Risk factors were assessed using univariate and multivariate analysis.
    Results: Among the 200 included victims, the rate of infected wounds was 11.5%. The median time between admission and the surgical revision for secondary wound infection was 11 days [IQR 9-20]. No patient died from an infectious cause. Infections were polymicrobial in 44% of the cases. The major risk factors for secondary wound infection were ISS (p < 0.001), SAPS II (p < 0.001), MGAP (p < 0.001), haemorrhagic shock (p = 0.003), use of vasopressors (p < 0.001), blood transfusion (p < 0.001), abdominal penetrating trauma (p = 0.003), open fracture (p = 0.01), vascular injury (p = 0.001), duration of surgery (p = 0.009), presence of surgical material (p = 0.01). In the multivariate analysis, the SAPS II score (OR 1.07 [1.014-1.182], p = 0.019) and the duration of surgery (OR 1.005 [1.000-1.012], p = 0.041) were the only risk factors identified.
    Conclusion: We report an 11.5% rate of secondary wound infection following high-energy ammunition injuries. Risk factors were an immediately severe condition and a prolonged surgery.
    MeSH term(s) Abdominal Injuries ; Humans ; Incidence ; Injury Severity Score ; Paris/epidemiology ; Retrospective Studies ; Risk Factors
    Language English
    Publishing date 2021-06-24
    Publishing country France
    Document type Journal Article
    ISSN 2352-5568
    ISSN (online) 2352-5568
    DOI 10.1016/j.accpm.2021.100908
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  7. Article ; Online: Dr Lew and colleagues respond.

    Lew, Peter P / Ngai, Steven S / Cho, John K / Varma, Rajeev K / Hamidi, Reyhaneh / Birnbaum, Ron A / Peng, David H

    Radiographics : a review publication of the Radiological Society of North America, Inc

    2015  Volume 35, Issue 1, Page(s) 297

    MeSH term(s) Bone Diseases/diagnosis ; Dermoscopy/methods ; Female ; Humans ; Skin Diseases/diagnosis ; Tomography, X-Ray Computed/methods
    Language English
    Publishing date 2015-01
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 603172-9
    ISSN 1527-1323 ; 0271-5333
    ISSN (online) 1527-1323
    ISSN 0271-5333
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  8. Article ; Online: Imaging of disorders affecting the bone and skin.

    Lew, Peter P / Ngai, Steven S / Hamidi, Reyhaneh / Cho, John K / Birnbaum, Ron A / Peng, David H / Varma, Rajeev K

    Radiographics : a review publication of the Radiological Society of North America, Inc

    2014  Volume 34, Issue 1, Page(s) 197–216

    Abstract: There are a variety of conditions that manifest not only in bone but also in skin. Bone and skin structures can share common embryologic origins, and genetic defects that occur early in cell differentiation may lead to disease in both organ systems. ... ...

    Abstract There are a variety of conditions that manifest not only in bone but also in skin. Bone and skin structures can share common embryologic origins, and genetic defects that occur early in cell differentiation may lead to disease in both organ systems. Alternatively, diseases of bone and skin may be caused by defects in genes that participate in directing or controlling both systems. Many diseases of bone and skin can manifest with atypical radiologic findings or mimic malignant bone lesions. Upon encountering such a disease process, a radiologist who is familiar with both aspects of the disorder and consequently looks for associated skin findings can greatly benefit the patient by making a definitive diagnosis. Similarly, a clinician who encounters suggestive skin lesions should be prompted to look for concomitant skeletal lesions. By synthesizing knowledge of bone and skin manifestations, radiologists and clinicians can help correctly diagnose a number of these disease processes, thereby helping patients avoid further, often nonspecific invasive workup and advancing patient care.
    MeSH term(s) Bone Diseases/diagnosis ; Dermoscopy/methods ; Diagnosis, Differential ; Female ; Humans ; Skin Diseases/diagnosis ; Syndrome ; Tomography, X-Ray Computed/methods
    Language English
    Publishing date 2014-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 603172-9
    ISSN 1527-1323 ; 0271-5333
    ISSN (online) 1527-1323
    ISSN 0271-5333
    DOI 10.1148/rg.341125112
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  9. Article ; Online: Meeting unmet needs of families of persons with mental illness: evaluation of a family peer support helpline.

    Shor, Ron / Birnbaum, Menachem

    Community mental health journal

    2012  Volume 48, Issue 4, Page(s) 482–488

    Abstract: Family members of persons with mental illness experience multiple stressors stemming from the burdens of caring for the ill family member. A potential source of help for this population is a family peer support helpline. Knowledge, however, is lacking ... ...

    Abstract Family members of persons with mental illness experience multiple stressors stemming from the burdens of caring for the ill family member. A potential source of help for this population is a family peer support helpline. Knowledge, however, is lacking about the types of help offered in such a service and its benefit for this population. In a study conducted in Israel, 800 calls made by family members of persons with mental illness to a family peer support helpline were analyzed utilizing an instrument developed for the family peers' evaluation of the calls. In addition, researchers conducted 77 follow-up interviews with callers who agreed to be interviewed. The findings indicate the importance of the life experience, flexibility and anonymity of the family peers in providing types of help that are complementary to the help provided by formal services. The most frequent categories of support provided were emotional support, information and advice. This help could assist family members of persons with mental illness with their care-giving role, as well as provide them with an alternative source of help if they experience difficulties with professionals. It could also serve as a catalyst in encouraging them to establish and maintain contact with the formal mental health services. Recognizing and supporting the contribution of a family peer support helpline would encourage its development within the range of services available for this population.
    MeSH term(s) Caregivers/psychology ; Community Mental Health Services/organization & administration ; Counseling/statistics & numerical data ; Family/psychology ; Female ; Follow-Up Studies ; Health Services Needs and Demand ; Hotlines/statistics & numerical data ; Humans ; Interviews as Topic ; Israel ; Male ; Mental Disorders/psychology ; Peer Group ; Qualitative Research ; Social Support ; Surveys and Questionnaires
    Language English
    Publishing date 2012-03-24
    Publishing country United States
    Document type Evaluation Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 215855-3
    ISSN 1573-2789 ; 0010-3853
    ISSN (online) 1573-2789
    ISSN 0010-3853
    DOI 10.1007/s10597-012-9504-3
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  10. Article ; Online: Innate immunity and Leishmania vaccination strategies.

    Birnbaum, Ron / Craft, Noah

    Dermatologic clinics

    2010  Volume 29, Issue 1, Page(s) 89–102

    Abstract: Despite the ubiquity and severity of parasitic diseases and our desire to prevent them, there are no effective antiparasitic vaccines in widespread clinical use. This review focuses on strategies for development of a vaccine against cutaneous ... ...

    Abstract Despite the ubiquity and severity of parasitic diseases and our desire to prevent them, there are no effective antiparasitic vaccines in widespread clinical use. This review focuses on strategies for development of a vaccine against cutaneous leishmaniasis as a representative parasitic disease of paramount interest to dermatologists and all who care for patients who live in or travel to the developing world. Any effective strategy will require attention to the central role that host innate immunity plays during induction of durable resistance to these virulent protozoa. The cell types, receptors, and molecules of the innate immune system that will likely play a role in any effective vaccine against cutaneous leishmaniasis are reviewed.
    MeSH term(s) Humans ; Immunity, Innate ; Leishmania/immunology ; Leishmaniasis Vaccines/immunology ; Leishmaniasis, Cutaneous/immunology ; Leishmaniasis, Cutaneous/parasitology ; Leishmaniasis, Cutaneous/prevention & control
    Chemical Substances Leishmaniasis Vaccines
    Language English
    Publishing date 2010-09-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 82798-8
    ISSN 1558-0520 ; 0733-8635
    ISSN (online) 1558-0520
    ISSN 0733-8635
    DOI 10.1016/j.det.2010.08.014
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