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  1. Article ; Online: Letter to the Editor from A.H. Jan Danser and Ingrid M. Garrelds: The clinical impact of sample storage at -20°C on renin reference intervals and aldosterone-renin ratio calculations.

    Danser, A H Jan / Garrelds, Ingrid M

    The Journal of clinical endocrinology and metabolism

    2024  

    Language English
    Publishing date 2024-04-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgae243
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.134: Show issues Location:
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  2. Article ; Online: Blood Pressure Monitoring Through Radiotelemetry: Exploring the Viability of Its Application in Multihoused Small Laboratory Animals.

    Cruz-López, Edwyn O / Merkus, Daphne / Danser, A H Jan

    Hypertension (Dallas, Tex. : 1979)

    2024  Volume 81, Issue 5, Page(s) 947–950

    MeSH term(s) Animals ; Blood Pressure/physiology ; Animals, Laboratory ; Blood Pressure Determination ; Monitoring, Physiologic ; Telemetry ; Heart Rate/physiology
    Language English
    Publishing date 2024-04-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.124.22756
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1488: Show issues Location:
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  3. Article ; Online: The MOVD/EDH 2019.

    Jan Danser, A H

    European heart journal

    2019  Volume 40, Issue 29, Page(s) 2385–2386

    Language English
    Publishing date 2019-09-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehz510
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    Zs.A 1563: Show issues Location:
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    Zs.MO 640: Show issues

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  4. Article ; Online: New Approaches Targeting the Renin-Angiotensin System: Inhibition of Brain Aminopeptidase A, ACE2 Ubiquitination, and Angiotensinogen.

    Lazartigues, Eric / Llorens-Cortes, Catherine / Danser, A H Jan

    The Canadian journal of cardiology

    2023  Volume 39, Issue 12, Page(s) 1900–1912

    Abstract: Despite the availability of various therapeutic classes of antihypertensive drugs, hypertension remains poorly controlled, in part because of poor adherence. Hence, there is a need for the development of antihypertensive drugs acting on new targets to ... ...

    Abstract Despite the availability of various therapeutic classes of antihypertensive drugs, hypertension remains poorly controlled, in part because of poor adherence. Hence, there is a need for the development of antihypertensive drugs acting on new targets to improve control of blood pressure. This review discusses novel insights (including the data of recent clinical trials) with regard to interference with the renin-angiotensin system, focusing on the enzymes aminopeptidase A and angiotensin-converting enzyme 2 (ACE2) in the brain, as well as the substrate of renin- angiotensinogen-in the liver. It raises the possibility that centrally acting amino peptidase A inhibitors (eg, firibastat), preventing the conversion of angiotensin II to angiotensin III in the brain, might be particularly useful in African Americans and patients with obesity. Firibastat additionally upregulates brain ACE2, allowing the conversion of angiotensin II to its protective metabolite angiotensin-(1-7). Furthermore, antisense oligonucleotides or small interfering ribonucleic acids suppress hepatic angiotensinogen for weeks to months after 1 injection and thus could potentially overcome adherence issues. Finally, interference with ACE2 ubiquitination is emerging as a future option for the treatment of neurogenic hypertension, given that ubiquitination resistance might upregulate ACE2 activity.
    MeSH term(s) Humans ; Renin-Angiotensin System/physiology ; Antihypertensive Agents/therapeutic use ; Glutamyl Aminopeptidase ; Angiotensin-Converting Enzyme 2/metabolism ; Angiotensin-Converting Enzyme 2/pharmacology ; Angiotensin-Converting Enzyme 2/therapeutic use ; Angiotensinogen/metabolism ; Angiotensinogen/pharmacology ; Angiotensinogen/therapeutic use ; Angiotensin II/metabolism ; Hypertension ; Brain/metabolism
    Chemical Substances firibastat (638KY4573I) ; Antihypertensive Agents ; Glutamyl Aminopeptidase (EC 3.4.11.7) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; Angiotensinogen (11002-13-4) ; Angiotensin II (11128-99-7)
    Language English
    Publishing date 2023-06-20
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
    DOI 10.1016/j.cjca.2023.06.013
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2150: Show issues Location:
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  5. Article ; Online: Brain angiotensin suppression in the DOCA-salt model: reversal by angiotensinogen small interfering RNA?

    Uijl, Estrellita / Danser, A H Jan

    Clinical science (London, England : 1979)

    2021  Volume 135, Issue 7, Page(s) 885–886

    MeSH term(s) Angiotensinogen ; Angiotensins ; Blood Pressure ; Brain ; Desoxycorticosterone Acetate ; RNA, Small Interfering
    Chemical Substances Angiotensins ; RNA, Small Interfering ; Angiotensinogen (11002-13-4) ; Desoxycorticosterone Acetate (6E0A168OB8)
    Language English
    Publishing date 2021-04-09
    Publishing country England
    Document type Letter
    ZDB-ID 206835-7
    ISSN 1470-8736 ; 0301-0538 ; 0009-0360 ; 0143-5221
    ISSN (online) 1470-8736
    ISSN 0301-0538 ; 0009-0360 ; 0143-5221
    DOI 10.1042/CS20210199
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  6. Article ; Online: The Role of Chemerin in Metabolic and Cardiovascular Disease: A Literature Review of Its Physiology and Pathology from a Nutritional Perspective.

    Tan, Lunbo / Lu, Xifeng / Danser, A H Jan / Verdonk, Koen

    Nutrients

    2023  Volume 15, Issue 13

    Abstract: Chemerin is a novel adipokine that plays a major role in adipogenesis and lipid metabolism. It also induces inflammation and affects insulin signaling, steroidogenesis and thermogenesis. Consequently, it likely contributes to a variety of metabolic and ... ...

    Abstract Chemerin is a novel adipokine that plays a major role in adipogenesis and lipid metabolism. It also induces inflammation and affects insulin signaling, steroidogenesis and thermogenesis. Consequently, it likely contributes to a variety of metabolic and cardiovascular diseases, including atherosclerosis, diabetes, hypertension and pre-eclampsia. This review describes its origin and receptors, as well as its role in various diseases, and subsequently summarizes how nutrition affects its levels. It concludes that vitamin A, fat, glucose and alcohol generally upregulate chemerin, while omega-3, salt and vitamin D suppress it. Dietary measures rather than drugs acting as chemerin receptor antagonists might become a novel tool to suppress chemerin effects, thereby potentially improving the aforementioned diseases. However, more detailed studies are required to fully understand chemerin regulation.
    MeSH term(s) Pregnancy ; Female ; Humans ; Intercellular Signaling Peptides and Proteins ; Cardiovascular Diseases ; Chemokines/metabolism ; Adipokines/metabolism ; Insulin Resistance
    Chemical Substances Intercellular Signaling Peptides and Proteins ; Chemokines ; Adipokines
    Language English
    Publishing date 2023-06-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15132878
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  7. Article ; Online: Mechanisms of Vasodilatation/Endothelium-dependent Hyperpolarization (MOVD/EDH) 2019-Rotterdam, The Netherlands.

    Danser, A H Jan / Simonsen, Ulf

    Basic & clinical pharmacology & toxicology

    2020  Volume 127, Issue 2, Page(s) 55–58

    MeSH term(s) Animals ; Endothelium, Vascular/physiology ; Humans ; Vasodilation/physiology
    Language English
    Publishing date 2020-06-05
    Publishing country England
    Document type Congress ; Editorial
    ZDB-ID 2134679-3
    ISSN 1742-7843 ; 1742-7835
    ISSN (online) 1742-7843
    ISSN 1742-7835
    DOI 10.1111/bcpt.13431
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    In stock of ZB MED Cologne/Königswinter

    Uf I Zs.144: Show issues Location:
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  8. Article ; Online: Letter to the Editor regarding "A microanalytical capillary electrophoresis mass spectrometry assay for quantifying angiotensin peptides in the brain".

    Danser, A H Jan / Poglitsch, Marko

    Analytical and bioanalytical chemistry

    2019  Volume 411, Issue 30, Page(s) 8163

    MeSH term(s) Angiotensins ; Brain ; Electrophoresis, Capillary ; Mass Spectrometry ; Peptides
    Chemical Substances Angiotensins ; Peptides
    Language English
    Publishing date 2019-11-11
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 201093-8
    ISSN 1618-2650 ; 0016-1152 ; 0372-7920
    ISSN (online) 1618-2650
    ISSN 0016-1152 ; 0372-7920
    DOI 10.1007/s00216-019-02162-w
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    In stock of ZB MED Bonn / Germany

    Z 4' 69/97: Show issues
    Archiv 3: Show issues
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  9. Article ; Online: Novel mechanisms of salt-sensitive hypertension.

    Vogt, Liffert / Marques, Francine Z / Fujita, Toshiro / Hoorn, Ewout J / Danser, A H Jan

    Kidney international

    2023  Volume 104, Issue 4, Page(s) 690–697

    Abstract: A high dietary sodium-consumption level is considered the most important lifestyle factor that can be modified to help prevent an increase in blood pressure and the development of hypertension. Despite numerous studies over the past decades, the ... ...

    Abstract A high dietary sodium-consumption level is considered the most important lifestyle factor that can be modified to help prevent an increase in blood pressure and the development of hypertension. Despite numerous studies over the past decades, the pathophysiology explaining why some people show a salt-sensitive blood pressure response and others do not is incompletely understood. Here, a brief overview of the latest mechanistic insights is provided, focusing on the mononuclear phagocytic system and inflammation, the gut-kidney axis, and epigenetics. The article also discusses the effects of 3 types of novel drugs on salt-sensitive hypertension-sodium-glucose cotransporter 2 inhibitors, nonsteroidal mineralocorticoid receptor antagonists, and aldosterone synthase inhibitors. The conclusion is that besides kidney-centered mechanisms, vasoconstrictor mechanisms are also relevant for both the understanding and treatment of this blood pressure phenotype.
    MeSH term(s) Humans ; Aldosterone ; Blood Pressure ; Hypertension/genetics ; Mineralocorticoid Receptor Antagonists/pharmacology ; Receptors, Mineralocorticoid ; Sodium Chloride, Dietary/adverse effects
    Chemical Substances Aldosterone (4964P6T9RB) ; Mineralocorticoid Receptor Antagonists ; Receptors, Mineralocorticoid ; Sodium Chloride, Dietary
    Language English
    Publishing date 2023-07-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2023.06.035
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    Zs.A 797: Show issues Location:
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  10. Article ; Online: Targeting Angiotensinogen With

    Ye, Dien / Cruz-López, Edwyn O / Tu, Ho-Chou / Zlatev, Ivan / Danser, A H Jan

    Arteriosclerosis, thrombosis, and vascular biology

    2023  Volume 43, Issue 12, Page(s) 2256–2264

    Abstract: Blood pressure management involves antihypertensive therapies blocking the renin-angiotensin system (RAS). Yet, it might be inadequate due to poor patient adherence or the so-called RAS escape phenomenon, elicited by the compensatory renin elevation upon ...

    Abstract Blood pressure management involves antihypertensive therapies blocking the renin-angiotensin system (RAS). Yet, it might be inadequate due to poor patient adherence or the so-called RAS escape phenomenon, elicited by the compensatory renin elevation upon RAS blockade. Recently, evidence points toward targeting hepatic AGT (angiotensinogen) as a novel approach to block the RAS pathway that could circumvent the RAS escape phenomenon. Removing AGT, from which all angiotensins originate, should prevent further angiotensin generation, even when renin rises. Furthermore, by making use of a trivalent
    MeSH term(s) Humans ; Acetylgalactosamine ; Angiotensin II Type 1 Receptor Blockers/pharmacology ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Angiotensinogen/genetics ; Angiotensinogen/metabolism ; Blood Pressure ; Hypertension/therapy ; Hypertension/drug therapy ; Renin/metabolism ; Renin-Angiotensin System/physiology ; RNA, Small Interfering/pharmacology
    Chemical Substances Acetylgalactosamine (KM15WK8O5T) ; Angiotensin II Type 1 Receptor Blockers ; Angiotensin-Converting Enzyme Inhibitors ; Angiotensinogen (11002-13-4) ; Renin (EC 3.4.23.15) ; RNA, Small Interfering
    Language English
    Publishing date 2023-10-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.123.319897
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