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  1. Article: Editorial: Case reports in hypertension: 2022.

    Iaccarino, Guido

    Frontiers in cardiovascular medicine

    2023  Volume 10, Page(s) 1210740

    Language English
    Publishing date 2023-05-22
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2023.1210740
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Editorial: Insights in hypertension: 2022.

    Iaccarino, Guido

    Frontiers in cardiovascular medicine

    2023  Volume 10, Page(s) 1264398

    Language English
    Publishing date 2023-09-08
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2023.1264398
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Editorial: Highlights in Hypertension: 2021.

    Iaccarino, Guido

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 926949

    Language English
    Publishing date 2022-06-15
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.926949
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Commentary: Studies in Zebrafish Demonstrate That

    Sorriento, Daniela / Iaccarino, Guido

    Frontiers in cardiovascular medicine

    2020  Volume 7, Page(s) 582101

    Language English
    Publishing date 2020-10-19
    Publishing country Switzerland
    Document type Journal Article ; Comment
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2020.582101
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The Case | A patient with autosomal dominant polycystic kidney disease with an atypical kidney magnetic resonance image.

    Riccio, Eleonora / Imbriaco, Massimo / Daniele, Aurora / Iaccarino, Guido / Pisani, Antonio

    Kidney international

    2023  Volume 104, Issue 3, Page(s) 625–626

    MeSH term(s) Humans ; Polycystic Kidney, Autosomal Dominant/complications ; Polycystic Kidney, Autosomal Dominant/diagnostic imaging ; Kidney/diagnostic imaging
    Language English
    Publishing date 2023-08-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2023.06.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 797: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article ; Online: The Cardiovascular Phenotype in Fabry Disease: New Findings in the Research Field.

    Sorriento, Daniela / Iaccarino, Guido

    International journal of molecular sciences

    2021  Volume 22, Issue 3

    Abstract: Fabry disease (FD) is a lysosomal storage disorder, depending on defects in alpha-galactosidase A (GAL) activity. At the clinical level, FD shows a high phenotype variability. Among them, cardiovascular dysfunction is often recurrent or, in some cases, ... ...

    Abstract Fabry disease (FD) is a lysosomal storage disorder, depending on defects in alpha-galactosidase A (GAL) activity. At the clinical level, FD shows a high phenotype variability. Among them, cardiovascular dysfunction is often recurrent or, in some cases, is the sole symptom (cardiac variant) representing the leading cause of death in Fabry patients. The existing therapies, besides specific symptomatic treatments, are mainly based on the restoration of GAL activity. Indeed, mutations of the galactosidase alpha gene (GLA) cause a reduction or lack of GAL activity leading to globotriaosylceramide (Gb3) accumulation in several organs. However, several other mechanisms are involved in FD's development and progression that could become useful targets for therapeutics. This review discusses FD's cardiovascular phenotype and the last findings on molecular mechanisms that accelerate cardiac cell damage.
    MeSH term(s) Animals ; Cardiovascular Diseases/complications ; Cardiovascular Diseases/genetics ; Cardiovascular Diseases/pathology ; Fabry Disease/complications ; Fabry Disease/genetics ; Fabry Disease/pathology ; Humans ; Inflammation/genetics ; Inflammation/pathology ; Mitochondria/genetics ; Mitochondria/pathology ; Mutation ; Phenotype ; Trihexosylceramides/genetics ; alpha-Galactosidase/genetics
    Chemical Substances Trihexosylceramides ; globotriaosylceramide (71965-57-6) ; alpha-Galactosidase (EC 3.2.1.22)
    Language English
    Publishing date 2021-01-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22031331
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: The Future Evolution of the Mortality Acceleration Due to the COVID-19: The Charlson Comorbidity Index in Stochastic Setting.

    Carannante, Maria / D'Amato, Valeria / Iaccarino, Guido

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 938086

    Abstract: The empirical evidence from different countries point out many of those who die from coronavirus would have died anyway in the relatively near future due to their existing frailties or co-morbidities. ... ...

    Abstract The empirical evidence from different countries point out many of those who die from coronavirus would have died anyway in the relatively near future due to their existing frailties or co-morbidities. The
    Language English
    Publishing date 2022-07-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.938086
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The Cardiovascular Phenotype in Fabry Disease

    Daniela Sorriento / Guido Iaccarino

    International Journal of Molecular Sciences, Vol 22, Iss 3, p

    New Findings in the Research Field

    2021  Volume 1331

    Abstract: Fabry disease (FD) is a lysosomal storage disorder, depending on defects in alpha-galactosidase A (GAL) activity. At the clinical level, FD shows a high phenotype variability. Among them, cardiovascular dysfunction is often recurrent or, in some cases, ... ...

    Abstract Fabry disease (FD) is a lysosomal storage disorder, depending on defects in alpha-galactosidase A (GAL) activity. At the clinical level, FD shows a high phenotype variability. Among them, cardiovascular dysfunction is often recurrent or, in some cases, is the sole symptom (cardiac variant) representing the leading cause of death in Fabry patients. The existing therapies, besides specific symptomatic treatments, are mainly based on the restoration of GAL activity. Indeed, mutations of the galactosidase alpha gene (GLA) cause a reduction or lack of GAL activity leading to globotriaosylceramide (Gb3) accumulation in several organs. However, several other mechanisms are involved in FD’s development and progression that could become useful targets for therapeutics. This review discusses FD’s cardiovascular phenotype and the last findings on molecular mechanisms that accelerate cardiac cell damage.
    Keywords fabry ; lysosomal disorder ; cardiovascular disease ; inflammation ; mitochondrial dysfunction ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Gene-environment interactions and vitamin D effects on cardiovascular risk.

    Iaccarino, Guido / Trimarco, Bruno

    BMC medicine

    2019  Volume 17, Issue 1, Page(s) 166

    MeSH term(s) Adult ; Cardiovascular Diseases ; Gene-Environment Interaction ; Humans ; Risk Factors ; Vascular Diseases ; Vitamin D ; Vitamin D Deficiency
    Chemical Substances Vitamin D (1406-16-2)
    Language English
    Publishing date 2019-08-30
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ISSN 1741-7015
    ISSN (online) 1741-7015
    DOI 10.1186/s12916-019-1402-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Physical Exercise: A Novel Tool to Protect Mitochondrial Health.

    Sorriento, Daniela / Di Vaia, Eugenio / Iaccarino, Guido

    Frontiers in physiology

    2021  Volume 12, Page(s) 660068

    Abstract: Mitochondrial dysfunction is a crucial contributor to heart diseases. Alterations in energetic metabolism affect crucial homeostatic processes, such asATP production, the generation of reactive oxygen species, and the release of pro-apoptotic factors, ... ...

    Abstract Mitochondrial dysfunction is a crucial contributor to heart diseases. Alterations in energetic metabolism affect crucial homeostatic processes, such asATP production, the generation of reactive oxygen species, and the release of pro-apoptotic factors, associated with metabolic abnormalities. In response to energetic deficiency, the cardiomyocytes activate the Mitochondrial Quality Control (MQC), a critical process in maintaining mitochondrial health. This process is compromised in cardiovascular diseases depending on the pathology's severity and represents, therefore, a potential therapeutic target. Several potential targeting molecules within this process have been identified in the last years, and therapeutic strategies have been proposed to ameliorate mitochondria monitoring and function. In this context, physical exercise is considered a non-pharmacological strategy to protect mitochondrial health. Physical exercise regulates MQC allowing the repair/elimination of damaged mitochondria and synthesizing new ones, thus recovering the metabolic state. In this review, we will deal with the effect of physical exercise on cardiac mitochondrial function tracing its ability to modulate specific steps in MQC both in physiologic and pathologic conditions.
    Language English
    Publishing date 2021-04-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2021.660068
    Database MEDical Literature Analysis and Retrieval System OnLINE

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