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  1. Article: Non-Tuberculous Mycobacterium facial cellulitis in an immunocompromised rheumatoid arthritis patient - Skin biopsy can help.

    Chen, Tsung-Chia / Wu, Chia-Hua

    IDCases

    2023  Volume 33, Page(s) e01869

    Language English
    Publishing date 2023-08-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2745454-X
    ISSN 2214-2509
    ISSN 2214-2509
    DOI 10.1016/j.idcr.2023.e01869
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Polymer Stabilization of Uniform Lying Helix Texture in a Bimesogen-Doped Cholesteric Liquid Crystal for Frequency-Modulated Electro-Optic Responses.

    Yu, Chia-Hua / Wu, Po-Chang / Lee, Wei

    Materials (Basel, Switzerland)

    2022  Volume 15, Issue 3

    Abstract: A polymer network (PN) can sustain the uniform lying helix (ULH) texture in a binary cholesteric liquid crystal (LC) comprising a calamitic LC and a bimesogenic LC dimer. Upon copolymerization of a bifunctional monomer with a trifunctional monomer at a ... ...

    Abstract A polymer network (PN) can sustain the uniform lying helix (ULH) texture in a binary cholesteric liquid crystal (LC) comprising a calamitic LC and a bimesogenic LC dimer. Upon copolymerization of a bifunctional monomer with a trifunctional monomer at a concentration of 5 wt% to create the desired polymer network structure, the PN-ULH was obtained with high stability and recoverability even when cycles of helical unwinding-to-rewinding processes were induced after the electrical or thermal treatment. Utilizing dielectric spectroscopy, the flexoelectric-polarization-dominated dielectric relaxation in the PN-ULH state was characterized to determine two frequency regions,
    Language English
    Publishing date 2022-01-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma15030771
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Transient receptor potential vanilloid 1 inhibition reduces brain damage by suppressing neuronal apoptosis after intracerebral hemorrhage.

    Chen, Chien-Cheng / Ke, Chia-Hua / Wu, Chun-Hu / Lee, Hung-Fu / Chao, Yuan / Tsai, Min-Chien / Shyue, Song-Kun / Chen, Szu-Fu

    Brain pathology (Zurich, Switzerland)

    2024  , Page(s) e13244

    Abstract: Intracerebral hemorrhage (ICH) induces a complex sequence of apoptotic cascades and inflammatory responses, leading to neurological impairment. Transient receptor potential vanilloid 1 (TRPV1), a nonselective cation channel with high calcium permeability, ...

    Abstract Intracerebral hemorrhage (ICH) induces a complex sequence of apoptotic cascades and inflammatory responses, leading to neurological impairment. Transient receptor potential vanilloid 1 (TRPV1), a nonselective cation channel with high calcium permeability, has been implicated in neuronal apoptosis and inflammatory responses. This study used a mouse ICH model and neuronal cultures to examine whether TRPV1 activation exacerbates brain damage and neurological deficits by promoting neuronal apoptosis and neuroinflammation. ICH was induced by injecting collagenase in both wild-type (WT) C57BL/6 mice and TRPV1
    Language English
    Publishing date 2024-02-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1051484-3
    ISSN 1750-3639 ; 1015-6305
    ISSN (online) 1750-3639
    ISSN 1015-6305
    DOI 10.1111/bpa.13244
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  4. Article ; Online: Barrier-Lowering Effects of Baird Antiaromaticity in Photoinduced Proton-Coupled Electron Transfer (PCET) Reactions.

    Karas, Lucas J / Wu, Chia-Hua / Wu, Judy I

    Journal of the American Chemical Society

    2021  Volume 143, Issue 43, Page(s) 17970–17974

    Abstract: Many popular organic chromophores that catalyze photoinduced proton-coupled electron transfer (PCET) reactions are aromatic in the ground state but become excited-state antiaromatic in the lowest ππ* state. We show that excited-state antiaromaticity ... ...

    Abstract Many popular organic chromophores that catalyze photoinduced proton-coupled electron transfer (PCET) reactions are aromatic in the ground state but become excited-state antiaromatic in the lowest ππ* state. We show that excited-state antiaromaticity makes electron transfer easier. Two representative photoinduced electron transfer processes are investigated: (1) the photolysis of phenol and (2) solar water splitting of a pyridine-water complex. In the selected reactions, the directions of electron transfer are opposite, but the net result is proton transfer following the direction of electron transfer. Nucleus-independent chemical shifts (NICS), ionization energies, electron affinities, and PCET energy profiles of selected [4
    MeSH term(s) Electrons ; Light ; Phenol/chemistry ; Phenol/radiation effects ; Photolysis ; Pyridines/chemistry ; Pyridines/radiation effects ; Quantum Theory ; Water/chemistry
    Chemical Substances Pyridines ; Water (059QF0KO0R) ; Phenol (339NCG44TV) ; pyridine (NH9L3PP67S)
    Language English
    Publishing date 2021-10-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.1c09324
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  5. Article ; Online: Effects of pesticide-adjuvant combinations used in almond orchards on olfactory responses to social signals in honey bees (Apis mellifera).

    Wu, Wen-Yen / Liao, Ling-Hsiu / Lin, Chia-Hua / Johnson, Reed M / Berenbaum, May R

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 15577

    Abstract: Exposure to agrochemical sprays containing pesticides and tank-mix adjuvants has been implicated in post-bloom mortality, particularly of brood, in honey bee colonies brought into California almond orchards for pollination. Although adjuvants are ... ...

    Abstract Exposure to agrochemical sprays containing pesticides and tank-mix adjuvants has been implicated in post-bloom mortality, particularly of brood, in honey bee colonies brought into California almond orchards for pollination. Although adjuvants are generally considered to be biologically inert, some adjuvants have exhibited toxicity and sublethal effects, including decreasing survival rates of next-generation queens. Honey bees have a highly developed olfactory system to detect and discriminate among social signals. To investigate the impact of pesticide-adjuvant combinations on honey bee signal perception, we performed electroantennography assays to assess alterations in their olfactory responsiveness to the brood ester pheromone (BEP), the volatile larval pheromone β-ocimene, and the alarm pheromone 2-heptanone. These assays aimed to uncover potential mechanisms underlying changes in social behaviors and reduced brood survival after pesticide exposure. We found that combining the adjuvant Dyne-Amic with the fungicide Tilt (propiconazole) and the insecticide Altacor (chlorantraniliprole) synergistically enhanced olfactory responses to three concentrations of BEP and as well exerted dampening and compensatory effects on responses to 2-heptanone and β-ocimene, respectively. In contrast, exposure to adjuvant alone or the combination of fungicide and insecticide had no effect on olfactory responses to BEP at most concentrations but altered responses to β-ocimene and 2-heptanone. Exposure to Dyne-Amic, Altacor, and Tilt increased BEP signal amplitude, indicating potential changes in olfactory receptor sensitivity or sensilla permeability to odorants. Given that, in a previous study, next-generation queens raised by nurses exposed to the same treated pollen experienced reduced survival, these new findings highlight the potential disruption of social signaling in honey bees and its implications for colony reproductive success.
    MeSH term(s) Humans ; Bees ; Animals ; Prunus dulcis ; Fungicides, Industrial ; Insecticides ; Pheromones ; Adjuvants, Immunologic ; Adjuvants, Pharmaceutic ; Pesticides/toxicity ; Esters
    Chemical Substances 2-heptanone (89VVP1B008) ; beta-ocimene (13877-91-3) ; Fungicides, Industrial ; Insecticides ; Pheromones ; Adjuvants, Immunologic ; Adjuvants, Pharmaceutic ; Pesticides ; Esters
    Language English
    Publishing date 2023-09-20
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-41818-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: How does excited-state antiaromaticity affect the acidity strengths of photoacids?

    Wen, Zhili / Karas, Lucas José / Wu, Chia-Hua / Wu, Judy I-Chia

    Chemical communications (Cambridge, England)

    2020  Volume 56, Issue 60, Page(s) 8380–8383

    Abstract: Photoacids like substituted naphthalenes (X = OH, NH3+, COOH) are aromatic in the S0 state and antiaromatic in the S1 state. Nucleus independent chemical shifts analyses reveal that deprotonation relieves antiaromaticity in the excited conjugate base, ... ...

    Abstract Photoacids like substituted naphthalenes (X = OH, NH3+, COOH) are aromatic in the S0 state and antiaromatic in the S1 state. Nucleus independent chemical shifts analyses reveal that deprotonation relieves antiaromaticity in the excited conjugate base, and that the degree of "antiaromaticity relief" explains why some photoacids are stronger than others.
    Language English
    Publishing date 2020-05-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d0cc02952a
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  7. Article: Growth Regulated Oncogene-α Upregulates TNF-α and COX-2 and Activates NOD1/RIPK2 mediated-MAPK Pathway in Head and Neck Squamous Cell Carcinoma.

    Chan, Leong-Perng / Tseng, Ya-Ping / Wang, Hui-Ching / Chien, Chen-Yu / Wu, Che-Wei / Wang, Ling-Feng / Liang, Chia-Hua

    Journal of Cancer

    2023  Volume 14, Issue 6, Page(s) 989–1000

    Abstract: Purpose: ...

    Abstract Purpose:
    Language English
    Publishing date 2023-04-09
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2573318-7
    ISSN 1837-9664
    ISSN 1837-9664
    DOI 10.7150/jca.82300
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  8. Article: Hydrogen bond design principles.

    Karas, Lucas J / Wu, Chia-Hua / Das, Ranjita / Wu, Judy I-Chia

    Wiley interdisciplinary reviews. Computational molecular science

    2020  Volume 10, Issue 6

    Abstract: Hydrogen bonding principles are at the core of supramolecular design. This overview features a discussion relating molecular structure to hydrogen bond strengths, highlighting the following electronic effects on hydrogen bonding: electronegativity, ... ...

    Abstract Hydrogen bonding principles are at the core of supramolecular design. This overview features a discussion relating molecular structure to hydrogen bond strengths, highlighting the following electronic effects on hydrogen bonding: electronegativity, steric effects, electrostatic effects, π-conjugation, and network cooperativity. Historical developments, along with experimental and computational efforts, leading up to the birth of the hydrogen bond concept, the discovery of nonclassical hydrogen bonds (C-H…O, O-H…π, dihydrogen bonding), and the proposal of hydrogen bond design principles (e.g., secondary electrostatic interactions, resonance-assisted hydrogen bonding, and aromaticity effects) are outlined. Applications of hydrogen bond design principles are presented.
    Language English
    Publishing date 2020-05-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2599565-0
    ISSN 1759-0884 ; 1759-0876
    ISSN (online) 1759-0884
    ISSN 1759-0876
    DOI 10.1002/wcms.1477
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  9. Article ; Online: Prevalence of Type IV Pili-Mediated Twitching Motility in Streptococcus sanguinis Strains and Its Impact on Biofilm Formation and Host Adherence.

    Chen, Yi-Ywan M / Wang, Hsing-Yi / Wu, Chia-Hua / Lin, Yu-Juan / Chiu, Cheng-Hsun

    Applied and environmental microbiology

    2022  Volume 88, Issue 18, Page(s) e0140322

    Abstract: Type IV pili (Tfp) are known to mediate several biological activities, including surface-dependent twitching motility. Although ... ...

    Abstract Type IV pili (Tfp) are known to mediate several biological activities, including surface-dependent twitching motility. Although a
    MeSH term(s) Adenosine Triphosphatases/metabolism ; Agar/metabolism ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Biofilms ; Fimbriae Proteins/genetics ; Fimbriae, Bacterial/genetics ; Fimbriae, Bacterial/metabolism ; Ligands ; Prevalence ; Streptococcus sanguis/genetics ; Streptococcus sanguis/metabolism
    Chemical Substances Bacterial Proteins ; Ligands ; Fimbriae Proteins (147680-16-8) ; Agar (9002-18-0) ; Adenosine Triphosphatases (EC 3.6.1.-)
    Language English
    Publishing date 2022-09-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 223011-2
    ISSN 1098-5336 ; 0099-2240
    ISSN (online) 1098-5336
    ISSN 0099-2240
    DOI 10.1128/aem.01403-22
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  10. Article ; Online: Designs and Applications of Multi-stimuli Responsive FRET Processes in AIEgen-Functionalized and Bi-fluorophoric Supramolecular Materials.

    Wu, Chia-Hua / Nhien, Pham Quoc / Cuc, Tu Thi Kim / Hue, Bui Thi Buu / Lin, Hong-Cheu

    Topics in current chemistry (Cham)

    2022  Volume 381, Issue 1, Page(s) 2

    Abstract: Materials capable of displaying strong ratiometric fluorescence with Förster resonance energy transfer (FRET) processes have attracted much research interest because of various chemosensor and biomedical applications. This review highlights several ... ...

    Abstract Materials capable of displaying strong ratiometric fluorescence with Förster resonance energy transfer (FRET) processes have attracted much research interest because of various chemosensor and biomedical applications. This review highlights several popular strategies in designing FRET-OFF/ON mechanisms of ratiometric fluorescence systems. In particular, the developments of organic and polymeric FRET materials featuring aggregation-induced emission-based luminogens (AIEgens), supramolecular assemblies, photochromic molecular switches and surfactant-induced AIE/FRET mechanisms are presented. AIEgens have been frequently employed as FRET donor and/or acceptor fluorophores to obtain enhanced ratiometric fluorescences in solution and solid states. Since AIE effects and FRET processes rely on controllable distances between fluorophores, many interesting fluorescent properties can be designed by regulating aggregation states in polymers and supramolecular systems. Photo-switchable fluorophores, such as spiropyran and diarylethene, provide drastic changes in fluorescence spectra upon photo-induced isomerizations, leading to photo-switching mechanisms to activate/deactivate FRET processes. Supramolecular assemblies offer versatile platforms to regulate responsive FRET processes effectively. In rotaxane structures, the donor-acceptor distance and FRET efficiency can be tuned by acid/base-controlled shuttling of the macrocycle component. The tunable supramolecular interactions are strongly influenced by external factors (such as pH values, temperatures, analytes, surfactants, UV-visible lights, etc.), which induce the assembly and disassembly of host-guest systems and thus their FRET-ON/FRET-OFF behavior. In addition, the changes in donor or acceptor fluorescence profiles upon detections of analytes can also sufficiently alter the FRET behavior and result in different ratiometric fluorescence outputs. The strategies and examples provided in this review offer the insights and toolkits for future FRET-based material developments.
    Language English
    Publishing date 2022-12-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2848485-X
    ISSN 2364-8961 ; 2365-0869
    ISSN (online) 2364-8961
    ISSN 2365-0869
    DOI 10.1007/s41061-022-00412-7
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