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  1. Article ; Online: Editorial.

    Sunavala-Dossabhoy, Gulshan

    Oral diseases

    2022  Volume 28, Issue 5, Page(s) 1305

    Language English
    Publishing date 2022-06-15
    Publishing country Denmark
    Document type Editorial ; Comment
    ZDB-ID 1290529-x
    ISSN 1601-0825 ; 1354-523X
    ISSN (online) 1601-0825
    ISSN 1354-523X
    DOI 10.1111/odi.14230
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4427: Show issues Location:
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  2. Article ; Online: Women pioneers in dental sciences.

    Sunavala-Dossabhoy, Gulshan / Buduneli, Nurcan

    Oral diseases

    2023  Volume 29 Suppl 1, Page(s) 857–859

    Language English
    Publishing date 2023-03-05
    Publishing country Denmark
    Document type Editorial
    ZDB-ID 1290529-x
    ISSN 1601-0825 ; 1354-523X
    ISSN (online) 1601-0825
    ISSN 1354-523X
    DOI 10.1111/odi.14534
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Disorder at the Start: The Contribution of Dysregulated Translation Initiation to Cancer Therapy Resistance.

    Sunavala-Dossabhoy, Gulshan

    Frontiers in oral health

    2021  Volume 2, Page(s) 765931

    Abstract: Translation of cellular RNA to protein is an energy-intensive process through which synthesized proteins dictate cellular processes and function. Translation is regulated in response to extracellular effectors and availability of amino acids ... ...

    Abstract Translation of cellular RNA to protein is an energy-intensive process through which synthesized proteins dictate cellular processes and function. Translation is regulated in response to extracellular effectors and availability of amino acids intracellularly. Most eukaryotic mRNA rely on the methyl 7-guanosine (m7G) nucleotide cap to recruit the translation machinery, and the uncoupling of translational control that occurs in tumorigenesis plays a significant role in cancer treatment response. This article provides an overview of the mammalian translation initiation process and the primary mechanisms by which it is regulated. An outline of how deregulation of initiation supports tumorigenesis and how initiation at a downstream open reading frame (ORF) of Tousled-like kinase 1 (TLK1) leads to treatment resistance is discussed.
    Language English
    Publishing date 2021-12-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2673-4842
    ISSN (online) 2673-4842
    DOI 10.3389/froh.2021.765931
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: In defense of open scientific discussion. Reply to Dr. McMahon.

    Lodi, Giovanni / Sunavala-Dossabhoy, Gulshan / Petti, Stefano

    Oral diseases

    2023  Volume 29, Issue 4, Page(s) 1887–1888

    Language English
    Publishing date 2023-03-29
    Publishing country Denmark
    Document type Letter ; Comment
    ZDB-ID 1290529-x
    ISSN 1601-0825 ; 1354-523X
    ISSN (online) 1601-0825
    ISSN 1354-523X
    DOI 10.1111/odi.14560
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4427: Show issues Location:
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  5. Article ; Online: Effect of recombinant human thyroid stimulating hormone on long-term salivary gland dysfunction in thyroid cancer patients treated with radioactive iodine. A systematic review.

    Sunavala-Dossabhoy, Gulshan / Petti, Stefano

    Oral oncology

    2022  Volume 136, Page(s) 106280

    Abstract: Adjuvant radioactive iodine (RAI) is administered to thyroid cancer patients following thyroidectomy for remnant tissue ablation and metastatic disease management. Patients are prepared with thyroid hormone withdrawal (THW) or recombinant human thyroid ... ...

    Abstract Adjuvant radioactive iodine (RAI) is administered to thyroid cancer patients following thyroidectomy for remnant tissue ablation and metastatic disease management. Patients are prepared with thyroid hormone withdrawal (THW) or recombinant human thyroid stimulating hormone (rhTSH). Long-term salivary gland dysfunction (LT-SGD) is a common, dosage-dependent, RAI adverse effect. Although rhTSH preparation seems to reduce LT-SGD, this effect could be due to lower RAI activity generally used in rhTSH-prepared patients. Therefore, this meta-analysis investigated the effect of preparation type on LT-SGD development. Literature search (PubMed, Medline, EmBase, Cochrane, Web of Science, LILACS, Google Scholar) was performed four times (January-November 2022) and studies reporting LT-SGD incidence ≥1 year after RAI in patients prepared with rhTSH/THW were identified. The LT-SGD risk ratio (RR) was estimated with various models considered for sensitivity analysis (fixed-effect, random-effects, study-quality adjusted, publication-bias adjusted, individual-patient-data meta-analysis adjusted for RAI). Subgroup analysis according to RAI activity (<3.7/≥3.7 GBq) also was performed. Literature search resulted in five studies (321 rhTSH, 632 THW patients). The pooled RRs according to various models were 0.65 (95% confidence interval -95CI, 0.49-0.86; fixed-effect); 0.62 (95CI, 0.38-1.02; random-effects); 0.72 (95CI, 0.54-0.96; quality adjusted); 0.76 (95CI, 0.58-0.99; publication-bias adjusted); 0.0.80 (95CI, 0.55-1.14; individual-patient-data meta-analysis). The pooled RRs stratified for RAI activity were 0.26 (95CI, 0.05-1.30) for <3.7 GBq; 0.75 (95CI, 0.57-0.98) for ≥3.7 GBq. The number of patients needed to be prepared with rhTSH to prevent one case of LT-SGD ranged between seven and thirty-seven. There is moderate-quality scientific evidence that rhTSH preparation may consistently protect salivary gland function.
    Language English
    Publishing date 2022-12-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1120465-5
    ISSN 1879-0593 ; 0964-1955 ; 1368-8375
    ISSN (online) 1879-0593
    ISSN 0964-1955 ; 1368-8375
    DOI 10.1016/j.oraloncology.2022.106280
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4869: Show issues Location:
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    Zs.A 456: Show issues Location:
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  6. Article: Debulking of the Femoral Stem in a Primary Total Hip Joint Replacement: A Novel Method to Reduce Stress Shielding.

    Sunavala-Dossabhoy, Gulshan / Saba, Brent M / McCarthy, Kevin J

    Bioengineering (Basel, Switzerland)

    2024  Volume 11, Issue 4

    Abstract: In current-generation designs of total primary hip joint replacement, the prostheses are fabricated from alloys. The modulus of elasticity of the alloy is substantially higher than that of the surrounding bone. This discrepancy plays a role in a ... ...

    Abstract In current-generation designs of total primary hip joint replacement, the prostheses are fabricated from alloys. The modulus of elasticity of the alloy is substantially higher than that of the surrounding bone. This discrepancy plays a role in a phenomenon known as stress shielding, in which the bone bears a reduced proportion of the applied load. Stress shielding has been implicated in aseptic loosening of the implant which, in turn, results in reduction in the in vivo life of the implant. Rigid implants shield surrounding bone from mechanical loading, and the reduction in skeletal stress necessary to maintain bone mass and density results in accelerated bone loss, the forerunner to implant loosening. Femoral stems of various geometries and surface modifications, materials and material distributions, and porous structures have been investigated to achieve mechanical properties of stems closer to those of bone to mitigate stress shielding. For improved load transfer from implant to femur, the proposed study investigated a strategic debulking effort to impart controlled flexibility while retaining sufficient strength and endurance properties. Using an iterative design process, debulked configurations based on an internal skeletal truss framework were evaluated using finite element analysis. The implant models analyzed were solid; hollow, with a proximal hollowed stem; FB-2A, with thin, curved trusses extending from the central spine; and FB-3B and FB-3C, with thick, flat trusses extending from the central spine in a balanced-truss and a hemi-truss configuration, respectively. As outlined in the International Organization for Standardization (ISO) 7206 standards, implants were offset in natural femur for evaluation of load distribution or potted in testing cylinders for fatigue testing. The commonality across all debulked designs was the minimization of proximal stress shielding compared to conventional solid implants. Stem topography can influence performance, and the truss implants with or without the calcar collar were evaluated. Load sharing was equally effective irrespective of the collar; however, the collar was critical to reducing the stresses in the implant. Whether bonded directly to bone or cemented in the femur, the truss stem was effective at limiting stress shielding. However, a localized increase in maximum principal stress at the proximal lateral junction could adversely affect cement integrity. The controlled accommodation of deformation of the implant wall contributes to the load sharing capability of the truss implant, and for a superior biomechanical performance, the collared stem should be implanted in interference fit. Considering the results of all implant designs, the truss implant model FB-3C was the best model.
    Language English
    Publishing date 2024-04-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2746191-9
    ISSN 2306-5354
    ISSN 2306-5354
    DOI 10.3390/bioengineering11040393
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  7. Article ; Online: Renin-angiotensin II-aldosterone axis in SARS-CoV-2-associated xerostomia.

    Sunavala-Dossabhoy, Gulshan

    Oral diseases

    2020  Volume 28 Suppl 1, Page(s) 977–978

    MeSH term(s) Aldosterone ; Angiotensin II ; COVID-19/complications ; Humans ; Renin ; SARS-CoV-2 ; Xerostomia/etiology
    Chemical Substances Angiotensin II (11128-99-7) ; Aldosterone (4964P6T9RB) ; Renin (EC 3.4.23.15)
    Keywords covid19
    Language English
    Publishing date 2020-08-31
    Publishing country Denmark
    Document type Letter
    ZDB-ID 1290529-x
    ISSN 1601-0825 ; 1354-523X
    ISSN (online) 1601-0825
    ISSN 1354-523X
    DOI 10.1111/odi.13594
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  8. Article ; Online: Dr. Ani John (1950-2007): An exemplary dental educator and administrator and the first female President of the Indian Academy of Oral Medicine and Radiology.

    Umarji, Hemant R / Parikh, Nipa / Deniz, Swapna / Sunavala-Dossabhoy, Gulshan

    Oral diseases

    2023  Volume 29 Suppl 1, Page(s) 893–897

    Language English
    Publishing date 2023-03-01
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1290529-x
    ISSN 1601-0825 ; 1354-523X
    ISSN (online) 1601-0825
    ISSN 1354-523X
    DOI 10.1111/odi.14519
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Smart cell-specific protein therapeutics for head and neck cancer.

    Sunavala-Dossabhoy, Gulshan

    Oral diseases

    2019  Volume 26, Issue 1, Page(s) 3–5

    MeSH term(s) Cell-Penetrating Peptides/therapeutic use ; Head and Neck Neoplasms/therapy ; Humans ; Molecular Targeted Therapy ; Protein Engineering
    Chemical Substances Cell-Penetrating Peptides
    Language English
    Publishing date 2019-10-27
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1290529-x
    ISSN 1601-0825 ; 1354-523X
    ISSN (online) 1601-0825
    ISSN 1354-523X
    DOI 10.1111/odi.13203
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  10. Article ; Online: Orofacial clefts: A compendium on non-syndromic cleft lip-cleft palate.

    Coletta, Ricardo D / Sunavala-Dossabhoy, Gulshan

    Oral diseases

    2022  Volume 28, Issue 5, Page(s) 1301–1304

    MeSH term(s) Case-Control Studies ; Cleft Lip ; Cleft Palate ; Humans
    Language English
    Publishing date 2022-05-13
    Publishing country Denmark
    Document type Editorial
    ZDB-ID 1290529-x
    ISSN 1601-0825 ; 1354-523X
    ISSN (online) 1601-0825
    ISSN 1354-523X
    DOI 10.1111/odi.14238
    Database MEDical Literature Analysis and Retrieval System OnLINE

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