Article ; Online: Serial quantitative angiographic study of target lumen enlargement after drug-coated balloon angioplasty for native coronary artery disease.
2023 Volume 101, Issue 4, Page(s) 713–721
Abstract: Background: Target lumen enlargement (TLE) or "late lumen enlargement" is often encountered after percutaneous coronary intervention (PCI) with drug-coated balloons (DCB). To date, the prognosis of coronary arterial lesions with or without TLE has not ... ...
| Abstract | Background: Target lumen enlargement (TLE) or "late lumen enlargement" is often encountered after percutaneous coronary intervention (PCI) with drug-coated balloons (DCB). To date, the prognosis of coronary arterial lesions with or without TLE has not been clearly elucidated. Aims: This study aimed to assess the long-term prognosis of coronary arterial lesions with or without TLE observed within 1 year (early TLE) after DCB angioplasty using serial quantitative angiographic follow-up. Methods: One hundred and ninety-three consecutive patients (de novo coronary arterial lesions, 251) who underwent follow-up angiography within 1 year after DCB angioplasty (early follow-up, median: 6 months) were retrospectively evaluated. Of these, 97 patients (125 lesions) also underwent angiography more than 1 year after DCB angioplasty (late follow-up, median: 37 months). TLE was defined as an increase in minimal lumen diameter (MLD) after PCI at each follow-up. Results: Early TLE was detected in 142 lesions (56.6%). Of these, 76 lesions were also evaluated at late follow-up. TLE persisted even at late follow-up in 67 of the 76 lesions (88.2%). An increase in MLD in early TLE (+) lesions was observed in the period between post-PCI and early follow-up (1.84 ± 0.06 vs. 2.12 ± 0.07 mm, p < 0.001) but not between early and late follow-up (2.12 ± 0.07 vs. 2.16 ± 0.07 mm, p = 0.74). In contrast, 49 of 109 lesions without early TLE were evaluated at late follow-up, of which 28 lesions (57.1%) showed TLE at late follow-up. The MLD of early TLE (-) lesions (n = 49) significantly increased from early (1.63 ± 0.061 mm) to late follow-up (1.84 ± 0.06 mm) (p < 0.001). No aneurysms were found in any of these cases. Conclusion: Early TLE was observed in more than half of the lesions, with the majority remaining at late follow-up. Alternatively, half of the lesions without early TLE showed late TLE, occurring biphasically after DCB angioplasty. |
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| MeSH term(s) | Humans ; Coronary Artery Disease/surgery ; Percutaneous Coronary Intervention ; Retrospective Studies ; Coronary Angiography ; Treatment Outcome ; Angioplasty, Balloon, Coronary ; Coronary Restenosis ; Coated Materials, Biocompatible |
| Chemical Substances | Coated Materials, Biocompatible |
| Language | English |
| Publishing date | 2023-02-25 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 1459995-8 |
| ISSN | 1522-726X ; 1522-1946 |
| ISSN (online) | 1522-726X |
| ISSN | 1522-1946 |
| DOI | 10.1002/ccd.30598 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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