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Article ; Online: Safety and Effectiveness of Apixaban Versus Warfarin in Japanese Patients with Nonvalvular Atrial Fibrillation Stratified by Renal Function: A Retrospective Cohort Study.

Morimoto, Takeshi / Hoshino, Haruhiko / Matsuo, Yukako / Ibuki, Tatsuki / Miyata, Kayoko / Koretsune, Yukihiro

American journal of cardiovascular drugs : drugs, devices, and other interventions

2023 Volume 23, Issue 6, Page(s) 721–733

MeSH term(s)	Humans ; Warfarin/adverse effects ; Atrial Fibrillation/complications ; Atrial Fibrillation/drug therapy ; Atrial Fibrillation/epidemiology ; Retrospective Studies ; East Asian People ; Anticoagulants/adverse effects ; Pyridones/adverse effects ; Stroke/epidemiology ; Stroke/etiology ; Stroke/prevention & control ; Hemorrhage/chemically induced ; Hemorrhage/epidemiology ; Kidney/physiology ; Rivaroxaban/adverse effects
Chemical Substances	Warfarin (5Q7ZVV76EI) ; apixaban (3Z9Y7UWC1J) ; Anticoagulants ; Pyridones ; Rivaroxaban (9NDF7JZ4M3)
Language	English
Publishing date	2023-10-17
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2052547-3
ISSN	1179-187X ; 1175-3277
ISSN (online)	1179-187X
ISSN	1175-3277
DOI	10.1007/s40256-023-00611-7
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Article ; Online: STAT1 regulates interferon-γ-induced angiotensinogen and MCP-1 expression in a bidirectional manner in primary cultured mesangial cells.

Penrose, Harrison M / Katsurada, Akemi / Miyata, Kayoko / Urushihara, Maki / Satou, Ryousuke

Journal of the renin-angiotensin-aldosterone system : JRAAS

2020 Volume 21, Issue 3, Page(s) 1470320320946527

Abstract: Objective: Intrarenal interferon-γ significantly contributes to the development of glomerular injury in which angiotensinogen and monocyte chemoattractant protein 1 levels are elevated. However, the exact nature of the role that interferon-γ plays in ... ...

Abstract	Objective: Intrarenal interferon-γ significantly contributes to the development of glomerular injury in which angiotensinogen and monocyte chemoattractant protein 1 levels are elevated. However, the exact nature of the role that interferon-γ plays in regulating angiotensinogen and monocyte chemoattractant protein 1 expression has not been fully delineated. Therefore, the aim of this study was to investigate the role that interferon-γ plays in angiotensinogen and monocyte chemoattractant protein 1 expression. Methods: Primary cultured rat mesangial cells were treated with 0-20 ng/mL interferon-γ for 2, 8 or 24 hours. Expression levels of angiotensinogen, monocyte chemoattractant protein 1, suppressors of cytokine signaling 1, an intracellular suppressor of Janus kinase-signal transducers and activators of transcription signaling and activity of the Janus kinase-signal transducers and activators of transcription pathway were evaluated by reverse transcriptase polymerase chain reaction and western blot analysis. Results: Interferon-γ increased angiotensinogen expression in mesangial cells with maximal augmentation observed following 5 ng/mL interferon-γ at 8 hours of treatment (1.87 ± 0.05, mRNA, relative ratio). Further increases were reduced or absent using higher concentrations of interferon-γ. Following treatments, monocyte chemoattractant protein 1 expression was induced in a linear dose-dependent manner (6.85 ± 0.62-fold by 20 ng/mL interferon-γ at 24 hours). In addition, interferon-γ induced STAT1 phosphorylation and suppressors of cytokine signaling 1 expression in a linear dose-dependent manner. The suppression of STAT1 and suppressors of cytokine signaling 1 expression by small interference RNAs facilitated an increase in interferon-γ-induced angiotensinogen expression, indicating that these two factors negatively regulate angiotensinogen expression. In contrast, the increase in interferon-γ-induced monocyte chemoattractant protein 1 expression was attenuated in STAT1-deficient mesangial cells, suggesting that STAT1 positively regulates monocyte chemoattractant protein 1 expression in mesangial cells. Conclusion: These results demonstrate that while interferon-γ increases both angiotensinogen and monocyte chemoattractant protein 1 expression, STAT1 plays an opposing role in the regulation of each factor in mesangial cells.
MeSH term(s)	Angiotensinogen/metabolism ; Animals ; Cells, Cultured ; Chemokine CCL2/metabolism ; Interferon-gamma/pharmacology ; Male ; Mesangial Cells/drug effects ; Mesangial Cells/metabolism ; Models, Biological ; Rats, Sprague-Dawley ; STAT1 Transcription Factor/metabolism ; STAT3 Transcription Factor/metabolism ; Suppressor of Cytokine Signaling 1 Protein/metabolism
Chemical Substances	Chemokine CCL2 ; STAT1 Transcription Factor ; STAT3 Transcription Factor ; Suppressor of Cytokine Signaling 1 Protein ; Angiotensinogen (11002-13-4) ; Interferon-gamma (82115-62-6)
Language	English
Publishing date	2020-05-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2086948-4
ISSN	1752-8976 ; 1470-3203
ISSN (online)	1752-8976
ISSN	1470-3203
DOI	10.1177/1470320320946527
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Article: Antibacterial coating of tooth surface with ion-releasing pre-reacted glass-ionomer (S-PRG) nanofillers.

Mayumi, Kayoko / Miyaji, Hirofumi / Miyata, Saori / Nishida, Erika / Furihata, Tomokazu / Kanemoto, Yukimi / Sugaya, Tsutomu / Shitomi, Kanako / Akasaka, Tsukasa

Heliyon

2021 Volume 7, Issue 2, Page(s) e06147

Abstract: Objectives: Surface pre-reacted glass-ionomer (S-PRG) fillers release antibacterial borate and fluoride ions. We fabricated nanoscale S-PRG fillers (S-PRG nanofillers) for antibacterial coating of tooth surfaces and assessed the antibacterial effects of ...

Abstract	Objectives: Surface pre-reacted glass-ionomer (S-PRG) fillers release antibacterial borate and fluoride ions. We fabricated nanoscale S-PRG fillers (S-PRG nanofillers) for antibacterial coating of tooth surfaces and assessed the antibacterial effects of this coating in vitro. In addition, we creating a canine model of periodontitis to evaluate the effectiveness of S-PRG nanofiller application on tooth roots and improvement of periodontal parameters. Methods: Human dentin blocks were coated with S-PRG nanofiller (average particle size: 0.48 μm) and then characterized by scanning electron microscopy (SEM), energy dispersive X-ray spectrometer (EDX), and ion-releasing test. Antibacterial effects of dentin blocks coated with S-PRG nanofiller were examined using bacterial strains, Results: SEM and EDX revealed that S-PRG nanofillers uniformly covered the dentin surface after coating. Dentin blocks coated with S-PRG nanofiller showed ion-releasing property, bacterial growth inhibition, and sterilization effects. In the experimental periodontitis model, S-PRG nanofiller coating significantly reduced clinical inflammatory parameters, such as GI (P < 0.01) and BOP (P < 0.05), compared to uncoated samples. In addition, PPD and CAL significantly decreased by S-PRG nanofiller coating (2 weeks: P < 0.05; 3 and 4 weeks: P < 0.01), suggesting the improvement of periodontitis. Micro-CT and histology revealed that bone healing of furcation defects was enhanced by S-PRG nanofiller coating. Conclusion: S-PRG nanofiller coating provides antibacterial effects to tooth surfaces and improves clinical parameters of periodontitis.
Language	English
Publishing date	2021-02-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2021.e06147
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Article ; Online: Significant Clinical Indexes of Exercise-Induced Pulmonary Hypertension in Patients With Connective Tissue Disease.

Ojima, Satoko / Kubozono, Takuro / Saihara, Keishi / Miyauchi, Takahiro / Kawasoe, Shin / Kubota, Kayoko / Shigemizu, Sanae / Ohtsubo, Hideo / Miyata, Masaaki / Ohishi, Mitsuru

Circulation reports

2019 Volume 1, Issue 12, Page(s) 610–616

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2019-11-09
Publishing country	Japan
Document type	Journal Article
ISSN	2434-0790
ISSN (online)	2434-0790
DOI	10.1253/circrep.CR-19-0087
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Article ; Online: STAT1 regulates interferon-γ-induced angiotensinogen and MCP-1 expression in a bidirectional manner in primary cultured mesangial cells

Harrison M Penrose / Akemi Katsurada / Kayoko Miyata / Maki Urushihara / Ryousuke Satou

Journal of the Renin-Angiotensin-Aldosterone System, Vol

2020 Volume 21

Abstract	Objective: Intrarenal interferon-γ significantly contributes to the development of glomerular injury in which angiotensinogen and monocyte chemoattractant protein 1 levels are elevated. However, the exact nature of the role that interferon-γ plays in regulating angiotensinogen and monocyte chemoattractant protein 1 expression has not been fully delineated. Therefore, the aim of this study was to investigate the role that interferon-γ plays in angiotensinogen and monocyte chemoattractant protein 1 expression. Methods: Primary cultured rat mesangial cells were treated with 0–20 ng/mL interferon-γ for 2, 8 or 24 hours. Expression levels of angiotensinogen, monocyte chemoattractant protein 1, suppressors of cytokine signaling 1, an intracellular suppressor of Janus kinase-signal transducers and activators of transcription signaling and activity of the Janus kinase-signal transducers and activators of transcription pathway were evaluated by reverse transcriptase polymerase chain reaction and western blot analysis. Results: Interferon-γ increased angiotensinogen expression in mesangial cells with maximal augmentation observed following 5 ng/mL interferon-γ at 8 hours of treatment (1.87 ± 0.05, mRNA, relative ratio). Further increases were reduced or absent using higher concentrations of interferon-γ. Following treatments, monocyte chemoattractant protein 1 expression was induced in a linear dose-dependent manner (6.85 ± 0.62-fold by 20 ng/mL interferon-γ at 24 hours). In addition, interferon-γ induced STAT1 phosphorylation and suppressors of cytokine signaling 1 expression in a linear dose-dependent manner. The suppression of STAT1 and suppressors of cytokine signaling 1 expression by small interference RNAs facilitated an increase in interferon-γ-induced angiotensinogen expression, indicating that these two factors negatively regulate angiotensinogen expression. In contrast, the increase in interferon-γ-induced monocyte chemoattractant protein 1 expression was attenuated in STAT1-deficient mesangial cells, suggesting ...
Keywords	Medicine (General) ; R5-920
Subject code	570
Language	English
Publishing date	2020-08-01T00:00:00Z
Publisher	Hindawi - SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Antibacterial coating of tooth surface with ion-releasing pre-reacted glass-ionomer (S-PRG) nanofillers

Kayoko Mayumi / Hirofumi Miyaji / Saori Miyata / Erika Nishida / Tomokazu Furihata / Yukimi Kanemoto / Tsutomu Sugaya / Kanako Shitomi / Tsukasa Akasaka

Heliyon, Vol 7, Iss 2, Pp e06147- (2021)

2021

Abstract	Objectives: Surface pre-reacted glass-ionomer (S-PRG) fillers release antibacterial borate and fluoride ions. We fabricated nanoscale S-PRG fillers (S-PRG nanofillers) for antibacterial coating of tooth surfaces and assessed the antibacterial effects of this coating in vitro. In addition, we creating a canine model of periodontitis to evaluate the effectiveness of S-PRG nanofiller application on tooth roots and improvement of periodontal parameters. Methods: Human dentin blocks were coated with S-PRG nanofiller (average particle size: 0.48 μm) and then characterized by scanning electron microscopy (SEM), energy dispersive X-ray spectrometer (EDX), and ion-releasing test. Antibacterial effects of dentin blocks coated with S-PRG nanofiller were examined using bacterial strains, Streptococcus mutans and Actinomyces naeslundii. Next, we created an experimental model of periodontitis in furcation of premolars of beagle dogs. Then, S-PRG nanofiller coating was applied onto exposed tooth root surfaces. Periodontal parameters, gingival index (GI), bleeding on probing (BOP), probing pocket depth (PPD), and clinical attachment level (CAL), were measured from baseline until 4 weeks. In addition, bone healing was radiographically and histologically examined. Results: SEM and EDX revealed that S-PRG nanofillers uniformly covered the dentin surface after coating. Dentin blocks coated with S-PRG nanofiller showed ion-releasing property, bacterial growth inhibition, and sterilization effects. In the experimental periodontitis model, S-PRG nanofiller coating significantly reduced clinical inflammatory parameters, such as GI (P < 0.01) and BOP (P < 0.05), compared to uncoated samples. In addition, PPD and CAL significantly decreased by S-PRG nanofiller coating (2 weeks: P < 0.05; 3 and 4 weeks: P < 0.01), suggesting the improvement of periodontitis. Micro-CT and histology revealed that bone healing of furcation defects was enhanced by S-PRG nanofiller coating. Conclusion: S-PRG nanofiller coating provides antibacterial effects to tooth surfaces and improves clinical parameters of periodontitis.
Keywords	Actinomyces naeslundii ; Animal model ; Antibacterial activity ; Anti-inflammatory ; Class II furcation defect ; Ion-releasing ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	620
Language	English
Publishing date	2021-02-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Brain stem as a target site for the metabolic side effects of olanzapine.

Anwar, Imran J / Miyata, Kayoko / Zsombok, Andrea

Journal of neurophysiology

2016 Volume 115, Issue 3, Page(s) 1389–1398

Abstract: Olanzapine, an atypical antipsychotic, is widely prescribed for the treatment of schizophrenia and bipolar disorder despite causing undesirable metabolic side effects. A variety of mechanisms and brain sites have been proposed as contributors to the side ...

Abstract	Olanzapine, an atypical antipsychotic, is widely prescribed for the treatment of schizophrenia and bipolar disorder despite causing undesirable metabolic side effects. A variety of mechanisms and brain sites have been proposed as contributors to the side effects; however, the role of the dorsal motor nucleus of the vagus nerve (DMV), which plays a crucial role in the regulation of subdiaphragmatic organs and thus governs energy and glucose homeostasis, is largely unknown. Identifying the effect of olanzapine on the excitability of DMV neurons in both sexes is thus crucial to understanding possible underlying mechanisms. Whole cell patch-clamp electrophysiological recordings were conducted in stomach- and liver-related DMV neurons identified with retrograde viral tracers and in random DMV neurons. The effect of olanzapine on the neuronal excitability of DMV neurons both in male and female mice was established. Our data demonstrate that olanzapine hyperpolarizes the DMV neurons in both sexes and this effect is reversible. The hyperpolarization is associated with decreased firing rate and input resistance. Olanzapine also decreases the excitability of a subset of stomach- and liver-related DMV neurons. Our study demonstrates that olanzapine has a powerful effect on DMV neurons in both sexes, indicating its ability to reduce vagal output to the subdiaphragmatic organs, which likely contributes to the metabolic side effects observed in both humans and experimental models. These findings suggest that the metabolic side effects of olanzapine may partially originate in the DMV.
MeSH term(s)	Action Potentials ; Animals ; Antipsychotic Agents/adverse effects ; Benzodiazepines/adverse effects ; Brain Stem/drug effects ; Brain Stem/physiology ; Female ; Liver/innervation ; Male ; Mice ; Mice, Inbred C57BL ; Motor Neurons/drug effects ; Motor Neurons/physiology ; Stomach/innervation ; Vagus Nerve/drug effects ; Vagus Nerve/physiology
Chemical Substances	Antipsychotic Agents ; Benzodiazepines (12794-10-4) ; olanzapine (N7U69T4SZR)
Language	English
Publishing date	2016-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	80161-6
ISSN	1522-1598 ; 0022-3077
ISSN (online)	1522-1598
ISSN	0022-3077
DOI	10.1152/jn.00387.2015
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Article ; Online: Impairment of Iodine-123-Metaiodobenzylguanidine (

Higo, Kenjuro / Kubota, Kayoko / Miyanaga, Sunao / Miyata, Masaaki / Nakajo, Masatoyo / Jinguji, Megumi / Ohishi, Mitsuru

International heart journal

2018 Volume 59, Issue 1, Page(s) 112–119

Abstract: According to recent studies, lung uptake of iodine-123-metaiodobenzylguanidine ( ...

Abstract	According to recent studies, lung uptake of iodine-123-metaiodobenzylguanidine (
MeSH term(s)	3-Iodobenzylguanidine/administration & dosage ; 3-Iodobenzylguanidine/pharmacokinetics ; Adult ; Aged ; Cardiac Catheterization ; Echocardiography ; Endothelium, Vascular/physiopathology ; Exercise Test ; Female ; Humans ; Hypertension, Pulmonary/diagnosis ; Hypertension, Pulmonary/metabolism ; Hypertension, Pulmonary/physiopathology ; Lung/diagnostic imaging ; Lung/metabolism ; Male ; Middle Aged ; Pulmonary Artery/diagnostic imaging ; Pulmonary Artery/physiopathology ; Pulmonary Wedge Pressure/physiology ; Radionuclide Imaging/methods ; Radiopharmaceuticals/administration & dosage ; Radiopharmaceuticals/pharmacokinetics ; Retrospective Studies ; Stroke Volume/physiology ; Tomography, X-Ray Computed ; Ventricular Function, Left/physiology ; Ventricular Function, Right/physiology ; Young Adult
Chemical Substances	Radiopharmaceuticals ; 3-Iodobenzylguanidine (35MRW7B4AD)
Language	English
Publishing date	2018-01-27
Publishing country	Japan
Document type	Comparative Study ; Journal Article
ZDB-ID	2187806-7
ISSN	1349-3299 ; 1349-2365
ISSN (online)	1349-3299
ISSN	1349-2365
DOI	10.1536/ihj.16-629
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Zs.A 211: Show issues

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Article ; Online: Bone forming ability of recombinant human collagen peptide granules applied with β-tricalcium phosphate fine particles.

Furihata, Tomokazu / Miyaji, Hirofumi / Nishida, Erika / Kato, Akihito / Miyata, Saori / Shitomi, Kanako / Mayumi, Kayoko / Kanemoto, Yukimi / Sugaya, Tsutomu / Akasaka, Tsukasa

Journal of biomedical materials research. Part B, Applied biomaterials

2020 Volume 108, Issue 7, Page(s) 3033–3044

Abstract: Recombinant human collagen peptide, developed based on human collagen type I, contains an arginyl-glycyl-aspartic acid (RGD)-rich motif to enhance cell behavior and is anticipated as a xeno-free polymer material for use in tissue engineering. We ... ...

Abstract	Recombinant human collagen peptide, developed based on human collagen type I, contains an arginyl-glycyl-aspartic acid (RGD)-rich motif to enhance cell behavior and is anticipated as a xeno-free polymer material for use in tissue engineering. We fabricated granules containing recombinant human collagen peptide (RCP) applied with beta-tricalcium phosphate fine particles (RCP/β-TCP) as bone filling scaffold material and assessed the bone forming ability of RCP/β-TCP. Recombinant peptide was thermal crosslinked and freeze-dried to prepare RCP. An aqueous dispersion of β-TCP fine particles was added to RCP to obtain RCP/β-TCP. Subsequently, RCP/β-TCP were characterized using scanning electron microscopy (SEM), energy dispersive X-ray spectrometry (EDX), and cell culture assessments. Furthermore, RCP/β-TCP were implanted into rat cranial bone defects for radiographic and histological evaluations. In SEM and EDX analyses of RCP/β-TCP, β-TCP particles dose-dependently covered the surface of RCP. Cell culture tests showed that RCP/β-TCP remarkably promoted proliferation and mRNA expression of various genes, such as integrin β1 and osteogenic markers, of osteoblastic MC3T3-E1 cells. Histomorphometric assessment at 4 weeks showed that RCP/β-TCP significantly promoted new skull bone formation compared to RCP (p < 0.05) and control (no application) (p < 0.01). Accordingly, these findings suggest RCP/β-TCP possess bone forming capability and would be beneficial for bone tissue engineering therapy.
MeSH term(s)	Animals ; Calcium Phosphates/chemistry ; Calcium Phosphates/pharmacology ; Cell Line ; Collagen/chemistry ; Collagen/pharmacology ; Humans ; Male ; Mice ; Osteoblasts/metabolism ; Osteogenesis/drug effects ; Peptides/chemistry ; Peptides/pharmacology ; Rats ; Rats, Wistar ; Recombinant Proteins/chemistry ; Recombinant Proteins/pharmacology
Chemical Substances	Calcium Phosphates ; Peptides ; Recombinant Proteins ; beta-tricalcium phosphate ; Collagen (9007-34-5)
Language	English
Publishing date	2020-05-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2099992-6
ISSN	1552-4981 ; 1552-4973 ; 0021-9304
ISSN (online)	1552-4981
ISSN	1552-4973 ; 0021-9304
DOI	10.1002/jbm.b.34632
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Article ; Online: [Investigation the contents of employment consultation and support in a cancer center hospital].

Kaku, Sawako / Miyata, Kayoko / Tsuchiya, Miyako / Kusaka, Sachiko / Koitabashi, Miho / Moroi, Natsuko / Shimizu, Rieko / Shimizu, Mariko / Arai, Mari / Yabumoto, Masako / Matsunaga, Naoko / Maeda, Ryoko / Iwasa, Satoru / Horinouchi, Hidehito / Satomi, Eriko

Sangyo eiseigaku zasshi = Journal of occupational health

2021 Volume 64, Issue 6, Page(s) 337–344

Abstract: Objectives: This study aimed to analyze and categorize the actual situation of employment consultation and support according to consultation times or employment status at the Consultation Support Center of the National Cancer Center Hospital of Japan.!## ...

Abstract	Objectives: This study aimed to analyze and categorize the actual situation of employment consultation and support according to consultation times or employment status at the Consultation Support Center of the National Cancer Center Hospital of Japan. Methods: We retrospectively analyzed the patient backgrounds, consultation contents, and the number of employment consultation cases conducted at the Consultation Support Center of the National Cancer Center Hospital during a 6-month period from May to December 2018. Results: During the study period, 117 patients (male: female = 46:71) visited the Consultation Support Center. The median age of patients was 48 years old. The most common primary cancer site was the breast in 28 patients followed by the lung in 16 patients, and then gynecologic cancer in 10 patients. The most common cancer treatment was chemotherapy in 53 patients (45.3%), and 12 patients (10.2%) were recurrent patients. Fifty-two patients were in regular employment, 24 were unemployed, 17 were of unknown employment status, 16 were in non-regular employment, and 8 were classified/categorized as other. In terms of working status, 40 were on leave, 35 were working, 15 were seeking work, 8 were unemployed, and 19 were categorized as other. The median number of consultations was 1 (1,11). The content of consultations was the social security system in 44 cases (37.6%) job seeking in 24 cases (20.5%), how to inform the workplace in 14 cases (12%), and workplace environment adjustment in 13 cases (11.1%). Conclusions: We conducted a survey on the actual status of employment consultation in a cancer center hospital. The majority of consultations were completed in one session. In terms of the content of consultations, there was a high need for consultations on the social security system and job seeking. Further study is needed on the characteristics of employment consultations according to employment status and other attributes.
MeSH term(s)	Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Employment ; Workplace ; Referral and Consultation ; Cancer Care Facilities ; Neoplasms
Language	Japanese
Publishing date	2021-12-16
Publishing country	Japan
Document type	English Abstract ; Journal Article
ZDB-ID	1234922-7
ISSN	1349-533X ; 1341-0725
ISSN (online)	1349-533X
ISSN	1341-0725
DOI	10.1539/sangyoeisei.2021-019-E
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