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  1. Article ; Online: Noninvasive Respiratory Support in Adult Patients With COVID-19: Current Role and Research Challenges.

    Ferreyro, Bruno L / Gorman, Ellen A / Angriman, Federico

    Critical care medicine

    2023  Volume 51, Issue 11, Page(s) 1602–1607

    MeSH term(s) Humans ; Adult ; COVID-19 ; SARS-CoV-2 ; Respiratory Insufficiency ; Noninvasive Ventilation
    Language English
    Publishing date 2023-10-12
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000005986
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1261: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: Reducing safety behaviors to prevent anxious symptoms: a pre-registered prevention intervention study.

    Gorman, Ellen L / Goodson, Jason T / Haeffel, Gerald J

    Cognitive behaviour therapy

    2023  Volume 52, Issue 6, Page(s) 641–653

    Abstract: The purpose of this pre-registered study was to test the efficacy of a simple, low-impact safety behavior prevention intervention for anxiety. The intervention was delivered online using a 4-week workbook format. Participants ( ...

    Abstract The purpose of this pre-registered study was to test the efficacy of a simple, low-impact safety behavior prevention intervention for anxiety. The intervention was delivered online using a 4-week workbook format. Participants (
    Language English
    Publishing date 2023-07-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2076060-7
    ISSN 1651-2316 ; 1650-6073
    ISSN (online) 1651-2316
    ISSN 1650-6073
    DOI 10.1080/16506073.2023.2237671
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    Zs.A 3702: Show issues Location:
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  3. Article: Case report: Dendritic cell-cytokine induced killer cell therapy in subjects with chronic lymphocytic leukemia and peritoneal cancer.

    Mehling, Brian / Wu, DongCheng / O'Gorman, Ellen / Sheridan, Daniel / Santora, Doreen / Mihályová, Renata

    Frontiers in medicine

    2023  Volume 10, Page(s) 1240330

    Abstract: This study aimed to characterize the safety and efficacy of DC-CIK therapy in two patients with previously treated chronic lymphocytic leukemia or peritoneal cancer, respectively. Participants had received conventional chemotherapy treatment for their ... ...

    Abstract This study aimed to characterize the safety and efficacy of DC-CIK therapy in two patients with previously treated chronic lymphocytic leukemia or peritoneal cancer, respectively. Participants had received conventional chemotherapy treatment for their specific cancers, and in addition, 1-2 treatments of DC-CIK therapy were administered to subjects over the course of 1 year. Subject A received an initial dosage of 3 intravenous infusions of DC-CIK therapy on three successive days and a repeat dosage 6 months later. Subject B received an initial dosage of 3 intravenous infusions of DC-CIK therapy on three successive days and received further chemotherapy after approximately 1 year. No treatment-related adverse events were reported, and both patients experienced favorable outcomes from the treatment, including enhanced treatment response, increased chemotherapy tolerance, and prolonged survival in comparison to typical 5-year survival rates.
    Language English
    Publishing date 2023-10-09
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1240330
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  4. Article ; Online: Acute respiratory distress syndrome in adults: diagnosis, outcomes, long-term sequelae, and management.

    Gorman, Ellen A / O'Kane, Cecilia M / McAuley, Daniel F

    Lancet (London, England)

    2022  Volume 400, Issue 10358, Page(s) 1157–1170

    Abstract: Acute respiratory distress syndrome (ARDS) is characterised by acute hypoxaemic respiratory failure with bilateral infiltrates on chest imaging, which is not fully explained by cardiac failure or fluid overload. ARDS is defined by the Berlin criteria. In ...

    Abstract Acute respiratory distress syndrome (ARDS) is characterised by acute hypoxaemic respiratory failure with bilateral infiltrates on chest imaging, which is not fully explained by cardiac failure or fluid overload. ARDS is defined by the Berlin criteria. In this Series paper the diagnosis, management, outcomes, and long-term sequelae of ARDS are reviewed. Potential limitations of the ARDS definition and evidence that could inform future revisions are considered. Guideline recommendations, evidence, and uncertainties in relation to ARDS management are discussed. The future of ARDS strives towards a precision medicine approach, and the framework of treatable traits in ARDS diagnosis and management is explored.
    MeSH term(s) Adult ; Diagnostic Imaging ; Humans ; Phenotype ; Respiratory Distress Syndrome/diagnosis ; Respiratory Distress Syndrome/etiology ; Respiratory Distress Syndrome/therapy ; Respiratory Insufficiency
    Language English
    Publishing date 2022-09-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(22)01439-8
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  5. Article: Transient Premature Ovarian Insufficiency Post-COVID-19 Infection.

    Gorman, Colleen N / Abdalla, Tori E / Sultan, Yasmina / Grabois, Spencer A / Wood, Ellen G

    Cureus

    2023  Volume 15, Issue 4, Page(s) e37379

    Abstract: Anti-ovarian antibodies (AOAs) have been linked to autoimmune premature ovarian insufficiency (POI). This report details a case in which a patient experienced transient POI after a COVID-19 infection and tested positive for AOA. After treatment with oral ...

    Abstract Anti-ovarian antibodies (AOAs) have been linked to autoimmune premature ovarian insufficiency (POI). This report details a case in which a patient experienced transient POI after a COVID-19 infection and tested positive for AOA. After treatment with oral contraceptives and subsequent high-dose oral corticosteroids, the patient underwent fertility treatment with in vitro fertilization (IVF). A total of 23 oocytes were retrieved. Two euploid blastocysts and three untested blastocysts were successfully created. This report hypothesizes the connection between autoimmune POI, AOA, and COVID-19. Conflicting data have been reported linking COVID-19 and ovarian injury. However, it is suggested that COVID-19 transiently impacts the menstrual cycle and anti-Mullerian hormone (AMH) levels. Treatment to overcome poor ovarian response due to AOA has not been adequately determined; however, similar autoimmune conditions have been successfully treated with corticosteroids.
    Language English
    Publishing date 2023-04-10
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.37379
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  6. Article ; Online: Feasibility of implementing patient-reported outcome measures into routine breast cancer care delivery using a novel collection and reporting platform.

    Tsangaris, Elena / Hyland, Colby / Liang, George / O'Gorman, Joanna / Huerta, Dany Thorpe / Kim, Ellen / Edelen, Maria / Pusic, Andrea

    JAMIA open

    2023  Volume 6, Issue 4, Page(s) ooad108

    Abstract: Objectives: imPROVE is a new Health Information Technology platform that enables systematic patient-reported outcome measure (PROM) collection through a mobile phone application. The purpose of this study is to describe our initial experience and ... ...

    Abstract Objectives: imPROVE is a new Health Information Technology platform that enables systematic patient-reported outcome measure (PROM) collection through a mobile phone application. The purpose of this study is to describe our initial experience and approach to implementing imPROVE among breast cancer patients treated in breast and plastic surgery clinics.
    Materials and methods: We describe our initial implementation in 4 phases between June 2021 and February 2022: preimplementation, followed by 3 consecutive implementation periods (P1, P2, P3). The Standards for Reporting Implementation Studies statement guided this study. Iterative Plan-Do-Study-Act (PDSA) cycles supported implementation, and success was evaluated using the Reach, Effectiveness, Adoption, Implementation, and Maintenance framework.
    Results: Qualitative interviews conducted during the preimplementation phase elicited 4 perceived implementation barriers. Further feedback collected during each phase of implementation resulted in the development of brochures, posters in clinic spaces, and scripts for clinic staff to streamline discussions with patients, and the resolution of technical issues concerning patient login capabilities, such as compatibility with cell phone software and barriers to downloading imPROVE. Feedback also generated ideas for facilitating provider interpretation of PROM results. By the end of P3, 2961 patients were eligible, 1375 (46.4%) downloaded imPROVE, and 1070 (36.1% of those eligible, 78% of those who downloaded) completed at least 1 PROM.
    Discussion and conclusion: Implementation efforts across 2 surgical departments at 2 academic teaching hospitals enabled collaboration across clinical specialties and longitudinal PROM reporting for patients receiving breast cancer care; the implementation effort also highlighted patient difficulties with mobile app-based PROM collection, particularly around initial engagement.
    Language English
    Publishing date 2023-12-26
    Publishing country United States
    Document type Journal Article
    ISSN 2574-2531
    ISSN (online) 2574-2531
    DOI 10.1093/jamiaopen/ooad108
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  7. Article ; Online: COVID-19 Convalescent Plasma for the Treatment of Immunocompromised Patients: A Systematic Review and Meta-analysis.

    Senefeld, Jonathon W / Franchini, Massimo / Mengoli, Carlo / Cruciani, Mario / Zani, Matteo / Gorman, Ellen K / Focosi, Daniele / Casadevall, Arturo / Joyner, Michael J

    JAMA network open

    2023  Volume 6, Issue 1, Page(s) e2250647

    Abstract: Importance: Patients who are immunocompromised have increased risk for morbidity and mortality associated with coronavirus disease 2019 (COVID-19) because they less frequently mount antibody responses to vaccines. Although neutralizing anti-spike ... ...

    Abstract Importance: Patients who are immunocompromised have increased risk for morbidity and mortality associated with coronavirus disease 2019 (COVID-19) because they less frequently mount antibody responses to vaccines. Although neutralizing anti-spike monoclonal-antibody treatment has been widely used to treat COVID-19, evolutions of SARS-CoV-2 have been associated with monoclonal antibody-resistant SARS-CoV-2 variants and greater virulence and transmissibility of SARS-CoV-2. Thus, the therapeutic use of COVID-19 convalescent plasma has increased on the presumption that such plasma contains potentially therapeutic antibodies to SARS-CoV-2 that can be passively transferred to the plasma recipient.
    Objective: To assess the growing number of reports of clinical experiences of patients with COVID-19 who are immunocompromised and treated with specific neutralizing antibodies via COVID-19 convalescent plasma transfusion.
    Data sources: On August 12, 2022, a systematic search was performed for clinical studies of COVID-19 convalescent plasma use in patients who are immunocompromised.
    Study selection: Randomized clinical trials, matched cohort studies, and case report or series on COVID-19 convalescent plasma use in patients who are immunocompromised were included. The electronic search yielded 462 unique records, of which 199 were considered for full-text screening.
    Data extraction and synthesis: The study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Data were extracted by 3 independent reviewers in duplicate and pooled.
    Main outcomes and meaures: The prespecified end point was all-cause mortality after COVID-19 convalescent plasma transfusion; exploratory subgroup analyses were performed based on putative factors associated with the potential mortality benefit of convalescent plasma.
    Results: This systematic review and meta-analysis included 3 randomized clinical trials enrolling 1487 participants and 5 controlled studies. Additionally, 125 case series or reports enrolling 265 participants and 13 uncontrolled large case series enrolling 358 participants were included. Separate meta-analyses, using models both stratified and pooled by study type (ie, randomized clinical trials and matched cohort studies), demonstrated that transfusion of COVID-19 convalescent plasma was associated with a decrease in mortality compared with the control cohort for the amalgam of both randomized clinical trials and matched cohort studies (risk ratio [RR], 0.63 [95% CI, 0.50-0.79]).
    Conclusions and relevance: These findings suggest that transfusion of COVID-19 convalescent plasma is associated with mortality benefit for patients who are immunocompromised and have COVID-19.
    MeSH term(s) Humans ; COVID-19/therapy ; COVID-19/etiology ; SARS-CoV-2 ; Blood Component Transfusion ; Immunization, Passive ; Plasma ; COVID-19 Serotherapy ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2023-01-03
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2022.50647
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  8. Article ; Online: Mesenchymal stromal cells for acute respiratory distress syndrome (ARDS), sepsis, and COVID-19 infection: optimizing the therapeutic potential.

    Gorman, Ellen / Millar, Jonathan / McAuley, Danny / O'Kane, Cecilia

    Expert review of respiratory medicine

    2020  Volume 15, Issue 3, Page(s) 301–324

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) COVID-19/epidemiology ; COVID-19/therapy ; Comorbidity ; Humans ; Mesenchymal Stem Cell Transplantation/methods ; Mesenchymal Stem Cells/cytology ; Pandemics ; Respiratory Distress Syndrome/epidemiology ; Respiratory Distress Syndrome/therapy ; SARS-CoV-2 ; Sepsis/epidemiology ; Sepsis/therapy
    Keywords covid19
    Language English
    Publishing date 2020-11-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2479146-5
    ISSN 1747-6356 ; 1747-6348
    ISSN (online) 1747-6356
    ISSN 1747-6348
    DOI 10.1080/17476348.2021.1848555
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    Zs.A 6963: Show issues Location:
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  9. Article ; Online: Non-invasive respiratory support strategies in COVID-19.

    Gorman, Ellen / Connolly, Bronwen / Couper, Keith / Perkins, Gavin D / McAuley, Daniel F

    The Lancet. Respiratory medicine

    2021  Volume 9, Issue 6, Page(s) 553–556

    MeSH term(s) COVID-19/physiopathology ; COVID-19/prevention & control ; COVID-19/therapy ; Humans ; Infection Control/organization & administration ; Infectious Disease Transmission, Patient-to-Professional/prevention & control ; Noninvasive Ventilation/classification ; Noninvasive Ventilation/methods ; Patient Selection ; Respiration, Artificial/adverse effects ; Respiration, Artificial/methods ; Respiratory Insufficiency/etiology ; Respiratory Insufficiency/therapy ; Risk Adjustment/methods ; Risk Assessment ; SARS-CoV-2 ; Time-to-Treatment
    Language English
    Publishing date 2021-04-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(21)00168-5
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    Zs.A 7041: Show issues Location:
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  10. Article ; Online: Development of an Institution-Wide Pediatric End-of-Life Summit.

    Edson, JoEllen / Abecassis, Leah / Beke, Dorothy M / McGorman, Tara

    Journal of hospice and palliative nursing : JHPN : the official journal of the Hospice and Palliative Nurses Association

    2023  Volume 26, Issue 1, Page(s) 36–40

    Abstract: End-of-life (EOL) care in pediatrics is a unique subspecialty lacking adequate provider education and training. Patient and family outcomes may improve when clinicians are provided with training in this care. Recognizing the need for this specialized ... ...

    Abstract End-of-life (EOL) care in pediatrics is a unique subspecialty lacking adequate provider education and training. Patient and family outcomes may improve when clinicians are provided with training in this care. Recognizing the need for this specialized education, a small group of bereavement coordinators created an institution-wide pediatric EOL summit at a large urban pediatric teaching hospital. One hundred forty-five clinicians from 14 diverse disciplines attended the first annual pediatric EOL summit. A survey was sent to the participants for feedback. The survey results suggested an overwhelmingly positive response to the summit. Continuing to provide this educational conference is critical to improving care for patients and families, particularly at the end of life.
    MeSH term(s) Humans ; Child ; Terminal Care ; Hospice Care ; Surveys and Questionnaires ; Bereavement ; Death
    Language English
    Publishing date 2023-10-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2070862-2
    ISSN 1539-0705 ; 1522-2179
    ISSN (online) 1539-0705
    ISSN 1522-2179
    DOI 10.1097/NJH.0000000000000982
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