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Article: Screening Eucalyptus cloeziana and E. argophloia Populations for Resistance to Puccinia psidii.

Lee, D J / Brawner, J T / Pegg, G S

2015 Volume 99, Issue 1, Page(s) 71–79

Abstract: ... E. argophloia. Artificial inoculation with a single-lesion isolate of P. psidii was used to screen ... to characterize resistance to P. psidii within these two distinct species: E. argophloia, a vulnerable species ... with a narrow distribution, and E. cloeziana, a species with a broad and extensive distribution in Queensland ...

Abstract	Disease screening to determine the threat Puccinia psidii poses to plantation and native eucalypts in Australia was undertaken in half-sib families of two contrasting eucalypt species, Eucalyptus cloeziana and E. argophloia. Artificial inoculation with a single-lesion isolate of P. psidii was used to screen these species for resistance to the biotype of P. psidii established in Australia. The objective was to characterize resistance to P. psidii within these two distinct species: E. argophloia, a vulnerable species with a narrow distribution, and E. cloeziana, a species with a broad and extensive distribution in Queensland. Results for E. cloeziana indicate that inland provenances are more resistant to P. psidii infection than provenances from coastal regions. Heritability estimates for the two assessment systems used (resistance on a 1-to-5 ordinal scale verses resistance on a 0-to-1 binomial scale) were low to high (0.24 to 0.63) for E. argophloia and moderate to high (0.4 to 0.91) for E. cloeziana, indicating a significant level of additive genetic variance for rust resistance within the populations. This study demonstrates the potential to select resistant families within the tested populations and indicates that P. psidii could detrimentally affect these species in native forests, nurseries, and plantations.
Language	English
Publishing date	2015-04-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	754182-x
ISSN	0191-2917
ISSN	0191-2917
DOI	10.1094/PDIS-04-14-0353-RE
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Article ; Online: Neural markers of emotion regulation difficulties in adolescent depression and risk for depression.

Dickey, Lindsay / Dao, Anh / Pegg, Samantha / Kujawa, Autumn

Journal of mood and anxiety disorders

2024 Volume 5

Abstract: ... than non-depressed individuals while using adaptive strategies (e.g., reappraisal) less frequently ...

Abstract	Depressed individuals tend to use maladaptive emotion regulation strategies more frequently than non-depressed individuals while using adaptive strategies (e.g., reappraisal) less frequently. Objective neural markers of emotion regulation ability could aid in identifying youth at greatest risk for depression and functional impairment more broadly. We used electroencephalography to examine emotion regulation in adolescents (aged 14-17;
Language	English
Publishing date	2024-01-19
Publishing country	United States
Document type	Journal Article
ISSN	2950-0044
ISSN (online)	2950-0044
DOI	10.1016/j.xjmad.2024.100051
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Article: Bone morphogenic protein signalling suppresses differentiation of pluripotent cells by maintaining expression of E-Cadherin.

Malaguti, Mattias / Nistor, Paul A / Blin, Guillaume / Pegg, Amy / Zhou, Xinzhi / Lowell, Sally

eLife

2013 Volume 2, Page(s) e01197

Abstract: Bone morphogenic protein (BMP) signalling contributes towards maintenance of pluripotency and favours mesodermal over neural fates upon differentiation, but the mechanisms by which BMP controls differentiation are not well understood. We report that BMP ... ...

Abstract	Bone morphogenic protein (BMP) signalling contributes towards maintenance of pluripotency and favours mesodermal over neural fates upon differentiation, but the mechanisms by which BMP controls differentiation are not well understood. We report that BMP regulates differentiation by blocking downregulation of Cdh1, an event that accompanies the earliest stages of neural and mesodermal differentiation. We find that loss of Cdh1 is a limiting requirement for differentiation of pluripotent cells, and that experimental suppression of Cdh1 activity rescues the BMP-imposed block to differentiation. We further show that BMP acts prior to and independently of Cdh1 to prime pluripotent cells for mesoderm differentiation, thus helping to reinforce the block to neural differentiation. We conclude that differentiation depends not only on exposure to appropriate extrinsic cues but also on morphogenetic events that control receptivity to those differentiation cues, and we explain how a key pluripotency signal, BMP, feeds into this control mechanism. DOI: http://dx.doi.org/10.7554/eLife.01197.001.
MeSH term(s)	Bone Morphogenetic Proteins/metabolism ; Cadherins/metabolism ; Cell Differentiation ; Humans ; Inhibitor of Differentiation Protein 1/genetics ; Pluripotent Stem Cells/cytology ; Pluripotent Stem Cells/metabolism ; Signal Transduction
Chemical Substances	Bone Morphogenetic Proteins ; Cadherins ; ID1 protein, human ; Inhibitor of Differentiation Protein 1
Language	English
Publishing date	2013-12-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2687154-3
ISSN	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.01197
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Article ; Online: The relevance of ice crystal formation for the cryopreservation of tissues and organs.

Pegg, David E

Cryobiology

2020 Volume 93, Page(s) 3–11

Abstract: This paper discusses the role of ice crystal formation in causing or contributing to the difficulties that have been encountered in attempts to develop effective methods for the cryopreservation of some tissues and all organs. It is shown that ... ...

Abstract	This paper discusses the role of ice crystal formation in causing or contributing to the difficulties that have been encountered in attempts to develop effective methods for the cryopreservation of some tissues and all organs. It is shown that extracellular ice can be severely damaging but also that cells in situ in tissues can behave quite differently from similar cells in a suspension with respect to intracellular freezing. It is concluded that techniques that avoid the formation of ice altogether are most likely to yield effective methods for the cryopreservation of recalcitrant tissues and vascularised organs.
MeSH term(s)	Cryopreservation/methods ; Freezing ; Humans ; Ice ; Kidney ; Microcirculation ; Organ Preservation/methods
Chemical Substances	Ice
Language	English
Publishing date	2020-02-12
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	80098-3
ISSN	1090-2392 ; 0011-2240
ISSN (online)	1090-2392
ISSN	0011-2240
DOI	10.1016/j.cryobiol.2020.01.005
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Book: Polyamines

Pegg, Anthony E. / Casero, Robert A.

methods and protocols

(Methods in molecular biology ; 720 ; Springer protocols)

2011

Author's details	ed. by Anthony E. Pegg ; Robert A. Casero
Series title	Methods in molecular biology ; 720 Springer protocols
Collection
Language	English
Size	XIV, 523 S. : Ill., graph. Darst.
Publisher	Humana Press
Publishing place	New York u.a.
Publishing country	United States
Document type	Book
HBZ-ID	HT016664040
ISBN	978-1-61779-033-1 ; 1-61779-033-8 ; 9781617790348 ; 1617790346
Database	Catalogue ZB MED Medicine, Health

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2011 A 1118	order for loan	Magazin

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Article ; Online: Pregabalin induces hepatic hypoxia and increases endothelial cell proliferation in mice, a process inhibited by dietary vitamin E supplementation.

Criswell, Kay A / Cook, Jon C / Morse, Dennis / Lawton, Michael / Somps, Christopher / Obert, Leslie / Roy, Marc / Sokolowski, Sharon / Koza-Taylor, Petra / Colangelo, Jennifer / Navetta, Kimberly / Brady, Joseph / Pegg, David / Wojcinski, Zbigniew / Rahbari, Ramin / Duddy, Steven / Anderson, Timothy

Toxicological sciences : an official journal of the Society of Toxicology

2012 Volume 128, Issue 1, Page(s) 42–56

Abstract: ... D. E., Jacobs, A. C., Klaunig, J. E., et al. (2009). Hemangiosarcoma in rodents: Mode-of-action ... species specificity. Dietary supplementation with vitamin E, which is known to have antioxidant and antiangiogenic ... Storer, R. D., Criswell, K. A., Doerrer, N. G., Dellarco, V. L., Pegg, D. G., Wojcinski, Z. W., Malarkey ...

Abstract	The preceding article identified key components of pregabalin's mode of action on nongenotoxic hemangiosarcoma formation in mice, including increased serum bicarbonate leading to decreased respiratory rate, increased blood pH, increased venous oxygen saturation, increased vascular endothelial growth factor and basic fibroblast growth factor expression, increased hepatic vascular endothelial growth factor receptor 2 expression, and increased iron-laden macrophages. Increased platelet count and platelet activation were early, species-specific biomarkers in mice. Dysregulated erythropoiesis, macrophage activation, and elevations of tissue growth factors were consistent with the unified mode of action for nongenotoxic hemangiosarcoma recently proposed at an international hemangiosarcoma workshop (Cohen, S. M., Storer, R. D., Criswell, K. A., Doerrer, N. G., Dellarco, V. L., Pegg, D. G., Wojcinski, Z. W., Malarkey, D. E., Jacobs, A. C., Klaunig, J. E., et al. (2009). Hemangiosarcoma in rodents: Mode-of-action evaluation and human relevance. Toxicol. Sci. 111, 4-18). In this article, we present evidence that pregabalin induces hypoxia and increases endothelial cell (EC) proliferation in a species-specific manner. Dietary administration of pregabalin produced a significant 35% increase in an immunohistochemical stain for hypoxia (Hypoxyprobe) in livers from pregabalin-treated mice. Increased Hypoxyprobe staining was not observed in the liver, bone marrow, or spleen of rats, supporting the hypothesis that pregabalin produces local tissue hypoxia in a species-specific manner. Transcriptional analysis supports that rats, unlike mice, adapt to pregabalin-induced hypoxia. Using a dual-label method, increased EC proliferation was observed as early as 2 weeks in mouse liver and 12 weeks in bone marrow following pregabalin administration. These same assays showed decreased EC proliferation in hepatic ECs of rats, further supporting species specificity. Dietary supplementation with vitamin E, which is known to have antioxidant and antiangiogenic activity, inhibited pregabalin-induced increases in mouse hepatic EC proliferation, providing confirmatory evidence for the proposed mode of action and its species-specific response.
MeSH term(s)	Animals ; Cell Hypoxia ; Cell Proliferation/drug effects ; Chromatography, High Pressure Liquid ; Diet ; Endothelium, Vascular/cytology ; Endothelium, Vascular/drug effects ; Female ; Liver/cytology ; Liver/drug effects ; Mice ; Pregabalin ; Vitamin E/administration & dosage ; gamma-Aminobutyric Acid/analogs & derivatives ; gamma-Aminobutyric Acid/toxicity
Chemical Substances	Vitamin E (1406-18-4) ; Pregabalin (55JG375S6M) ; gamma-Aminobutyric Acid (56-12-2)
Language	English
Publishing date	2012-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1420885-4
ISSN	1096-0929 ; 1096-6080
ISSN (online)	1096-0929
ISSN	1096-6080
DOI	10.1093/toxsci/kfs148
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Article ; Online: Unique Characteristics of the Parasite Polyamine Pathway.

Pegg, Anthony E

Structure (London, England : 1993)

2018 Volume 26, Issue 11, Page(s) 1427–1429

Abstract: A critical function of spermidine is in the formation of hypusine, an essential post-translational modification of eukaryotic initiation factor eIF5A. In this issue of Structure, Afandor et al. (2018) determine the crystal structure of trypanosomal ... ...

Abstract	A critical function of spermidine is in the formation of hypusine, an essential post-translational modification of eukaryotic initiation factor eIF5A. In this issue of Structure, Afandor et al. (2018) determine the crystal structure of trypanosomal deoxyhypusine synthase, which shows that gene duplication and subsequent mutations provide significant differences from the mammalian equivalent exploitable for drug design.
MeSH term(s)	Animals ; Oxidoreductases Acting on CH-NH Group Donors ; Parasites ; Peptide Initiation Factors ; Polyamines ; RNA-Binding Proteins
Chemical Substances	Peptide Initiation Factors ; Polyamines ; RNA-Binding Proteins ; Oxidoreductases Acting on CH-NH Group Donors (EC 1.5.-) ; deoxyhypusine synthase (EC 1.5.1.-)
Language	English
Publishing date	2018-12-21
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	1213087-4
ISSN	1878-4186 ; 0969-2126
ISSN (online)	1878-4186
ISSN	0969-2126
DOI	10.1016/j.str.2018.10.018
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Article ; Online: Introduction to the Thematic Minireview Series: Sixty plus years of polyamine research.

Pegg, Anthony E

The Journal of biological chemistry

2018 Volume 293, Issue 48, Page(s) 18681–18692

Abstract: Polyamines have a long history in biochemistry and physiology, dating back to 1678 when Leeuwenhoek first reported crystals that were composed of spermine phosphate in seminal fluid. Their quantification and biosynthetic pathway were first described by ... ...

Abstract	Polyamines have a long history in biochemistry and physiology, dating back to 1678 when Leeuwenhoek first reported crystals that were composed of spermine phosphate in seminal fluid. Their quantification and biosynthetic pathway were first described by Herb and Celia Tabor in collaboration with Sanford Rosenthal in the late 1950s. This work led to immense interest in their physiological functions. The 11 Minireviews in this collection illustrate many of the wide-ranging biochemical effects of the polyamines. This series provides a fitting tribute to Herb Tabor on the occasion of his 100th birthday, demonstrating clearly the importance and growth of the research field that he pioneered in the late 1950s and has contributed to for many years. His studies of the synthesis, function, and toxicity of polyamines have yielded multiple insights into fundamental biochemical processes and formed the basis of successful and continuing drug development. This Minireview series reviews the highly diverse properties of polyamines in bacteria, protozoa, and mammals, highlighting the importance of these molecules in growth, development, and response to the environment, and their involvement in diseases, including cancer, and those caused by parasitic protozoans.
MeSH term(s)	Animals ; Biomedical Research/history ; History, 17th Century ; History, 18th Century ; History, 19th Century ; History, 20th Century ; History, 21st Century ; Humans ; Neoplasms/genetics ; Neoplasms/history ; Neoplasms/metabolism ; Polyamines/chemistry ; Polyamines/history ; Polyamines/metabolism
Chemical Substances	Polyamines
Language	English
Publishing date	2018-10-30
Publishing country	United States
Document type	Historical Article ; Journal Article ; Review
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.TM118.006291
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Article ; Online: Bone morphogenic protein signalling suppresses differentiation of pluripotent cells by maintaining expression of E-Cadherin

Mattias Malaguti / Paul A Nistor / Guillaume Blin / Amy Pegg / Xinzhi Zhou / Sally Lowell

eLife, Vol

2013 Volume 2

Abstract	Bone morphogenic protein (BMP) signalling contributes towards maintenance of pluripotency and favours mesodermal over neural fates upon differentiation, but the mechanisms by which BMP controls differentiation are not well understood. We report that BMP regulates differentiation by blocking downregulation of Cdh1, an event that accompanies the earliest stages of neural and mesodermal differentiation. We find that loss of Cdh1 is a limiting requirement for differentiation of pluripotent cells, and that experimental suppression of Cdh1 activity rescues the BMP-imposed block to differentiation. We further show that BMP acts prior to and independently of Cdh1 to prime pluripotent cells for mesoderm differentiation, thus helping to reinforce the block to neural differentiation. We conclude that differentiation depends not only on exposure to appropriate extrinsic cues but also on morphogenetic events that control receptivity to those differentiation cues, and we explain how a key pluripotency signal, BMP, feeds into this control mechanism.
Keywords	BMP ; Id1 ; pluripotent stem cell ; Cdh1 ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
Subject code	571
Language	English
Publishing date	2013-12-01T00:00:00Z
Publisher	eLife Sciences Publications Ltd
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: The relevance of ice crystal formation for the cryopreservation of tissues and organs

Pegg, David E

Cryobiology. 2020 Apr., v. 93

2020

Abstract	This paper discusses the role of ice crystal formation in causing or contributing to the difficulties that have been encountered in attempts to develop effective methods for the cryopreservation of some tissues and all organs. It is shown that extracellular ice can be severely damaging but also that cells in situ in tissues can behave quite differently from similar cells in a suspension with respect to intracellular freezing. It is concluded that techniques that avoid the formation of ice altogether are most likely to yield effective methods for the cryopreservation of recalcitrant tissues and vascularised organs.
Keywords	cryobiology ; cryopreservation ; ice
Language	English
Dates of publication	2020-04
Size	p. 3-11.
Publishing place	Elsevier Inc.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	80098-3
ISSN	1090-2392 ; 0011-2240
ISSN (online)	1090-2392
ISSN	0011-2240
DOI	10.1016/j.cryobiol.2020.01.005
Database	NAL-Catalogue (AGRICOLA)

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