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Article: Tretinoin 0.05% Lotion for the Once-Daily Treatment of Moderate and Severe Acne Vulgaris in Females: Effect of Age on Efficacy and Tolerability

Stein Gold, Linda / Pariser, David M. / Guenin, Eric

2019 Volume 18, Issue 12, Page(s) 1218–1225

MeSH term(s)	Acne Vulgaris/drug therapy ; Acne Vulgaris/pathology ; Administration, Cutaneous ; Adolescent ; Adult ; Age Factors ; Double-Blind Method ; Female ; Humans ; Keratolytic Agents/administration & dosage ; Keratolytic Agents/adverse effects ; Quality of Life ; Severity of Illness Index ; Skin Cream ; Surveys and Questionnaires ; Treatment Outcome ; Tretinoin/administration & dosage ; Tretinoin/adverse effects ; Young Adult
Chemical Substances	Keratolytic Agents ; Tretinoin (5688UTC01R)
Language	English
Publishing date	2019-12-20
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial
ZDB-ID	2145090-0
ISSN	1545-9616
ISSN	1545-9616
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Article: Contact Reflectance Spectroscopy for Rapid, Accurate, and Nondestructive

Gold, Kaitlin M / Townsend, Philip A / Larson, Eric R / Herrmann, Ittai / Gevens, Amanda J

Phytopathology

2020 Volume 110, Issue 4, Page(s) 851–862

Abstract: Populations ... ...

Abstract	Populations of
MeSH term(s)	Genotype ; Phytophthora infestans ; Plant Diseases ; Solanum tuberosum ; Spectrum Analysis
Language	English
Publishing date	2020-02-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	208889-7
ISSN	1943-7684 ; 0031-949X
ISSN (online)	1943-7684
ISSN	0031-949X
DOI	10.1094/PHYTO-08-19-0294-R
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Zs.B 698: Show issues

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Article: A Longitudinal Examination of Real-World Sedentary Behavior in Adults with Schizophrenia-Spectrum Disorders in a Clinical Trial of Combined Oxytocin and Cognitive Behavioral Social Skills Training.

Browne, Julia / Harvey, Philip D / Buchanan, Robert W / Kelly, Deanna L / Strauss, Gregory P / Gold, James M / Holden, Jason L / Granholm, Eric

Behavioral sciences (Basel, Switzerland)

2022 Volume 12, Issue 3

Abstract: Sedentary behavior contributes to a shortened life expectancy in individuals with schizophrenia-spectrum disorders (SSDs), highlighting the need for effective interventions to improve health. This study examined whether reduced ecological momentary ... ...

Abstract	Sedentary behavior contributes to a shortened life expectancy in individuals with schizophrenia-spectrum disorders (SSDs), highlighting the need for effective interventions to improve health. This study examined whether reduced ecological momentary assessment (EMA) measures of sedentary activities were observed in individuals with SSDs who participated in a 24-week randomized trial of cognitive behavioral social skills training (CBSST) and either intranasal oxytocin or placebo (NCT01752712). Participants (
Language	English
Publishing date	2022-02-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2651997-5
ISSN	2076-328X
ISSN	2076-328X
DOI	10.3390/bs12030060
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Article: Age-Related Decline in BBB Function is More Pronounced in Males than Females.

Shao, Xingfeng / Shou, Qinyang / Felix, Kimberly / Ojogho, Brandon / Jiang, Xuejuan / Gold, Brian T / Herting, Megan M / Goldwaser, Eric L / Kochunov, Peter / Hong, L Elliot / Pappas, Ioannis / Braskie, Meredith / Kim, Hosung / Cen, Steven / Jann, Kay / Wang, Danny Jj

bioRxiv : the preprint server for biology

2024

Abstract: The blood-brain barrier (BBB) plays a pivotal role in protecting the central nervous system (CNS), shielding it from potential harmful entities. A natural decline of BBB function with aging has been reported in both animal and human studies, which may ... ...

Abstract	The blood-brain barrier (BBB) plays a pivotal role in protecting the central nervous system (CNS), shielding it from potential harmful entities. A natural decline of BBB function with aging has been reported in both animal and human studies, which may contribute to cognitive decline and neurodegenerative disorders. Limited data also suggest that being female may be associated with protective effects on BBB function. Here we investigated age and sex-dependent trajectories of perfusion and BBB water exchange rate (kw) across the lifespan in 186 cognitively normal participants spanning the ages of 8 to 92 years old, using a novel non-invasive diffusion prepared pseudo-continuous arterial spin labeling (DP-pCASL) MRI technique. We found that the pattern of BBB kw decline with aging varies across brain regions. Moreover, results from our novel DP-pCASL technique revealed a remarkable decline in BBB kw beginning in the early 60s, which was more pronounced in males. In addition, we observed sex differences in parietotemporal and hippocampal regions. Our findings provide in vivo results demonstrating sex differences in the decline of BBB function with aging, which may serve as a foundation for future investigations into perfusion and BBB function in neurodegenerative and other brain disorders.
Language	English
Publishing date	2024-01-15
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.01.12.575463
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Article: Tianeptine, an Antidepressant with Opioid Agonist Effects: Pharmacology and Abuse Potential, a Narrative Review.

Edinoff, Amber N / Sall, Saveen / Beckman, Scott P / Koepnick, Andrew D / Gold, Logan C / Jackson, Eric D / Wenger, Danielle M / Cornett, Elyse M / Murnane, Kevin S / Kaye, Adam M / Kaye, Alan D

Pain and therapy

2023 Volume 12, Issue 5, Page(s) 1121–1134

Abstract: Tianeptine is an antidepressant drug approved for the treatment of major depressive disorder in countries other than the US. It is classified as an atypical tricyclic antidepressant and has shown potential benefits in addressing anxiety and irritable ... ...

Abstract	Tianeptine is an antidepressant drug approved for the treatment of major depressive disorder in countries other than the US. It is classified as an atypical tricyclic antidepressant and has shown potential benefits in addressing anxiety and irritable bowel disease. However, it is important to note that tianeptine is not approved for any use by the United States Federal Drug Administration (FDA). Despite its lack of approval by the FDA, tianeptine has been distributed online and at small retail locations. The term "gas station drugs" refers to a wide range of substances typically available for purchase from gas stations, corner stores, bodegas, mini marts, smoke shops, and the Internet. These substances may be produced commercially by drug manufacturers or in clandestine laboratories to mimic the effects of more well-known illicit/controlled substances such as marijuana, cocaine, opioids, etc. Tianeptine has made its way to convenience stores and gas station shelves, branded as "Zaza" and "Tianna Red." It can also be obtained online from independent vendors without a prescription. Misuse of tianeptine can lead to euphoric, opioid-like highs with the potential for chronic users to develop dependence and tolerance. Overdose and use in suicide attempts have also been documented. This manuscript is a narrative review, highlighting the dangers of tianeptine and other gas station drugs and underscoring the urgent need to regulate these substances.
Language	English
Publishing date	2023-07-15
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2701614-6
ISSN	2193-651X ; 2193-8237
ISSN (online)	2193-651X
ISSN	2193-8237
DOI	10.1007/s40122-023-00539-5
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Article ; Online: Genetics re-establish the utility of 2-methylhopanes as cyanobacterial biomarkers before 750 million years ago.

Hoshino, Yosuke / Nettersheim, Benjamin J / Gold, David A / Hallmann, Christian / Vinnichenko, Galina / van Maldegem, Lennart M / Bishop, Caleb / Brocks, Jochen J / Gaucher, Eric A

Nature ecology & evolution

2023 Volume 7, Issue 12, Page(s) 2045–2054

Abstract: Fossilized lipids offer a rare glimpse into ancient ecosystems. 2-Methylhopanes in sedimentary rocks were once used to infer the importance of cyanobacteria as primary producers throughout geological history. However, the discovery of hopanoid C-2 ... ...

Abstract	Fossilized lipids offer a rare glimpse into ancient ecosystems. 2-Methylhopanes in sedimentary rocks were once used to infer the importance of cyanobacteria as primary producers throughout geological history. However, the discovery of hopanoid C-2 methyltransferase (HpnP) in Alphaproteobacteria led to the downfall of this molecular proxy. In the present study, we re-examined the distribution of HpnP in a new phylogenetic framework including recently proposed candidate phyla and re-interpreted a revised geological record of 2-methylhopanes based on contamination-free samples. We show that HpnP was probably present in the last common ancestor of cyanobacteria, while the gene appeared in Alphaproteobacteria only around 750 million years ago (Ma). A subsequent rise of sedimentary 2-methylhopanes around 600 Ma probably reflects the expansion of Alphaproteobacteria that coincided with the rise of eukaryotic algae-possibly connected by algal dependency on microbially produced vitamin B
MeSH term(s)	Phylogeny ; Ecosystem ; Cyanobacteria/genetics ; Plants ; Biomarkers
Chemical Substances	2-methylhopane ; Biomarkers
Language	English
Publishing date	2023-10-26
Publishing country	England
Document type	Journal Article
ISSN	2397-334X
ISSN (online)	2397-334X
DOI	10.1038/s41559-023-02223-5
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Article ; Online: Thyroid cancer necrosis not evident on imaging: A cautionary case series on poorly differentiated thyroid carcinoma diagnosed only on final pathology.

Beute, John E / Silberzweig, Alex M / Gold, Brandon S / Shaari, Ariana L / Kapustin, Danielle A / Matloob, Ammar / Dowling, Eric M / Starc, Michael T / Fan, Jun / Khorsandi, Azita S / Brandwein-Weber, Margaret / Urken, Mark L / Chai, Raymond L

American journal of otolaryngology

2023 Volume 45, Issue 1, Page(s) 104054

Abstract: Objective: Poorly-differentiated thyroid cancer (PDTC) is a highly aggressive malignancy which is recently defined and understudied in the radiologic literature. Necrosis is a key histopathologic criterion for the diagnosis of PDTC. We illustrate the ... ...

Abstract	Objective: Poorly-differentiated thyroid cancer (PDTC) is a highly aggressive malignancy which is recently defined and understudied in the radiologic literature. Necrosis is a key histopathologic criterion for the diagnosis of PDTC. We illustrate the current difficulty in accurate identification of histopathologic necrosis on preoperative imaging. Methods: A series of seven patients with the final diagnosis of PDTC from our institution were identified. Multimodality preoperative imaging was analyzed by two head and neck radiologists. Final pathology reports were queried confirming histopathologic evidence of necrosis. Results: Patients presented with a wide range of preoperative imaging features. A consistent imaging appearance confirming necrosis was not identified. All patients were subsequently upstaged to PDTC following final pathological analysis. Conclusion: A lack of definitive evidence of necrosis on preoperative imaging does not exclude the possibility of PDTC. We demonstrate the need for further research to establish a clear methodology for the preoperative diagnosis of PDTC.
MeSH term(s)	Humans ; Thyroid Neoplasms/diagnostic imaging ; Thyroid Neoplasms/surgery ; Adenocarcinoma ; Necrosis
Chemical Substances	prolinedithiocarbamate (135467-92-4)
Language	English
Publishing date	2023-09-15
Publishing country	United States
Document type	Case Reports
ZDB-ID	604541-8
ISSN	1532-818X ; 0196-0709
ISSN (online)	1532-818X
ISSN	0196-0709
DOI	10.1016/j.amjoto.2023.104054
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Article ; Online: Antimicrobial effects of blue light therapy against cutibacterium acnes: optimal dosing and impact of serial treatments.

Cotter, Eric J / Cotter, Lisa M / Riley, Colleen N / Dixon, Jonah / VanDerwerker, Nicholas / Ufot, Aniekanabasi Ime / Godfrey, Jared / Gold, David / Hetzel, Scott J / Safdar, Nasia / Grogan, Brian F

JSES international

2023 Volume 8, Issue 2, Page(s) 328–334

Abstract: Background: Blue light therapy (BLT) is a Food and Drug Administration cleared modality used in dermatology as an effective treatment of acne. The primary purpose of this study is to determine if there are dose-dependent antimicrobial effects of BLT ... ...

Abstract	Background: Blue light therapy (BLT) is a Food and Drug Administration cleared modality used in dermatology as an effective treatment of acne. The primary purpose of this study is to determine if there are dose-dependent antimicrobial effects of BLT against Methods: A known strain of Results: All BLT treatment regimens resulted in significantly fewer CFUs than their aggregate control plate CFUs ( Conclusion: BLT is an effective antimicrobial agent against this single virulent strain of
Language	English
Publishing date	2023-12-18
Publishing country	United States
Document type	Journal Article
ISSN	2666-6383
ISSN (online)	2666-6383
DOI	10.1016/j.jseint.2023.11.020
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Article: Early and Sustained Acne Lesion Reductions With Fixed-Dose Clindamycin Phosphate 1.2%/Adapalene 0.15%/Benzoyl Peroxide 3.1% Gel.

Harper, Julie C / Kircik, Leon H / Gold, Michael / Hebert, Adelaide A / Sugarman, Jeffrey L / Green, Lawrence / Gold, Linda Stein / Baldwin, Hilary / Guenin, Eric / DelRosso, James Q

Journal of drugs in dermatology : JDD

2024 Volume 23, Issue 3, Page(s) 125–131

Abstract: Background: A once-daily, three-pronged approach using an antibiotic, antibacterial, and retinoid may provide faster acne improvement versus monotherapy or dual-combination products. This post hoc analysis compared threshold acne lesion reductions with ... ...

Abstract	Background: A once-daily, three-pronged approach using an antibiotic, antibacterial, and retinoid may provide faster acne improvement versus monotherapy or dual-combination products. This post hoc analysis compared threshold acne lesion reductions with clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide 3.1% (CAB) gel—the first FDA-approved triple-combination topical acne product—to its dyads and vehicle. Methods: Phase 2 (N=741; NCT03170388) and phase 3 (N=183; N=180; NCT04214639; NCT04214652), double-blind, 12-week studies randomized participants aged ≥9 years with moderate-to-severe acne to once-daily CAB or vehicle gel; the phase 2 study included three additional dyad gel arms. The pooled percentage of participants achieving ≥33%, ≥50%, and ≥75% reduction in inflammatory and noninflammatory acne lesions was evaluated. Results: As early as week 4 in the phase 2 study, ≥33% reduction in inflammatory lesions occurred in a significantly greater percentage of CAB gel-treated participants (82.7%) than with the 3 dyads and vehicle (61.1-69.8%; P<0.05, all). These early reductions were sustained throughout the study, with significantly (P<0.05) more CAB-treated participants achieving ≥50% reduction in inflammatory lesions versus dyads and vehicle from weeks 4-12. By week 12, CAB led to substantial reductions of ≥75% in significantly more participants than dyads and vehicle (65.8% vs 49.9-51.2% and 21.6%; P<0.05, all). Similar trends were observed for noninflammatory lesions in the phase 2 study and for inflammatory and noninflammatory lesions in the phase 3 studies. Conclusions: Lesion count reductions were significantly greater with CAB versus its dyads and vehicle gel as early as week 4, with substantial reductions observed after 12 weeks of treatment. This faster-acting and sustained efficacy of CAB gel—coupled with its optimized formulation, once-daily dosing, and tolerability—may positively impact treatment adherence. J Drugs Dermatol. 2024;23(3): doi:10.36849/JDD.7907.
MeSH term(s)	Humans ; Acne Vulgaris/diagnosis ; Acne Vulgaris/drug therapy ; Adapalene, Benzoyl Peroxide Drug Combination ; Anti-Bacterial Agents/administration & dosage ; Clindamycin/administration & dosage ; Child
Chemical Substances	Adapalene, Benzoyl Peroxide Drug Combination ; Anti-Bacterial Agents ; Clindamycin (3U02EL437C) ; clindamycin phosphate (EH6D7113I8)
Language	English
Publishing date	2024-03-04
Publishing country	United States
Document type	Clinical Trial, Phase II ; Clinical Trial, Phase III ; Journal Article ; Randomized Controlled Trial
ZDB-ID	2145090-0
ISSN	1545-9616
ISSN	1545-9616
DOI	10.36849/jdd.7907
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Article ; Online: Comparison of pain perception in patients undergoing manual cataract surgery versus refractive laser-assisted cataract surgery.

Cioana, Milena / Gupta, Rishi B / Tam, Eric S / Chiu, Hannah H / Gold, Ileana / Somani, Sohel

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

2023

Abstract: Objectives: To assess pain perception in patients undergoing manual cataract surgery versus femtosecond laser-assisted cataract surgery (FLACS) and pain perception of patients receiving anaesthesia at 2 different time points during the FLACS procedure. ... ...

Abstract	Objectives: To assess pain perception in patients undergoing manual cataract surgery versus femtosecond laser-assisted cataract surgery (FLACS) and pain perception of patients receiving anaesthesia at 2 different time points during the FLACS procedure. We also aimed to assess the factors affecting pain perception in these different study groups. Design: Prospective cohort comparison of patient-selected surgical approach. Participants: Patients undergoing delayed sequential bilateral cataract surgery at an ambulatory surgical centre in Ontario. Methods: Patients were assigned to 3 groups: a manual cataract surgery cohort (n = 30) and 2 FLACS cohorts, those who received neurolept anaesthesia just prior to draping for phacoemulsification (FLACS standard cohort; n = 38) and those who received neurolept anaesthesia prior to the femtosecond laser part of the procedure (FLACS early cohort; n = 35). Outcome metrics included pain scores on the visual analogue scale on postoperative day 0 and at postoperative week 1. Secondary outcome measures included anxiety scores, surgeon or anaesthesiologist patient cooperation scores, ocular metrics, and perioperative systemic vitals. Results: There were no significant differences in pain perception on postoperative day 0 and at postoperative week 1 among the manual cataract surgery and FLACS standard cohorts (p = 0.94 and p = 0.72, respectively) or FLACS early and FLACS standard cohorts (p = 0.76 and p = 0.67, respectively). Patients had higher pain scores during second-eye procedures than first-eye procedures. Conclusions: Cataract surgery technique or timing of anaesthesia for FLACS procedures does not affect pain perception postoperatively. Second-eye procedures are associated with higher pain scores than first-eye procedures.
Language	English
Publishing date	2023-04-14
Publishing country	England
Document type	Journal Article
ZDB-ID	80091-0
ISSN	1715-3360 ; 0008-4182
ISSN (online)	1715-3360
ISSN	0008-4182
DOI	10.1016/j.jcjo.2023.03.013
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