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Article ; Online: Incidence of post-COVID psychiatric disorders according to the periods of SARS-CoV-2 variant dominance: The LIFE study.

Murata, Fumiko / Maeda, Megumi / Murayama, Keitaro / Nakao, Tomohiro / Fukuda, Haruhisa

2024 Volume 174, Page(s) 12–18

Abstract: This retrospective cohort study examined the incidence of post-COVID psychiatric disorders in older adults according to hospitalization status and SARS-CoV-2 variant period in Japan. Claims data, COVID-19 case-related information, and vaccination records ...

Abstract	This retrospective cohort study examined the incidence of post-COVID psychiatric disorders in older adults according to hospitalization status and SARS-CoV-2 variant period in Japan. Claims data, COVID-19 case-related information, and vaccination records were obtained from three Japanese municipalities. We identified individuals aged ≥65 years who had COVID-19 or other respiratory tract infection (RTI) between March 2021 and December 2022. Participants were categorized into non-hospitalized and hospitalized patients, and the study period was divided into the Alpha (March to May 2021), Delta (June to December 2021), Omicron BA.1/BA.2 (January to June 2022), and Omicron BA.5 (July to December 2022) periods. Modified Poisson regression analyses were performed to estimate the incidence rate ratios (IRRs) for the occurrence of psychiatric disorders (organic mental disorders, psychotic disorders, mood disorders, anxiety disorders, and insomnia) three months after COVID-19 (reference: other RTI). For overall psychiatric disorders, we analyzed 19,489 non-hospitalized patients (COVID-19: 6,728, Other RTI: 12,761) and 2925 hospitalized patients (COVID-19: 1,036, Other RTI: 1889). When compared with other RTI cases, COVID-19 cases had significantly lower IRRs for overall psychiatric disorders in both non-hospitalized (IRR: 0.59, P < 0.001) and hospitalized cases (IRR: 0. 83, P = 0.045) during the Omicron BA.1/BA.2 period, but only in non-hospitalized cases (IRR: 0.45, P < 0.001) during the Omicron BA.5 period. The incidences of the individual post-COVID psychiatric disorders varied according to disorder type, hospitalization status, and SARS-CoV-2 variant period. These findings provide a foundation for further research to explore these variations and improve the provision of psychiatric care in future epidemics.
MeSH term(s)	Humans ; COVID-19/epidemiology ; COVID-19/psychology ; Male ; Female ; Aged ; Incidence ; Mental Disorders/epidemiology ; Hospitalization/statistics & numerical data ; SARS-CoV-2 ; Japan/epidemiology ; Retrospective Studies ; Aged, 80 and over
Language	English
Publishing date	2024-04-04
Publishing country	England
Document type	Journal Article
ZDB-ID	3148-3
ISSN	1879-1379 ; 0022-3956
ISSN (online)	1879-1379
ISSN	0022-3956
DOI	10.1016/j.jpsychires.2024.04.010
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Article ; Online: Associations between COVID-19 vaccination and incident psychiatric disorders after breakthrough SARS-CoV-2 infection: The VENUS Study.

Murata, Fumiko / Maeda, Megumi / Murayama, Keitaro / Nakao, Tomohiro / Fukuda, Haruhisa

Brain, behavior, and immunity

2024 Volume 117, Page(s) 521–528

Abstract: Background: The associations between COVID-19 vaccination and post-COVID psychiatric disorders are unclear. Furthermore, it is uncertain if these associations differ depending on the dominant SARS-CoV-2 variant at the time of infection. This ... ...

Abstract	Background: The associations between COVID-19 vaccination and post-COVID psychiatric disorders are unclear. Furthermore, it is uncertain if these associations differ depending on the dominant SARS-CoV-2 variant at the time of infection. This retrospective cohort study aimed to clarify the associations between COVID-19 vaccination and incident psychiatric disorders after breakthrough infection according to the different variant periods in Japan. Methods: Medical claims data, COVID-19 case-related information, and vaccination records were collected from three Japanese municipalities. The study population comprised public insurance enrollees aged ≥65 years who developed COVID-19 between June 2021 and December 2022. The study exposure was each participant's vaccination status 14 days before infection, and the outcomes were the occurrence of psychiatric disorders within three months of infection. Multivariable logistic regression analyses were performed to calculate the odds ratios (ORs) and 95 % confidence intervals (CIs) of vaccination for the occurrence of psychiatric disorders. Analyses were conducted for the Delta period (June to December 2021), Omicron BA.1/BA.2 period (January to June 2022), and Omicron BA.5 period (July to December 2022). Results: We analyzed 270 participants (vaccinated: 149) in the Delta period, 2,963 participants (vaccinated: 2,699) in the Omicron BA.1/BA.2 period, and 7,723 participants (vaccinated: 7,159) in the Omicron BA.5 period. During the Delta period, vaccinated participants had significantly lower odds for psychotic disorders (OR: 0.23, 95 % CI: 0.06-0.88, P = 0.032) than unvaccinated participants. During the Omicron BA.5 period, vaccinated participants had significantly lower odds for organic mental disorders (OR: 0.54, 95 % CI: 0.30-0.95, P = 0.033), psychotic disorders (OR: 0.31, 95 % CI: 0.19-0.53, P < 0.001), mood disorders (OR: 0.53, 95 % CI: 0.29-0.99, P = 0.046), and insomnia (OR: 0.48, 95 % CI: 0.32-0.72, P < 0.001) than unvaccinated participants. There were no significant differences in psychiatric disorders between the vaccinated and unvaccinated groups during the Omicron BA.1/BA.2 period. Conclusions: This is the first study to demonstrate that the associations between COVID-19 vaccination and post-COVID psychiatric disorders vary among the different variant periods. Future studies on these associations should be conducted with consideration to the prevalent circulating variants.
MeSH term(s)	Humans ; SARS-CoV-2 ; COVID-19 Vaccines ; COVID-19/prevention & control ; Retrospective Studies ; Mental Disorders/epidemiology ; Vaccination
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2024-02-12
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639219-2
ISSN	1090-2139 ; 0889-1591
ISSN (online)	1090-2139
ISSN	0889-1591
DOI	10.1016/j.bbi.2024.02.018
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Article ; Online: Spontaneous Bony Union of Bilateral Pseudoarthrotic Lumbar Spondylolysis without Surgery: A Case Report.

Asukai, Mitsuru / Banno, Tomohiro / Suzuki, Yoshiji / Yamashita, Daisuke / Murata, Hideyuki / Matsuyama, Yukihiro

Spine surgery and related research

2023 Volume 8, Issue 2, Page(s) 221–224

Language	English
Publishing date	2023-10-13
Publishing country	Japan
Document type	Journal Article
ISSN	2432-261X
ISSN (online)	2432-261X
DOI	10.22603/ssrr.2023-0153
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Article: Severe Left Ventricular Failure Unmanageable by Impella 5.0.

Mano, Akiko / Murata, Tomohiro / Inui, Akitoshi / Kawata, Mitsuhiro / Kyo, Shunei

Cureus

2023 Volume 15, Issue 10, Page(s) e47882

Abstract: Mechanical circulatory support can be beneficial for patients with cardiogenic shock. Of these, the Impella has recently become the first-line device due to its feasibility, minimal invasiveness, and efficacy. We had a 58-year-old male with acute ... ...

Abstract	Mechanical circulatory support can be beneficial for patients with cardiogenic shock. Of these, the Impella has recently become the first-line device due to its feasibility, minimal invasiveness, and efficacy. We had a 58-year-old male with acute myocardial infarction followed by cardiogenic shock. We initially placed the patient on intra-aortic balloon pumping, which was switched to Impella 2.5 and could stabilize him. Unfortunately, the Impella 2.5 device suddenly stopped on the fifth day, thus, we tried to manage him by inotropes. However, his condition gradually deteriorated, so we applied Impella 5.0. Although his systemic circulation could be maintained, severe pulmonary hypertension persisted on Impella 5.0. He developed flash pulmonary edema, thus, we emergently added venoarterial extracorporeal membrane oxygenation on Impella 5.0 (ECPELLA). Then, we removed Impella 5.0 and changed peripheral venoarterial extracorporeal membrane oxygenation to central venoarterial extracorporeal membrane oxygenation. In this central venoarterial extracorporeal membrane oxygenation, we inserted the cannulas in the pulmonary artery and the left ventricle in addition to the usual cannulas in the ascending aorta and the right atrium. We aimed to control pulmonary arterial blood flow for lung protection as well as left ventricular unloading by this modification. However, his cardiac function showed no signs of recovery, and his lung condition showed further exacerbation. He was complicated by fungal sepsis and finally died of multi-organ failure. Although the Impella is an option, it is crucial to evaluate patients' condition carefully and to escalate the device, if needed, without delay.
Language	English
Publishing date	2023-10-28
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.47882
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Article: Stress Dependence on Relaxation of Deformation Induced by Laser Spot Heating.

Murata, Yuma / Sasaki, Tomohiro / Yoshida, Sanichiro

Materials (Basel, Switzerland)

2022 Volume 15, Issue 18

Abstract: This paper deals with a non-destructive analysis of residual stress through the visualization of deformation behaviors induced by a local spot heating. Deformation was applied to the surface of an aluminum alloy with an infrared spot laser. The heating ... ...

Abstract	This paper deals with a non-destructive analysis of residual stress through the visualization of deformation behaviors induced by a local spot heating. Deformation was applied to the surface of an aluminum alloy with an infrared spot laser. The heating process is non-contact, and the applied strain is reversible in the range of room temperature to approximately +10 °C. The specimen was initially pulled up to elastic tensile stress using a tensile test machine under the assumption that the material was subject to the tensile residual stress. The relaxation behaviors of the applied strain under tensile stress conditions were evaluated using contact and non-contact methods, i.e., two strain gauges (the contact method) and a two-dimensional electronic speckle pattern interferometer (non-contact method). The results are discussed based on the stress dependencies of the thermal expansion coefficient and the elasticity of the materials.
Language	English
Publishing date	2022-09-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma15186330
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Article ; Online: Severe Aortic Regurgitation by Nonbacterial Thrombotic Endocarditis Treated with Anticoagulation Therapy.

Murata, Azusa / Kagiyama, Nobuyuki / Miyazaki, Sakiko / Kaneko, Tomohiro / Shimada, Naoko / Mitsuishi, Youichiro / Minamino, Tohru

CASE (Philadelphia, Pa.)

2022 Volume 6, Issue 5, Page(s) 205–208

Language	English
Publishing date	2022-05-20
Publishing country	United States
Document type	Case Reports
ISSN	2468-6441
ISSN (online)	2468-6441
DOI	10.1016/j.case.2022.04.002
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Article ; Online: Epoxide Ring-Opening Reactions for Abundant Production of Mugineic Acids and Nicotianamine Probes.

Kayano, Kimika / Tsutsumi, Tomohiro / Murata, Yoshiko / Ogasa, Chie / Watanabe, Takehiro / Sato, Ryota / Karanjit, Sangita / Namba, Kosuke

Angewandte Chemie (International ed. in English)

2024 Volume 63, Issue 20, Page(s) e202401411

Abstract: A succinct synthetic approach to mugineic acids and 2'-hydroxynicotianamine was established. Unlike all other synthetic methods, this approach utilized epoxide ring-opening reactions to form two C-N bonds and is characterized by the absence of redox ... ...

Abstract	A succinct synthetic approach to mugineic acids and 2'-hydroxynicotianamine was established. Unlike all other synthetic methods, this approach utilized epoxide ring-opening reactions to form two C-N bonds and is characterized by the absence of redox reactions. Mugineic acid was synthesized from three readily available fragments on a gram scale in 6 steps. The protected 2'-hydroxynicotianamine was also synthesized in 4 steps, and the dansyl group, serving as a fluorophore, was introduced through a click reaction after propargylation of the 2'-hydroxy group. The dansyl-labeled nicotianamine (NA) iron complexes were internalized by oocytes overexpressing ZmYS1 (from maize) or PAT1 (from human) transporters, indicating successful transport of the synthesized NA-probe through these transporters.
MeSH term(s)	Epoxy Compounds/chemistry ; Epoxy Compounds/metabolism ; Humans ; Molecular Structure ; Azetidinecarboxylic Acid/analogs & derivatives ; Azetidinecarboxylic Acid/metabolism ; Azetidinecarboxylic Acid/chemistry
Chemical Substances	Epoxy Compounds ; nicotianamine (34441-14-0) ; mugineic acid (KR256JY76I) ; Azetidinecarboxylic Acid (5GZ3E0L9ZU)
Language	English
Publishing date	2024-04-09
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202401411
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Article: A case of fulminant myocarditis with full recovery after a 38-h sustained asystole.

Akutsu, Tomohiro / Endo, Akira / Sonobe, Hiroyuki / Suzuki, Keisuke / Murata, Kiyoshi / Otomo, Yasuhiro

Clinical case reports

2023 Volume 11, Issue 8, Page(s) e7722

Abstract: Key clinical message: Even if cardiac rhythm deteriorated to asystole in the clinical course of fulminant myocarditis, cardiac function may recover, and the patient may be discharged without brain damage, if circulation could be maintained by ... ...

Abstract	Key clinical message: Even if cardiac rhythm deteriorated to asystole in the clinical course of fulminant myocarditis, cardiac function may recover, and the patient may be discharged without brain damage, if circulation could be maintained by appropriate mechanical cardiac supports. Abstract: A 69-year-old man was diagnosed with fulminant myocarditis with circulatory collapse. His cardiac rhythm deteriorated to asystole on the second day; however, circulatory status was maintained through extracorporeal membrane oxygenation and intra-aortic balloon pumping. After 38 h-lasting asystole, his heart resumed beating. He was discharged without neurological deficits on Day 25.
Language	English
Publishing date	2023-07-30
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.7722
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Article ; Online: Detection of Trace Amounts of Water in Organic Solvents by DNA-Based Nanomechanical Sensors.

Murata, Tomohiro / Minami, Kosuke / Yamazaki, Tomohiko / Yoshikawa, Genki / Ariga, Katsuhiko

Biosensors

2022 Volume 12, Issue 12

Abstract: The detection of trace amounts of water in organic solvents is of great importance in the field of chemistry and in the industry. Karl Fischer titration is known as a classic method and is widely used for detecting trace amounts of water; however, it has ...

Abstract	The detection of trace amounts of water in organic solvents is of great importance in the field of chemistry and in the industry. Karl Fischer titration is known as a classic method and is widely used for detecting trace amounts of water; however, it has some limitations in terms of rapid and direct detection because of its time-consuming sample preparation and specific equipment requirements. Here, we found that a DNA-based nanomechanical sensor exhibits high sensitivity and selectivity to water vapor, leading to the detection and quantification of trace amounts of water in organic solvents as low as 12 ppm in THF, with a ppb level of LoD through their vapors. Since the present method is simple and rapid, it can be an alternative technique to the conventional Karl Fischer titration.
Language	English
Publishing date	2022-12-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662125-3
ISSN	2079-6374 ; 2079-6374
ISSN (online)	2079-6374
ISSN	2079-6374
DOI	10.3390/bios12121103
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Article: Multiple cardiac surgical procedures in a case of an octogenarian with essential thrombocythemia.

Maeda, Motohiro / Sakamoto, Shun-Ichiro / Murata, Tomohiro / Hiromoto, Atsushi / Suzuki, Kenji / Ishii, Yosuke

Surgical case reports

2023 Volume 9, Issue 1, Page(s) 96

Abstract: Background: Essential thrombocythemia (ET) is a chronic myeloproliferative disorder characterized by an elevation of platelet counts with a tendency for thrombosis and hemorrhage. The perioperative management of cardiovascular surgery of an ET patient ... ...

Abstract	Background: Essential thrombocythemia (ET) is a chronic myeloproliferative disorder characterized by an elevation of platelet counts with a tendency for thrombosis and hemorrhage. The perioperative management of cardiovascular surgery of an ET patient is complicated. There is limited literature on the perioperative management of patients with ET undergoing cardiovascular surgery, particularly those requiring multiple procedures. Case presentation: An 85-year-old woman with a history of essential thrombocythemia (ET), which resulted in an abnormally high platelet count, was diagnosed with aortic valve stenosis, ischemic heart disease and paroxysmal atrial fibrillation. She underwent aortic valve replacement, coronary artery bypass grafting, and pulmonary vein isolation. The postoperative course was uneventful, nor hemorrhage and thrombosis. Conclusions: We represent a case of perioperative management and successful treatment of three combined cardiac surgery for an octogenarian ET patient who is the oldest case ever reported.
Language	English
Publishing date	2023-06-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2809613-7
ISSN	2198-7793
ISSN	2198-7793
DOI	10.1186/s40792-023-01682-z
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