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  1. Article ; Online: Web Exclusive. Annals Graphic Medicine - Be Calm.

    Powell, Jesse

    Annals of internal medicine

    2020  Volume 172, Issue 11, Page(s) W136–W139

    Language English
    Publishing date 2020-05-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/G19-0052
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Web Exclusive. Annals Graphic Medicine - An Abbreviated History of My Medical Training.

    Powell, Jesse

    Annals of internal medicine

    2019  Volume 171, Issue 2, Page(s) W5–W8

    Language English
    Publishing date 2019-07-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/G18-0014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Reply.

    Powell, Jesse / Khalili, Mandana

    Hepatology communications

    2020  Volume 4, Issue 12, Page(s) 1880

    Language English
    Publishing date 2020-10-18
    Publishing country United States
    Document type Journal Article
    ISSN 2471-254X
    ISSN (online) 2471-254X
    DOI 10.1002/hep4.1613
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Revaccination for Hepatitis B in Previous Nonresponders Following Hepatitis C Eradication.

    Powell, Jesse G / Goble, Spencer R / Debes, Jose D

    The Journal of infectious diseases

    2023  Volume 229, Issue 2, Page(s) 341–345

    Abstract: Background: Patients with chronic hepatitis C virus (HCV) do not respond to hepatitis B virus (HBV) vaccination as efficiently as the general population. We assessed if revaccination after HCV treatment resulted in improved response.: Methods: ... ...

    Abstract Background: Patients with chronic hepatitis C virus (HCV) do not respond to hepatitis B virus (HBV) vaccination as efficiently as the general population. We assessed if revaccination after HCV treatment resulted in improved response.
    Methods: Previous HBV vaccine nonresponders were prospectively recruited for revaccination after HCV eradication. Hepatitis B surface antibody (HBsAb) testing was performed 1 month after series completion.
    Results: Follow-up HBsAb testing was performed in 31 of 34 enrolled patients with 21 (67.7%) reactive results. There were no significant differences in HBsAb reactivity based on age, sex, race, or advanced fibrosis presence.
    Conclusions: HBV vaccine nonresponders should be considered for revaccination following HCV cure.
    MeSH term(s) Humans ; Immunization, Secondary ; Hepatitis C, Chronic/drug therapy ; Hepatitis C, Chronic/prevention & control ; Hepatitis B/prevention & control ; Hepatitis B virus ; Hepatitis B Vaccines ; Hepatitis B Antibodies ; Hepatitis B Surface Antigens ; Hepatitis C
    Chemical Substances Hepatitis B Vaccines ; Hepatitis B Antibodies ; Hepatitis B Surface Antigens
    Language English
    Publishing date 2023-02-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiad301
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Gaps in Hepatitis A and Hepatitis B Vaccination Among Hepatitis C Antibody-Positive Individuals Experiencing Homelessness.

    Partida, Diana / Powell, Jesse / Gonzalez, Daniel / Khalili, Mandana

    Open forum infectious diseases

    2022  Volume 9, Issue 5, Page(s) ofac175

    Abstract: Vaccination for both hepatitis A (HAV) and hepatitis B (HBV) is recommended in hepatitis C infection (HCV). Among HCV antibody-positive persons experiencing homelessness, we identified high rates of HAV (34%) and HBV vaccine (35%) eligibility, ... ...

    Abstract Vaccination for both hepatitis A (HAV) and hepatitis B (HBV) is recommended in hepatitis C infection (HCV). Among HCV antibody-positive persons experiencing homelessness, we identified high rates of HAV (34%) and HBV vaccine (35%) eligibility, highlighting critical gaps in HCV preventative services. Following education, 54% and 72% underwent HAV and HBV vaccination, respectively.
    Language English
    Publishing date 2022-04-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofac175
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Single-cell genomics analysis reveals complex genetic interactions in an

    Schillo, Jacob L / Feddersen, Charlotte R / Peplinski, Rebekah M / Powell, Lexy S / Varzavand, Afshin / Stipp, Christopher S / Riordan, Jesse D / Dupuy, Adam J

    NAR cancer

    2024  Volume 6, Issue 1, Page(s) zcad061

    Abstract: The evolution of therapeutic resistance is a major obstacle to the success of targeted oncology drugs. While both inter- and intratumoral heterogeneity limit our ability to detect resistant subpopulations that pre-exist or emerge during treatment, our ... ...

    Abstract The evolution of therapeutic resistance is a major obstacle to the success of targeted oncology drugs. While both inter- and intratumoral heterogeneity limit our ability to detect resistant subpopulations that pre-exist or emerge during treatment, our ability to analyze tumors with single-cell resolution is limited. Here, we utilized a cell-based transposon mutagenesis method to identify mechanisms of BRAF inhibitor resistance in a model of cutaneous melanoma. This screen identified overexpression of NEDD4L and VGLL3 as significant drivers of BRAF inhibitor resistance
    Language English
    Publishing date 2024-01-11
    Publishing country England
    Document type Journal Article
    ISSN 2632-8674
    ISSN (online) 2632-8674
    DOI 10.1093/narcan/zcad061
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Statin Utilization Among Individuals Infected With Hepatitis C Virus: A Retrospective Cohort Study.

    Goble, Spencer R / Nyembo, Philippe / Rodin, Holly / Konstantinides, George / Powell, Jesse / Noska, Amanda J

    Cureus

    2023  Volume 15, Issue 3, Page(s) e36049

    Abstract: Introduction and Objectives Statin use for primary prevention of coronary artery disease (CAD) has historically been limited in patients with chronic liver disease due to concerns for increased adverse events with statin use in this population. We aimed ... ...

    Abstract Introduction and Objectives Statin use for primary prevention of coronary artery disease (CAD) has historically been limited in patients with chronic liver disease due to concerns for increased adverse events with statin use in this population. We aimed to quantify the underutilization of statins among individuals with a history of HCV infection in a community health system to understand the clinical implications of statin underutilization in a diverse, generalizable population of patients infected with HCV. Materials and Methods We performed a single-center retrospective study of individuals with a history of HCV infection aged 40-75 years from 2019-2021. Statin eligibility was determined using the 2019 American College of Cardiology/American Heart Association (ACC/AHA) guidelines with the 2013 Pooled Cohort Equation used to determine atherosclerotic cardiovascular disease (ASCVD) risk. Baseline characteristics and adverse events of statin and non-statin users were compared, and factors associated with statin use were determined using multivariable logistical regression. Results Based on 2019 ACC/AHA guidelines, 752/1,077 (69.8%) subjects had an indication for a statin, 280/752 (37.2%) of which were treated with a statin. Cirrhosis was independently associated with statin underutilization. Diabetes, anti-hypertensive use, and Black race were all independently associated with statin use in subjects with an indication for therapy. Statin use was not associated with adverse events. Conclusions Statins were underutilized and well tolerated in the cohort of individuals with a history of HCV infection. This high-risk population would benefit from increased CAD screening and utilization of statins for the primary prevention of CAD.
    Language English
    Publishing date 2023-03-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.36049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Phosphorylation of aryl hydrocarbon receptor interacting protein by TBK1 negatively regulates IRF7 and the type I interferon response.

    Kazzaz, Sarah A / Shaikh, Kashif A / White, Jesse / Zhou, Qinjie / Powell, Wade H / Harhaj, Edward W

    The Journal of biological chemistry

    2023  Volume 300, Issue 1, Page(s) 105525

    Abstract: The innate antiviral response to RNA viruses is initiated by sensing of viral RNAs by RIG-I-like receptors and elicits type I interferon (IFN) production, which stimulates the expression of IFN-stimulated genes that orchestrate the antiviral response to ... ...

    Abstract The innate antiviral response to RNA viruses is initiated by sensing of viral RNAs by RIG-I-like receptors and elicits type I interferon (IFN) production, which stimulates the expression of IFN-stimulated genes that orchestrate the antiviral response to prevent systemic infection. Negative regulation of type I IFN and its master regulator, transcription factor IRF7, is essential to maintain immune homeostasis. We previously demonstrated that AIP (aryl hydrocarbon receptor interacting protein) functions as a negative regulator of the innate antiviral immune response by binding to and sequestering IRF7 in the cytoplasm, thereby preventing IRF7 transcriptional activation and type I IFN production. However, it remains unknown how AIP inhibition of IRF7 is regulated. We show here that the kinase TBK1 phosphorylates AIP and Thr40 serves as the primary target for TBK1 phosphorylation. AIP Thr40 plays critical roles in regulating AIP stability and mediating its interaction with IRF7. The AIP phosphomimetic T40E exhibited increased proteasomal degradation and enhanced interaction with IRF7 compared with wildtype AIP. AIP T40E also blocked IRF7 nuclear translocation, which resulted in reduced type I IFN production and increased viral replication. In sharp contrast, AIP phosphonull mutant T40A had impaired IRF7 binding, and stable expression of AIP T40A in AIP-deficient mouse embryonic fibroblasts elicited a heightened type I IFN response and diminished RNA virus replication. Taken together, these results demonstrate that TBK1-mediated phosphorylation of AIP at Thr40 functions as a molecular switch that enables AIP to interact with and inhibit IRF7, thus preventing overactivation of type I IFN genes by IRF7.
    MeSH term(s) Animals ; Mice ; Fibroblasts ; Immunity, Innate ; Interferon Regulatory Factor-7/genetics ; Interferon Regulatory Factor-7/metabolism ; Interferon Type I/metabolism ; Phosphorylation ; Protein Serine-Threonine Kinases/metabolism ; Receptors, Aryl Hydrocarbon/metabolism ; RNA Viruses/immunology ; RNA Virus Infections/immunology ; Humans ; HEK293 Cells
    Chemical Substances Interferon Regulatory Factor-7 ; Interferon Type I ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Receptors, Aryl Hydrocarbon ; Tbk1 protein, mouse (EC 2.7.1.-)
    Language English
    Publishing date 2023-12-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2023.105525
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: EKG Abnormalities in a Youth Athlete Following COVID-19: It's Not Always Myocarditis!

    Powell, Adam W / Urbina, Elaine M / Orr, William B / Hansen, Jesse E / Baskar, Shankar

    Pediatric cardiology

    2022  Volume 43, Issue 8, Page(s) 1922–1925

    Abstract: COVID-19 associated myocarditis following mild infections is rare while incidental findings may be more common. A young athlete fully recovered from a mild COVID-19 infection presented with inferolateral T-wave inversions and left ventricular hypertrophy ...

    Abstract COVID-19 associated myocarditis following mild infections is rare while incidental findings may be more common. A young athlete fully recovered from a mild COVID-19 infection presented with inferolateral T-wave inversions and left ventricular hypertrophy on imaging. Exercise testing aided in correctly diagnosing the patient with masked systolic hypertension.
    MeSH term(s) Humans ; Adolescent ; Myocarditis/diagnostic imaging ; Myocarditis/etiology ; COVID-19 ; Hypertrophy, Left Ventricular/complications ; Arrhythmias, Cardiac/complications ; Masked Hypertension ; Athletes ; Electrocardiography
    Language English
    Publishing date 2022-05-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 800857-7
    ISSN 1432-1971 ; 0172-0643
    ISSN (online) 1432-1971
    ISSN 0172-0643
    DOI 10.1007/s00246-022-02935-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Erratum to: Adherence to Hepatitis C Therapy in a Shelter-Based Education and Treatment Model Among Persons Experiencing Homelessness.

    Powell, Jesse / Ricco, Margaret / Naugle, Jessica / Magee, Catherine / Hassan, Hayat / Masson, Carmen / Braimoh, Grace / Zevin, Barry / Khalili, Mandana

    Open forum infectious diseases

    2022  Volume 9, Issue 3, Page(s) ofab652

    Abstract: This corrects the article DOI: 10.1093/ofid/ofab488.]. ...

    Abstract [This corrects the article DOI: 10.1093/ofid/ofab488.].
    Language English
    Publishing date 2022-02-23
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofab652
    Database MEDical Literature Analysis and Retrieval System OnLINE

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