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Article ; Online: Arsenic pollution concerning surface water and sediment of Jie River: A pilot area where gold smelting enterprises are concentrated.

Jin, Yan / Zhu, Weichen / Li, Jia / Cui, Dayong / Zhang, Zhibin / Sun, Guoxin / Zhu, Yongguan / Yang, Huanhuan / Zhang, Xu

Environmental research

2024 Volume 249, Page(s) 118384

Abstract: ... and sediment is performed in the Jie River basin, where gold smelting enterprises are concentrated ... euglena are the main phytoplankton in the Jie River while toxic cyanobacteria exhibits lower resistance ...

Abstract	A comprehensive monitoring and risk assessment of arsenic (As) pollution concerning surface water and sediment is performed in the Jie River basin, where gold smelting enterprises are concentrated. The study area is divide into six regions, labeled as A, B, C, D, E, and F, from sewage outlets to downstream. Results shows that with far away from the sewage outlets, the total As concentrations in water and sediment gradually decrease from regions A to F. However, in region F, the concentration of bioavailable As significantly increases in the sediment due to the higher pH, leading to the transformation of As(V) into more mobile As(III). In sediment, Paracladius sp. exhibits strong resistance to As pollution in sediment, which can potentially elevate the risk of disease transmission. In water bodies, diatoms and euglena are the main phytoplankton in the Jie River while toxic cyanobacteria exhibits lower resistance to As pollution. Overall, measures should be taken to ecologically remediate the sediment in downstream while implementing appropriate isolation methods to prevent the spread of highly contaminated sediments from regions near sewage outlets.
MeSH term(s)	Geologic Sediments/chemistry ; Geologic Sediments/analysis ; Arsenic/analysis ; Rivers/chemistry ; Water Pollutants, Chemical/analysis ; Environmental Monitoring ; Gold ; China ; Metallurgy ; Pilot Projects
Chemical Substances	Arsenic (N712M78A8G) ; Water Pollutants, Chemical ; Gold (7440-57-5)
Language	English
Publishing date	2024-02-01
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2024.118384
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Article: Elucidation of the anti-lung cancer mechanism of Juan-Liu-San-Jie prescription based on network pharmacology and experimental validation.

Wang, Yuli / Pan, Yanbin / Luo, Yingbin / Wu, Jianchun / Fang, Zhihong / Teng, Wenjing / Guan, Yu / Li, Yan

Heliyon

2023 Volume 9, Issue 8, Page(s) e18298

Abstract: ... being the most prevalent subtype. Our preliminary studies have demonstrated that the Juan-Liu-San-Jie ...

Abstract	Lung cancer is a malignancy characterized by high morbidity and mortality, with lung adenocarcinoma being the most prevalent subtype. Our preliminary studies have demonstrated that the Juan-Liu-San-Jie (JLSJ) prescription, a Traditional Chinese Medicine prescription, possesses anti-lung adenocarcinoma cancer properties. However, the molecular mechanism underlying the therapeutic effects of the JLSJ prescription for lung adenocarcinoma remains incompletely elucidated. To address the knowledge gap, the present study employed network pharmacology to identify potential therapeutic targets. Specifically, the study utilized TCMSP, TCMID, and related references, as well as ChemMapper, to identify and predict the main active components and potential targets. Additionally, differentially expressed genes associated with the disease were obtained from the microarray dataset GSE19804 and GSE118370. The protein-protein Interaction network and Target-pathway network were then constructed. We also conducted Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses, and subsequently presented the top 20 enriched pathways. The results indicated that the anti-lung cancer effects of JLSJ prescription may be attributed to its ability to mediate apoptosis of tumor cells, potentially through the PI3K/Akt signaling pathway. Then, a series of in vitro and in vivo experiments were conducted to validate the molecular mechanism predicted by network pharmacology. The findings of the in vivo study suggested that the JLSJ prescription could inhibit the growth of xenograft tumors of lung adenocarcinoma with fewer adverse effects. Also, the in vitro experiments corroborated that the JLSJ prescription could induce apoptosis of A549 cells. Furthermore, the upregulation of pro-apoptosis-related proteins and mRNAs, coupled with the downregulation of anti-apoptotic-related proteins and mRNAs, was observed. In conclusion, inducing apoptosis by inhibiting the PI3K/Akt signaling pathway was one of the underlying mechanisms by which the JLSJ prescription exerted its anti-lung adenocarcinoma effect.
Language	English
Publishing date	2023-07-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e18298
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Article ; Online: Modified Huang-Lian-Jie-Du Decoction Ameliorates A

Liu, Yan / Du, Ting / Zhang, Wenlong / Lu, Weiye / Peng, Zhichao / Huang, Shuqiong / Sun, Xiangdong / Zhu, Xiaoqin / Chen, Chaojun / Qian, Linchao / Wen, Lei / Xu, Pingyi / Zhang, Yunlong

Oxidative medicine and cellular longevity

2019 Volume 2019, Page(s) 8340192

Abstract: ... dysfunction; however, the therapeutic strategies are not fully understood. Huang-Lian-Jie-Du-Decoction (HLJDD ...

Abstract	Alzheimer's disease (AD) is a common neurodegenerative disease, characterized by cognitive dysfunction; however, the therapeutic strategies are not fully understood. Huang-Lian-Jie-Du-Decoction (HLJDD) is a famous traditional Chinese herbal formula that has been widely used clinically to treat dementia. Recently, according to previous study and our clinical practice, we generate a new modification of HLJDD (named modified-HLJDD). In this study, we indicated that modified-HLJDD attenuated learning and memory deficiencies in A
MeSH term(s)	Alzheimer Disease/drug therapy ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/metabolism ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Disease Models, Animal ; Drugs, Chinese Herbal/pharmacology ; Humans ; Male ; Mice ; Neuronal Plasticity/drug effects ; Peptide Fragments/metabolism ; Synapses/chemistry ; Synapses/metabolism ; Synapses/pathology ; Synaptic Transmission/drug effects
Chemical Substances	Amyloid beta-Peptides ; Anti-Inflammatory Agents, Non-Steroidal ; Drugs, Chinese Herbal ; Peptide Fragments ; amyloid beta-protein (1-42) ; oren gedoku to
Language	English
Publishing date	2019-11-03
Publishing country	United States
Document type	Journal Article
ISSN	1942-0994
ISSN (online)	1942-0994
DOI	10.1155/2019/8340192
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Article: Ancient Chinese Herbal Recipe Huanglian Jie Du Decoction for Ischemic Stroke: An Overview of Current Evidence.

Yu, Chao-Chao / Liu, Le-Bin / Chen, Shi-Yuan / Wang, Xiao-Fei / Wang, Li / Du, Yan-Jun

Aging and disease

2022 Volume 13, Issue 6, Page(s) 1733–1744

Abstract: ... on the neuroprotective effects of Huanglian Jie Du decoction (HLJDD), an ancient and classical Chinese herbal formula ...

Abstract	Ischemic stroke is a major cause of mortality and neurological morbidity worldwide. The underlying pathophysiology of ischemic stroke is highly complicated and correlates with various pathological processes, including neuroinflammation, oxidative stress injury, altered cell apoptosis and autophagy, excitotoxicity, and acidosis. The current treatment for ischemic stroke is limited to thrombolytic therapy such as recombinant tissue plasminogen activator. However, tissue plasminogen activator is limited by a very narrow therapeutic time window (<4.5 hours), selective efficacy, and hemorrhagic complication. Hence, the development of novel therapies to prevent ischemic damage to the brain is urgent. Chinese herbal medicine has a long history in treating stroke and its sequela. In the past decades, extensive studies have focused on the neuroprotective effects of Huanglian Jie Du decoction (HLJDD), an ancient and classical Chinese herbal formula that can treat a wide spectrum of disorders including ischemic stroke. In this review, the current evidence of HLJDD and its bioactive components for ischemic stroke is comprehensively reviewed, and their potential application directions in ischemic stroke management are discussed.
Language	English
Publishing date	2022-12-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2625789-0
ISSN	2152-5250
ISSN	2152-5250
DOI	10.14336/AD.2022.0311
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Article: Bioactive Components and Potential Mechanism Prediction of Kui Jie Kang against Ulcerative Colitis via Systematic Pharmacology and UPLC-QE-MS Analysis.

He, Jinbiao / Wan, Chunping / Li, Xiaosi / Zhang, Zishu / Yang, Yu / Wang, Huaning / Qi, Yan

Evidence-based complementary and alternative medicine : eCAM

2022 Volume 2022, Page(s) 9122315

Abstract: Kui Jie Kang (KJK)-a traditional Chinese medicine-has demonstrated clinical therapeutic efficacy ...

Abstract	Kui Jie Kang (KJK)-a traditional Chinese medicine-has demonstrated clinical therapeutic efficacy against ulcerative colitis (UC). However, the active compounds and their underlying mechanisms have not yet been fully characterized. Therefore, the current study sought to identify the volatile compounds in KJK responsible for eliciting the therapeutic effect against UC, while also analyzing key targets and potential mechanisms. To this end, systematic network pharmacology analysis was employed to obtain UC targets by using GeneCards, DisGeNET, OMIM, among others. A total of 145 candidate ingredients, 412 potential targets of KJK (12 herbs), and 1605 UC targets were identified. Of these KJK and UC targets, 205 intersected and further identified AKT1, JUN, MAPK, ESR, and TNF as the core targets and the PI3K/AKT signaling pathway as the top enriched pathway. Moreover, molecular docking and ultra-performance liquid chromatography Q Exactive-mass spectrometry analysis identified quercetin, kaempferol, luteolin, wogonin, and nobiletin as the core effective compounds of KJK.
Language	English
Publishing date	2022-06-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2022/9122315
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Article ; Online: Kui Jie Tong Ameliorates Ulcerative Colitis by Regulating Gut Microbiota and NLRP3/Caspase-1 Classical Pyroptosis Signaling Pathway.

Xue, Shigui / Xue, Yan / Dou, Danbo / Wu, Huan / Zhang, Ping / Gao, Yang / Tang, Yini / Xia, Zehua / Yang, Sen / Gu, Sizhen

Disease markers

2022 Volume 2022, Page(s) 2782112

Abstract: Ulcerative colitis (UC) is one of the most refractory digestive diseases in the world. Kui jie tong ...

Abstract	Ulcerative colitis (UC) is one of the most refractory digestive diseases in the world. Kui jie tong (KJT) is an effective traditional Chinese medicine used clinically to treat UC. This study observed the regulatory effects of KJT on NIMA-related kinase 7- (NEK7-) activated nod-like receptor protein-3 (NLRP3)/caspase-1 classical pyroptosis pathway and intestinal flora in UC model rats. KJT components were analyzed using an ultraperformance liquid chromatography-tandem mass spectrometer (UPLC-MS/MS). A UC Sprague Dawley (SD) rat model was established using sodium dextran sulfate (DSS). Rats were randomly divided into four groups: control group (CG), UC model group (UG), KJT group (KG), and sulfasalazine (SASP) group (SG). After seven days of intervention, each group's body weight, disease activity index (DAI) scores, and colon length were recorded. Intestinal mucosal injury to each group was observed using hematoxylin-eosin staining. Additionally, we investigated the expression levels of NEK7, NLRP3, ASC, caspase-1, and GSDMD in intestinal mucosa, as well as serum interleukin- (IL-) 1
MeSH term(s)	Animals ; Caspase 1/metabolism ; Caspase 1/pharmacology ; Chromatography, Liquid ; Colitis, Ulcerative/chemically induced ; Colitis, Ulcerative/drug therapy ; Colitis, Ulcerative/metabolism ; Colon/pathology ; Disease Models, Animal ; Gastrointestinal Microbiome ; Interleukin-18/metabolism ; Interleukin-33/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Pyroptosis ; RNA, Ribosomal, 16S ; Rats ; Rats, Sprague-Dawley ; Signal Transduction ; Tandem Mass Spectrometry
Chemical Substances	Interleukin-18 ; Interleukin-33 ; NLR Family, Pyrin Domain-Containing 3 Protein ; Nlrp3 protein, rat ; RNA, Ribosomal, 16S ; Caspase 1 (EC 3.4.22.36)
Language	English
Publishing date	2022-07-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	604951-5
ISSN	1875-8630 ; 0278-0240
ISSN (online)	1875-8630
ISSN	0278-0240
DOI	10.1155/2022/2782112
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Zs.A 1856: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Anti-atopic dermatitis effect of a modified Huang-Lian-Jie-Du decoction and its active fraction on 2,4-dinitrobenzene and MC903-induced mouse models.

Wang, Lan / Hu, Zhen / Yang, Wen / Loo, Steven King Fan / Ip, Siu Po / Xian, Yan-Fang / Lin, Zhi-Xiu

Phytomedicine : international journal of phytotherapy and phytopharmacology

2022 Volume 104, Page(s) 154346

Abstract: Background: Huang-Lian-Jie-Du Decoction is a traditional Chinese medicine formula which has long ...

Abstract	Background: Huang-Lian-Jie-Du Decoction is a traditional Chinese medicine formula which has long been used to treat inflammatory skin disease including AD. However, Gardeniae Fructus, a component herb of HLJDD, has noticeable toxicity in liver and kidney. We therefore replaced Gardeniae Fructus with Dictamni Cortex with a hope to derive at a modified HLJDD (MHLJDD) with better safety profile. Purpose: The present study aimed to develop MHLJDD and identify its active fraction as innovative therapeutic agents for AD using 2,4-dinitrobenzene (DNCB) and calcipotriol (MC903)-sensitized mouse models of AD. Methods: MHLJDD and the combination of the 1-butanol-soluble-fraction and the water-soluble-fraction (MHLJDD-F) were given intragastrically to the DNCB-induced mice and MC903-induced mice for two weeks. The body weight, dorsal skin/ear thickness and severity of AD symptoms of the mice were measured throughout the study. Scratching behaviors were observed after drug treatment. The blood and dorsal skin/ear tissues of mice were harvested for histopathological examination and biochemical analyses. Results: The results revealed that DNCB- and MC903-induced AD symptoms, including skin thickening, dryness, erythema and excoriations, in the dorsal skin and ears were significantly alleviated in the MHLJDD and MHLJDD-F-treated mice. Ceramides content and protein expressions of filaggrin and loricrin were also up-regulated after treatment with MHLJDD and MHLJDD-F. In addition, skin inflammation induced by DNCB and MC903 were markedly suppressed in the MHLJDD and MHLJDD-F-treated mice, and the action mechanisms involve suppression of the release of inflammatory cytokines, as well as downregulation of the activation of NF-κB and MAPKs pathways. Besides, MHLJDD and MHLJDD-F could reverse the abundance of gut microbiota induced by DNCB in mice. Conclusions: MHLJDD and MHLJDD-F could markedly relieve AD-like symptoms induced by DNCB and MC903 in mice through, at least in part, improving the epidermal barrier function and inhibiting skin inflammation via suppressing the activation of NF-κB and MAPKs pathways and regulation of the gut microflora dysbiosis. This study reported for the first time that MHLJDD and its active fraction could be used as innovative therapeutic agents for AD.
MeSH term(s)	Animals ; Coptis chinensis ; Cytokines/metabolism ; Dermatitis, Atopic/chemically induced ; Dermatitis, Atopic/drug therapy ; Dermatitis, Atopic/metabolism ; Dinitrobenzenes ; Dinitrochlorobenzene ; Disease Models, Animal ; Inflammation/drug therapy ; Mice ; Mice, Inbred BALB C ; NF-kappa B/metabolism ; Skin/metabolism
Chemical Substances	2,4-dinitrobenzene ; Cytokines ; Dinitrobenzenes ; Dinitrochlorobenzene ; NF-kappa B
Language	English
Publishing date	2022-07-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2022.154346
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Article: Chemomics-Integrated Proteomics Analysis of Jie-Geng-Tang to Ameliorate Lipopolysaccharide-Induced Acute Lung Injury in Mice.

Tao, Jin / Nie, Yan / Hou, Yuanyuan / Ma, Xiaoyao / Ding, Guoyu / Gao, Jie / Jiang, Min / Bai, Gang

Evidence-based complementary and alternative medicine : eCAM

2016 Volume 2016, Page(s) 7379146

Abstract: Jie-Geng-Tang (JGT), a classic and famous traditional Chinese medicine (TCM) prescription composed ...

Abstract	Jie-Geng-Tang (JGT), a classic and famous traditional Chinese medicine (TCM) prescription composed of Platycodon grandiflorum (Jacq.) A. DC. (PG) and Glycyrrhiza uralensis Fisch. (GU), is well known for "clearing heat and relieving toxicity" and its ability to "diffuse the lung and relieve sore throat." However, the mechanism underlying its action remains unclear. In this study, potential anti-inflammatory ingredients were screened and submitted to PharmMapper and the KEGG bioinformatics website to predict the target proteins and related pathways, respectively. Differentially expressed candidate proteins from acute lung injury (ALI) mice treated with JGT were identified by isobaric tags for relative and absolute quantitation (iTRAQ) and LC Triple-TOF. Eleven potential anti-inflammatory ingredients were found, including the derivatives of glycyrrhizic acid, licorice-saponin, liquiritin, and platycodigenin. A total of sixty-seven differentially expressed proteins were confirmed after JGT treatment with four therapeutic functions, including immunoregulation, anti-inflammation, ribosome, and muscle contraction. PG and GU comediate PI3K/Akt signal pathway inhibition of NF-κB, VCAM1, and ICAM1 release which primarily act on PI3K, PDK1, AKT, and GSK3β. GU markedly inhibits the ERK/MAPK signaling pathways and primarily acts on LCK, RAS, and MEK. A network was constructed using bioactive ingredients, targets, and pathways to determine the mechanism underlying JGT treatment of ALI.
Language	English
Publishing date	2016-08-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2016/7379146
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Article ; Online: Pharmacokinetic-Pharmacodynamic Analysis on Inflammation Rat Model after Oral Administration of Huang Lian Jie Du Decoction.

Ren, Wei / Zuo, Ran / Wang, Yao-Nan / Wang, Hong-Jie / Yang, Jian / Xin, Shao-Kun / Han, Ling-Yu / Zhao, Hai-Yu / Han, Shu-Yan / Gao, Bo / Hu, Hao / Hu, Yuan-Jia / Bian, Bao-Lin / Si, Nan

PloS one

2016 Volume 11, Issue 6, Page(s) e0156256

Abstract: Huang-Lian-Jie-Du Decoction (HLJDD) is a classical Traditional Chinese Medicine (TCM) formula ...

Abstract	Huang-Lian-Jie-Du Decoction (HLJDD) is a classical Traditional Chinese Medicine (TCM) formula with heat-dissipating and detoxifying effects. It is used to treat inflammation-associated diseases. However, no systematic pharmacokinetic (PK) and pharmacodynamic (PD) data concerning the activity of HLJDD under inflammatory conditions is available to date. In the present study, the concentration-time profiles and the hepatic clearance rates (HCR) of 41 major components in rat plasma in response to the oral administration of a clinical dose of HLJDD were investigated by LC-QqQ-MS using a dynamic multiple reaction monitoring (DMRM) method. Additionally, the levels of 7 cytokines (CKs) in the plasma and the body temperature of rats were analyzed. Furthermore, a PK-PD model was established to describe the time course of the hemodynamic and anti-inflammatory effects of HLJDD. As one of the three major active constituents in HLJDD, iridoids were absorbed and eliminated more easily and quickly than alkaloids and flavonoids. Compared with the normal controls, the flavonoids, alkaloids and iridoids in inflamed rats exhibited consistently changing trends of PK behaviors, such as higher bioavailability, slower elimination, delays in reaching the maximum concentration (Tmax) and longer substantivity. The HCR of iridoids was different from that of alkaloids and flavonoids in inflamed rats. Furthermore, excellent pharmacodynamic effects of HLJDD were observed in inflamed rats. The levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), IL-1β, IL-10, and macrophage inflammatory protein-2 (MIP-2) and body temperature significantly decreased after the administration of HLJDD. Based on PK-PD modeling with the three-phase synchronous characterization of time-concentration-effect, flavonoids exhibited one mechanism of action in the anti-inflammatory process, while iridoids and alkaloids showed another mechanism of action. Taken together, the results demonstrated that HLJDD may restrain inflammation synergistically via its major constituents (alkaloids, flavonoids and iridoids). A correlation between the exposure concentration of different types of compounds and their anti-inflammatory effects in the body was shown. This study provides a comprehensive understanding of the anti-inflammatory activity of HLJDD.
MeSH term(s)	Administration, Oral ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal/pharmacokinetics ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Chromatography, Liquid ; Cytokines/blood ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/pharmacokinetics ; Drugs, Chinese Herbal/pharmacology ; Inflammation/blood ; Inflammation/drug therapy ; Male ; Mass Spectrometry ; Rats ; Rats, Sprague-Dawley
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal ; Cytokines ; Drugs, Chinese Herbal ; oren gedoku to
Language	English
Publishing date	2016-06-09
Publishing country	United States
Document type	Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0156256
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Article ; Online: Bioactive Components and Potential Mechanism Prediction of Kui Jie Kang against Ulcerative Colitis via Systematic Pharmacology and UPLC-QE-MS Analysis

Jinbiao He / Chunping Wan / Xiaosi Li / Zishu Zhang / Yu Yang / Huaning Wang / Yan Qi

Evidence-Based Complementary and Alternative Medicine, Vol

2022 Volume 2022

Abstract: Kui Jie Kang (KJK)—a traditional Chinese medicine—has demonstrated clinical therapeutic efficacy ...

Abstract	Kui Jie Kang (KJK)—a traditional Chinese medicine—has demonstrated clinical therapeutic efficacy against ulcerative colitis (UC). However, the active compounds and their underlying mechanisms have not yet been fully characterized. Therefore, the current study sought to identify the volatile compounds in KJK responsible for eliciting the therapeutic effect against UC, while also analyzing key targets and potential mechanisms. To this end, systematic network pharmacology analysis was employed to obtain UC targets by using GeneCards, DisGeNET, OMIM, among others. A total of 145 candidate ingredients, 412 potential targets of KJK (12 herbs), and 1605 UC targets were identified. Of these KJK and UC targets, 205 intersected and further identified AKT1, JUN, MAPK, ESR, and TNF as the core targets and the PI3K/AKT signaling pathway as the top enriched pathway. Moreover, molecular docking and ultra-performance liquid chromatography Q Exactive-mass spectrometry analysis identified quercetin, kaempferol, luteolin, wogonin, and nobiletin as the core effective compounds of KJK. In vivo murine studies revealed that KJK exposure increases the body weight and colon length, while reducing colonic epithelial injury, and the expression of inflammatory factors in colitis tissues such as TNF-α, IL-6, and IL-1β. Furthermore, KJK treatment downregulates the expression of pi3k and akt genes, as well as p-PI3K/PI3K and p-AKT/AKT proteins. Collectively, these findings describe the therapeutic effects and mechanisms of KJK in UC and highlight KJK as a potentially valuable therapeutic option for UC via modulation of the PI3K/AKT signaling pathway, thus providing a theoretical reference for the broader application of KJK in the clinical management of UC.
Keywords	Other systems of medicine ; RZ201-999
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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