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Article ; Online: Retraction statement: ‘Urotensin II inhibits autophagy in renal tubular epithelial cells and induces extracellular matrix production in early diabetic mice’ by Guan‐Jong Chen, Fei Wu, Xin‐Xin Pang, Ai‐Hua Zhang, Jun‐Bao Shi, Min Lu and Chao‐Shu Tang

Chen, Guan-Jong / Wu, Fei / Pang, Xin-Xin / Zhang, Ai-Hua / Shi, Jun-Bao / Lu, Min / Tang, Chao-Shu

2016 Volume 8, Issue 4, Page(s) 629

Abstract: Aims/introduction: Urotensin II (UII) and autophagy have been considered as important components in the pathogenesis of diabetic nephropathy. The present study explores whether UII can regulate autophagy in the kidney, and its effect in diabetes.: ... ...

Abstract	Aims/introduction: Urotensin II (UII) and autophagy have been considered as important components in the pathogenesis of diabetic nephropathy. The present study explores whether UII can regulate autophagy in the kidney, and its effect in diabetes. Materials and methods: Immunohistochemistry and western blot were carried out on the kidney tissues of diabetic UII receptor (UT) gene knockout mice, wild-type diabetic mice and normal control mice. For the in vitro experiment, HK-2 cells were treated with UII (10 Results: In diabetic UT knockout mice, expression of LC3-II is increased and p62 was reduced in comparison with that of the normal diabetic mice. Fibronectin and collagen IV were downregulated in diabetic UT knockout mice when compared with that of the normal diabetic mice. For the in vitro cell experiment, UII was shown to inhibit expression LC3-II and increase expression of p62 in comparison with that of the normal control. Treatment with SB-657510 can block UII-induced downregulation of LC3-II and upregulation of p62 while inhibiting UII-induced upregulation of fibronectin and collagen IV. Adding autophagy inducer, rapamycin, also inhibited UII-induced upregulation of fibronectin and collagen IV. Conclusions: The present study is the first to show that UII can downregulate autophagy in the kidney while accompanying the increased production of extracellular matrix in early diabetes. Our in vitro study also showed that upregulation of autophagy can decrease UII-induced production of extracellular matrix in HK-2 cells.
Language	English
Publishing date	2016-07-26
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2625840-7
ISSN	2040-1124 ; 2040-1116
ISSN (online)	2040-1124
ISSN	2040-1116
DOI	10.1111/jdi.12557
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Zs.A 6920: Show issues

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Book: Bu tong wen hua ren qun ai zi bing wen ti de she hui xue yan jiu

Zhang, Shengkang

Sociological research for AIDS about different cultural groups

2008

Title variant	Sociological research for Aids about different cultural groups
Author's details	Zhang Shengkang, Wang Shuguang, Zou Qin zhu
MeSH term(s)	Acquired Immunodeficiency Syndrome/prevention & control ; Unsafe Sex/psychology ; Social Class
Keywords	China
Language	Chinese ; English
Size	5, 2, 1, 7, 313 p. :, ill. ;, 21 cm.
Edition	Di 1 ban.
Publisher	Sichuan da xue chu ban she
Publishing place	Chengdu Shi
Document type	Book
Note	Abstract also in English.
ISBN	9787561441497 ; 7561441495
Database	Catalogue of the US National Library of Medicine (NLM)

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Article ; Online: YKL-40 (chitinase-3-like protein 1) serum levels are associated with abdominal aortic calcification in hemodialysis patients.

Bi, Shu-Hong / Su, Chunyan / A, La-Ta / Wang, Yue / He, Lian / Zhang, Ai-Hua

International urology and nephrology

2024

Abstract: Background: Vascular calcification (VC) is highly prevalent and predicts cardiovascular mortality in dialysis patients. The mechanisms are still unclear. Inflammation is a well-known inducer of VC. YKL-40 has been suggested as a novel biomarker of ... ...

Abstract	Background: Vascular calcification (VC) is highly prevalent and predicts cardiovascular mortality in dialysis patients. The mechanisms are still unclear. Inflammation is a well-known inducer of VC. YKL-40 has been suggested as a novel biomarker of inflammation and has been demonstrated to be associated with cardiovascular mortality in hemodialysis patients. This study aims to evaluate the relationship between serum YKL-40 and VC in hemodialysis (HD) patients. Methods: A total of 109 HD patients and 31 healthy controls were enrolled in the study from September 2014 to December 2014. We evaluated the abdominal aortic calcification (AAC) score by plain X-ray films of the abdomen and measured serum YKL-40 concentrations using enzyme-linked immunosorbent assay. We also examined the relationship between YKL-40 levels and AAC scores in HD patients. Results: Serum YKL-40 levels in HD patients were significantly higher than those in healthy controls [199.8 (144.8, 288.7) vs. 71.9 (52.8, 89.3) ng/ml; P < 0.001]. There was a tendency that YKL-40 levels in diabetic hemodialysis patients were higher than those in nondiabetic patients [217.8 (155.3, 335.8) vs. 192.9 (135.9, 274.4) ng/ml; P = 0.093]. A significant positive correlation was found between serum YKL-40 level and AAC score in these patients (r = 0.410, P = 0.003). Multiple regression analysis showed that Ln(YKL-40) was independently associated with AAC score in HD patients (P = 0.044). Conclusion: This study showed high serum YKL-40 concentrations in chronic HD patients and that YKL-40 was independently associated with increased AAC in hemodialysis patients.
Language	English
Publishing date	2024-03-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	204048-7
ISSN	1573-2584 ; 0301-1623 ; 0042-1162
ISSN (online)	1573-2584
ISSN	0301-1623 ; 0042-1162
DOI	10.1007/s11255-024-03986-x
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Zs.A 733: Show issues

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Article ; Online: Phospholipase A2 Receptor Antibodies and Clinical Prognosis in Patients with Idiopathic Membranous Nephropathy: An Updated Systematic Review and Meta-Analysis.

Zhang, Jialing / Fan, Zhengjia / Wang, Peixin / Zhang, Ai-Hua

Kidney & blood pressure research

2023 Volume 48, Issue 1, Page(s) 102–113

Abstract: Background: Idiopathic membranous nephropathy (IMN) is the most common form of primary nephrotic syndrome in adults. Antibodies against the M-type phospholipase A2 receptor (PLA2R-ab) are considered as diagnostic biomarkers of IMN.: Objective: Here, ... ...

Abstract	Background: Idiopathic membranous nephropathy (IMN) is the most common form of primary nephrotic syndrome in adults. Antibodies against the M-type phospholipase A2 receptor (PLA2R-ab) are considered as diagnostic biomarkers of IMN. Objective: Here, we performed an updated meta-analysis to assess the diagnostic value of PLA2R-ab for clinical remission in IMN patients. Method: PubMed, Embase, and Cochrane databases were searched for relevant studies published before September 2022. Odds ratios and corresponding 95% confidence intervals were determined using a fixed or random effects model. The heterogeneity among studies was explored by subgroup analysis. Results: Sixteen studies involving 1,761 IMN participants were included. There were significant differences between PLA2R-ab (+) and PLA2R-ab (-) patients in terms of complete remission (CR) and spontaneous remission. The rates of partial remission (PR) and relapse were similar between the two groups. Patients with PLA2R-ab (-) were at a higher CR rate when treated with a calcineurin inhibitor or a treatment course for 3 months and 6 months, while the spontaneous remission rate was higher in PLA2R-ab seronegative patients from Asia. However, the CR and spontaneous remission rate only significantly declined in IMN patients with the highest titer, but not a middle titer, when compared to those with the lowest titer. Conclusion: In contrast with previous meta-analyses, our results verified that PLA2R-ab can likely predict CR and spontaneous remission in IMN patients, instead of PR and relapse. Race, immunosuppressive agents, and duration of treatment may affect the prognostic value of PLA2R-ab. Considering that the remission rate of IMN patients with a middle level of PLA2R-ab was not different from that of patients with the lowest level, a proper cut-off value of PLA2R-ab for prognosis should be clarified.
MeSH term(s)	Adult ; Humans ; Glomerulonephritis, Membranous/diagnosis ; Glomerulonephritis, Membranous/drug therapy ; Receptors, Phospholipase A2 ; Remission, Spontaneous ; Antibodies ; Prognosis ; Pathologic Complete Response ; Recurrence
Chemical Substances	Receptors, Phospholipase A2 ; Antibodies
Language	English
Publishing date	2023-01-31
Publishing country	Switzerland
Document type	Systematic Review ; Meta-Analysis
ZDB-ID	1326018-2
ISSN	1423-0143 ; 1420-4096
ISSN (online)	1423-0143
ISSN	1420-4096
DOI	10.1159/000529415
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Zs.A 1458: Show issues

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Article ; Online: Impact of perioperative enhanced recovery after surgery on wound infection in patients undergoing orthopaedic surgery: A meta-analysis.

Niu, Gui-Xia / Lv, Ai-Hua / Peng, Yan-Jun / Zhang, Gui-Qin

International wound journal

2023 Volume 21, Issue 4, Page(s) e14555

Abstract: The aim of this study was to evaluate the effects of perioperative application of enhanced recovery after surgery (ERAS) concepts on wound infections and post-operative complications in patients receiving orthopaedic surgery, to provide a theoretical ... ...

Abstract	The aim of this study was to evaluate the effects of perioperative application of enhanced recovery after surgery (ERAS) concepts on wound infections and post-operative complications in patients receiving orthopaedic surgery, to provide a theoretical basis for post-operative care. Randomised controlled trials (RCTs) on the application of ERAS to patients receiving orthopaedic surgery, published up to October 2023, were identified in PubMed, Web of Science, Cochrane Library, Embase, Wanfang, China Biomedical Literature Database and China National Knowledge Infrastructure databases. Literature was screened and evaluated by two reviewers based on the inclusion and exclusion criteria, and data were extracted from the final included articles. Data were analysed using RevMan 5.4 software. A total of 20 RCTs were included in the analysis, which included 1875 patients undergoing orthopaedic surgery, of whom 938 and 937 were in the ERAS and control groups, respectively. The analysis revealed that in patients undergoing orthopaedic surgery, implementation of ERAS in the perioperative period was associated with a significantly reduced the rate of wound infections (1.6% vs. 6.19%, risk ratio [RR]: 0.30, 95% confidence interval [CI]: 0.18-0.50, p < 0.001) and complication (5.12% vs. 21.88%, RR: 0.23, 95% CI: 0.17-0.32, p < 0.001) and can effectively shorten the hospital length of stay (standardised mean difference [SMD]: -2.50 days, 95% CI: -3.17 to -1.83 days, p < 0.001) compared with that of conventional care. The available evidence suggests that the implementation of ERAS in the perioperative period of patients undergoing orthopaedic surgery could effectively reduce the rate of wound infections and complications, shorten the hospital length of stay and promote the early recovery of patients.
MeSH term(s)	Humans ; Enhanced Recovery After Surgery ; Postoperative Care ; Postoperative Complications/etiology ; Orthopedic Procedures/adverse effects ; Wound Infection ; Length of Stay
Language	English
Publishing date	2023-12-29
Publishing country	England
Document type	Meta-Analysis ; Journal Article
ZDB-ID	2170920-8
ISSN	1742-481X ; 1742-4801
ISSN (online)	1742-481X
ISSN	1742-4801
DOI	10.1111/iwj.14555
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Zs.A 6006: Show issues

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Article ; Online: Maximizing Polysaccharides and Phycoerythrin in

Yi, Sanjiong / Zhang, Ai-Hua / Huang, Jianke / Yao, Ting / Feng, Bo / Zhou, Xinghu / Hu, Yadong / Pan, Mingxuan

Marine drugs

2024 Volume 22, Issue 3

Abstract: Phycoerythrin and polysaccharides have significant commercial value in medicine, cosmetics, and food industries due to their excellent bioactive functions. To maximize the production of biomass, phycoerythrin, and polysaccharides ... ...

Abstract	Phycoerythrin and polysaccharides have significant commercial value in medicine, cosmetics, and food industries due to their excellent bioactive functions. To maximize the production of biomass, phycoerythrin, and polysaccharides in
MeSH term(s)	Porphyridium ; Phycoerythrin ; Calcium Gluconate ; Polysaccharides ; Gluconates
Chemical Substances	Phycoerythrin (11016-17-4) ; gluconic acid (R4R8J0Q44B) ; Calcium Gluconate (SQE6VB453K) ; Polysaccharides ; Gluconates
Language	English
Publishing date	2024-03-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175190-0
ISSN	1660-3397 ; 1660-3397
ISSN (online)	1660-3397
ISSN	1660-3397
DOI	10.3390/md22030138
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Article ; Online: Spatial Responses of Ecosystem Service Trade-offs and Synergies to Impact Factors in Liaoning Province.

Ren, Dong-Feng / Qiu, Ai-Ya / Cao, Ai-Hua / Zhang, Wen-Zhi / Xu, Ming-Wei

Environmental management

2023

Abstract: Global ecosystem services (ESs) are experiencing a significant decline, necessitating the development of robust environmental governance policies. To address the lack of integrated planning with heavy industry as the research object and a lack of ... ...

Abstract	Global ecosystem services (ESs) are experiencing a significant decline, necessitating the development of robust environmental governance policies. To address the lack of integrated planning with heavy industry as the research object and a lack of knowledge of ES trade-offs and synergies in China's ecological and environmental governance. In this study, the spatial and temporal variations of four ESs (water yield (WY), soil conservation (SC), carbon storage (CS), and habitat quality (HQ)) were determined in the study area of Liaoning Province. Explore the mechanisms that shape ecosystem service trade-offs and synergies and the factors that influence them. Spearman's correlation and difference analyses were proposed to determine the spatial and temporal distributions of trade-offs and synergistic relationships among ESs. In addition, we constructed a multiscale geo-weighted regression (MGWR) model to investigate driver spatial heterogeneity affecting trade-offs and synergies. The results revealed that (1) In the study area, ESs were on the rise in Liaoning Province. (2) Temporally, ESs were overwhelmingly dominated by synergies; at the spatial scale, ESs were dominated by trade-offs of varying degrees, with the area of synergy between WY and SC being the highest. (3) ESs demonstrated spatial heterogeneity in intensity and were more impacted by natural factors such as vegetation cover, elevation, and precipitation than by characteristics related to human activity. This study helps improve understanding of the interactions and dependencies among ESs and can provide a reference for ecological governance and improvements in Liaoning Province.
Language	English
Publishing date	2023-12-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1478932-2
ISSN	1432-1009 ; 0364-152X
ISSN (online)	1432-1009
ISSN	0364-152X
DOI	10.1007/s00267-023-01919-5
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Article: [Evaluation of the efficacy of sodium fluoride dental protective agent combined with pit and fissure sealant in prevention of dental caries in preschool children].

Zhang, Ai-Hua / Li, Jing

Shanghai kou qiang yi xue = Shanghai journal of stomatology

2020 Volume 28, Issue 5, Page(s) 553–556

Abstract: Purpose: To explore the effect of sodium fluoride tooth protector combined with pit and fissure sealing to prevent caries in preschool children.: Methods: Two hundred preschool children who were treated with pit and fissure closure from January 2014 ... ...

Abstract	Purpose: To explore the effect of sodium fluoride tooth protector combined with pit and fissure sealing to prevent caries in preschool children. Methods: Two hundred preschool children who were treated with pit and fissure closure from January 2014 to September 2014 were selected as subjects. According to random number table method, 100 cases were divided into the combined group and the control group. Children in the control group were treated with pit and fissure sealant for prevention of caries, while children in the combined group were treated with sodium fluoride tooth protector combined with pit and fissure sealant for caries prevention. The incidence of dental caries, proximal caries, mean DMFT, and expulsion rate of the sealants were compared between the two groups at 1 year and 2 years. Data analysis was performed using SPSS 16.0 software package for data analysis. Results: At 1 year of follow-up, there was no significant difference in the incidence of dental caries, proximal caries, and mean DMFT between the two groups (P>0.05). The incidence of caries and mean DMFT in the combined group were significantly lower than those in the control group at 2 years of follow-up (P<0.05). The incidence of proximal caries in the combined group was not significantly different from that in the control group (P>0.05). The retension rate of the pit and fissure sealant in the combined group was significantly higher than that in the control group (P<0.05). There was no significant difference in the partial shedding rate and complete expulsion rate between the two groups (P>0.05). Conclusions: Sodium fluoride tooth protector combined with pit and fissure sealing has better anti-caries effect than the use of pit and fissure sealant alone in preschool children.
MeSH term(s)	Cariostatic Agents ; Child, Preschool ; Dental Caries ; Humans ; Pit and Fissure Sealants ; Research Design ; Sodium Fluoride
Chemical Substances	Cariostatic Agents ; Pit and Fissure Sealants ; Sodium Fluoride (8ZYQ1474W7)
Language	Chinese
Publishing date	2020-03-26
Publishing country	China
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2269714-7
ISSN	1006-7248
ISSN	1006-7248
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Zs.A 6471: Show issues

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Article: Editorial: Molecular Mechanism and Therapeutic Approach to Renal Interstitial Fibrosis.

Li, Mao-Ting / Tang, Xiao-Han / Cai, Hui / Zhang, Ai-Hua / Guo, Zhi-Yong

Frontiers in medicine

2022 Volume 9, Page(s) 879927

Language	English
Publishing date	2022-05-04
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2022.879927
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Article: The Value of Peripheral Blood Cell Ratios in Primary Membranous Nephropathy: A Single Center Retrospective Study.

Zhang, Ai-Hua / Dai, Guang-Xia / Zhang, Qi-Dong / Huang, Hong-Dong / Liu, Wen-Hu

Journal of inflammation research

2023 Volume 16, Page(s) 1017–1025

Abstract: Background: Primary membranous nephropathy (PMN) is a common cause of nephrotic syndrome in adults. Forty percent of the patients continue to progress and eventually develop into chronic renal failure. Although phospholipase A2 receptor (PLA2R) is the ... ...

Abstract	Background: Primary membranous nephropathy (PMN) is a common cause of nephrotic syndrome in adults. Forty percent of the patients continue to progress and eventually develop into chronic renal failure. Although phospholipase A2 receptor (PLA2R) is the major antigen of PMN, the clinical features do not often parallel with the antibody titers. Therefore, it is significant to find relative credible markers to predict the treatment response. Methods: One hundred and eighteen PMN patients were recruited. The response to treatment was defined as ALB≥30g/L at 6 months and complete remission (CR) or not at the end of the follow-up. Renal outcome endpoint was defined as 50% or more Cr increase at the end. Results: The patients with poor treatment effects had numerically higher platelet-lymphocytes ratio (PLR). For patients with CR or not, the difference was near to statistic significant ( Conclusion: PMN patients with poor treatment response tended to have higher PLR at the time of renal biopsy, and a higher MLR was associated with poor renal outcomes. Our findings suggested that PLR and MLR might be used to predict treatment efficacy and prognosis for PMN patients, respectively.
Language	English
Publishing date	2023-03-09
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494878-0
ISSN	1178-7031
ISSN	1178-7031
DOI	10.2147/JIR.S404591
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