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Article ; Online: Racial Disparities Persist in Cancer Screening: New USPSTF Colorectal Cancer Screening Guidelines Illuminate Inadequate Breast Cancer Screening Guidelines for Black Women.

Edmonds, Christine E / Zuckerman, Samantha P / Guerra, Carmen E

2022 Volume 37, Issue 6, Page(s) 1534–1536

MeSH term(s)	Breast Neoplasms/diagnosis ; Colorectal Neoplasms/diagnosis ; Early Detection of Cancer ; Female ; Healthcare Disparities ; Humans ; Mass Screening ; Racial Groups ; United States/epidemiology
Language	English
Publishing date	2022-01-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	639008-0
ISSN	1525-1497 ; 0884-8734
ISSN (online)	1525-1497
ISSN	0884-8734
DOI	10.1007/s11606-021-07368-2
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Article ; Online: The Effect of Prior Comparison MRI on Interpretive Performance of Screening Breast MRI.

Burk, Kristine S / Edmonds, Christine E / Mercaldo, Sarah F / Lehman, Constance D / Sippo, Dorothy A

Journal of breast imaging

2024 Volume 2, Issue 1, Page(s) 36–42

Abstract: Objective: To evaluate the effect of prior comparison MRI on interpretive performance of screening breast MRI.: Methods: After institutional review board approval, all screening breast MRI examinations performed from January 2011 through December ... ...

Abstract	Objective: To evaluate the effect of prior comparison MRI on interpretive performance of screening breast MRI. Methods: After institutional review board approval, all screening breast MRI examinations performed from January 2011 through December 2014 were retrospectively reviewed. Screening performance metrics were estimated and compared for exams with and without a prior comparison MRI, using logistic regression models to adjust for age and screening indication (BRCA mutation or thoracic radiation versus breast cancer history versus high-risk lesion history versus breast cancer family history). Results: Most exams, 4509 (87%), had a prior comparison MRI (incidence round), while 661 (13%) did not (prevalence round). Abnormal interpretation rate (6% vs 20%, P < 0.01), biopsy rate (3% vs 9%, P < 0.01), and false-positive biopsy recommendation rate per 1000 exams (21 vs 71, P < 0.01) were significantly lower in the incidence rounds compared to the prevalence rounds, while specificity was significantly higher (95% vs 81%, P < 0.01). There was no difference in cancer detection rate (CDR) per 1000 exams (12 vs 20, P = 0.1), positive predictive value of biopsies performed (PPV3) (35% vs 23%, P = 0.1), or sensitivity (86% vs 76%, P = 0.4). Conclusion: Presence of a prior comparison significantly improves incidence round screening breast MRI examination performance compared with prevalence round screening. Consideration should be given to updating the BI-RADS breast MRI screening benchmarks and auditing prevalence and incidence round examinations separately.
Language	English
Publishing date	2024-02-29
Publishing country	United States
Document type	Journal Article
ISSN	2631-6129
ISSN (online)	2631-6129
DOI	10.1093/jbi/wbz076
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Article ; Online: Reply to "Unilateral Axillary Lymphadenopathy After Coronavirus Disease (COVID-19) Vaccination".

Edmonds, Christine E / Zuckerman, Samantha P / Conant, Emily F

AJR. American journal of roentgenology

2021 Volume 216, Issue 5, Page(s) W28

MeSH term(s)	COVID-19 ; Coronavirus ; Humans ; Lymphadenopathy/diagnostic imaging ; SARS-CoV-2 ; Vaccination
Language	English
Publishing date	2021-03-31
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	82076-3
ISSN	1546-3141 ; 0361-803X ; 0092-5381
ISSN (online)	1546-3141
ISSN	0361-803X ; 0092-5381
DOI	10.2214/AJR.21.25838
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Article ; Online: Patient-Assisted Compression in Screening Mammography: Patient Experience and Image Quality.

Dontchos, Brian N / Edmonds, Christine E / Mercaldo, Sarah F / Miles, Randy C / Chu, Katrina F / Lehman, Constance D

Journal of breast imaging

2024 Volume 1, Issue 3, Page(s) 192–198

Abstract: Objective: Screening mammography is critical to reduce breast cancer mortality, yet many women cite pain from compression as a reason they avoid this test. We evaluated patient experience and image quality in screening patients opting for a handheld ... ...

Abstract	Objective: Screening mammography is critical to reduce breast cancer mortality, yet many women cite pain from compression as a reason they avoid this test. We evaluated patient experience and image quality in screening patients opting for a handheld patient-assisted compression (PAC) device. Methods: After institutional review board approval, women screened between February and July 2018 with a synthetic 2D/tomosynthesis mammography unit were offered use of a handheld PAC device. Patient experience through survey, image quality, compression thickness, compression force, and average glandular dose were evaluated and compared between women opting for PAC and women opting for technologist-controlled compression (TC). Multivariable ordinal logistic and linear regression models were estimated to control for age and breast density. In addition, for women opting for PAC, image quality obtained with their current PAC mammogram was compared with that obtained with their prior TC mammogram, by using Wilcoxon/Pearson tests. Results: Seventy-three percent of women preferred their mammogram experience with PAC compared with their prior mammogram without PAC. Women using PAC reported decreased anxiety compared with those using TC, after controlling for age and breast density (adjusted odds ratio [aOR] 0.22 [95% confidence interval (CI): 0.09-0.49]). There were no significant differences in image quality, compression thickness, or average glandular dose in exams for women using PAC compared with exams for women using TC. Women using PAC had significantly more compression force than women using TC had (P = 0.012). Conclusions: Mammography with PAC improves patient experience and results in similar image quality compared with mammography with TC.
Language	English
Publishing date	2024-02-29
Publishing country	United States
Document type	Journal Article
ISSN	2631-6129
ISSN (online)	2631-6129
DOI	10.1093/jbi/wbz024
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Article ; Online: Mammographic Breast Density: Current Assessment Methods, Clinical Implications, and Future Directions.

Edmonds, Christine E / O'Brien, Sophia R / Conant, Emily F

Seminars in ultrasound, CT, and MR

2022 Volume 44, Issue 1, Page(s) 35–45

Abstract: Mammographic breast density is widely accepted as an independent risk factor for the development of breast cancer. In addition, because dense breast tissue may mask breast malignancies, breast density is inversely related to the sensitivity of screening ... ...

Abstract	Mammographic breast density is widely accepted as an independent risk factor for the development of breast cancer. In addition, because dense breast tissue may mask breast malignancies, breast density is inversely related to the sensitivity of screening mammography. Given the risks associated with breast density, as well as ongoing efforts to stratify individual risk and personalize breast cancer screening and prevention, numerous studies have sought to better understand the factors that impact breast density, and to develop and implement reproducible, quantitative methods to assess mammographic density. Breast density assessments have been incorporated into risk assessment models to improve risk stratification. Recently, novel techniques for analyzing mammographic parenchymal complexity, or texture, have been explored as potential means of refining mammographic tissue-based risk assessment beyond breast density.
MeSH term(s)	Humans ; Female ; Breast Density ; Breast Neoplasms/diagnostic imaging ; Mammography/methods ; Early Detection of Cancer/methods ; Risk Factors
Language	English
Publishing date	2022-11-04
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1353113-x
ISSN	1558-5034 ; 0887-2171
ISSN (online)	1558-5034
ISSN	0887-2171
DOI	10.1053/j.sult.2022.11.001
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Zs.A 1594: Show issues

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Article ; Online: Outcomes of COVID-19 Vaccination-Related Incidental Axillary Adenopathy in Women Undergoing Breast MRI.

Zuckerman, Samantha P / McDonald, Elizabeth S / Weinstein, Susan P / Birnbaum, Julia A / Tobey, Jennifer D / Conant, Emily F / Edmonds, Christine E

Journal of breast imaging

2024 Volume 4, Issue 4, Page(s) 392–399

Abstract: Objective: To assess the frequency, management, and early outcomes of COVID-19 vaccine-related adenopathy on breast MRI.: Methods: This IRB-exempt retrospective study reviewed patients who underwent breast MRI following COVID-19 vaccine approval in ... ...

Abstract	Objective: To assess the frequency, management, and early outcomes of COVID-19 vaccine-related adenopathy on breast MRI. Methods: This IRB-exempt retrospective study reviewed patients who underwent breast MRI following COVID-19 vaccine approval in the U.S. from December 14, 2020, to April 11, 2021 (N = 1912) and compared patients who underwent breast MRI the year prior to the pandemic, March 13, 2019, to March 12, 2020 (N = 5342). Study indication, patient age, date of study, date and type of vaccination(s), time difference between study and vaccinations, lymph node-specific and overall management recommendations, and outcomes of additional examinations were recorded. Differences in the final assessment categories between the subjects scanned pre-pandemic and post-vaccine were compared using the Fisher exact test. Results: Vaccine-related adenopathy was mentioned in 67 breast MRI reports; only 1 in the pre-pandemic group. There were no clinically relevant differences in patient demographics between groups. There was a statistically significant increase in BI-RADS 0 assessments between the pre-pandemic and post-vaccine approval groups-0.8% (45/5342) versus 1.8% (34/1912) (P = 0.001) and BI-RADS 3 assessments-6.5% (348/5342) versus 9.2% (176/1912) (P < 0.0001). Of the 29 patients who underwent additional imaging (range, 2-94 days following MRI) and the 2 patients who underwent biopsy, 47% (31/66), none were found to have malignant adenopathy. Conclusion: COVID-19 vaccination is associated with transient axillary adenopathy of variable duration. This leads to additional imaging in women undergoing breast MRI, so far with benign outcomes, and this may affect audits of outcomes of MRI.
Language	English
Publishing date	2024-02-28
Publishing country	United States
Document type	Journal Article
ISSN	2631-6129
ISSN (online)	2631-6129
DOI	10.1093/jbi/wbac036
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Article ; Online: Management of Unilateral Axillary Lymphadenopathy Detected on Breast MRI in the Era of COVID-19 Vaccination.

Edmonds, Christine E / Zuckerman, Samantha P / Conant, Emily F

AJR. American journal of roentgenology

2021 Volume 217, Issue 4, Page(s) 831–834

Abstract: Early clinical experience with COVID-19 vaccination suggests that approved COVID-19 vaccines cause a notably higher incidence of axillary lymphadenopathy on breast MRI compared with other vaccines. Guidelines are needed to appropriately manage unilateral ...

Abstract	Early clinical experience with COVID-19 vaccination suggests that approved COVID-19 vaccines cause a notably higher incidence of axillary lymphadenopathy on breast MRI compared with other vaccines. Guidelines are needed to appropriately manage unilateral axillary lymphadenopathy detected by MRI in the era of COVID-19 vaccination and to avoid biopsies of benign reactive nodes. This article examines the available data on vaccine-related lymphadenopathy and offers a basic strategy for assessing axillary lymphadenopathy on MRI and guiding management. At our institution, we are adding questions regarding the date(s) and laterality of administration of COVID-19 vaccination to the intake form given to patients before all breast imaging examinations. We consider MRI-detected isolated unilateral axillary lymphadenopathy ipsilateral to the vaccination arm to most likely be related to the COVID-19 vaccine if it develops within 4 weeks of administration of either dose. In these cases, we assess the lymphadenopathy as BI-RADS 3 and recommend that follow-up ultrasound be performed within 6-8 weeks after administration of the second dose. These guidelines may be refined as we acquire further data on the expected time course of axillary lymphadenopathy after COVID-19 vaccination. Until that time, this management pathway will help avoid unnecessary biopsies of benign vaccine-related reactive lymphadenopathy.
MeSH term(s)	Adult ; Axilla ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; COVID-19 Vaccines/therapeutic use ; Female ; Humans ; Lymph Nodes/diagnostic imaging ; Lymphadenopathy/diagnostic imaging ; Lymphadenopathy/etiology ; Magnetic Resonance Imaging/methods ; Middle Aged ; SARS-CoV-2
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2021-02-05
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	82076-3
ISSN	1546-3141 ; 0361-803X ; 0092-5381
ISSN (online)	1546-3141
ISSN	0361-803X ; 0092-5381
DOI	10.2214/AJR.21.25604
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Article ; Online: 16α-[

Mankoff, David A / Clark, Amy S / Edmonds, Christine E / O'Brien, Sophia R / Pantel, Austin R

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2022 Volume 40, Issue 31, Page(s) 3660–3663

MeSH term(s)	Humans ; Female ; Receptors, Estrogen/metabolism ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/drug therapy ; Breast Neoplasms/metabolism ; Positron-Emission Tomography ; Estradiol ; Estrogens ; Radiopharmaceuticals
Chemical Substances	Receptors, Estrogen ; Estradiol (4TI98Z838E) ; Estrogens ; Radiopharmaceuticals
Language	English
Publishing date	2022-08-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	604914-x
ISSN	1527-7755 ; 0732-183X
ISSN (online)	1527-7755
ISSN	0732-183X
DOI	10.1200/JCO.22.01055
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Zs.A 1847: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Novel applications of molecular imaging to guide breast cancer therapy.

Edmonds, Christine E / O'Brien, Sophia R / Mankoff, David A / Pantel, Austin R

Cancer imaging : the official publication of the International Cancer Imaging Society

2022 Volume 22, Issue 1, Page(s) 31

Abstract: The goals of precision oncology are to provide targeted drug therapy based on each individual's specific tumor biology, and to enable the prediction and early assessment of treatment response to allow treatment modification when necessary. Thus, ... ...

Abstract	The goals of precision oncology are to provide targeted drug therapy based on each individual's specific tumor biology, and to enable the prediction and early assessment of treatment response to allow treatment modification when necessary. Thus, precision oncology aims to maximize treatment success while minimizing the side effects of inadequate or suboptimal therapies. Molecular imaging, through noninvasive assessment of clinically relevant tumor biomarkers across the entire disease burden, has the potential to revolutionize clinical oncology, including breast oncology. In this article, we review breast cancer positron emission tomography (PET) imaging biomarkers for providing early response assessment and predicting treatment outcomes. For 2-
MeSH term(s)	Biomarkers, Tumor/metabolism ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/drug therapy ; Female ; Fluorodeoxyglucose F18/therapeutic use ; Humans ; Molecular Imaging/methods ; Positron-Emission Tomography/methods ; Precision Medicine ; Radiopharmaceuticals/therapeutic use
Chemical Substances	Biomarkers, Tumor ; Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2022-06-21
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2104862-9
ISSN	1470-7330 ; 1470-7330
ISSN (online)	1470-7330
ISSN	1470-7330
DOI	10.1186/s40644-022-00468-0
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Article ; Online: 18

O'Brien, Sophia R / Edmonds, Christine E / Lanzo, Shannon M / Weeks, Joanna K / Mankoff, David A / Pantel, Austin R

Radiographics : a review publication of the Radiological Society of North America, Inc

2023 Volume 43, Issue 3, Page(s) e220143

Abstract: In the United States, breast cancer is the second leading cause of cancer death in all women and the leading cause of cancer death in Black women. The breast cancer receptor profile, assessed with immunohistochemical staining of tissue samples, allows ... ...

Abstract	In the United States, breast cancer is the second leading cause of cancer death in all women and the leading cause of cancer death in Black women. The breast cancer receptor profile, assessed with immunohistochemical staining of tissue samples, allows prediction of outcomes and direction of patient treatment. Approximately 80% of newly diagnosed breast cancers are hormone receptor (HR) positive, which is defined as estrogen receptor (ER) and/or progesterone receptor (PR) positive. Patients with ER-positive disease can be treated with therapies targeting the ER; however, the assessment of ER expression with immunohistochemical staining of biopsy specimens has several limitations including sampling error, false-negative results, challenging or inaccessible biopsy sites, and the inability to synchronously and serially assess all metastatic sites to identify spatial and/or temporal ER heterogeneity. In May 2020, after decades of research, the U.S. Food and Drug Administration approved the PET radiotracer fluorine 18 (
MeSH term(s)	Humans ; Female ; Estradiol ; Breast Neoplasms/pathology ; Receptors, Estrogen/metabolism ; Biopsy ; Positron-Emission Tomography/methods
Chemical Substances	Estradiol (4TI98Z838E) ; Receptors, Estrogen
Language	English
Publishing date	2023-02-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	603172-9
ISSN	1527-1323 ; 0271-5333
ISSN (online)	1527-1323
ISSN	0271-5333
DOI	10.1148/rg.220143
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