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  1. Article ; Online: Reply to Alizazgar J. Dangers of the use of hydroxychloroquine and azithromycin combination in COVID-19 patients.

    Honoré, Stéphane / Gautret, Philippe

    Travel medicine and infectious disease

    2021  Volume 40, Page(s) 101984

    MeSH term(s) Azithromycin/adverse effects ; COVID-19/drug therapy ; Drug Therapy, Combination ; Humans ; Hydroxychloroquine/adverse effects ; SARS-CoV-2
    Chemical Substances Hydroxychloroquine (4QWG6N8QKH) ; Azithromycin (83905-01-5)
    Language English
    Publishing date 2021-02-05
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 2170891-5
    ISSN 1873-0442 ; 1477-8939
    ISSN (online) 1873-0442
    ISSN 1477-8939
    DOI 10.1016/j.tmaid.2021.101984
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The impact of attention bias modification training on behavioral and physiological responses.

    Ranfaing, Stéphane / De Zorzi, Lucas / Ruyffelaere, Rémi / Honoré, Jacques / Critchley, Hugo / Sequeira, Henrique

    Biological psychology

    2024  Volume 186, Page(s) 108753

    Abstract: Attention bias modification training aims to alter attentional deployment to symptom-relevant emotionally salient stimuli. Such training has therapeutic applications in the management of disorders including anxiety, depression, addiction and chronic pain. ...

    Abstract Attention bias modification training aims to alter attentional deployment to symptom-relevant emotionally salient stimuli. Such training has therapeutic applications in the management of disorders including anxiety, depression, addiction and chronic pain. In emotional reactions, attentional biases interact with autonomically-mediated changes in bodily arousal putatively underpinning affective feeling states. Here we examined the impact of attention bias modification training on behavioral and autonomic reactivity. Fifty-eight participants were divided into two groups. A training group (TR) received attention bias modification training to enhance attention to pleasant visual information, while a control group (CT) performed a procedure that did not modify attentional bias. After training, participants performed an evaluation task in which pairs of emotional and neutral images (unpleasant-neutral, pleasant-neutral, neutral-neutral) were presented, while behavioral (eye movements) and autonomic (skin conductance; heart rate) responses were recorded. At the behavioral level, trained participants were faster to orientate attention to pleasant images, and slower to orientate to unpleasant images. At the autonomic level, trained participants showed attenuated skin conductance responses to unpleasant images, while stronger skin conductance responses were generally associated with higher anxiety. These data argue for the use of attentional training to address both the attentional and the physiological sides of emotional responses, appropriate for anxious and depressive symptomatology, characterized by atypical attentional deployment and autonomic reactivity.
    MeSH term(s) Humans ; Emotions/physiology ; Anxiety/therapy ; Anxiety Disorders/psychology ; Bias ; Attentional Bias/physiology
    Language English
    Publishing date 2024-01-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 185105-6
    ISSN 1873-6246 ; 0301-0511
    ISSN (online) 1873-6246
    ISSN 0301-0511
    DOI 10.1016/j.biopsycho.2024.108753
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Implementation of a patient-teaching workshop to improve pharmacy students' competencies in patient-centered communication: a case report.

    Hache, Caroline / Honoré, Stéphane / Hache, Guillaume

    BMC medical education

    2022  Volume 22, Issue 1, Page(s) 555

    Abstract: Background: The pharmacist-patient relationship has evolved over recent decades and the development of clinical pharmacy requires pharmacists to take patient-centered responsibilities. This requires a specific set of skills, such as patient-centered ... ...

    Abstract Background: The pharmacist-patient relationship has evolved over recent decades and the development of clinical pharmacy requires pharmacists to take patient-centered responsibilities. This requires a specific set of skills, such as patient-centered communication. Evaluation of students' competencies in patient-centered communication is challenging in academic settings and complementary assessment methods may be designed in order to overcome the limits of traditional preceptors' ratings or objective structured clinical examination (OSCE). There is increasing interest in a more active patient role in healthcare professional education and there are very few reports about patient-led education in pharmacies. Thus, the objective of this work was to implement a patient-teaching workshop and to assess its impact on pharmacy students' competencies in patient-centered communication.
    Methods: The workshop was developed in collaboration between four patients, a senior clinical pharmacist and a lecturer in education sciences and implemented in the hospital pharmacy residency program. The main course objective was acquiring the three competencies of the Calgary-Cambridge guide to the medical interview: (i) building a relationship, (ii) conducting structured interview and (iii) gathering information. The learning process integrated: working on participants' perception of pharmacists-patient communication, a first simulated interview, didactic learning and a second simulated interview. After simulated interviews, patients and peer residents assessed learner's performance with a competency chart and provided individual feedback. Assessment methods included comparisons between the first and second interview scores and an anonymous post-course survey.
    Results: Forty-seven residents and 19 patient teachers attended the session. Competency scores were higher after the second interview in all three competencies as rated by both patients (+ 25%) and peer residents (+ 29%). Residents expressed a high satisfaction and reported learning about conducting interviews and soft skills contributing to the development of a relationship with patients. "The involvement of patients" was expressed as most appreciated in the majority of the evaluation charts (87%) and the residents valued the importance of collaborative and interprofessional learning during the workshop. Three themes emerged: (1) patients' expertise, (2) reliability and (3) relationship, which underlined that the students estimated the patients were credible sources of information in this pedagogical context.
    Conclusion: This patient-teaching approach improved patient-centered competencies of pharmacy residents and promoted partnership between patients and pharmacy students.
    MeSH term(s) Communication ; Curriculum ; Education, Pharmacy/methods ; Humans ; Patient-Centered Care ; Pharmacists ; Reproducibility of Results ; Students, Pharmacy
    Language English
    Publishing date 2022-07-18
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2044473-4
    ISSN 1472-6920 ; 1472-6920
    ISSN (online) 1472-6920
    ISSN 1472-6920
    DOI 10.1186/s12909-022-03618-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Continuous infusion of beta-lactam antibiotics in pediatric intensive care unit: A monocenter before/after implementation study.

    Ragonnet, Gwendoline / Guilhaumou, Romain / Hanafia, Omar / Néant, Nadège / Denante, Solène / Vanel, Noémie / Honoré, Stéphane / Michel, Fabrice

    Anaesthesia, critical care & pain medicine

    2024  Volume 43, Issue 3, Page(s) 101354

    Abstract: Context: Beta-lactam continuous infusion (CI) is currently recommended in adult intensive care units to achieve target concentrations. In pediatric intensive care (PICU), few studies suggest the value of Beta-lactam CI to achieve target concentration. ... ...

    Abstract Context: Beta-lactam continuous infusion (CI) is currently recommended in adult intensive care units to achieve target concentrations. In pediatric intensive care (PICU), few studies suggest the value of Beta-lactam CI to achieve target concentration. Our objective was to analyze the impact of Beta-lactam CI protocolization on the achievement of target concentration in PICU patients.
    Material and methods: We conducted a single-center retrospective study in patients with beta-lactam treatment for more than 2 days and at least one sample for therapeutic drug monitoring (TDM). From January 2018 to February 2022 (period 1, P1), BL were administered as an intermittent infusion with TDM upon request. From February to September 2022 (period 2, P2), Beta-lactam CI with TDM at day one was protocolized. The primary endpoint concerned achieving fT>4× Minimum Inhibitory Concentration = 100%.
    Results: In P1, 214 assays involved 103 patients; in P2, 199 assays involved 72 patients. Target concentration achievement was more frequent in P2 (P2 = 73.7% vs. P1 = 29.1%; p < 0.001). At day 5/6 after Beta-lactam initiation, c-reactive protein concentrations were P1 = 84.9 ± 79.2 mg/L; P2 = 53.7±49.8 mg/L (p < 0.05). In the multivariable logistic regression model: P2, BSA, and albumin were positively associated with target achievement; urea, and male sex were negatively associated with target achievement. The daily average cost of beta-lactam vial consumption per child was: P1 = 5.04 ± 2.6 € vs. P2 = 3.21 ± 2.7 € (p-value < 0.001). The daily average reconstitution time of Beta-lactam syringes per child was: P1 = 23.5 ± 8.7 min, P2 = 13.9 ± 9.2 min (p-value < 0.001).
    Conclusion: Protocolization of Beta-lactam continuous infusion was associated with more frequent target concentration achievements in PICU. This implementation could be cost-effective and nurse time-saving.
    Language English
    Publishing date 2024-02-13
    Publishing country France
    Document type Journal Article
    ISSN 2352-5568
    ISSN (online) 2352-5568
    DOI 10.1016/j.accpm.2024.101354
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Elderly patients whose hospitalization was medication-related were more likely to receive medication recommendations by clinical pharmacist than patients whose hospitalization was unlikely medication-related in non-geriatric units.

    Protzenko, Dorian / Nakache, Jérémie / De la Brosse, Sonia / Honoré, Stéphane / Hache, Guillaume

    Research in social & administrative pharmacy : RSAP

    2023  Volume 19, Issue 10, Page(s) 1386–1390

    Abstract: Background: Elderly patients are often polymedicated, and drug-related hospitalizations are common in this population. In our hospital, pharmacists from the mobile geriatric team (MGT) coordinate medication reviews (MR) for elderly patients hospitalized ...

    Abstract Background: Elderly patients are often polymedicated, and drug-related hospitalizations are common in this population. In our hospital, pharmacists from the mobile geriatric team (MGT) coordinate medication reviews (MR) for elderly patients hospitalized in non-geriatric wards, to prevent iatrogenic.
    Objective: The aim of this work is to determine whether the drug-related origin of hospitalizations can be considered as a targeting criterion for performing MRs.
    Material and method: We conducted a retrospective study of data from patients who received a MGT's MR between March 2021 and December 2022, from a single center of more than 1000 beds. The drug-related origin of the hospitalization was estimated as probable or unlikely by the AT-HARM10 tool. Between the two groups, we compared the number of potentially inappropriate prescriptions detected by the PIM-check and START/STOPP tools, drug-drug interactions (DI), unintended discrepancies (UDI) at entry reconciliation, the drug burden index (DBI), and the number of drug-related problems (DRP) i.e., START/STOPP score + DI + UDI. Linear regression of the number of DRP by AT-HARM10 score was computed.
    Results: 110 patients were included. 56 hospitalizations were estimated MRH and 54 non-MRH. Mean age (85.1 ± 7.0), ADL (3.8 ± 1.9), IADL (2.0 ± 1.6), and number of medications at entry (8.9 ± 3.8) were comparable in the 2 groups. Compared with non-MRH group, MRH group had a higher number of START/STOPP criteria (5.7 ± 3.5 vs 3.0 ± 2.6; p < 0.05), PIM-check overuses (2.1 ± 1.7 vs 1.4 ± 1.4; p < 0.05), DI (8.4 ± 9.0 vs 4.7 ± 4.7; p < 0.05), UDI at entry (4.0 ± 3.34 vs 2.2 ± 2.1; p < 0.05), and higher DBI score (0.9 ± 0.7 vs 0.3 ± 0.4; p < 0.05). The number of DRP was higher in group P (17.6 ± 10.8 vs 9.8 ± 6.3; p < 0.00.5). Linear regression showed a positive correlation between AT-HARM10 score and the number of DRP (r = 0.5, p < 0.05) with a coefficient of 7.7 (CI95% = [4.3; 11.1]) and an intercept of 9.8.
    Discussion: These results allow us to consider AT-HARM10 score as a targeting criterion for performing MR for elderly patients, as part of a curative approach to drug iatrogenic for these patients.
    MeSH term(s) Humans ; Aged ; Pharmacists ; Retrospective Studies ; Hospitalization ; Inappropriate Prescribing/prevention & control ; Iatrogenic Disease
    Language English
    Publishing date 2023-06-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2192059-X
    ISSN 1934-8150 ; 1551-7411
    ISSN (online) 1934-8150
    ISSN 1551-7411
    DOI 10.1016/j.sapharm.2023.06.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Active involvement of patients in pharmacist education has a positive impact on students' perspective: a pilot study.

    Hache, Caroline / Honoré, Stéphane / Hache, Guillaume

    BMC medical education

    2020  Volume 20, Issue 1, Page(s) 322

    Abstract: Background: Patient-led education contributes to the implementation of practical experience of working with patients in health care professional curricula. There are few descriptions of patients' involvement in pharmacists' training and most often, the ... ...

    Abstract Background: Patient-led education contributes to the implementation of practical experience of working with patients in health care professional curricula. There are few descriptions of patients' involvement in pharmacists' training and most often, the patients have been used as passive props to facilitate training. More recently, greater emphasis has been given to a more active form of patient involvement but the application in the curriculum of pharmacy has not been conceptualized. Thus, the aim of our study was to implement a workshop involving patients as partners in undergraduate pharmacy educational programme, and to evaluate its impact of on students' perspectives.
    Method: On a prospective observational study basis, the impact was assessed in terms of relevance, learning outcomes and achievement transfer using the Kirkpatrick training assessment method. In addition, we evaluated social representations of the students before and after the workshop.
    Results: Ninety-four students attended the sessions. All participants were satisfied and emphasized the relevance of the involvement of patients. Postworkshop scores were significantly improved in both competencies to be acquired. At the end of the workshop, students reported two to three actions to implement in order to meet patients' expectations, illustrating an intent to transfer learning outcomes in professional context. Interestingly, about patients' expectations on pharmacist's role, students' social representations had evolved significantly after the session.
    Conclusion: These results highlight the positive impact of the innovative workshops and the additive value of patients' involvement in the pharmacy undergraduate programme.
    MeSH term(s) Curriculum ; Education, Pharmacy ; Humans ; Learning ; Pharmacists ; Pilot Projects ; Students ; Students, Pharmacy
    Language English
    Publishing date 2020-09-21
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 2044473-4
    ISSN 1472-6920 ; 1472-6920
    ISSN (online) 1472-6920
    ISSN 1472-6920
    DOI 10.1186/s12909-020-02241-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Safety profile of hydroxychloroquine and azithromycin combined treatment in COVID-19 patients.

    Gautret, Philippe / Honoré, Stéphane / Lagier, Jean-Christophe / Raoult, Didier

    International journal of antimicrobial agents

    2021  Volume 57, Issue 1, Page(s) 106236

    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Antimalarials/therapeutic use ; Antiviral Agents/therapeutic use ; Azithromycin/therapeutic use ; COVID-19/virology ; Clinical Trials as Topic ; Drug Combinations ; Drug Interactions ; Drug Repositioning ; Drug Synergism ; Electrocardiography ; Humans ; Hydroxychloroquine/therapeutic use ; Hyperkalemia/prevention & control ; Hypokalemia/prevention & control ; Long QT Syndrome/prevention & control ; SARS-CoV-2/pathogenicity ; COVID-19 Drug Treatment
    Chemical Substances Anti-Bacterial Agents ; Antimalarials ; Antiviral Agents ; Drug Combinations ; Hydroxychloroquine (4QWG6N8QKH) ; Azithromycin (83905-01-5)
    Language English
    Publishing date 2021-01-07
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1093977-5
    ISSN 1872-7913 ; 0924-8579
    ISSN (online) 1872-7913
    ISSN 0924-8579
    DOI 10.1016/j.ijantimicag.2020.106236
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Low concentrations of vorinostat decrease EB1 expression in GBM cells and affect microtubule dynamics, cell survival and migration.

    Perez, Thomas / Bergès, Raphaël / Maccario, Hélène / Oddoux, Sarah / Honoré, Stéphane

    Oncotarget

    2021  Volume 12, Issue 4, Page(s) 304–315

    Abstract: Glioblastoma multiform (GBM) is the most frequent primitive brain tumor with a high recurrence and mortality. Histone deacetylase inhibitors (HDACi) have evoked great interest because they are able to change transcriptomic profiles to promote tumor cell ... ...

    Abstract Glioblastoma multiform (GBM) is the most frequent primitive brain tumor with a high recurrence and mortality. Histone deacetylase inhibitors (HDACi) have evoked great interest because they are able to change transcriptomic profiles to promote tumor cell death but also induce side effects due to the lack of selectivity. We show in this paper new anticancer properties and mechanisms of action of low concentrations of vorinostat on various GBM cells which acts by affecting microtubule cytoskeleton in a non-histone 3 (H3) manner. Indeed, vorinostat induces tubulin acetylation and detyrosination, affects EB stabilizing cap on microtubule plus ends and suppresses microtubule dynamic instability. We previously identified EB1 overexpression as a marker of bad prognostic in GBM. Interestingly, we show for the first time to our knowledge, a strong decrease of EB1 expression in GBM cells by a drug. Altogether, our results suggest that low dose vorinostat, which is more selective for HDAC6 inhibition, could therefore represent an interesting therapeutic option for GBM especially in patients with EB1 overexpressing tumor with lower expected side effects. A validation of our hypothesis is needed during future clinical trials with this drug in GBM.
    Language English
    Publishing date 2021-02-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.27892
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Autonomic reactivity to emotion: A marker of sub-clinical anxiety and depression symptoms?

    De Zorzi, Lucas / Ranfaing, Stéphane / Honoré, Jacques / Sequeira, Henrique

    Psychophysiology

    2021  Volume 58, Issue 4, Page(s) e13774

    Abstract: Anxiety and depression are both characterized by dysregulated autonomic reactivity to emotion. However, most experiments until now have focused on autonomic reactivity to stimuli presented in central vision (CV) even if affective saliency is also ... ...

    Abstract Anxiety and depression are both characterized by dysregulated autonomic reactivity to emotion. However, most experiments until now have focused on autonomic reactivity to stimuli presented in central vision (CV) even if affective saliency is also observed in peripheral vision (PV). We compared autonomic reactivity to CV and PV emotional stimulation in 58 participants with high anxious (HA) or low anxious (LA) and high depressive (HD) or low depressive (LD) symptomatology, based on STAI-B and BDI scores, respectively. Unpleasant (U), pleasant (P), and neutral (N) pictures from IAPS were presented at three eccentricities (0°: CV; -12 and 12°: PV). Skin conductance (SC), skin temperature, pupillary diameter, and heart rate (HR) were recorded. First, HA participants showed greater pupil dilation to emotional than to neutral stimuli in PV than in CV. Second, in contrast to HD, the valence effect indexed by SC and emotional arousal effect indexed by skin temperature were observed in LD. Third, both anxiety and depression lead to a valence effect indexed by pupillary light reflex and heart rate. These results suggest a hyperreactivity to emotion and hypervigilance to PV in anxiety. Depression is associated with an attenuation of positive effect and a global blunted autonomic reactivity to emotion. Moreover, anxiety mostly modulates the early processes of autonomic reactivity whereas depression mainly affects the later processes. The differential impact of emotional information over the visual field suggests the use of new stimulation strategies in order to attenuate anxious and depressive symptoms.
    MeSH term(s) Adult ; Anxiety/physiopathology ; Arousal/physiology ; Autonomic Nervous System/physiopathology ; Depression/physiopathology ; Electrocardiography ; Emotions/physiology ; Female ; Galvanic Skin Response/physiology ; Heart Rate/physiology ; Humans ; Male ; Pattern Recognition, Visual/physiology ; Pupil/physiology ; Reflex/physiology ; Young Adult
    Language English
    Publishing date 2021-02-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209486-1
    ISSN 1540-5958 ; 0048-5772
    ISSN (online) 1540-5958
    ISSN 0048-5772
    DOI 10.1111/psyp.13774
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Active involvement of patients in pharmacist education has a positive impact on students’ perspective

    Caroline Hache / Stéphane Honoré / Guillaume Hache

    BMC Medical Education, Vol 20, Iss 1, Pp 1-

    a pilot study

    2020  Volume 9

    Abstract: Abstract Background Patient-led education contributes to the implementation of practical experience of working with patients in health care professional curricula. There are few descriptions of patients’ involvement in pharmacists’ training and most ... ...

    Abstract Abstract Background Patient-led education contributes to the implementation of practical experience of working with patients in health care professional curricula. There are few descriptions of patients’ involvement in pharmacists’ training and most often, the patients have been used as passive props to facilitate training. More recently, greater emphasis has been given to a more active form of patient involvement but the application in the curriculum of pharmacy has not been conceptualized. Thus, the aim of our study was to implement a workshop involving patients as partners in undergraduate pharmacy educational programme, and to evaluate its impact of on students’ perspectives. Method On a prospective observational study basis, the impact was assessed in terms of relevance, learning outcomes and achievement transfer using the Kirkpatrick training assessment method. In addition, we evaluated social representations of the students before and after the workshop. Results Ninety-four students attended the sessions. All participants were satisfied and emphasized the relevance of the involvement of patients. Postworkshop scores were significantly improved in both competencies to be acquired. At the end of the workshop, students reported two to three actions to implement in order to meet patients’ expectations, illustrating an intent to transfer learning outcomes in professional context. Interestingly, about patients’ expectations on pharmacist’s role, students’ social representations had evolved significantly after the session. Conclusion These results highlight the positive impact of the innovative workshops and the additive value of patients’ involvement in the pharmacy undergraduate programme.
    Keywords Educational device ; Patient educational training ; Patient-led education ; Pharmacy ; University curriculum ; Special aspects of education ; LC8-6691 ; Medicine ; R
    Subject code 370
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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