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Article ; Online: Correction: Feng et al. Nicotinamide Phosphoribosyltransferase (Nampt)/Nicotinamide Adenine Dinucleotide (NAD) Axis Suppresses Atrial Fibrillation by Modulating the Calcium Handling Pathway.

Feng, Duo / Xu, DongZhu / Murakoshi, Nobuyuki / Tajiri, Kazuko / Qin, Rujie / Yonebayashi, Saori / Okabe, Yuta / Li, Siqi / Yuan, Zixun / Aonuma, Kazutaka / Ieda, Masaki

International journal of molecular sciences

2021 Volume 22, Issue 19

Abstract: The authors wish to make the following corrections to this paper [ ... ]. ...

Abstract	The authors wish to make the following corrections to this paper [...].
Language	English
Publishing date	2021-10-08
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms221910881
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Mechanisms and molecular targets of the Yu-Ping-Feng powder for allergic rhinitis, based on network pharmacology.

Yang, Shasha / Fu, Qinwei / Deng, Hua / Liu, Zhiqing / Zhong, Juan / Zhu, Xiaoyu / Wang, Qian / Sun, Chuanhui / Wu, Jing

Medicine

2021 Volume 100, Issue 35, Page(s) e26929

Abstract: Abstract: In traditional Chinese medicine (TCM), Yu-Ping-Feng powder (YPFP) has been used to treat ...

Abstract	Abstract: In traditional Chinese medicine (TCM), Yu-Ping-Feng powder (YPFP) has been used to treat allergic rhinitis (AR) for centuries. However, the mechanisms underlying its effects or its molecular targets in AR treatment are yet to be elucidated. Therefore, the active compounds of YPFP and their targets were collected and identified from the Traditional Chinese Medicine Systems Pharmacology database. Moreover, AR-associated targets were acquired from the GeneCards and Online Mendelian Inheritance in Man database. Proteins interactions network of YPFP presumed targets and AR-associated targets were examined and merged to reveal the candidate YPFP targets against AR.Cytoscape software and BisoGenet Database were employed to perform the Visualization and Integrated Discovery (Cluster Profiler R package, version: 3.8.1). Kyoto Encyclopedia of Genes and Genomes and genome pathway analyses. To identify the key target genes, a gene-pathway network has been constructed.We identified 44 effective active compounds and 622 YPFP targets. Also 1324 target genes related to AR were identified. Twenty pathways, including those of AGE-RAGE signaling, fluid shear stress, atherosclerosis, PI3K-Akt signaling, and tumor necrosis factor signaling was enriched significantly. MAPK1 was identified as the core gene, while others including RELA, AKT1, NFKBIA, IL6, and JUN, were also important in the gene-pathway network. Clearly, network pharmacology can be applied in revealing the molecular targets and mechanisms of action of complex herbal preparations.These findings suggested that YPFP could treat AR by regulating immunological functions, diminishing inflammation, and improving immunity through different pathways.
MeSH term(s)	Drugs, Chinese Herbal/pharmacokinetics ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Pharmacology/methods ; Protein Interaction Maps/drug effects ; Rhinitis, Allergic/drug therapy
Chemical Substances	Drugs, Chinese Herbal ; yu ping feng san
Language	English
Publishing date	2021-09-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000026929
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Mechanisms of Yu Ping Feng San in Tracking the Cisplatin-Resistance by Regulating ATP-Binding Cassette Transporter and Glutathione S-Transferase in Lung Cancer Cells.

Du, Yingqing / Zheng, Yuzhong / Yu, Ciel Xiaomei / Zhong, Lishan / Li, Yafang / Wu, Baomeng / Hu, Weihui / Zhu, Elsa Wanyi / Xie, Venus Wei / Xu, Qitian / Zhan, Xingri / Huang, Yamiao / Zeng, Liyi / Zhang, Zhenxia / Liu, Xi / Yin, Jiachuan / Zha, Guangcai / Chan, Kelvin / Tsim, Karl Wah Keung

Frontiers in pharmacology

2021 Volume 12, Page(s) 678126

Abstract: ... however, the chemotherapeutic drug resistance is still a major obstacle of cisplatin in treating cancers. Yu Ping Feng San (YPFS ...

Abstract	Cisplatin is one of the first line anti-cancer drugs prescribed for treatment of solid tumors; however, the chemotherapeutic drug resistance is still a major obstacle of cisplatin in treating cancers. Yu Ping Feng San (YPFS), a well-known ancient Chinese herbal combination formula consisting of Astragali Radix, Atractylodis Macrocephalae Rhizoma and Saposhnikoviae Radix, is prescribed as a herbal decoction to treat immune disorders in clinic. To understand the fast-onset action of YPFS as an anti-cancer drug to fight against the drug resistance of cisplatin, we provided detailed analyses of intracellular cisplatin accumulation, cell viability, and expressions and activities of ATP-binding cassette transporters and glutathione S-transferases (GSTs) in YPFS-treated lung cancer cell lines. In cultured A549 or its cisplatin-resistance A549/DDP cells, application of YPFS increased accumulation of intracellular cisplatin, resulting in lower cell viability. In parallel, the activities and expressions of ATP-binding cassette transporters and GSTs were down-regulated in the presence of YPFS. The expression of p65 subunit of NF-κB complex was reduced by treating the cultures with YPFS, leading to a high ratio of Bax/Bcl-2, i.e. increasing the rate of cell death. Prim-O-glucosylcimifugin, one of the abundant ingredients in YPFS, modulated the activity of GSTs, and then elevated cisplatin accumulation, resulting in increased cell apoptosis. The present result supports the notion of YPFS in reversing drug resistance of cisplatin in lung cancer cells by elevating of intracellular cisplatin, and the underlying mechanism may be down regulating the activities and expressions of ATP-binding cassette transporters and GSTs.
Language	English
Publishing date	2021-05-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.678126
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effect of the Fu Zheng Method Applied by Hong-Feng CHEN on the Quality of Life in TNBC Patients and Empirical Research Based on Data Mining

Yu-Zhu ZHANG / Yue ZHOU / Bai-Ling SHI / Hong-Feng CHEN / Li-Juan CHE

Digital Chinese Medicine, Vol 1, Iss 4, Pp 272-

2018 Volume 279

Abstract: ... resistance against pathogenic factors) applied by Professor Hong-Feng CHEN in improving the quality of life ... TCM) formulas applied by Professor Hong-Feng CHEN in the treatment of TNBC in order to explore ... Feng CHEN were summarized.Conclusion The TCM formulas applied by Professor Hong-Feng CHEN can alleviate ...

Abstract	ABSTRACT: Objective To preliminarily evaluate the efficacy of the Fu Zheng method (supporting resistance against pathogenic factors) applied by Professor Hong-Feng CHEN in improving the quality of life in patients with triple-negative breast cancer (TNBC) to collect and organize the traditional Chinese medicine (TCM) formulas applied by Professor Hong-Feng CHEN in the treatment of TNBC in order to explore the patterns in prescription.Methods The Functional Assessment of Cancer Therapy-Breast scale (FACT-B V4.0) were collected before and after treatment; the database and data mining platform for prescribed TCM formulas were constructed using Microsoft SQL Server 2005, and the patterns in drug pairing and combination were summarized by correlation analysis of data mining.Results The formulas improved the mean scores of the patients’ physical well-being, social/family well-being, emotional well-being, physical function well-being and additional concerns (P < 0.01); the drug combinations and pairs frequently used by Professor Hong-Feng CHEN were summarized.Conclusion The TCM formulas applied by Professor Hong-Feng CHEN can alleviate adverse physiological reactions, improve psychological conditions and improve function in patients. The formulas take spleen invigoration and stomach nourishment as well as blood circulation promotion and stagnation dissipation as the therapeutic principles, with simplicity in prescription and focus on care and protection the foundation of acquired constitution. Keywords: Triple-negative breast cancer, Data mining, Traditional Chinese medicine formulas, Quality of life, Hong-Feng CHEN
Keywords	Medicine ; R ; Other systems of medicine ; RZ201-999
Subject code	616
Language	English
Publishing date	2018-12-01T00:00:00Z
Publisher	KeAi Communications Co., Ltd.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: The Ancient Chinese Decoction Yu-Ping-Feng Suppresses Orthotopic Lewis Lung Cancer Tumor Growth Through Increasing M1 Macrophage Polarization and CD4

Wang, Lixin / Wu, Wenbin / Zhu, Xiaowen / Ng, Wanyi / Gong, Chenyuan / Yao, Chao / Ni, Zhongya / Yan, Xuewei / Fang, Cheng / Zhu, Shiguo

Frontiers in pharmacology

2019 Volume 10, Page(s) 1333

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2019-11-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2019.01333
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [Next generation sequencing and transcriptome analysis of root bark from Paeonia suffruticosa cv. Feng Dan].

Xie, Dong-Mei / Yu, Nian-Jun / Huang, Lu-Qi / Peng, Dai-Yin / Liu, Cong-Bin / Zhu, Yue-Jian / Huang, Hao

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2017 Volume 42, Issue 15, Page(s) 2954–2961

Abstract: ... from the root bark of Paeonia suffruticosa cv. Feng Dan for its extracted various active components ...

Abstract	Moutan Cortex is an important traditional Chinese medicine, "Fengdan Pi" was known as Dao-di herbs from the root bark of Paeonia suffruticosa cv. Feng Dan for its extracted various active components. However, the genetic basis for their activity is virtually unknown. The transcriptome of the root bark from "Fengdan" was sequenced using the Illumina HiSeq 4000 sequencing platform. The clean reads were then de novo assembled into 72 997 unigenes. Among them, the number of unigenes which could been annotated by dataset Nr and GO was 41 139 and 34 592. The 20 016 unigenes could been annotated by KEGG dataset, which were involved in 5 major categories, 34 middle categories, and 352 metabolism pathways. The number of unigenes which were mapped to the phenylpropanoid biosynthesis pathway, terpenoid backbone biosynthesis pathway, terpenoid biosynthesis pathway, alkaloid biosynthesis pathway, and flavonoid biosynthesis pathway was 214, 104, 152, 55 and 36 respectively, suggesting that they are involves in these pathways of pharmaceutically important. Furthermore, there also showed remarkable differences in groups which enrichment ratio of the different expressed gene compared. In addition, a total of 9 939 SSRs were identified from the sequence of 72 997 unigenes. This study not only provides many valuable basal data which was important gene in the synthesis pathway of secondary metabolites with gene searching, but also has important significance to find molecular marker in germplasm for breeding and improvement.
MeSH term(s)	Gene Expression Profiling ; High-Throughput Nucleotide Sequencing ; Paeonia/chemistry ; Paeonia/genetics ; Plant Roots/chemistry ; Plants, Medicinal/chemistry ; Plants, Medicinal/genetics ; Secondary Metabolism ; Transcriptome
Language	Chinese
Publishing date	2017-12-15
Publishing country	China
Document type	Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20170714.001
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: NK Cell-Dependent Growth Inhibition of Lewis Lung Cancer by Yu-Ping-Feng, an Ancient Chinese Herbal Formula.

Luo, Yingbin / Wu, Jianchun / Zhu, Xiaowen / Gong, Chenyuan / Yao, Chao / Ni, Zhongya / Wang, Lixin / Ni, Lulu / Li, Yan / Zhu, Shiguo

Mediators of inflammation

2016 Volume 2016, Page(s) 3541283

Abstract: Little is known about Yu-Ping-Feng (YPF), a typical Chinese herbal decoction, for its antitumor ...

Abstract	Little is known about Yu-Ping-Feng (YPF), a typical Chinese herbal decoction, for its antitumor efficacy in non-small-cell lung cancer (NSCLC). Here, we found that YPF significantly inhibited the growth of Lewis lung cancer, prolonged the survival of tumor-bearing mice, promoted NK cell tumor infiltration, increased the population of NK cells in spleen, and enhanced NK cell-mediated killing activity. The growth suppression of tumors by YPF was significantly reversed by the depletion of NK cells. Furthermore, we found that YPF significantly downregulated the expression of TGF-β, indoleamine 2,3-dioxygenase, and IL-10 in tumor microenvironment. These results demonstrated that YPF has a NK cell-dependent inhibitory effect on Lewis lung cancer.
MeSH term(s)	Animals ; Carcinoma, Lewis Lung/drug therapy ; Carcinoma, Lewis Lung/immunology ; Carcinoma, Lewis Lung/metabolism ; Drugs, Chinese Herbal/therapeutic use ; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism ; Interleukin-10/metabolism ; Killer Cells, Natural/drug effects ; Killer Cells, Natural/metabolism ; Lung Neoplasms/drug therapy ; Lung Neoplasms/immunology ; Lung Neoplasms/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Transforming Growth Factor beta/metabolism
Chemical Substances	Drugs, Chinese Herbal ; IL10 protein, human ; Indoleamine-Pyrrole 2,3,-Dioxygenase ; Transforming Growth Factor beta ; Interleukin-10 (130068-27-8)
Language	English
Publishing date	2016
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1137605-3
ISSN	1466-1861 ; 0962-9351
ISSN (online)	1466-1861
ISSN	0962-9351
DOI	10.1155/2016/3541283
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 3575: Show issues

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Article ; Online: Screening active components from Yu-ping-feng-san for regulating initiative key factors in allergic sensitization.

Shen, Dandan / Xie, Xuejian / Zhu, Zhijie / Yu, Xi / Liu, Hailiang / Wang, Huizhu / Fan, Hongwei / Wang, Dawei / Jiang, Guorong / Hong, Min

PloS one

2014 Volume 9, Issue 9, Page(s) e107279

Abstract: Yu-ping-feng-san (YPFS) is a Chinese medical formula that is used clinically for allergic diseases ...

Abstract	Yu-ping-feng-san (YPFS) is a Chinese medical formula that is used clinically for allergic diseases and characterized by reducing allergy relapse. Our previous studies demonstrated that YPFS efficiently inhibited T helper 2 cytokines in allergic inflammation. The underlying mechanisms of action of YPFS and its effective components remain unclear. In this study, it was shown that YPFS significantly inhibited production of thymic stromal lymphopoietin (TSLP), an epithelial cell-derived initiative factor in allergic inflammation, in vitro and in vivo. A method of human bronchial epithelial cell (16HBE) binding combined with HPLC-MS (named 16HBE-HPLC-MS) was established to explore potential active components of YPFS. The following five components bound to 16HBE cells: calycosin-7-glucoside, ononin, claycosin, sec-o-glucosylhamaudol and formononetin. Serum from YPFS-treated mice was analyzed and three major components were detected claycosin, formononetin and cimifugin. Among these, claycosin and formononetin were detected by 16HBE-HPLC-MS and in the serum of YPFS-treated mice. Claycosin and formononetin decreased the level of TSLP markedly at the initial stage of allergic inflammation in vivo. Nuclear factor (NF)-κB, a key transcription factor in TSLP production, was also inhibited by claycosin and formononetin, either in terms of transcriptional activation or its nuclear translocation in vitro. Allergic inflammation was reduced by claycosin and formononetin when they are administered only at the initial stage in a murine model of atopic contact dermatitis. Thus, epithelial cell binding combined with HPLC-MS is a valid method for screening active components from complex mixtures of Chinese medicine. It was demonstrated that the compounds screened from YPFS significantly attenuated allergic inflammation probably by reducing TSLP production via regulating NF-κB activation.
MeSH term(s)	Animals ; Bronchi/cytology ; Cell Line ; Cytokines/biosynthesis ; Cytokines/blood ; Drug Evaluation, Preclinical ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Humans ; Hypersensitivity/blood ; Hypersensitivity/drug therapy ; Hypersensitivity/metabolism ; Isoflavones/analysis ; Isoflavones/metabolism ; Isoflavones/pharmacology ; Mice ; Mice, Inbred BALB C ; NF-kappa B/genetics ; NF-kappa B/metabolism ; Protein Transport/drug effects ; Time Factors ; Transcriptional Activation/drug effects
Chemical Substances	Cytokines ; Drugs, Chinese Herbal ; Isoflavones ; NF-kappa B ; yu ping feng san ; formononetin (295DQC67BJ) ; thymic stromal lymphopoietin (GT0IL38SP4)
Language	English
Publishing date	2014-09-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0107279
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: Xuan he feng shi gao li tu jing

Xu, Jing / Zhu, Yi'an

(Quan song bi ji : 全宋筆記 ; : di 3 bian / Zhu yi an ... [et al.] zhu bian; shang hai shi fan da xue gu ji zheng li yan jiu suo bian ; 8)

2008

Institution	Shang hai shi fan da xue / Gu ji zheng li yan jiu suo 上海師範大學 / 古籍整理硏究所
Author's details	Xu jing zhuan
Series title	Quan song bi ji : 全宋筆記 ; : di 3 bian / Zhu yi an ... [et al.] zhu bian; shang hai shi fan da xue gu ji zheng li yan jiu suo bian ; 8
Language	Chinese
Size	218 p
Edition	Di 1 ban
Publisher	Da xiang chu ban she
Publishing place	Zheng zhou
Document type	Book
Note	Die Vorlage enth. insgesamt 2 Werke
ISBN	9787534748998 ; 7534748992
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: Screening active components from Yu-ping-feng-san for regulating initiative key factors in allergic sensitization.

Dandan Shen / Xuejian Xie / Zhijie Zhu / Xi Yu / Hailiang Liu / Huizhu Wang / Hongwei Fan / Dawei Wang / Guorong Jiang / Min Hong

PLoS ONE, Vol 9, Iss 9, p e

2014 Volume 107279

Abstract: Yu-ping-feng-san (YPFS) is a Chinese medical formula that is used clinically for allergic diseases ...

Abstract	Yu-ping-feng-san (YPFS) is a Chinese medical formula that is used clinically for allergic diseases and characterized by reducing allergy relapse. Our previous studies demonstrated that YPFS efficiently inhibited T helper 2 cytokines in allergic inflammation. The underlying mechanisms of action of YPFS and its effective components remain unclear. In this study, it was shown that YPFS significantly inhibited production of thymic stromal lymphopoietin (TSLP), an epithelial cell-derived initiative factor in allergic inflammation, in vitro and in vivo. A method of human bronchial epithelial cell (16HBE) binding combined with HPLC-MS (named 16HBE-HPLC-MS) was established to explore potential active components of YPFS. The following five components bound to 16HBE cells: calycosin-7-glucoside, ononin, claycosin, sec-o-glucosylhamaudol and formononetin. Serum from YPFS-treated mice was analyzed and three major components were detected claycosin, formononetin and cimifugin. Among these, claycosin and formononetin were detected by 16HBE-HPLC-MS and in the serum of YPFS-treated mice. Claycosin and formononetin decreased the level of TSLP markedly at the initial stage of allergic inflammation in vivo. Nuclear factor (NF)-κB, a key transcription factor in TSLP production, was also inhibited by claycosin and formononetin, either in terms of transcriptional activation or its nuclear translocation in vitro. Allergic inflammation was reduced by claycosin and formononetin when they are administered only at the initial stage in a murine model of atopic contact dermatitis. Thus, epithelial cell binding combined with HPLC-MS is a valid method for screening active components from complex mixtures of Chinese medicine. It was demonstrated that the compounds screened from YPFS significantly attenuated allergic inflammation probably by reducing TSLP production via regulating NF-κB activation.
Keywords	Medicine ; R ; Science ; Q
Subject code	570
Language	English
Publishing date	2014-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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