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  1. Article ; Online: Promising New Diagnostic and Treatment Modalities for Allergic Rhinitis: What's Coming Next?

    Barrett, Thomas F / Roland, Lauren T

    Otolaryngologic clinics of North America

    2023  Volume 57, Issue 2, Page(s) 243–251

    Abstract: Novel diagnostic tests may help diagnose patients with local allergic rhinitis (AR) when systemic testing is negative or inconclusive. Surgical approaches including septoplasty, inferior turbinate reduction, nasal swell body reduction, and posterior ... ...

    Abstract Novel diagnostic tests may help diagnose patients with local allergic rhinitis (AR) when systemic testing is negative or inconclusive. Surgical approaches including septoplasty, inferior turbinate reduction, nasal swell body reduction, and posterior nasal nerve ablation may improve symptoms in patients whose symptoms are refractory to medical therapy, though high-quality evidence is lacking in the AR population. Intralymphatic and epicutaneous immunotherapy have the potential to improve adherence to allergen immunotherapy, though comparisons with current gold standard treatments are lacking and studies reporting long-term outcomes are needed. Immunomodulatory agents in combination with subcutaneous immunotherapy (SCIT) may improve tolerance of SCIT but reports to date do not demonstrate a clear benefit in symptom alleviation. Future work in these areas may support these options as beneficial for testing and treatment of AR.
    MeSH term(s) Humans ; Rhinitis, Allergic/diagnosis ; Rhinitis, Allergic/therapy ; Desensitization, Immunologic ; Rhinoplasty ; Nose ; Allergens
    Chemical Substances Allergens
    Language English
    Publishing date 2023-09-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 417489-6
    ISSN 1557-8259 ; 0030-6665
    ISSN (online) 1557-8259
    ISSN 0030-6665
    DOI 10.1016/j.otc.2023.08.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Strategies for Evaluating Anosmia Therapeutics in the COVID-19 Era-Coming to Our Senses.

    Roland, Lauren T / Levy, Joshua M

    JAMA otolaryngology-- head & neck surgery

    2022  Volume 148, Issue 9, Page(s) 837–839

    MeSH term(s) Anosmia ; COVID-19 ; Humans ; Olfaction Disorders/therapy ; SARS-CoV-2
    Language English
    Publishing date 2022-07-07
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2701825-8
    ISSN 2168-619X ; 2168-6181
    ISSN (online) 2168-619X
    ISSN 2168-6181
    DOI 10.1001/jamaoto.2022.1575
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  3. Article ; Online: Knowledge Gaps and Research Needs for Biologic Therapy in Rhinology Practice.

    Roland, Lauren T / Levy, Joshua M

    Otolaryngologic clinics of North America

    2021  Volume 54, Issue 4, Page(s) 709–716

    Abstract: Biologic agents are emerging for chronic rhinosinusitis with nasal polyposis (CRSwNP) patients with recalcitrant disease. Although early work has shown promise, and several trials are ongoing, there is significant work to be done in this field. CRS ... ...

    Abstract Biologic agents are emerging for chronic rhinosinusitis with nasal polyposis (CRSwNP) patients with recalcitrant disease. Although early work has shown promise, and several trials are ongoing, there is significant work to be done in this field. CRS patients form a heterogeneous group, and identification of appropriate patients for the use of biologic agents is critical. The determination of endotype-specific biomarkers will help define patient selection and predict treatment response. As more biologic agents become approved, head-to-head trials will be needed to compare them with similar products. Ultimately, cost-effectiveness analyses and further quality of life studies will guide treatment recommendations.
    MeSH term(s) Biological Therapy ; Chronic Disease ; Humans ; Nasal Polyps/drug therapy ; Quality of Life ; Rhinitis/drug therapy ; Sinusitis/drug therapy
    Language English
    Publishing date 2021-06-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 417489-6
    ISSN 1557-8259 ; 0030-6665
    ISSN (online) 1557-8259
    ISSN 0030-6665
    DOI 10.1016/j.otc.2021.04.002
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  4. Article ; Online: When inflammation is not just inflammation-A review of systemic diseases of the nose and sinuses part 1: IgG4-related disease and sarcoidosis.

    Cler, Samuel J / Ogden, M Allison / Farrell, Nyssa Fox / Roland, Lauren T / Diffie, Colin E / Schneider, John S

    American journal of otolaryngology

    2024  Volume 45, Issue 3, Page(s) 104213

    Abstract: Background: Chronic rhinosinusitis is a very common condition. IgG4-related disease (IgG4-RD) and sarcoidosis are systemic diseases which can contribute to the development of chronic rhinosinusitis in select patients.: Objective: Characterize the ... ...

    Abstract Background: Chronic rhinosinusitis is a very common condition. IgG4-related disease (IgG4-RD) and sarcoidosis are systemic diseases which can contribute to the development of chronic rhinosinusitis in select patients.
    Objective: Characterize the presenting features, diagnostic criteria, workup, and management of sinonasal IgG4-RD and sarcoidosis as they are encountered in otolaryngology clinics.
    Methods: Full length manuscripts published 2000 or later were reviewed. A separate search was conducted for each disease. Pertinent clinical features related to sinonasal manifestations of IgG4-RD and sarcoidosis were collected and reported in this review.
    Results: 404 references were discovered during literature review process. In total, 42 references for IgG4-RD and 34 references for sarcoidosis were included in this review.
    Conclusion: IgG4-RD and sarcoidosis are autoimmune inflammatory conditions that can affect many systems of the body. For both disease entities, sinonasal disease is a less common presentation which can lead to delayed diagnosis. Sinonasal IgG4-RD commonly presents in the setting of multisystem disease. All with other clinical features, biopsy plays a key role in the diagnosis for both diseases. Treatment for IgG4-RD consists primarily of steroids and rituximab which can lead to excellent and durable remission. A variety of immunosuppressive agents are used in the management of sarcoidosis. Surgery for IgG4-RD is primarily utilized for tissue biopsy, although resection or debulking may be considered. For sarcoidosis, surgery can be used for tissue biopsy and functional sinus surgery can offer symptomatic relief in many patients.
    Language English
    Publishing date 2024-01-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604541-8
    ISSN 1532-818X ; 0196-0709
    ISSN (online) 1532-818X
    ISSN 0196-0709
    DOI 10.1016/j.amjoto.2023.104213
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  5. Article ; Online: Prognostic Factors for Survival Using a Clinical Severity Staging System Among Patients With Acute Invasive Fungal Sinusitis.

    Munyemana, Marie-Ange / Kallogjeri, Dorina / Chernock, Rebecca / Farrell, Nyssa F / Schneider, John S / Piccirillo, Jay F / Roland, Lauren T

    JAMA otolaryngology-- head & neck surgery

    2024  Volume 150, Issue 4, Page(s) 328–334

    Abstract: Importance: Despite the aggressive progression of fulminant acute invasive fungal sinusitis (AIFS), data on prognostic factors have been disparate, hindering the development of a staging system. A composite staging system may improve prognostication for ...

    Abstract Importance: Despite the aggressive progression of fulminant acute invasive fungal sinusitis (AIFS), data on prognostic factors have been disparate, hindering the development of a staging system. A composite staging system may improve prognostication for patient counseling and conduct of clinical research.
    Objective: To identify prognostically important factors in AIFS and to incorporate the factors into a comprehensive Functional Severity Staging System and Clinical Severity Staging System.
    Design, setting, and participants: This retrospective cohort study included adult patients diagnosed with pathology-proven AIFS from June 1, 1992, to December 31, 2022, at Washington University Medical Center and Barnes-Jewish Hospital, a tertiary care center in St Louis, Missouri. Data were analyzed from April to July 2023.
    Main outcome and measures: Sequential sequestration and conjunctive consolidation was used to develop a composite staging system to predict 6-month overall survival.
    Results: Of 71 patients with pathology-proven AIFS over the 30-year period, the median (range) age of the cohort was 56 (19-63) years, and there were 47 (66%) male patients. The median (range) follow-up time was 2 (0-251) months. There were 28 patients alive within 6 months, for a 39% survival rate. Symptoms, comorbidity burden, and presence and duration of severe neutropenia were associated with 6-month survival and were consolidated into a 3-category Clinical Severity Staging System with 6-month survival of 75% for stage A (n = 16), 41% for stage B (n = 27), and 18% for stage C (n = 28). The discriminative power of the composite staging system was moderate (C statistic, 0.63).
    Conclusion and relevance: This cohort study supports the clinical importance of symptomatology, comorbidity burden, and prolonged severe neutropenia at the time of AIFS presentation. The composite clinical staging system may be useful for clinicians when counseling patients with AIFS and conducting clinical research.
    MeSH term(s) Adult ; Humans ; Male ; Middle Aged ; Female ; Prognosis ; Cohort Studies ; Retrospective Studies ; Sinusitis/diagnosis ; Neutropenia ; Neoplasm Staging
    Language English
    Publishing date 2024-02-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701825-8
    ISSN 2168-619X ; 2168-6181
    ISSN (online) 2168-619X
    ISSN 2168-6181
    DOI 10.1001/jamaoto.2024.0042
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  6. Article ; Online: HRCT-MRI fusion: A novel imaging protocol surpasses current modalities in localizing spontaneous cerebrospinal fluid leaks.

    Goyal, Sabrina S / Everett, Travis / Reis, Martin / Fox Farrell, Nyssa / Parsons, Matthew S / Roland, Lauren T / Schneider, John S

    International forum of allergy & rhinology

    2023  Volume 13, Issue 11, Page(s) 2119–2122

    Abstract: Key points: HRCT-MRI fusion is a new imaging modality that can be used to diagnose spontaneous CSF leaks. HRCT-MRI fusion has better accuracy in localizing CSF leaks compared to MRI and HRCT alone. ...

    Abstract Key points: HRCT-MRI fusion is a new imaging modality that can be used to diagnose spontaneous CSF leaks. HRCT-MRI fusion has better accuracy in localizing CSF leaks compared to MRI and HRCT alone.
    Language English
    Publishing date 2023-05-19
    Publishing country United States
    Document type Letter
    ZDB-ID 2625826-2
    ISSN 2042-6984 ; 2042-6976
    ISSN (online) 2042-6984
    ISSN 2042-6976
    DOI 10.1002/alr.23174
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    Zs.A 6927: Show issues Location:
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  7. Article ; Online: Is Tranexamic Acid Effective for Hemostasis During Endoscopic Sinus Surgery?

    Douglas, Zachary H / Piccirillo, Jay F / Schneider, John / Roland, Lauren T / Farrell, Nyssa Fox

    The Laryngoscope

    2022  Volume 133, Issue 4, Page(s) 716–718

    MeSH term(s) Humans ; Tranexamic Acid/therapeutic use ; Endoscopy ; Antifibrinolytic Agents/therapeutic use ; Hemostasis ; Blood Loss, Surgical/prevention & control ; Hemostasis, Surgical
    Chemical Substances Tranexamic Acid (6T84R30KC1) ; Antifibrinolytic Agents
    Language English
    Publishing date 2022-12-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.30513
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  8. Article ; Online: Progression of noninvasive fungal sinusitis to invasive fungal sinusitis: A systematic review.

    Goyal, Sabrina S / Doering, Michelle / Kendall, Peggy L / Farrell, Nyssa / Schneider, John S / Roland, Lauren T

    International forum of allergy & rhinology

    2022  Volume 13, Issue 6, Page(s) 1024–1033

    MeSH term(s) Humans ; Mycoses/diagnosis ; Mycoses/microbiology ; Sinusitis/diagnosis ; Sinusitis/microbiology ; Invasive Fungal Infections/diagnosis
    Language English
    Publishing date 2022-11-08
    Publishing country United States
    Document type Systematic Review ; Journal Article
    ZDB-ID 2625826-2
    ISSN 2042-6984 ; 2042-6976
    ISSN (online) 2042-6984
    ISSN 2042-6976
    DOI 10.1002/alr.23097
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  9. Article ; Online: The Treatment Paradigm of Chronic Rhinosinusitis with Nasal Polyps in the COVD-19 Era.

    Roland, Lauren T / Pinto, Jayant M / Naclerio, Robert M

    The journal of allergy and clinical immunology. In practice

    2020  Volume 8, Issue 8, Page(s) 2492–2494

    MeSH term(s) Chronic Disease ; Humans ; Nasal Polyps/therapy ; Rhinitis/diagnosis ; Rhinitis/epidemiology ; Sinusitis/diagnosis ; Sinusitis/therapy
    Keywords covid19
    Language English
    Publishing date 2020-06-24
    Publishing country United States
    Document type Editorial
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2020.06.029
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  10. Article ; Online: Reply to: Challenges in interpreting the diagnostic performance of symptoms to predict COVID-19 status: the case of anosmia.

    Roland, Lauren T / Loftus, Patricia A / Chang, Jolie L

    International forum of allergy & rhinology

    2020  Volume 10, Issue 9, Page(s) 1116–1117

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Olfaction Disorders ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-17
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2625826-2
    ISSN 2042-6984 ; 2042-6976
    ISSN (online) 2042-6984
    ISSN 2042-6976
    DOI 10.1002/alr.22648
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