Article ; Online: Reposition of montelukast either alone or in combination with levocetirizine against SARS-CoV-2.
2020 Volume 144, Page(s) 110046
Abstract: It has been hypothesised that antiallergic medications (AAMs) like montelukast and levocetirizine both the two bitter chloro compounds could be repurposed either alone or combinedly as an antiviral against SARS-CoV-2, like chloroquine/hydroxychloroquine ( ...
Abstract | It has been hypothesised that antiallergic medications (AAMs) like montelukast and levocetirizine both the two bitter chloro compounds could be repurposed either alone or combinedly as an antiviral against SARS-CoV-2, like chloroquine/hydroxychloroquine (CQ/HCQ), another two bitter chloro compounds. Both AAMs and CQ/HCQ are bitter tasted chloro compounds. Depending on their these two similar physical properties and the safety and efficacy of AAMs by controlling over post viral episodes as comparing with viral inhibitory activities including SARS-CoV-2 by CQ/HCQ, a reposition of AAMs either alone/combinedly could be rationalised as an antiviral approach to nCoV. |
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MeSH term(s) | Acetates/therapeutic use ; Anti-Asthmatic Agents/therapeutic use ; Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; Cetirizine/therapeutic use ; Clinical Trials as Topic ; Drug Repositioning ; Histamine H1 Antagonists, Non-Sedating/therapeutic use ; Humans ; Hypersensitivity/drug therapy ; Models, Theoretical ; Patient Safety ; Quinolines/therapeutic use ; Taste |
Chemical Substances | Acetates ; Anti-Asthmatic Agents ; Antiviral Agents ; Histamine H1 Antagonists, Non-Sedating ; Quinolines ; levocetirizine (6U5EA9RT2O) ; montelukast (MHM278SD3E) ; Cetirizine (YO7261ME24) |
Language | English |
Publishing date | 2020-06-28 |
Publishing country | United States |
Document type | Letter |
ZDB-ID | 193145-3 |
ISSN | 1532-2777 ; 0306-9877 |
ISSN (online) | 1532-2777 |
ISSN | 0306-9877 |
DOI | 10.1016/j.mehy.2020.110046 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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