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  1. Book ; Online: PARPs, PAR and NAD Metabolism and Their Inhibitors in Cancer

    Curtin, Nicola / Bay, Péter

    2023  

    Keywords Research & information: general ; Biology, life sciences ; Biochemistry ; MDS ; PARP inhibitors ; olaparib ; hematopoietic differentiation ; PARP1 ; AML ; poly-ADP-ribose polymerase 1 (PARP1) ; brahma-related gene 1 (BRG1) ; histone acetyltransferase p300 (EP300) ; gene transcription ; cancer cell ; head and neck squamous cell carcinoma ; CAL27 ; SCC90 ; p60/p150 CAF-1 subunits ; DNA repair ; homologous recombination ; biomarkers ; personalized treatment ; UVB ; PARP ; mitochondria ; metabolism ; biogenesis ; autophagy ; carcinogenesis ; transcription ; PARylation ; DNA damage ; transcription silencing ; carryover effect ; TOP1 activity ; TDP1 ; irinotecan ; immunomodulation ; tumor microenvironment ; trapping ; cancer therapeutic strategy ; arginine-specific mono-ADP-ribosylation ; bacterial toxin ; cholera toxin ; ART1 ; ARH1 ; tumorigenesis ; loss of heterozygosity ; membrane repair ; gender bias ; Syk ; EGFR ; squamous cell carcinoma ; PARP-Akt interplay ; PI3K ; mTOR ; cytoprotection ; apoptosis resistance ; oxidative stress ; mitochondrial protection ; drug development ; synthetic lethality ; clinical trials ; ADP-ribosylation ; cancer ; macrodomain ; ADP-ribosyl hydrolase ; ARTD ; MACROD1 ; MACROD2 ; TARG1 ; ATM ; ATR ; PARP inhibitor ; prostate cancer ; pancreatic cancer ; lung cancer ; Tumor microenvironment ; PARPs ; hypoxia ; CHK1 ; replication stress ; homologous recombination DNA repair ; cell cycle ; cytotoxicity ; PARP Inhibitors ; beta-lapachone ; NQO1 ; PARG ; NAMPT ; cancer therapeutics ; cMET ; poly (ADP-ribose) glycohydrolase ; radiosensitization ; poly (ADP-ribose) polymerase ; ES cells ; poly (ADP-ribose) polymerase inhibitors (PARPi) ; ataxia telangiectasia and Rad3 related inhibitors (ATRi) ; cell cycle checkpoints ; NAD+ ; NMNAT1 ; cisplatin ; chemotherapy ; apoptosis ; osteosarcoma ; DNA damage response ; immunotherapy ; immune checkpoint inhibitor ; PD-1 ; PD-L1 ; CTLA-4 ; combination therapy ; solid tumors ; the PARP inhibitor PJ34 ; distorted mitotic spindles ; exclusive eradication of human cancer cells ; nucleolus ; poly(ADP-ribosyl)ation ; ARTDs ; n/a
    Language English
    Size 1 electronic resource (462 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030382221
    ISBN 9783036581576 ; 303658157X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: Targeting the DNA damage response for anti-cancer therapy

    Pollard, John / Curtin, Nicola

    (Cancer drug discovery and development)

    2018  

    Author's details John Pollard, Nicola Curtin editors
    Series title Cancer drug discovery and development
    Keywords Medicine ; Cancer research ; Gene therapy
    Subject code 614.5999
    Language English
    Size 1 Online-Ressource (ix, 401 Seiten), Illustrationen, Diagramme
    Publisher Humana Press
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019744713
    ISBN 978-3-319-75836-7 ; 9783319758343 ; 3-319-75836-5 ; 3319758349
    DOI 10.1007/978-3-319-75836-7
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: 25 years of

    Curtin, Nicola

    Expert reviews in molecular medicine

    2023  Volume 25, Page(s) e12

    MeSH term(s) Humans ; Anti-Bacterial Agents ; Erythromycin
    Chemical Substances Anti-Bacterial Agents ; Erythromycin (63937KV33D)
    Language English
    Publishing date 2023-04-18
    Publishing country England
    Document type Journal Article
    ISSN 1462-3994
    ISSN (online) 1462-3994
    DOI 10.1017/erm.2023.8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Targeting the DNA damage response for cancer therapy.

    Curtin, Nicola J

    Biochemical Society transactions

    2023  Volume 51, Issue 1, Page(s) 207–221

    Abstract: The DNA damage response (DDR) is an elegant system, coordinating DNA repair with cell cycle checkpoints, that evolved to protect living organisms from the otherwise fatal levels of DNA damage inflicted by endogenous and environmental sources. Since many ... ...

    Abstract The DNA damage response (DDR) is an elegant system, coordinating DNA repair with cell cycle checkpoints, that evolved to protect living organisms from the otherwise fatal levels of DNA damage inflicted by endogenous and environmental sources. Since many agents used to treat cancer; radiotherapy and cytotoxic chemotherapy, work by damaging DNA the DDR represents a mechanism of resistance. The original rational for the development of drugs to inhibit the DDR was to overcome this mechanism of resistance but clinical studies using this approach have not led to improvements in the therapeutic index. A more exciting approach is to exploit cancer-specific defects in the DDR, that represent vulnerabilities in the tumour and an opportunity to selectively target the tumour. PARP inhibitors (PARPi) selectively kill homologous recombination repair defective (HRD, e.g. through BRCA mutation) cells. This approach has proven successful clinically and there are now six PARPi approved for cancer therapy. Drugs targeting other aspects of the DDR are under pre-clinical and clinical evaluation as monotherapy agents and in combination studies. For this promising approach to cancer therapy to be fully realised reliable biomarkers are needed to identify tumours with the exploitable defect for monotherapy applications. The possibility that some combinations may result in toxicity to normal tissues also needs to be considered. A brief overview of the DDR, the development of inhibitors targeting the DDR and the current clinical status of such drugs is described here.
    MeSH term(s) Humans ; DNA Damage ; DNA Repair ; Neoplasms/pathology ; Poly(ADP-ribose) Polymerase Inhibitors/therapeutic use ; Biomarkers
    Chemical Substances Poly(ADP-ribose) Polymerase Inhibitors ; Biomarkers
    Language English
    Publishing date 2023-03-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 184237-7
    ISSN 1470-8752 ; 0300-5127
    ISSN (online) 1470-8752
    ISSN 0300-5127
    DOI 10.1042/BST20220681
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 944: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Correction: Combination treatment with rucaparib (Rubraca) and MDM2 inhibitors, Nutlin-3 and RG7388, has synergistic and dose reduction potential in ovarian cancer.

    Zanjirband, Maryam / Curtin, Nicola / Edmondson, Richard J / Lunec, John

    Oncotarget

    2024  Volume 15, Page(s) 142

    Language English
    Publishing date 2024-02-22
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.28523
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The Development of Rucaparib/Rubraca®: A Story of the Synergy Between Science and Serendipity.

    Curtin, Nicola J

    Cancers

    2020  Volume 12, Issue 3

    Abstract: The poly(ADP-ribose) polymerase (PARP) inhibitor, Rubraca®, was given its first accelerated approval for BRCA-mutated ovarian cancer by the FDA at the end of 2016, and further approval by the FDA, EMA and NICE followed. Scientists at Newcastle University ...

    Abstract The poly(ADP-ribose) polymerase (PARP) inhibitor, Rubraca®, was given its first accelerated approval for BRCA-mutated ovarian cancer by the FDA at the end of 2016, and further approval by the FDA, EMA and NICE followed. Scientists at Newcastle University initiated the early stages, and several collaborations with scientists in academia and the pharmaceutical industry enabled its final development to the approval stage. Although originally considered as a chemo- or radiosensitiser, its current application is as a single agent exploiting tumour-specific defects in DNA repair. As well as involving intellectual and physical effort, there have been a series of fortuitous occurrences and coincidences of timing that ensured its success. This review describes the history of the relationship between science and serendipity that brought us to the current position.
    Language English
    Publishing date 2020-02-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers12030564
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Examining the implementation of a community paediatric clinic in a socially disadvantaged Irish community: A retrospective process evaluation.

    Buckley, Lynn / Gibson, Louise / Harford, Katherine / Cornally, Nicola / Curtin, Margaret

    PloS one

    2024  Volume 19, Issue 2, Page(s) e0295521

    Abstract: Background: Understanding interventions and their implementation is essential for improving community initiatives. Kidscope is a community paediatric development clinic providing free health and developmental assessment and onward referral for children ... ...

    Abstract Background: Understanding interventions and their implementation is essential for improving community initiatives. Kidscope is a community paediatric development clinic providing free health and developmental assessment and onward referral for children aged zero to six years in an urban area of southern Ireland where many children experience complex needs. Established in 2010, Kidscope developed an inter-disciplinary, multi-agency community team by drawing on the strengths of local services and practitioners to deliver holistic approaches to child health and development. Recent studies examining stakeholder engagement and Kidscope outcomes highlighted the need to examine implementation to better understand the processes and mechanisms of the clinic and how events have affected outcomes.
    Methods: Guided by the UK Medical Research Council Framework for Developing and Evaluating Complex Interventions, this study used a post-hoc qualitative process evaluation study design with multiple data sources; stakeholder perspectives (interviews, focus group, questionnaires) and document analysis (annual reports, meeting minutes, work plans). A diverse set of research questions were developed in conjunction with a Patient and Public Involvement Group. Guiding frameworks supported thematic analysis of primary data, document analysis of secondary data, and triangulation of findings across datasets.
    Results: Data analysis yielded 17 themes and 18 sub-themes. Successful implementation hinged on developing a coalition of linked practitioners and services whose skills were utilised and enhanced within Kidscope to deliver a high-quality healthcare model to vulnerable children and families. Relational and multi-disciplinary working, innovative approaches to implementation and sustainability, training and education provision, and the accessible community location were among the mechanisms of change resulting in improved child, family, practitioner, and system-level outcomes. External factors such as COVID-19 and deficits in Ireland's disability services posed significant barriers to fidelity.
    Conclusion: This study provides evidence of the processes, mechanisms, and model of care employed by a community-based paediatric clinic to successfully engage society's most vulnerable families and promote health equity. This study makes an important contribution to the field of implementation research by offering an example of a robust approach to conceptualising and measuring implementation outcomes of community healthcare initiative in a changing, real-world context.
    MeSH term(s) Humans ; Child ; Health Promotion ; Retrospective Studies ; Ambulatory Care Facilities ; Community Health Services ; Focus Groups
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0295521
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: PARPs, PAR and NAD Metabolism and Their Inhibitors in Cancer.

    Curtin, Nicola / Bai, Péter

    Cancers

    2020  Volume 12, Issue 12

    Abstract: The role of poly(ADP-ribose) polymerase-1 (PARP1) in DNA repair and as a potential target for anticancer therapy has been under investigation for more than 50 years [ ... ]. ...

    Abstract The role of poly(ADP-ribose) polymerase-1 (PARP1) in DNA repair and as a potential target for anticancer therapy has been under investigation for more than 50 years [...].
    Language English
    Publishing date 2020-11-24
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers12123494
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Sustainable Development Goals in Ireland: How Public Health Nurses Are Contributing Through Engagement in an Interagency Community Pediatric Clinic.

    Buckley, Lynn / Gibson, Louise / Harford, Katherine / Cornally, Nicola / Curtin, Margaret

    SAGE open nursing

    2023  Volume 9, Page(s) 23779608231207221

    Abstract: Introduction: United Nations Sustainable Development Goals (SDGs) were adopted as a plan of action for people, planet, and prosperity by 2030. SDG 3 aims to ensure healthy lives and promote well-being for all ages, and other goals focus on reduction of ... ...

    Abstract Introduction: United Nations Sustainable Development Goals (SDGs) were adopted as a plan of action for people, planet, and prosperity by 2030. SDG 3 aims to ensure healthy lives and promote well-being for all ages, and other goals focus on reduction of inequality, abolition of poverty, decent work for all, and building effective, accountable, and inclusive institutions. A community pediatric clinic, Kidscope, was established in a vulnerable Irish community offering free developmental assessment and onward referral of children 0 to 6 years. The Kidscope model involves multiagency input with local public health nurses (PHNs) acting as fundamental partners in the provision of specialist early years support to vulnerable children and families. This study evaluates PHN involvement in Kidscope in the context of SDGs.
    Objective: To record and understand PHN roles within Kidscope and to capture their contribution to achieving SDGs in a disadvantaged Irish community.
    Methods: Qualitative stakeholder analysis and mapping design. Snowball sampling identified participants. Data collection involved scoping interviews, questionnaires, one-to-one interviews, and a focus group. A Stakeholder Matrix Table was developed in line with the guiding framework. Transcripts were thematically analyzed.
    Results: PHNs are key stakeholders in Kidscope contributing to clinic development, delivery, and sustainability. Six themes were identified: lead referrers, in-clinic support, learning and education, child and family follow-up, specialist early years role, and partnership working. PHNs contribute to six SDGs through the Kidscope model.
    Conclusion: PHNs are fundamental partners in achieving SDGs in a disadvantaged Irish community through ameliorating childhood developmental delay by intercepting the gap within Ireland's early intervention system and disrupting the impact exclusion to healthcare has on vulnerable children and their families. Findings underscore a shift from the current "cradle to grave" model of working toward a specialist early years PHN role.
    Language English
    Publishing date 2023-10-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2865437-7
    ISSN 2377-9608 ; 2377-9608
    ISSN (online) 2377-9608
    ISSN 2377-9608
    DOI 10.1177/23779608231207221
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Parent perspectives of engaging with a community paediatric clinic with linked child development supports in a disadvantaged area of Ireland.

    Buckley, Lynn / Harford, Katherine / Gibson, Louise / Cornally, Nicola / Curtin, Margaret

    Journal of child health care : for professionals working with children in the hospital and community

    2023  , Page(s) 13674935231210947

    Abstract: Parent experiences of child health services can be used to understand their value and optimise the support provision to families during critical developmental periods. A gap in the literature exists regarding parental perspectives of linked child ... ...

    Abstract Parent experiences of child health services can be used to understand their value and optimise the support provision to families during critical developmental periods. A gap in the literature exists regarding parental perspectives of linked child development supports, particularly in disadvantaged areas. This study examined parent experiences of the impact and value of a community paediatric clinic (Kidscope) with linked, multi-agency supports in a disadvantaged area of Ireland. Using a qualitative analysis design, 10 parents participated in one-to-one interviews. A Community Advisory Group consulted on interview schedules. Data was thematically analysed in line with Braun & Clarke's Framework. Five themes and twenty-two sub-themes emerged. Kidscope's linked, multi-agency approach was valuable for engaging families, addressing developmental delay, supporting readiness for education, and developing parent-child relationships. Relational working and a child and family centred model of care empowered parents to become active agents in children's health. Coronavirus disease 2019, national deficits in healthcare, and staff turnover impeded service delivery. Kidscope and linked supports work in partnership to disrupt the impact exclusion from healthcare has on vulnerable children and families. This study provides evidence of an effective integrated paediatric service delivery model designed around vulnerable children and families and highlights areas for improvement.
    Language English
    Publishing date 2023-11-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2299167-0
    ISSN 1741-2889 ; 1367-4935
    ISSN (online) 1741-2889
    ISSN 1367-4935
    DOI 10.1177/13674935231210947
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6662: Show issues Location:
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