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  1. Article: [Factors associated with postpartum weight retention based on the generalized estimation equation in Kaifu Districtin Changsha].

    Li, Ling / Yan, Yan / Sha, Tingting / Gao, Xiao / He, Qiong / Chen, Cheng / Cheng, Gang / Wu, Xialing / Tian, Qianling / Yang, Fan / Liu, Shiping / Zeng, Guangyu / Yan, Qiang

    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences

    2019  Volume 44, Issue 1, Page(s) 59–66

    Abstract: Objective: To investigate the current status of the postpartum weight retention (PPWR) in Kaifu ... at the health service centers of 3 street communities in Kaifu District of Changsha during 2015. According ...

    Abstract Objective: To investigate the current status of the postpartum weight retention (PPWR) in Kaifu District of Changsha, and explore the influential factors with PPWR based on the generalized estimating equation model.
 Methods: A cluster sampling method was applied to select women who gave birth at the health service centers of 3 street communities in Kaifu District of Changsha during 2015. According to the inclusion and exclusion criteria, 783 cases were finally included in the study. Data on PPWR were collected prospectively by using the self-made questionnaire at 1, 3, 6 and 8 months after childbirth. Analysis were performed to investigate the associations between PPWR and its potential factors with generalized estimation equation model.
 Results: The mean PPWR of women was gradually decreased with the increase of postpartum time, and 34.6% of them have returned to the pre-pregnancy weight in the 8 months postpartum. Our findings revealed that gestation weight gain (GWG), pre-pregnancy body mass index, feeding patterns, and delivery mode were significantly associated with maternal PPWR (P<0.05). In contrast, maternal age, educational level, per capita income of family, parity and postpartum depression were not contributed to PPWR (P>0.05).
 Conclusion: GWG is one of the most important predictors for PPWR. The key to reducing PPWR is to control GWG systematically. Early targeted interventions and health education should be taken to prevent women from excessive PPWR at the first-year postpartum, in particular to the women who underwent cesarean deliveries and breastfed their infants. It is conducive to reduce the risks of overweight or obesity caused by PPWR.
    MeSH term(s) Body Mass Index ; Female ; Gestational Weight Gain ; Humans ; Obesity ; Overweight ; Postpartum Period ; Pregnancy
    Language Chinese
    Publishing date 2019-03-05
    Publishing country China
    Document type Journal Article
    ZDB-ID 2168533-2
    ISSN 1672-7347
    ISSN 1672-7347
    DOI 10.11817/j.issn.1672-7347.2019.01.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: [Influential factors for postpartum depression based on the structural equation model in Kaifu District in Changsha].

    Sha, Tingting / Yan, Yan / Gao, Xiao / Xiang, Shiting / He, Qiong / Zeng, Guangyu / Liu, Shiping / Li, Hongyan / Tan, Shan / Yan, Qiang

    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences

    2017  Volume 42, Issue 10, Page(s) 1191–1197

    Abstract: Objective: To investigate the current status of the postpartum depression in Kaifu District ... effects on postpartum depression.
 Conclusion: The incidence of postpartum depression in Kaifu District is ...

    Abstract Objective: To investigate the current status of the postpartum depression in Kaifu District in Changsha, and to explore the influential factors for postpartum depression.
 Methods: We selected the mothers, who had a delivery and met the inclusion criteria in Changsha during 2015, as the participants and established a prospective birth cohort study. The social demographic characteristics and health-related information for the mothers and their families were collected by using self-made questionnaire. The mothers' depression symptoms after one month postpartum were assessed by the Edinburgh Postnatal Depression Scale. We used the structural equation model to analyze the influential factors for postpartum depression.
 Results: A total of 961 cases were investigated. 82 of them whose scores of EPDS were≥9 points, and the incidence of PPD was 8.2%. The results of structural equation model revealed the influential factors and their correlations with postpartum depression. It has been shown that maternal age, maternal education level, per capita income of family, intention of pregnancy, pregnancy-related complications, mode of conception, mode of delivery, feeding patterns, birth weight, baby gender, and infant illness could exert effects on postpartum depression.
 Conclusion: The incidence of postpartum depression in Kaifu District is at a low level and the structural equation model can be applied to analyze the influential factors and their relations with postpartum depression.
    MeSH term(s) China/epidemiology ; Depression, Postpartum/epidemiology ; Depression, Postpartum/etiology ; Educational Status ; Female ; Humans ; Incidence ; Income ; Maternal Age ; Mothers ; Postpartum Period ; Pregnancy ; Pregnancy Complications/psychology ; Prospective Studies ; Risk Factors
    Language Chinese
    Publishing date 2017-11-01
    Publishing country China
    Document type Journal Article
    ZDB-ID 2168533-2
    ISSN 1672-7347
    ISSN 1672-7347
    DOI 10.11817/j.issn.1672-7347.2017.10.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Mixed Ion/Electron Conductive Li

    Gao, De / Deng, Shuzhen / Chen, Xiaoyan / Zhang, Yingxi / Lv, Tuan / He, Yang / Zhou, Feng / Zhang, Wen / Chu, Paul K / Huo, Kaifu

    ACS applied materials & interfaces

    2023  Volume 15, Issue 17, Page(s) 21066–21074

    Abstract: Lithium (Li) metal is a promising anode for high-energy-density batteries; however, its practical viability is hampered by the unstable metal Li-electrolyte interface and Li dendrite growth. Herein, a mixed ion/electron conductive ... ...

    Abstract Lithium (Li) metal is a promising anode for high-energy-density batteries; however, its practical viability is hampered by the unstable metal Li-electrolyte interface and Li dendrite growth. Herein, a mixed ion/electron conductive Li
    Language English
    Publishing date 2023-04-21
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c01528
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Transcriptional inhibition after irradiation occurs preferentially at highly expressed genes in a manner dependent on cell cycle progression.

    Chen, Zulong / Wang, Xin / Gao, Xinlei / Arslanovic, Nina / Chen, Kaifu / Tyler, Jessica

    bioRxiv : the preprint server for biology

    2023  

    Abstract: In response to DNA double strand damage, ongoing transcription is inhibited to facilitate accurate DNA repair while transcriptional recovery occurs after DNA repair is complete. However, the mechanisms at play and identity of the transcripts being ... ...

    Abstract In response to DNA double strand damage, ongoing transcription is inhibited to facilitate accurate DNA repair while transcriptional recovery occurs after DNA repair is complete. However, the mechanisms at play and identity of the transcripts being regulated in this manner are unclear. In contrast to the situation following UV damage, we found that transcriptional recovery after ionizing radiation (IR) occurs in a manner independent of the HIRA histone chaperone. Sequencing of the nascent transcripts identified a programmed transcriptional response, where certain transcripts and pathways are rapidly downregulated after IR, while other transcripts and pathways are upregulated. Specifically, most of the loss of nascent transcripts occurring after IR is due to inhibition of transcriptional initiation of the highly transcribed histone genes and the rDNA. To identify factors responsible for transcriptional inhibition after IR in an unbiased manner, we performed a whole genome gRNA library CRISPR / Cas9 screen. Many of the top hits in our screen were factors required for protein neddylation. However, at short times after inhibition of neddylation, transcriptional inhibition still occurred after IR, even though neddylation was effectively inhibited. Persistent inhibition of neddylation blocked transcriptional inhibition after IR, and it also leads to cell cycle arrest. Indeed, we uncovered that many inhibitors and conditions that lead to cell cycle arrest in G
    Language English
    Publishing date 2023-11-20
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.11.20.567799
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Structural insights into the elevator-type transport mechanism of a bacterial ZIP metal transporter

    Yao Zhang / Yuhan Jiang / Kaifu Gao / Dexin Sui / Peixuan Yu / Min Su / Guo-Wei Wei / Jian Hu

    Nature Communications, Vol 14, Iss 1, Pp 1-

    2023  Volume 14

    Abstract: The ZIP family (SLC39A) is involved in transition metal homeostasis. Here, authors use integrated approaches to conclude that the ZIP from Bordetella bronchiseptica (BbZIP) utilizes the elevator-type transport mechanism to achieve alternating access. ...

    Abstract The ZIP family (SLC39A) is involved in transition metal homeostasis. Here, authors use integrated approaches to conclude that the ZIP from Bordetella bronchiseptica (BbZIP) utilizes the elevator-type transport mechanism to achieve alternating access.
    Keywords Science ; Q
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Mechanistic insights into CO

    Zhang, Huihui / Xu, Chang / Zhan, Xiaowen / Yu, Yu / Zhang, Kaifu / Luo, Qiquan / Gao, Shan / Yang, Jinlong / Xie, Yi

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 6029

    Abstract: The implementation of low-cost transition-metal complexes in ... ...

    Abstract The implementation of low-cost transition-metal complexes in CO
    Language English
    Publishing date 2022-10-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-33689-9
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  7. Article ; Online: Prediction and mitigation of mutation threats to COVID-19 vaccines and antibody therapies.

    Chen, Jiahui / Gao, Kaifu / Wang, Rui / Wei, Guowei

    ArXiv

    2021  

    Abstract: Antibody therapeutics and vaccines are among our last resort to end the raging COVID-19 pandemic. They, however, are prone to over 5,000 mutations on the spike (S) protein uncovered by a Mutation Tracker based on over 200,000 genome isolates. It is ... ...

    Abstract Antibody therapeutics and vaccines are among our last resort to end the raging COVID-19 pandemic. They, however, are prone to over 5,000 mutations on the spike (S) protein uncovered by a Mutation Tracker based on over 200,000 genome isolates. It is imperative to understand how mutations would impact vaccines and antibodies in the development. In this work, we study the mechanism, frequency, and ratio of mutations on the S protein. Additionally, we use 56 antibody structures and analyze their 2D and 3D characteristics. Moreover, we predict the mutation-induced binding free energy (BFE) changes for the complexes of S protein and antibodies or ACE2. By integrating genetics, biophysics, deep learning, and algebraic topology, we reveal that most of 462 mutations on the receptor-binding domain (RBD) will weaken the binding of S protein and antibodies and disrupt the efficacy and reliability of antibody therapies and vaccines. A list of 31 vaccine escape mutants is identified, while many other disruptive mutations are detailed as well. We also unveil that about 65\% existing RBD mutations, including those variants recently found in the United Kingdom (UK) and South Africa, are binding-strengthen mutations, resulting in more infectious COVID-19 variants. We discover the disparity between the extreme values of RBD mutation-induced BFE strengthening and weakening of the bindings with antibodies and ACE2, suggesting that SARS-CoV-2 is at an advanced stage of evolution for human infection, while the human immune system is able to produce optimized antibodies. This discovery implies the vulnerability of current vaccines and antibody drugs to new mutations. Our predictions were validated by comparison with more than 1,400 deep mutations on the S protein RBD. Our results show the urgent need to develop new mutation-resistant vaccines and antibodies and to prepare for seasonal vaccinations.
    Keywords covid19
    Language English
    Publishing date 2021-03-09
    Publishing country United States
    Document type Preprint
    ISSN 2331-8422
    ISSN (online) 2331-8422
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Structural and Interfacial Manipulation of Multifunctional Skeletons Enabled Shuttling-Free and Dendrite-Free Li-S Full Batteries.

    Zhang, Miaomiao / Luo, Rongjie / Guo, Qifei / Tang, Zihuan / Li, Xingxing / Gao, Biao / Zhang, Xuming / Huo, Kaifu / Zheng, Yang

    Small (Weinheim an der Bergstrasse, Germany)

    2023  Volume 19, Issue 49, Page(s) e2303784

    Abstract: Li-S batteries are regarded as promising devices for energy storage systems owing to high energy density, low cost, and environmental friendliness. However, challenges of polysulfides shuttling in sulfur cathode and dendrite growth of lithium anode ... ...

    Abstract Li-S batteries are regarded as promising devices for energy storage systems owing to high energy density, low cost, and environmental friendliness. However, challenges of polysulfides shuttling in sulfur cathode and dendrite growth of lithium anode severely hinder the practical application. Developing advanced skeletons simultaneously regulating the cathode and anode is significant and challenging. Hence, a novel and scalable strategy combining spray drying and topological nitriding is proposed, and hierarchically assembled rGO hollow microspheres encapsulated highly porous nanospheres consisted of ultrafine Nb
    Language English
    Publishing date 2023-08-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202303784
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Bidirectional Interphase Modulation of Phosphate Electrolyte Enables Intrinsic Safety and Superior Stability for High-Voltage Lithium-Metal Batteries.

    Guo, Qifei / Luo, Rongjie / Tang, Zihuan / Li, Xingxing / Feng, Xiaoyu / Ding, Zhao / Gao, Biao / Zhang, Xuming / Huo, Kaifu / Zheng, Yang

    ACS nano

    2023  Volume 17, Issue 23, Page(s) 24227–24241

    Abstract: Developing advanced high voltage lithium-metal batteries (LMBs) with superior stability and intrinsic safety is of great significance for practical applications. However, the easy flammability of conventional carbonate solvents and inferior compatibility ...

    Abstract Developing advanced high voltage lithium-metal batteries (LMBs) with superior stability and intrinsic safety is of great significance for practical applications. However, the easy flammability of conventional carbonate solvents and inferior compatibility of commercial electrolytes for both highly reactive Li anodes and high-voltage cathodes severely hinder the implementation process. Hence, we rationally designed an intrinsically nonflammable and low-cost phosphate electrolyte toward stable high-voltage LMBs by bidirectionally modulating the interphases. Benefiting from the synergistic regulation of LiNO
    Language English
    Publishing date 2023-11-22
    Publishing country United States
    Document type Journal Article
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.3c09643
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Author Correction: Analysis of SARS-CoV-2 mutations in the United States suggests presence of four substrains and novel variants.

    Wang, Rui / Chen, Jiahui / Gao, Kaifu / Hozumi, Yuta / Yin, Changchuan / Wei, Guo-Wei

    Communications biology

    2021  Volume 4, Issue 1, Page(s) 311

    Language English
    Publishing date 2021-03-03
    Publishing country England
    Document type Published Erratum
    ISSN 2399-3642
    ISSN (online) 2399-3642
    DOI 10.1038/s42003-021-01867-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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