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Article ; Online: J-shaped curve for cardiovascular mortality: systolic or diastolic blood pressure?

Robles, Nicolás Roberto / Fici, Francesco / Grassi, Guido

2018 Volume 32, Issue 3, Page(s) 347–353

Abstract: Aggressive reduction of blood pressure (BP) may increase cardiovascular events (the J-curve ... that provide strong evidence for J-shaped relationships between both diastolic and systolic BP and main ...

Abstract	Aggressive reduction of blood pressure (BP) may increase cardiovascular events (the J-curve phenomenon) in certain populations. There is a high number of available studies of antihypertensive treatment that provide strong evidence for J-shaped relationships between both diastolic and systolic BP and main cardiovascular outcomes. Nonetheless, most available studies were observational, and randomized trials might not have or lost their statistical power in post-hoc analysis. Contrariwise, most of prospective trial to demonstrate the benefits of intensive blood pressure control were inconclusive. Therefore, further studies are still necessary in order to clarify this issue.
MeSH term(s)	Blood Pressure/physiology ; Cardiovascular Diseases/mortality ; Cardiovascular Diseases/physiopathology ; Diastole ; Global Health ; Humans ; Risk Factors ; Survival Rate/trends ; Systole
Language	English
Publishing date	2018-09-17
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	1093991-x
ISSN	1724-6059 ; 1120-3625 ; 1121-8428
ISSN (online)	1724-6059
ISSN	1120-3625 ; 1121-8428
DOI	10.1007/s40620-018-0535-x
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Article ; Online: Does a blood pressure J curve exist for patients with chronic kidney disease?

Robles, Nicolás Roberto / Hernandez-Gallego, Roman / Fici, Francesco / Grassi, Guido

Journal of clinical hypertension (Greenwich, Conn.)

2017 Volume 19, Issue 8, Page(s) 764–770

Abstract: Aggressive reduction of blood pressure may increase cardiovascular events (the J-curve phenomenon ... in certain populations. In this regard, most studies in patients with chronic kidney disease have shown a J ...

Abstract	Aggressive reduction of blood pressure may increase cardiovascular events (the J-curve phenomenon) in certain populations. In this regard, most studies in patients with chronic kidney disease have shown a J curve for cardiovascular morbidity and mortality, and this phenomenon persists after adjusting for confounding factors. Since there is no evidence that a straighter blood pressure target (<130/70 mm Hg) could improve renal outcomes, the increased cardiovascular risk associated with extreme blood pressure reduction should be seen as undesirable. Moreover, the intensive control of blood pressure may induce an unintended reduction of renal function and this decrease, in turn, may increase cardiovascular risk.
MeSH term(s)	Antihypertensive Agents/therapeutic use ; Blood Pressure ; Blood Pressure Determination ; Female ; Humans ; Hypertension/drug therapy ; Hypertension/physiopathology ; Male ; Middle Aged ; Renal Insufficiency, Chronic/physiopathology
Chemical Substances	Antihypertensive Agents
Language	English
Publishing date	2017-06-07
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2077222-1
ISSN	1751-7176 ; 1524-6175
ISSN (online)	1751-7176
ISSN	1524-6175
DOI	10.1111/jch.13024
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Zs.A 5723: Show issues

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Article ; Online: ¿Es peligroso reducir excesivamente la presión arterial?: la curva J.

Robles, Nicolás Roberto

Medicina clinica

2012 Volume 139, Issue 12, Page(s) 535–537

Title translation	Is it dangerous to reduce excessively blood pressure? The J curve.
MeSH term(s)	Antihypertensive Agents/administration & dosage ; Antihypertensive Agents/adverse effects ; Antihypertensive Agents/therapeutic use ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/mortality ; Cardiovascular Diseases/prevention & control ; Comorbidity ; Diabetes Complications/etiology ; Diabetes Complications/mortality ; Diastole ; Follow-Up Studies ; Humans ; Hypertension/drug therapy ; Hypertension/epidemiology ; Hypertension/physiopathology ; Hypotension/chemically induced ; Hypotension/epidemiology ; Incidence ; Meta-Analysis as Topic ; Multicenter Studies as Topic/statistics & numerical data ; Myocardial Infarction/epidemiology ; Myocardial Infarction/etiology ; Randomized Controlled Trials as Topic/statistics & numerical data ; Risk ; Risk Assessment
Chemical Substances	Antihypertensive Agents
Language	Spanish
Publishing date	2012-11-17
Publishing country	Spain
Document type	Editorial
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/j.medcli.2012.05.031
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Article: Alkaloids of Phaedranassa dubia (Kunth) J.F. Macbr. and Phaedranassa brevifolia Meerow (Amaryllidaceae) from Ecuador and its cholinesterase-inhibitory activity

León, Karen Acosta / Inca, Alexandra / Tallini, Luciana R / Osorio, Edison H / Robles, Jessica / Bastida, Jaume / Oleas, Nora H

SAAB South African journal of botany. 2021 Jan., v. 136

2021

Abstract: Alzheimer's disease is considered the most common cause of dementia and, in an increasingly aging population worldwide, the quest for treatment is a priority. Amaryllidaceae alkaloids are of main interest because of their cholinesterase inhibition ... ...

Abstract	Alzheimer's disease is considered the most common cause of dementia and, in an increasingly aging population worldwide, the quest for treatment is a priority. Amaryllidaceae alkaloids are of main interest because of their cholinesterase inhibition potential, which is the main palliative treatment available for this disease. We evaluated the alkaloidal profile and the in vitro inhibitory activity on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) of bulb alkaloid extract of Phaedranassa dubia and Phaedranassa brevifolia collected in Ecuador. Using gas chromatography coupled to mass spectrometry (GC-MS), we identified typical Amaryllidaceae alkaloids in these species, highlighting the presence of lycorine-type alkaloids in P. dubia and haemanthamine/crinine-type in P. brevifolia. The species P. dubia and P. brevifolia showed inhibitory activities against AChE (IC₅₀ values of 25.48 ± 0.39 and 3.45 ± 0.29 μg.mL⁻¹, respectively) and BuChE (IC₅₀ values of 114.96 ± 4.94 and 58.89 ± 0.55 μg.mL⁻¹, respectively). Computational experiments allowed us to understand the interactions of the alkaloids identified in these samples toward the active sites of AChE and BuChE. In silico, some alkaloids detected in these Amaryllidaceae species presented higher estimated binding free energy toward BuChE than galanthamine. This is the first study about the alkaloid profile and biological potential of P. brevifolia species.
Keywords	Alzheimer disease ; Amaryllidaceae ; Gibbs free energy ; acetylcholinesterase ; active sites ; alkaloids ; bulbs ; cholinesterase ; computer simulation ; gas chromatography ; mass spectrometry ; sampling ; Ecuador
Language	English
Dates of publication	2021-01
Size	p. 91-99.
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-light
ZDB-ID	2126918-X
ISSN	0254-6299
ISSN	0254-6299
DOI	10.1016/j.sajb.2020.09.007
Database	NAL-Catalogue (AGRICOLA)

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Article: Breves comentarios al trabajo de N.E. Asuad Sanén y J.M. Sánchez Gamboa, "methodological proposal for the construction of a regional input-output matrix using a bottom-up approach and its statistical assessment"

Callicó López, Josefina / Asuad Sanén, Normand Eduardo / González Robles, Evaristo Jaime / Sánchez Gamboa, José Manuel

Investigación económica : revista de la Faculdad de Economía de la Universidad Nacional Autónoma de México Bd. LXXV.2016 (Okt./Dez.)=Nr. 298, Seite 49-50

2016

Author's details	por Josefina Callicó López y Evaristo Jaime González Robles
Language	Spanish
Dates of publication	2016-9999
Publisher	Univ
Publishing place	Mexico
Document type	Article
ZDB-ID	41666-6 ; 2523762-7
ISSN	0185-1667
ISSN	0185-1667
Database	ECONomics Information System

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Book: Pedro J. Ramírez

Ramírez, Pedro J / Robles, Marta

el mundo en mis manos

(Hojas nuevas)

1991

Author's details	Pedro J. Ramírez y Marta Robles
Series title	Hojas nuevas
Language	Spanish
Size	469 p, Ill, 24 cm
Edition	1. ed
Publisher	Grijalbo
Publishing place	Barcelona
Document type	Book
Note	Includes index ; Spine title: El mundo en mis manos
ISBN	8425323355 ; 9788425323355
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: Mutations in the cardiac L-type calcium channel associated with inherited J-wave syndromes and sudden cardiac death.

Burashnikov, Elena / Pfeiffer, Ryan / Barajas-Martinez, Héctor / Delpón, Eva / Hu, Dan / Desai, Mayurika / Borggrefe, Martin / Häissaguerre, Michel / Kanter, Ronald / Pollevick, Guido D / Guerchicoff, Alejandra / Laiño, Ruben / Marieb, Mark / Nademanee, Koonlawee / Nam, Gi-Byoung / Robles, Roberto / Schimpf, Rainer / Stapleton, Dwight D / Viskin, Sami /

Winters, Stephen / Wolpert, Christian / Zimmern, Samuel / Veltmann, Christian / Antzelevitch, Charles

Heart rhythm

2010 Volume 7, Issue 12, Page(s) 1872–1882

Abstract: ... to which LTCC mutations contribute to the J-wave syndromes associated with sudden cardiac death.: Objective ... percentage of probands with J-wave syndromes associated with inherited cardiac arrhythmias, suggesting ...

Abstract	Background: L-type calcium channel (LTCC) mutations have been associated with Brugada syndrome (BrS), short QT (SQT) syndrome, and Timothy syndrome (LQT8). Little is known about the extent to which LTCC mutations contribute to the J-wave syndromes associated with sudden cardiac death. Objective: The purpose of this study was to identify mutations in the α1, β2, and α2δ subunits of LTCC (Ca(v)1.2) among 205 probands diagnosed with BrS, idiopathic ventricular fibrillation (IVF), and early repolarization syndrome (ERS). CACNA1C, CACNB2b, and CACNA2D1 genes of 162 probands with BrS and BrS+SQT, 19 with IVF, and 24 with ERS were screened by direct sequencing. Methods/results: Overall, 23 distinct mutations were identified. A total of 12.3%, 5.2%, and 16% of BrS/BrS+SQT, IVF, and ERS probands displayed mutations in α1, β2, and α2δ subunits of LTCC, respectively. When rare polymorphisms were included, the yield increased to 17.9%, 21%, and 29.1% for BrS/BrS+SQT, IVF, and ERS probands, respectively. Functional expression of two CACNA1C mutations associated with BrS and BrS+SQT led to loss of function in calcium channel current. BrS probands displaying a normal QTc had additional variations known to prolong the QT interval. Conclusion: The study results indicate that mutations in the LTCCs are detected in a high percentage of probands with J-wave syndromes associated with inherited cardiac arrhythmias, suggesting that genetic screening of Ca(v) genes may be a valuable diagnostic tool in identifying individuals at risk. These results are the first to identify CACNA2D1 as a novel BrS susceptibility gene and CACNA1C, CACNB2, and CACNA2D1 as possible novel ERS susceptibility genes.
MeSH term(s)	Adult ; Animals ; Arrhythmias, Cardiac/genetics ; Brugada Syndrome/genetics ; Calcium Channels/genetics ; Calcium Channels, L-Type/genetics ; DNA Mutational Analysis ; Death, Sudden, Cardiac ; Electrocardiography ; Electrophysiologic Techniques, Cardiac ; Female ; Genetic Association Studies ; Genetic Predisposition to Disease/genetics ; Genetic Variation ; Humans ; Male ; Middle Aged ; Mutation ; Polymorphism, Single Nucleotide ; Syndrome ; Ventricular Fibrillation/genetics
Chemical Substances	CACNA1C protein, human ; CACNA2D1 protein, human ; CACNB2 protein, human ; Calcium Channels ; Calcium Channels, L-Type
Language	English
Publishing date	2010-10-14
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2229357-7
ISSN	1556-3871 ; 1547-5271
ISSN (online)	1556-3871
ISSN	1547-5271
DOI	10.1016/j.hrthm.2010.08.026
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Zs.A 6278: Show issues

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Article: Enterocyte proliferation and intestinal hyperplasia induced by simian virus 40 T antigen require a functional J domain.

Rathi, Abhilasha V / Sáenz Robles, M Teresa / Pipas, James M

Journal of virology

2007 Volume 81, Issue 17, Page(s) 9481–9489

Abstract: ... the inactivation of Rb proteins requires both a J domain in TAg that interacts with hsc70 and an LXCXE motif ... from their association with Rb family members. We have generated transgenic mice that express a J domain mutant (D44N ... proliferation. Histological and morphological examination revealed that mice expressing the J domain mutant have ...

Abstract	Transgenic mice expressing the simian virus 40 large T antigen (TAg) in enterocytes develop intestinal hyperplasia that progresses to dysplasia with age. This induction requires TAg action on the retinoblastoma (Rb) family of tumor suppressors and is independent of the p53 pathway. In cell culture systems, the inactivation of Rb proteins requires both a J domain in TAg that interacts with hsc70 and an LXCXE motif that directs association with Rb proteins. Together these elements are sufficient to release E2Fs from their association with Rb family members. We have generated transgenic mice that express a J domain mutant (D44N) in villus enterocytes. In contrast to wild-type TAg, the D44N mutant is unable to induce enterocyte proliferation. Histological and morphological examination revealed that mice expressing the J domain mutant have normal intestines without loss of growth control. Unlike mice expressing wild-type TAg, mice expressing D44N do not reduce the protein levels of p130 and are also unable to dissociate p130-E2F DNA binding complexes. Furthermore, mice expressing D44N in a null p130 background are still unable to develop hyperplasia. These studies demonstrate that the ectopic proliferation of enterocytes by TAg requires a functional J domain and suggest that the J domain is necessary to inactivate all three pRb family members.
MeSH term(s)	Amino Acid Substitution/genetics ; Animals ; Antigens, Polyomavirus Transforming/chemistry ; Antigens, Polyomavirus Transforming/genetics ; Antigens, Polyomavirus Transforming/physiology ; Cell Proliferation ; Disease Models, Animal ; Enterocytes/cytology ; Enterocytes/virology ; Hyperplasia/virology ; Immunohistochemistry ; Intestines/pathology ; Mice ; Mice, Transgenic ; Mutation, Missense ; Polyomavirus Infections/pathology ; Protein Structure, Tertiary ; Retinoblastoma Protein/metabolism ; Simian virus 40/genetics ; Simian virus 40/physiology ; Tumor Virus Infections/pathology
Chemical Substances	Antigens, Polyomavirus Transforming ; Retinoblastoma Protein
Language	English
Publishing date	2007-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/JVI.00922-07
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Article: Estudio clínico y microbiológico de los micetomas observados en el hospital de infecciosas Francisco J. Muñiz en el período 1989-2004.

Negroni, R / López Daneri, G / Arechavala, A / Bianchi, M H / Robles, A M

Revista Argentina de microbiologia

2006 Volume 38, Issue 1, Page(s) 13–18

Abstract: This work presents clinical, microbiological and outcome data collected from 76 patients with mycetomas at the Muñiz Hospital from 1989 to 2004. Forty-nine patients were male and 27 female; the mean age was 43.4 years. The majority of the patients ... ...

Title translation	Clinical and microbiological study of mycetomas at the Muñiz hospital of Buenos Aires between 1989 and 2004.
Abstract	This work presents clinical, microbiological and outcome data collected from 76 patients with mycetomas at the Muñiz Hospital from 1989 to 2004. Forty-nine patients were male and 27 female; the mean age was 43.4 years. The majority of the patients acquired the infection in Argentina: the most affected provinces were Santiago del Estero with 31 cases, and Chaco with 11; 8 cases came from other countries (Bolivia 6 and Paraguay 2). The mean evolution of the disease was 9.2 years. The most frequently observed sites were: feet 63 cases, ankles 3, and knees 2. Forty-eight patients had bone lesions and 5, adenomegalies. The following etiological agents were identified: Madurella grisea 29 cases, Actinomadura madurae 26, Scedosporium apiospermum 5, Nocardia brasiliensis 5, Acremonium spp. 4 (Acremonium falciforme 2, Acremonium kiliense 1, Acremonium recifei 1), Madurella mycetomatis 3, Fusarium solani 2, Nocardia asteroides 1 and Streptomyces somaliensis 1. The main drugs used in the treatments were ketoconazole and itraconazole for maduromycotic mycetomas, and cotrimoxazole associated with ciprofloxacin or amikacin for actinomycetic mycetoma. Six patients had to undergo amputation, 25 cases achieved complete clinical remission and 34 showed remarkable improvement.
MeSH term(s)	Actinomycetales/isolation & purification ; Actinomycetales Infections/drug therapy ; Actinomycetales Infections/epidemiology ; Actinomycetales Infections/microbiology ; Actinomycetales Infections/surgery ; Adolescent ; Adult ; Aged ; Agricultural Workers' Diseases/drug therapy ; Agricultural Workers' Diseases/epidemiology ; Agricultural Workers' Diseases/microbiology ; Agricultural Workers' Diseases/surgery ; Amputation ; Anti-Bacterial Agents/therapeutic use ; Antifungal Agents/therapeutic use ; Argentina/epidemiology ; Combined Modality Therapy ; Female ; Foot Dermatoses/drug therapy ; Foot Dermatoses/epidemiology ; Foot Dermatoses/microbiology ; Foot Dermatoses/surgery ; Fusarium ; Humans ; Madurella/drug effects ; Madurella/isolation & purification ; Male ; Middle Aged ; Mitosporic Fungi/isolation & purification ; Mycetoma/drug therapy ; Mycetoma/epidemiology ; Mycetoma/microbiology ; Mycetoma/surgery ; Nocardia Infections/drug therapy ; Nocardia Infections/epidemiology ; Nocardia Infections/microbiology ; Nocardia Infections/surgery ; Osteitis/drug therapy ; Osteitis/etiology ; Osteitis/microbiology ; Osteitis/surgery ; Remission Induction ; Retrospective Studies ; Treatment Outcome
Chemical Substances	Anti-Bacterial Agents ; Antifungal Agents
Language	Spanish
Publishing date	2006-01
Publishing country	Argentina
Document type	English Abstract ; Journal Article
ZDB-ID	731952-6
ISSN	0325-7541
ISSN	0325-7541
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Article ; Online: Description of

Robles, M-C / Abolafia, J

Journal of helminthology

2024 Volume 98, Page(s) e14

Abstract: A new species of the ... ...

Abstract	A new species of the genus
MeSH term(s)	Male ; Animals ; Rhabditida ; Nematoda/genetics ; Europe ; Soil ; Microscopy ; Trees ; Phylogeny
Chemical Substances	Soil
Language	English
Publishing date	2024-02-02
Publishing country	England
Document type	Journal Article
ZDB-ID	390188-9
ISSN	1475-2697 ; 0022-149X
ISSN (online)	1475-2697
ISSN	0022-149X
DOI	10.1017/S0022149X24000051
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