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  1. Book ; Online ; E-Book: Handbook of systemic family therapy / Volume 1,

    Wampler, Karen S. / Miller, Richard B. / Seedall, Ryan B.

    2020  

    Author's details editor in chief, Karen S. Wampler ; volume editors, Richard B. Miller, Ryan B. Seedall
    Keywords Family psychotherapy
    Subject code 616.89156
    Language English
    Size 1 online resource (xxxvi, 800 pages) :, illustrations
    Publisher Wiley Blackwell
    Publishing place Hoboken, NJ
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-119-79018-2 ; 1-119-70215-1 ; 1-119-70217-8 ; 978-1-119-79018-1 ; 978-1-119-70215-3 ; 978-1-119-70217-7
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: The handbook of systemic family therapy / Volume 1 /

    Wampler, Karen S. / Miller, Richard B. / Seedall, Ryan B.

    2020  

    Abstract: A first of its kind resource for clinicians, researchers, educators, graduate students, and policymakers, this authoritative four-volume Handbook is a ground-breaking reference work on both the profession and the practice of systemic family therapy. The ...

    Author's details editor in chief, Karen S. Wampler ; volume editors, Richard B. Miller, Ryan B. Seedall
    Abstract "A first of its kind resource for clinicians, researchers, educators, graduate students, and policymakers, this authoritative four-volume Handbook is a ground-breaking reference work on both the profession and the practice of systemic family therapy. The Handbook integrates the scholarly literature on systemic interventions focused on children, couples, and families into a single resource. Volume 1 includes critical information on the theoretical, practice, research, and policy foundations of the profession of systemic family therapy and its roles in an integrated health care system. Topics in Volume 2 (children and adolescents), Volume 3 (couples), and Volume 4 (family over the lifespan) reflect established and emerging interventions for the core difficulties in relationships that impact the mental and physical health of individuals, couples, and families. Contributors provide a balanced, integrative, and forward-looking analysis of the research, theory and interventions related to their topic illustrated with clinical examples. Particular attention is paid to cultural and family diversity throughout the work"--
    Keywords Family psychotherapy
    Subject code 616.89156
    Language English
    Size 1 online resource (3,456 pages)
    Publisher Wiley Blackwell
    Publishing place Hoboken, New Jersey ; West, Sussex, England
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-119-78837-4 ; 1-119-43851-9 ; 1-119-43855-1 ; 978-1-119-78837-9 ; 978-1-119-43851-9 ; 978-1-119-43855-7
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Unifying the Conversation: Membrane Separation Performance in Energy, Water, and Industrial Applications.

    Dischinger, Sarah M / Miller, Daniel J / Vermaas, David A / Kingsbury, Ryan S

    ACS ES&T engineering

    2024  Volume 4, Issue 2, Page(s) 277–289

    Abstract: Dense polymer membranes enable a diverse range of separations and clean energy technologies, including gas separation, water treatment, and renewable fuel production or conversion. The transport of small molecular and ionic solutes in the majority of ... ...

    Abstract Dense polymer membranes enable a diverse range of separations and clean energy technologies, including gas separation, water treatment, and renewable fuel production or conversion. The transport of small molecular and ionic solutes in the majority of these membranes is described by the same solution-diffusion mechanism, yet a comparison of membrane separation performance across applications is rare. A better understanding of how structure-property relationships and driving forces compare among applications would drive innovation in membrane development by identifying opportunities for cross-disciplinary knowledge transfer. Here, we aim to inspire such cross-pollination by evaluating the selectivity and electrochemical driving forces for 29 separations across nine different applications using a common framework grounded in the physicochemical characteristics of the permeating and rejected solutes. Our analysis shows that highly selective membranes usually exhibit high solute rejection, rather than fast solute permeation, and often exploit contrasts in the size and charge of solutes rather than a nonelectrostatic chemical property, polarizability. We also highlight the power of selective driving forces (e.g., the fact that applied electric potential acts on charged solutes but not on neutral ones) to enable effective separation processes, even when the membrane itself has poor selectivity. We conclude by proposing several research opportunities that are likely to impact multiple areas of membrane science. The high-level perspective of membrane separation across fields presented herein aims to promote cross-pollination and innovation by enabling comparisons of solute transport and driving forces among membrane separation applications.
    Language English
    Publishing date 2024-01-26
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2690-0645
    ISSN (online) 2690-0645
    DOI 10.1021/acsestengg.3c00475
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Vascular Inflammation and Smooth Muscle Contractility: The Role of Nox1-Derived Superoxide and LRRC8 Anion Channels.

    Lamb, Fred S / Choi, Hyehun / Miller, Michael R / Stark, Ryan J

    Hypertension (Dallas, Tex. : 1979)

    2024  Volume 81, Issue 4, Page(s) 752–763

    Abstract: Vascular inflammation underlies the development of hypertension, and the mechanisms by which it increases blood pressure remain the topic of intense investigation. Proinflammatory factors including glucose, salt, vasoconstrictors, cytokines, wall stress, ...

    Abstract Vascular inflammation underlies the development of hypertension, and the mechanisms by which it increases blood pressure remain the topic of intense investigation. Proinflammatory factors including glucose, salt, vasoconstrictors, cytokines, wall stress, and growth factors enhance contractility and impair relaxation of vascular smooth muscle cells. These pathways share a dependence upon redox signaling, and excessive activation promotes oxidative stress that promotes vascular aging. Vascular smooth muscle cell phenotypic switching and migration into the intima contribute to atherosclerosis, while hypercontractility increases systemic vascular resistance and vasospasm that can trigger ischemia. Here, we review factors that drive the initiation and progression of this vasculopathy in vascular smooth muscle cells. Emphasis is placed on the contribution of reactive oxygen species generated by the Nox1 NADPH oxidase which produces extracellular superoxide (O
    MeSH term(s) Humans ; Superoxides/metabolism ; Muscle, Smooth, Vascular/metabolism ; NADPH Oxidase 1/metabolism ; NADPH Oxidases/metabolism ; Reactive Oxygen Species/metabolism ; Hypertension/metabolism ; Myocytes, Smooth Muscle/metabolism ; Cells, Cultured
    Chemical Substances Superoxides (11062-77-4) ; NADPH Oxidase 1 (EC 1.6.3.-) ; NADPH Oxidases (EC 1.6.3.-) ; Reactive Oxygen Species
    Language English
    Publishing date 2024-01-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.123.19434
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1488: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Medication Safety Counseling Practices of Pediatric Primary Care Clinicians.

    Ryan, Leticia Manning / Solomon, Barry S / Miller, Michael J / McDonald, Eileen / DiNucci, Anna / Omaki, Elise / Shields, Wendy / Weinfield, Nancy S

    Health promotion practice

    2024  , Page(s) 15248399241228242

    Abstract: Medication exposures and poisonings are a major cause of pediatric morbidity and mortality. Unsafe patient practices are well documented despite the American Academy of Pediatrics recommending that pediatric primary care clinicians discuss medication ... ...

    Abstract Medication exposures and poisonings are a major cause of pediatric morbidity and mortality. Unsafe patient practices are well documented despite the American Academy of Pediatrics recommending that pediatric primary care clinicians discuss medication safety with patients. Current clinician counseling practices for pediatric patients are unknown. Studies of adult patients suggest that physician counseling practices often focus on administration but not storage or disposal. To address this gap, we administered a web-based survey to clinically active pediatric primary care clinicians in two mid-Atlantic health care systems. Survey content focused on characteristics of medication safety counseling practices by age group, including safe medication storage, administration, and disposal. Of 151 clinicians emailed, 40 (26.5%) responded. The majority were physicians (93.5%), female (87.1%), and completed residency/clinical training in pediatrics >15 years ago (58.1%). Most (82.5%) reported having >1 pediatric patient (aged < 19 years) in their practice who experienced an unintentional or intentional medication exposure or poisoning event. Reported practices for medication safety counseling often varied by patient age but safe disposal was rarely addressed for any age group. Respondents generally felt less knowledgeable and less comfortable with providing counseling on safe disposal in comparison to safe storage and safe administration. Nearly all respondents (97%) would like to provide more counseling about medication safety, and the majority (81.3%) wanted additional educational resources. In this survey, we identified several modifiable deficits in pediatric medical counseling practices and a need for additional clinician training and resources, most notably in the content area of safe disposal.
    Language English
    Publishing date 2024-01-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2036801-X
    ISSN 1552-6372 ; 1524-8399
    ISSN (online) 1552-6372
    ISSN 1524-8399
    DOI 10.1177/15248399241228242
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Developmental pyrethroid exposure disrupts folate metabolism in mouse brain.

    Curtis, Melissa A / Saferin, Nilanjana / Nguyen, Jennifer H / Imami, Ali S / Ryan, William G / Neifer, Kari L / Miller, Gary W / Burkett, James P

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Environmental and genetic risk factors, and their interactions, contribute significantly to the etiology of neurodevelopmental disorders (NDDs). Recent epidemiology studies have implicated pyrethroid pesticides as an environmental risk factor for autism ... ...

    Abstract Environmental and genetic risk factors, and their interactions, contribute significantly to the etiology of neurodevelopmental disorders (NDDs). Recent epidemiology studies have implicated pyrethroid pesticides as an environmental risk factor for autism and developmental delay. Our previous research showed that low-dose developmental exposure to the pyrethroid pesticide deltamethrin in mice caused male-biased changes in the brain and in NDD-relevant behaviors in adulthood. Here, we used a metabolomics approach to determine the broadest possible set of metabolic changes in the adult male mouse brain caused by low-dose pyrethroid exposure during development. Using a litter-based design, we exposed mouse dams during pregnancy and lactation to deltamethrin (3 mg/kg or vehicle every 3 days) at a concentration well below the EPA-determined benchmark dose used for regulatory guidance. We raised male offspring to adulthood and collected whole brain samples for untargeted high-resolution metabolomics analysis. Developmentally exposed mice had disruptions in 116 metabolites which clustered into pathways for folate biosynthesis, retinol metabolism, and tryptophan metabolism. As a cross-validation, we integrated metabolomics and transcriptomics data from the same samples, which confirmed previous findings of altered dopamine signaling. These results suggest that pyrethroid exposure during development leads to disruptions in folate metabolism in the adult brain, which may inform both prevention and therapeutic strategies.
    Language English
    Publishing date 2024-03-26
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.10.13.562226
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Probing the drivers of

    Howard, Matthew K / Miller, Karlie R / Sohn, Brian S / Ryan, Jeremy J / Xu, Andy / Jackrel, Meredith E

    mBio

    2023  Volume 14, Issue 4, Page(s) e0058723

    Abstract: Phenol-soluble modulins (PSMs) are the primary proteinaceous component ... ...

    Abstract Phenol-soluble modulins (PSMs) are the primary proteinaceous component of
    MeSH term(s) Humans ; Staphylococcus aureus/metabolism ; Methicillin-Resistant Staphylococcus aureus/genetics ; Methicillin-Resistant Staphylococcus aureus/metabolism ; Saccharomyces cerevisiae/metabolism ; Biofilms ; Amyloid/genetics ; Amyloid/metabolism ; Staphylococcal Infections/microbiology ; Peptides/metabolism ; Phenols/metabolism
    Chemical Substances Amyloid ; Peptides ; Phenols
    Language English
    Publishing date 2023-05-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.00587-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A critical threshold of MCM10 is required to maintain genome stability during differentiation of induced pluripotent stem cells into natural killer cells.

    Schmit, Megan M / Baxley, Ryan M / Wang, Liangjun / Hinderlie, Peter / Kaufman, Marissa / Simon, Emily / Raju, Anjali / Miller, Jeffrey S / Bielinsky, Anja-Katrin

    Open biology

    2024  Volume 14, Issue 1, Page(s) 230407

    Abstract: Natural killer (NK) cell deficiency (NKD) is a rare disease in which NK cell function is reduced, leaving affected individuals susceptible to repeated viral infections and cancer. Recently, a patient with NKD was identified carrying compound heterozygous ...

    Abstract Natural killer (NK) cell deficiency (NKD) is a rare disease in which NK cell function is reduced, leaving affected individuals susceptible to repeated viral infections and cancer. Recently, a patient with NKD was identified carrying compound heterozygous variants of
    MeSH term(s) Humans ; Induced Pluripotent Stem Cells ; Cell Differentiation ; Genes, Essential ; Genomic Instability ; Killer Cells, Natural ; Minichromosome Maintenance Proteins
    Chemical Substances MCM10 protein, human ; Minichromosome Maintenance Proteins (EC 3.6.4.12)
    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2630944-0
    ISSN 2046-2441 ; 2046-2441
    ISSN (online) 2046-2441
    ISSN 2046-2441
    DOI 10.1098/rsob.230407
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Relationships Among Environmental Variables, Physical Capacity, Balance Self-Efficacy, and Real-World Walking Activity Post-Stroke.

    Miller, Allison / Pohlig, Ryan T / Reisman, Darcy S

    Neurorehabilitation and neural repair

    2022  Volume 36, Issue 8, Page(s) 535–544

    Abstract: Background: Social and physical environmental factors affect real-world walking activity in individuals with stroke. However, environmental factors are often non-modifiable, presenting a challenge for clinicians working with individuals with stroke ... ...

    Abstract Background: Social and physical environmental factors affect real-world walking activity in individuals with stroke. However, environmental factors are often non-modifiable, presenting a challenge for clinicians working with individuals with stroke whose real-world walking is limited due to environmental barriers.
    Objective: The purpose of this work was to test a model hypothesizing the relationships among environmental factors (specifically, living situation and area deprivation), modifiable factors, and real-world walking activity to understand opportunities for intervention. We hypothesized that balance self-efficacy would mediate the relationship between the environment and real-world walking and that physical capacity would moderate this mediation.
    Methods: This was a cross-sectional study of 282 individuals with chronic (≥6 months) stroke. We tested the indirect effect to determine if mediation was present. Multiple group structural equation modeling was used to test if physical capacity moderated this mediation. A
    Results: Balance self-efficacy mediated the relationship between area deprivation and real-world walking (indirect effect:
    Conclusions: Targeting balance self-efficacy may be an effective approach to improving real-world walking in persons with stroke who experience barriers within the physical environment. A stroke survivor's physical capacity may not impact this approach. Future work should consider utilizing more specific measures of the social and physical environment to better understand their influences on real-world walking activity in individuals with stroke. However, the results of this work provide excellent targets for future longitudinal studies targeting real-world walking activity in stroke.
    MeSH term(s) Cross-Sectional Studies ; Humans ; Postural Balance ; Self Efficacy ; Stroke ; Stroke Rehabilitation/methods ; Walking
    Language English
    Publishing date 2022-08-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1491637-x
    ISSN 1552-6844 ; 1545-9683 ; 0888-4390
    ISSN (online) 1552-6844
    ISSN 1545-9683 ; 0888-4390
    DOI 10.1177/15459683221115409
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    Zs.B 3096: Show issues Location:
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  10. Article: C9orf72

    Broce, Iris J / Sirkis, Daniel W / Nillo, Ryan M / Bonham, Luke W / Lee, Suzee E / Miller, Bruce L / Castruita, Patricia A / Sturm, Virginia E / Sugrue, Leo S / Desikan, Rahul S / Yokoyama, Jennifer S

    Frontiers in neuroscience

    2024  Volume 18, Page(s) 1258996

    Abstract: Introduction: A hexanucleotide repeat expansion (HRE) intronic to chromosome 9 open reading frame 72 (: Methods: We leveraged mRNA expression data in healthy brain from the Allen Human Brain Atlas to evaluate : Results: A total of 2,120 genes ... ...

    Abstract Introduction: A hexanucleotide repeat expansion (HRE) intronic to chromosome 9 open reading frame 72 (
    Methods: We leveraged mRNA expression data in healthy brain from the Allen Human Brain Atlas to evaluate
    Results: A total of 2,120 genes showed an anatomical distribution of gene expression in the brain similar to
    Conclusion: Considered together, we identified a network of
    Language English
    Publishing date 2024-02-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2024.1258996
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