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  1. Article ; Online: Für Christian Hotz war eine IV-Rente statt eines eigenen Lohns keine Perspektive

    Hotz, Christian

    Curaviva : Fachzeitschrift ; 2101595-8 ; 1663-6058 ; 89 ; 2018 ; 10 ; 17

    "Das Leben selbst verdienen"

    2018  

    Publisher Curaviva - Verband Heime und Institutionen Schweiz
    Publishing country ch
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: "Das Leben selbst verdienen" : für Christian Hotz war eine IV- Rente statt eines eigenen Lohns keine Perspektive

    Hotz, Christian

    Curaviva (Deutsche Ausg.)

    2018  Volume 89, Issue 10, Page(s) 17

    Keywords IV-Rente ; Psychische Krankheit ; Arbeitsmarkt
    Language German
    Document type Article
    ZDB-ID 2101595-8
    ISSN 1663-6058
    ISSN 1663-6058
    Database bibnet.org

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  3. Conference proceedings: Einfluss des ersten Corona-Lockdowns 2020 auf die Versorgungszeiten der proximalen Femurfraktur in einem Level 1-Trauma Center

    Hotz, Carla / Gogol, Manfred / Liodakis, Emmanouil / Macke, Christian / Sehmisch, Stephan

    2023  , Page(s) AB18–3391

    Event/congress Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2023); Berlin; ; Berufsverband für Orthopädie und Unfallchirurgie; 2023
    Keywords Medizin, Gesundheit
    Publishing date 2023-10-23
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/23dkou048
    Database German Medical Science

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  4. Book ; Thesis: Lebensqualität in der stationären onkologischen Nachsorge

    Hotz, Thomas C.

    1997  

    Author's details vorgelegt von Thomas C. Hotz
    Language German
    Size 71 S. : graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis München, Univ., Diss., 1997
    HBZ-ID HT008012597
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    97 D 3349 order for loan Magazin

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  5. Article ; Online: Harnessing the immune system to fight cancer with Toll-like receptor and RIG-I-like receptor agonists.

    Bourquin, Carole / Pommier, Aurélien / Hotz, Christian

    Pharmacological research

    2019  Volume 154, Page(s) 104192

    Abstract: Cancer immunotherapy has come of age with the advent of immune checkpoint inhibitors. In this article we review how agonists for receptors of the innate immune system, the Toll-like receptors and the RIG-I-like receptors, impact anticancer immune ... ...

    Abstract Cancer immunotherapy has come of age with the advent of immune checkpoint inhibitors. In this article we review how agonists for receptors of the innate immune system, the Toll-like receptors and the RIG-I-like receptors, impact anticancer immune responses. Treatment with these agonists enhances the activity of anticancer effector cells, such as cytotoxic T cells and NK cells, and at the same time blocks the activity of immunosuppressive cell types such as regulatory T cells and myeloid-derived suppressor cells. These compounds also impact the recruitment of immune cells to the tumor. The phenomena of pattern-recognition receptor tolerance and reprogramming and their implications for immunotherapy are discussed. Finally, novel delivery systems that target the immune-stimulating drugs to the tumor or the tumor-draining lymph nodes to enhance their efficacy and safety are presented.
    MeSH term(s) Animals ; DEAD Box Protein 58/immunology ; Humans ; Immunotherapy ; Neoplasms/immunology ; Neoplasms/therapy ; Receptors, Immunologic/agonists ; Receptors, Immunologic/immunology ; Toll-Like Receptors/agonists ; Toll-Like Receptors/immunology
    Chemical Substances Receptors, Immunologic ; Toll-Like Receptors ; RIGI protein, human (EC 3.6.1.-) ; DEAD Box Protein 58 (EC 3.6.4.13)
    Language English
    Publishing date 2019-03-02
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1003347-6
    ISSN 1096-1186 ; 0031-6989 ; 1043-6618
    ISSN (online) 1096-1186
    ISSN 0031-6989 ; 1043-6618
    DOI 10.1016/j.phrs.2019.03.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Mitochondrial RNA modifications shape metabolic plasticity in metastasis.

    Delaunay, Sylvain / Pascual, Gloria / Feng, Bohai / Klann, Kevin / Behm, Mikaela / Hotz-Wagenblatt, Agnes / Richter, Karsten / Zaoui, Karim / Herpel, Esther / Münch, Christian / Dietmann, Sabine / Hess, Jochen / Benitah, Salvador Aznar / Frye, Michaela

    Nature

    2022  Volume 607, Issue 7919, Page(s) 593–603

    Abstract: Aggressive and metastatic cancers show enhanced metabolic ... ...

    Abstract Aggressive and metastatic cancers show enhanced metabolic plasticity
    MeSH term(s) 5-Methylcytosine/biosynthesis ; 5-Methylcytosine/metabolism ; CD36 Antigens ; Cell Survival ; Cytosine/analogs & derivatives ; Cytosine/metabolism ; Disease Progression ; Glycolysis/drug effects ; Humans ; Methylation/drug effects ; Methyltransferases/antagonists & inhibitors ; Methyltransferases/metabolism ; Mitochondria/drug effects ; Mitochondria/genetics ; Mitochondria/metabolism ; Mouth Neoplasms/genetics ; Mouth Neoplasms/metabolism ; Mouth Neoplasms/pathology ; Neoplasm Metastasis/drug therapy ; Neoplasm Metastasis/genetics ; Neoplasm Metastasis/pathology ; Oxidative Phosphorylation/drug effects ; Protein Biosynthesis/drug effects ; RNA, Mitochondrial/genetics ; RNA, Mitochondrial/metabolism ; RNA, Transfer, Met/genetics ; RNA, Transfer, Met/metabolism
    Chemical Substances 5-formylcytosine ; CD36 Antigens ; RNA, Mitochondrial ; RNA, Transfer, Met ; 5-Methylcytosine (6R795CQT4H) ; Cytosine (8J337D1HZY) ; Methyltransferases (EC 2.1.1.-) ; NSUN3 protein, human (EC 2.1.1.-)
    Language English
    Publishing date 2022-06-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-022-04898-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 244: Show issues

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  7. Article: Systemic cancer immunotherapy with Toll-like receptor 7 agonists: Timing is everything.

    Hotz, Christian / Bourquin, Carole

    Oncoimmunology

    2012  Volume 1, Issue 2, Page(s) 227–228

    Abstract: Toll-like receptor (TLR) 7 agonists represent a promising strategy for the immunotherapy of cancer. We have recently investigated the influence of TLR tolerance on the efficacy of systemic tumor treatment with TLR7 ligands. We propose that considering ... ...

    Abstract Toll-like receptor (TLR) 7 agonists represent a promising strategy for the immunotherapy of cancer. We have recently investigated the influence of TLR tolerance on the efficacy of systemic tumor treatment with TLR7 ligands. We propose that considering the kinetics of receptor sensitivity highly improves the outcome of cancer immunotherapy.
    Language English
    Publishing date 2012-05-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2645309-5
    ISSN 2162-402X ; 2162-4011
    ISSN (online) 2162-402X
    ISSN 2162-4011
    DOI 10.4161/onci.1.2.18169
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: CIMT 2017: Anniversary symposium - Report on the 15th CIMT Annual Meeting of the Association for Cancer Immunotherapy.

    Kranz, Lena M / Beck, Jan D / Grunwitz, Christian / Hotz, Christian / Vormehr, Mathias / Diken, Mustafa

    Human vaccines & immunotherapeutics

    2017  Volume 13, Issue 10, Page(s) 2272–2279

    MeSH term(s) Adoptive Transfer/methods ; Anniversaries and Special Events ; Antineoplastic Agents, Immunological/therapeutic use ; Cancer Vaccines/therapeutic use ; Costimulatory and Inhibitory T-Cell Receptors/antagonists & inhibitors ; Epigenesis, Genetic/immunology ; Humans ; Immunotherapy/methods ; Neoplasms/genetics ; Neoplasms/immunology ; Neoplasms/therapy ; T-Lymphocytes/immunology ; T-Lymphocytes/transplantation ; Tumor Microenvironment/immunology
    Chemical Substances Antineoplastic Agents, Immunological ; Cancer Vaccines ; Costimulatory and Inhibitory T-Cell Receptors
    Language English
    Publishing date 2017-08-28
    Publishing country United States
    Document type Congress
    ZDB-ID 2664176-8
    ISSN 2164-554X ; 2164-5515
    ISSN (online) 2164-554X
    ISSN 2164-5515
    DOI 10.1080/21645515.2017.1358327
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Comparative hard x-ray tomography for virtual histology of zebrafish larva, human tooth cementum, and porcine nerve.

    Migga, Alexandra / Schulz, Georg / Rodgers, Griffin / Osterwalder, Melissa / Tanner, Christine / Blank, Holger / Jerjen, Iwan / Salmon, Phil / Twengström, William / Scheel, Mario / Weitkamp, Timm / Schlepütz, Christian M / Bolten, Jan S / Huwyler, Jörg / Hotz, Gerhard / Madduri, Srinivas / Müller, Bert

    Journal of medical imaging (Bellingham, Wash.)

    2022  Volume 9, Issue 3, Page(s) 31507

    Abstract: Purpose: ...

    Abstract Purpose:
    Language English
    Publishing date 2022-03-31
    Publishing country United States
    Document type Journal Article
    ISSN 2329-4302
    ISSN 2329-4302
    DOI 10.1117/1.JMI.9.3.031507
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  10. Article ; Online: The effector program of human CD8 T cells supports tissue remodeling.

    Delacher, Michael / Schmidleithner, Lisa / Simon, Malte / Stüve, Philipp / Sanderink, Lieke / Hotz-Wagenblatt, Agnes / Wuttke, Marina / Schambeck, Kathrin / Ruhland, Brigitte / Hofmann, Veronika / Bittner, Sebastian / Ritter, Uwe / Pant, Asmita / Helbich, Sara Salome / Voss, Morten / Lemmermann, Niels A / Bessiri-Schake, Lisa / Bohn, Toszka / Eigenberger, Andreas /
    Menevse, Ayse Nur / Gebhard, Claudia / Strieder, Nicholas / Abken, Hinrich / Rehli, Michael / Huehn, Jochen / Beckhove, Philipp / Hehlgans, Thomas / Junger, Henrik / Geissler, Edward K / Prantl, Lukas / Werner, Jens M / Schmidl, Christian / Brors, Benedikt / Imbusch, Charles D / Feuerer, Markus

    The Journal of experimental medicine

    2024  Volume 221, Issue 2

    Abstract: CD8 T lymphocytes are classically viewed as cytotoxic T cells. Whether human CD8 T cells can, in parallel, induce a tissue regeneration program is poorly understood. Here, antigen-specific assay systems revealed that human CD8 T cells not only mediated ... ...

    Abstract CD8 T lymphocytes are classically viewed as cytotoxic T cells. Whether human CD8 T cells can, in parallel, induce a tissue regeneration program is poorly understood. Here, antigen-specific assay systems revealed that human CD8 T cells not only mediated cytotoxicity but also promoted tissue remodeling. Activated CD8 T cells could produce the epidermal growth factor receptor (EGFR)-ligand amphiregulin (AREG) and sensitize epithelial cells for enhanced regeneration potential. Blocking the EGFR or the effector cytokines IFN-γ and TNF could inhibit tissue remodeling. This regenerative program enhanced tumor spheroid and stem cell-mediated organoid growth. Using single-cell gene expression analysis, we identified an AREG+, tissue-resident CD8 T cell population in skin and adipose tissue from patients undergoing abdominal wall or abdominoplasty surgery. These tissue-resident CD8 T cells showed a strong TCR clonal relation to blood PD1+TIGIT+ CD8 T cells with tissue remodeling abilities. These findings may help to understand the complex CD8 biology in tumors and could become relevant for the design of therapeutic T cell products.
    MeSH term(s) Humans ; CD8-Positive T-Lymphocytes ; T-Lymphocytes, Cytotoxic ; ErbB Receptors ; Adipose Tissue ; Cell Cycle
    Chemical Substances ErbB Receptors (EC 2.7.10.1)
    Language English
    Publishing date 2024-01-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20230488
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