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Article ; Online: Protective effect of Tao Hong Si Wu Decoction against inflammatory injury caused by intestinal flora disorders in an ischemic stroke mouse model.

Zhang, Lijuan / Xue, Sujun / Fei, Changyi / Yu, Chao / Li, Jingjing / Li, Yumeng / Wang, Ni / Chu, Furui / Pan, Lingyu / Duan, Xianchun / Peng, Daiyin

BMC complementary medicine and therapies

2024 Volume 24, Issue 1, Page(s) 124

Abstract: ... Tao Hong Si Wu Decoction (THSWD), against inflammatory injury after IS and its underlying mechanisms ...

Abstract	Background and aims: Recent studies have shown that intestinal flora are involved in the pathological process of ischemic stroke (IS). The potential protective effect of the traditional Chinese prescription, Tao Hong Si Wu Decoction (THSWD), against inflammatory injury after IS and its underlying mechanisms of action were investigated in the current study. Methods: Fifty SPF(Specefic pathogen Free) male C57 mice were randomly assigned to sham operation, model, THSWD low-dose (6.5 g/kg), medium-dose (13 g/kg) and high-dose (26 g/kg) groups (10 mice per group). Mouse models of transient middle cerebral artery occlusion were prepared via thread embolism. Neurological function score, hematoxylin-eosin (HE) staining, immunohistochemistry, enzyme-linked immunosorbent assay (ELISA), 16S ribosomal DNA (rDNA) sequencing, quantitative reverse transcription PCR (qRT-PCR) and other methods were employed to elucidate the underlying molecular mechanisms. Results: Notably, THSWD induced a reduction in the neurological function score (P < 0.01) and neuronal injury in brain tissue, increase in protein expression of Claudin-5 and zonula occludens-1 (ZO-1) in brain tissue(P < 0.01), and decrease in serum lipopolysaccharide (LPS)(P < 0.01), diamine oxidase (DAO)(P < 0.01) and D-lactic acid(P < 0.01, P < 0.05) levels to a significant extent. THSWD also inhibited the levels of tumor necrosis factor-α (TNF-α)(P < 0.01) and interleukin - 1β (IL-1β)(P < 0.01) in brain tissue, and increased alpha and beta diversity in ischemic stroke mice, along with a certain reversal effect on different microflora. Finally, THSWD inhibited the polarization of microglia cells(P < 0.01) and decreased the protein and gene expression of toll-like receptor-4 (TLR-4)(P < 0.01, P < 0.05) and nuclear factor kappa B (NF-κB)(P < 0.01) in brain tissue. Conclusion: Our data indicate that THSWD may interfere with inflammatory response in ischemic stroke by regulating intestinal flora and promoting intestinal barrier repair.
MeSH term(s)	Mice ; Male ; Animals ; Ischemic Stroke ; Gastrointestinal Microbiome ; Drugs, Chinese Herbal/pharmacology ; NF-kappa B/metabolism
Chemical Substances	Taohong Siwu decoction II ; Drugs, Chinese Herbal ; NF-kappa B
Language	English
Publishing date	2024-03-18
Publishing country	England
Document type	Journal Article
ISSN	2662-7671
ISSN (online)	2662-7671
DOI	10.1186/s12906-024-04417-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Exploration of the Potential Mechanism of Tao Hong Si Wu Decoction for the Treatment of Breast Cancer Based on Network Pharmacology and

Huang, Shi / Chen, Yan / Pan, Lingyu / Fei, Changyi / Wang, Ni / Chu, Furui / Peng, Daiyin / Duan, Xianchun / Wang, Yongzhong

Frontiers in oncology

2021 Volume 11, Page(s) 731522

Abstract: Background: Tao Hong Si Wu Decoction (THSWD) is a well-known traditional Chinese medicine used ...

Abstract	Background: Tao Hong Si Wu Decoction (THSWD) is a well-known traditional Chinese medicine used clinically alone or combined with drugs to treat breast cancer. However, there has been no study to date on the underlying mechanisms of its therapeutic effects. Objectives: To explore the potential mechanism of THSWD for the treatment of breast cancer using network pharmacology and experimental research. Methods: The active ingredients of THSWD were screened according to Lipinski's rule of five based on the 107 ingredients of THSWD identified by UPLC-Q-TOF-MS Results: In total, 27 active ingredients including 8 core components, were obtained from 107 ingredients and 218 THSWD target genes for the treatment of breast cancer were identified. THSWD is active in the treatment of breast cancer by targeting Ras, FoxO, PI3K-Akt and other signaling pathways. MCF-7 and MDA-MB-231 cell proliferation was inhibited by THSWD serum in a time and concentration dependent manner. THSWD could regulated the RNA and protein expression of core targets HRAS, MAPK1, AKT1, GRB2, and MAPK14 for treatment of breast cancer. Conclusion: The results of network pharmacology study showed that THSWD is active against breast cancer by intervening with multiple targets and pathways. Luteolin, kaempferol, senkyunolide E, and other 8 compounds may be the core active ingredients of THSWD in the treatment of breast cancer. THSWD treatment of breast cancer may be related to targeting Ras, FoxO, PI3K-Akt, and other signal pathways associated with the core targets HRAS, MAPK1, AKT1, GRB2, and MAPK14.
Language	English
Publishing date	2021-08-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2021.731522
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Metabolic Insight Into the Neuroprotective Effect of Tao-He-Cheng-Qi (THCQ) Decoction on ICH Rats Using Untargeted Metabolomics.

Yang, Rui-Pei / Cai, Da-Ke / Chen, Yu-Xing / Gang, Hai-Ning / Wei, Mei / Zhu, De-Quan / Li, Su-Mei / Yang, Jiu-Mei / Luo, Si-Ni / Bi, Xiao-Li / Sun, Dong-Mei

Frontiers in pharmacology

2021 Volume 12, Page(s) 636457

Abstract: Tao-He-Cheng-Qi decoction (THCQ) is an effective traditional Chinese medicine used to treat ...

Abstract	Tao-He-Cheng-Qi decoction (THCQ) is an effective traditional Chinese medicine used to treat intracerebral hemorrhage (ICH). This study was performed to investigate the possible neuroprotective effect of THCQ decoction on secondary brain damage in rats with intracerebral hemorrhage and to elucidate the potential mechanism based on a metabolomics approach. Sprague-Dawley (SD) rats were randomly divided into five groups: the sham group, collagenase-induced ICH model group, THCQ low-dose (THCQ-L)-treated group, THCQ moderate-dose (THCQ-M)-treated group and THCQ high-dose (THCQ-H)-treated group. Following 3 days of treatment, behavioral changes and histopathological lesions in the brain were estimated. Untargeted metabolomics analysis with multivariate statistics was performed by using ultrahigh-performance liquid chromatography-mass spectrometry (UPLC-Q-Exactive Orbitrap MS). THCQ treatment at two dosages (5.64 and 11.27 g/kg·d) remarkably improved behavior (
Language	English
Publishing date	2021-05-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.636457
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Metabolic Insight Into the Neuroprotective Effect of Tao-He-Cheng-Qi (THCQ) Decoction on ICH Rats Using Untargeted Metabolomics

Rui-Pei Yang / Da-Ke Cai / Yu-Xing Chen / Hai-Ning Gang / Mei Wei / De-Quan Zhu / Su-Mei Li / Jiu-Mei Yang / Si-Ni Luo / Xiao-Li Bi / Dong-Mei Sun

Frontiers in Pharmacology, Vol

2021 Volume 12

Abstract: Tao-He-Cheng-Qi decoction (THCQ) is an effective traditional Chinese medicine used to treat ...

Abstract	Tao-He-Cheng-Qi decoction (THCQ) is an effective traditional Chinese medicine used to treat intracerebral hemorrhage (ICH). This study was performed to investigate the possible neuroprotective effect of THCQ decoction on secondary brain damage in rats with intracerebral hemorrhage and to elucidate the potential mechanism based on a metabolomics approach. Sprague-Dawley (SD) rats were randomly divided into five groups: the sham group, collagenase-induced ICH model group, THCQ low-dose (THCQ-L)-treated group, THCQ moderate-dose (THCQ-M)-treated group and THCQ high-dose (THCQ-H)-treated group. Following 3 days of treatment, behavioral changes and histopathological lesions in the brain were estimated. Untargeted metabolomics analysis with multivariate statistics was performed by using ultrahigh-performance liquid chromatography–mass spectrometry (UPLC-Q-Exactive Orbitrap MS). THCQ treatment at two dosages (5.64 and 11.27 g/kg·d) remarkably improved behavior (p < 0.05), brain water content (BMC) and hemorheology (p < 0.05) and improved brain nerve tissue pathology and inflammatory infiltration in ICH rats. Moreover, a metabolomic analysis demonstrated that the serum metabolic profiles of ICH patients were significantly different between the sham group and the ICH-induced model group. Twenty-seven biomarkers were identified that potentially predict the clinical benefits of THCQ decoction. Of these, 4 biomarkers were found to be THCQ-H group-specific, while others were shared between two clusters. These metabolites are mainly involved in amino acid metabolism and glutamate-mediated cell excitotoxicity, lipid metabolism-mediated oxidative stress, and mitochondrial dysfunction caused by energy metabolism disorders. In addition, a correlation analysis showed that the behavioral scores, brain water content and hemorheology were correlated with levels of serum metabolites derived from amino acid and lipid metabolism. In conclusion, the results indicate that THCQ decoction significantly attenuates ICH-induced secondary ...
Keywords	intracerebral hemorrhage ; traditional Chinese medicine ; Tao-He-Cheng-Qi decoction ; metabolomics ; secondary brain injury ; Therapeutics. Pharmacology ; RM1-950
Subject code	616
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Exploration of the Potential Mechanism of Tao Hong Si Wu Decoction for the Treatment of Breast Cancer Based on Network Pharmacology and In Vitro Experimental Verification

Shi Huang / Yan Chen / Lingyu Pan / Changyi Fei / Ni Wang / Furui Chu / Daiyin Peng / Xianchun Duan / Yongzhong Wang

Frontiers in Oncology, Vol

2021 Volume 11

Abstract: BackgroundTao Hong Si Wu Decoction (THSWD) is a well-known traditional Chinese medicine used ...

Abstract	BackgroundTao Hong Si Wu Decoction (THSWD) is a well-known traditional Chinese medicine used clinically alone or combined with drugs to treat breast cancer. However, there has been no study to date on the underlying mechanisms of its therapeutic effects.ObjectivesTo explore the potential mechanism of THSWD for the treatment of breast cancer using network pharmacology and experimental research.MethodsThe active ingredients of THSWD were screened according to Lipinski’s rule of five based on the 107 ingredients of THSWD identified by UPLC-Q-TOF-MSE. The targets of THSWD and breast cancer from multiple databases were collected, and a Compound-Target-Pathway network based on protein-protein interaction (PPI) was constructed. Gene ontology (GO) analysis and KEGG pathway analysis were performed via the DAVID server. Molecular docking studies verified the selected key ingredients and key targets. The results of network pharmacology were verified by in vitro experiments. Including the effects of THSWD drug-containing rat serum (THSWD serum) on cell proliferation, and on the targets HRAS, MAPK1, AKT1, GRB2, and MAPK14 were assayed by RT-qPCR and Western blot assays.ResultsIn total, 27 active ingredients including 8 core components, were obtained from 107 ingredients and 218 THSWD target genes for the treatment of breast cancer were identified. THSWD is active in the treatment of breast cancer by targeting Ras, FoxO, PI3K-Akt and other signaling pathways. MCF-7 and MDA-MB-231 cell proliferation was inhibited by THSWD serum in a time and concentration dependent manner. THSWD could regulated the RNA and protein expression of core targets HRAS, MAPK1, AKT1, GRB2, and MAPK14 for treatment of breast cancer.ConclusionThe results of network pharmacology study showed that THSWD is active against breast cancer by intervening with multiple targets and pathways. Luteolin, kaempferol, senkyunolide E, and other 8 compounds may be the core active ingredients of THSWD in the treatment of breast cancer. THSWD treatment of breast cancer ...
Keywords	Taohong Siwu Decoction (THSWD) ; network pharmacology ; breast cancer ; traditional Chinese medicine ; target identification ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282
Subject code	616
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: CuO/Ta₂O₅ core/shell nanoparticles produced by arc-discharge in water

Delaportas, D / Svarnas, P / Alexandrou, I / Georga, S.N / Krontiras, C.A / Xanthopoulos, N.I / Siokou, A / Chalker, P.R

Materials letters. 2011 Aug., v. 65, no. 15-16

2011

Abstract: The formation of novel nanoparticles, i.e. CuO/Ta₂O₅ core/shell, via anodic arc-discharge in water ...

Abstract	The formation of novel nanoparticles, i.e. CuO/Ta₂O₅ core/shell, via anodic arc-discharge in water is reported. Typical core diameters and shell thicknesses are about 20 and 5nm, respectively. Both core and shell are crystalline. The resulting core/shell-structured nanopowder exhibits dielectric behavior.
Keywords	copper ; nanoparticles ; tantalum ; water
Language	English
Dates of publication	2011-08
Size	p. 2337-2340.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1491964-3
ISSN	1873-4979 ; 0167-577X
ISSN (online)	1873-4979
ISSN	0167-577X
DOI	10.1016/j.matlet.2011.05.044
Database	NAL-Catalogue (AGRICOLA)

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Book: You zhi tao xin pin zhong feng chan zai pei

Wang, Guoping / Hong, Ni

2000

Title variant	Youzhili xinpinzhong fengchan zaipei
Author's details	Wang Guoping, Hong Ni bian zhu
Keywords	Peach/Varieties
Language	Chinese
Size	5, 180 p., 20 p. of plates :, ill. ;, 19 cm.
Edition	Di 1 ban.
Publisher	Jin dun chu ban she
Publishing place	Beijing
Document type	Book
ISBN	7508211014 ; 9787508211015
Database	NAL-Catalogue (AGRICOLA)

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Book: Tao ku yü ta mi ti ch'u ts'ang

Ni, Chao-chen / Wan, Mu-lin

1981

Title translation	Storage of rice.
Author's details	Ni Chao-chen, Wan Mu-lin pien [hsieh]. --
Keywords	Rice/Storage.
Language	Chinese
Size	102 p. :, ill. ;, 19 cm.
Edition	Ti 1 pan. --
Publisher	Chung-kuo ts'ai cheng ching chi ch'u pan she ; Hsin hua shu tien Pei-ching fa hsing so fa hsing
Publishing place	Pei-ching
Document type	Book
Note	Errata slip inserted.
Database	NAL-Catalogue (AGRICOLA)

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Book: Tsʻan chung hsüeh shih yen shih hsi chih tao

Tsʻai, Yen-chang / Ni, Hung-tʻung

tsʻan sang chuan yeh yung

1984

Institution	Che-chiang sheng shao hsing ti chʻü nung yeh hsüeh hsiao
Author's details	Che-chiang sheng shao hsing ti chʻü nung yeh hsüeh hsiao pien ; [pien che Tsʻai Yen-chang, Ni Hung-tʻung]
Keywords	Silkworms/Study and teaching
Language	Chinese
Size	2, 44 p. :, ill. ;, 19 cm.
Edition	Ti 1 pan.
Publisher	Nung yeh chʻu pan she ; Hsin hua shu tien Pei-ching fa hsing so fa hsing
Publishing place	Pei-ching
Document type	Book
Note	"Chʻüan kuo chung teng nung yeh hsüeh hsiao shih yung chiao tsʻai." ; "Tsʻan sang chuan yeh yung."
Database	NAL-Catalogue (AGRICOLA)

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Article: [Data-Driven Construction of Operation Evaluation System for Large Medical Equipment in Children's Hospital].

Tao, Qilin / Zhang, Xiaobo / Shao, Peng / Ni, Jiasheng

Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation

2024 Volume 48, Issue 1, Page(s) 114–118

Abstract: Objective: Through data collection and analysis, the method of evaluating the operation quality of large medical equipment in children's hospital is explored and suggestions on the use and configuration of large medical equipment is put forward.: ... ...

Abstract	Objective: Through data collection and analysis, the method of evaluating the operation quality of large medical equipment in children's hospital is explored and suggestions on the use and configuration of large medical equipment is put forward. Methods: Collect the equipment operation data through the Internet of Things, and combine the hospital HIS, RIS, HRP and other information system data to establish the operation evaluation system of large medical equipment of children's hospital. CRITIC method is used to quantitatively evaluate single type of equipment and single equipment. Results: Hospital big data platform realizes the longitudinal analysis of the operation data of a single large equipment and forms a visual chart, which is displayed on the PC and mobile terminals. Municipal platform can conduct horizontal analysis on the equipment operation data to realize the comprehensive quantitative evaluation of the operation level of large equipment of children's hospital and put forward suggestions for use and configuration. Conclusion: A large equipment operation evaluation system for children's hospital is established through data collection and analysis, and the fine management level of large medical equipment is improved.
MeSH term(s)	Child ; Humans ; Hospitals ; Data Collection ; Surgical Equipment ; Internet
Language	Chinese
Publishing date	2024-02-22
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	1671-7104
ISSN	1671-7104
DOI	10.3969/j.issn.1671-7104.230180
Database	MEDical Literature Analysis and Retrieval System OnLINE

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