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  1. Article: Augmentation des températures et menace du paludisme en Europe : un retour indésirable ?

    Lovey, Thibault / Schlagenhauf, Patricia

    Revue medicale suisse

    2023  Volume 19, Issue 825, Page(s) 849–852

    Abstract: Rising temperatures pose a threat to malaria transmission in Europe. Anopheles vectors are becoming more stable and widespread, putting some areas at increased risk of transmission for extended periods. By 2030 or 2050, the period of susceptibility is ... ...

    Title translation Rising temperatures and the threat of malaria in Europe: an unwelcome return?
    Abstract Rising temperatures pose a threat to malaria transmission in Europe. Anopheles vectors are becoming more stable and widespread, putting some areas at increased risk of transmission for extended periods. By 2030 or 2050, the period of susceptibility is expected to extend to 3-6 months in some European countries and Anopheles mosquitoes are expected to migrate northward. In addition, climate change has led to a substantial increase in the number of climate refugees in Europe, increasing the risk of spread of the disease from endemic areas to susceptible regions. Urgent action is needed to prevent the transmission of malaria and other climate change-related diseases in Europe.
    MeSH term(s) Animals ; Humans ; Temperature ; Mosquito Vectors ; Malaria/epidemiology ; Malaria/prevention & control ; Europe/epidemiology ; Anopheles
    Language French
    Publishing date 2023-02-21
    Publishing country Switzerland
    Document type English Abstract ; Journal Article
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
    DOI 10.53738/REVMED.2023.19.825.849
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The art of travel medicine and infectious disease.

    Schlagenhauf, Patricia

    Travel medicine and infectious disease

    2019  Volume 27, Page(s) 9–10

    Language English
    Publishing date 2019-01-25
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 2170891-5
    ISSN 1873-0442 ; 1477-8939
    ISSN (online) 1873-0442
    ISSN 1477-8939
    DOI 10.1016/j.tmaid.2019.01.014
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  3. Article: Measles matter: Recent outbreaks highlight the need for catch-up vaccination in Europe and around the globe.

    Al-Tawfiq, Jaffar A / Jain, Nityanand / Tanasov, Andrei / Schlagenhauf, Patricia

    New microbes and new infections

    2024  Volume 58, Page(s) 101238

    Language English
    Publishing date 2024-03-16
    Publishing country England
    Document type Editorial
    ZDB-ID 2750179-6
    ISSN 2052-2975
    ISSN 2052-2975
    DOI 10.1016/j.nmni.2024.101238
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  4. Article ; Online: Concerts and COVID: can the beat go on?

    Schlagenhauf, Patricia / Deuel, Jeremy

    The Lancet. Infectious diseases

    2021  Volume 22, Issue 3, Page(s) 299–301

    MeSH term(s) COVID-19 ; Humans
    Language English
    Publishing date 2021-11-26
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(21)00721-0
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  5. Article ; Online: Hair concentrations of anti-malarials in returned travellers-the HAIR study: Proof of principle analysis.

    Steiner, Regula / Kaulich, Anne / Müller, Daniel / Schlagenhauf, Patricia

    Travel medicine and infectious disease

    2023  Volume 54, Page(s) 102590

    Abstract: Background: Hair analysis to identify substance use is an established methodology. This could also be a method to monitor adherence to antimalarial drugs. We aimed to establish a methodology to determine hair concentrations of atovaquone, proguanil and ... ...

    Abstract Background: Hair analysis to identify substance use is an established methodology. This could also be a method to monitor adherence to antimalarial drugs. We aimed to establish a methodology to determine hair concentrations of atovaquone, proguanil and mefloquine in travellers using chemoprophylaxis.
    Methods: A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for simultaneous analysis of the antimalarial drugs -atovaquone (ATQ), proguanil (PRO) and mefloquine (MQ), in human hair. The hair samples from five volunteers were used for this proof-of-concept analysis. Three volunteers were taking daily atovaquone/proguanil (ATQ/PRO) chemoprophylaxis and two volunteers were using weekly mefloquine (MQ) chemoprophylaxis.
    Results: With this proof-of-principle analysis, we could show that ATQ/PRO and MQ are integrated into the hair matrix. Chemoprophylaxis could be quantified with the established method. In hair segments, maximal concentrations of 3.0 ng/mL/20 mg hair proguanil, 1.3 ng/mL/20 mg hair atovaquone and 78.3 ng/mL/20 mg hair mefloquine were measured. Moreover, malaria drug concentration changes correlated with the time interval since finishing the chemoprophylaxis regimen.
    Conclusions: The validated method was used successfully for the analysis of antimalarial-drug positive hair samples containing atovaquone, proguanil or mefloquine. This research shows that hair can be used for adherence monitoring of chemoprophylaxis and paves the way for larger studies and optimized procedures.
    MeSH term(s) Humans ; Antimalarials/therapeutic use ; Proguanil/therapeutic use ; Atovaquone/therapeutic use ; Mefloquine/therapeutic use ; Chromatography, Liquid ; Drug Therapy, Combination ; Travel ; Tandem Mass Spectrometry ; Drug Combinations
    Chemical Substances Antimalarials ; Proguanil (S61K3P7B2V) ; Atovaquone (Y883P1Z2LT) ; Mefloquine (TML814419R) ; Drug Combinations
    Language English
    Publishing date 2023-05-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2170891-5
    ISSN 1873-0442 ; 1477-8939
    ISSN (online) 1873-0442
    ISSN 1477-8939
    DOI 10.1016/j.tmaid.2023.102590
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  6. Article ; Online: In for the long-haul? Seropositivity and sequelae 1 year post COVID-19.

    Deuel, Jeremy Werner / Schlagenhauf, Patricia

    BMC medicine

    2021  Volume 19, Issue 1, Page(s) 200

    MeSH term(s) COVID-19 ; Disease Progression ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2021-09-14
    Publishing country England
    Document type Letter ; Comment
    ISSN 1741-7015
    ISSN (online) 1741-7015
    DOI 10.1186/s12916-021-02084-4
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  7. Article ; Online: Primaquine and the power of adherence in radical cure.

    Grobusch, Martin P / Schlagenhauf, Patricia

    The Lancet. Infectious diseases

    2021  Volume 22, Issue 3, Page(s) 304–305

    MeSH term(s) Humans ; Malaria, Vivax ; Plasmodium vivax ; Primaquine/therapeutic use
    Chemical Substances Primaquine (MVR3634GX1)
    Language English
    Publishing date 2021-10-25
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(21)00389-3
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  8. Article: Upsurge in cases of travellers' malaria ex Zanzibar indicates that malaria is on the rebound in the archipelago.

    Florescu, Simin Aysel / Larsen, Carsten Schade / Helleberg, Marie / Marin, Alexandru / Popescu, Corneliu Petru / Schlagenhauf, Patricia

    New microbes and new infections

    2024  Volume 57, Page(s) 101226

    Language English
    Publishing date 2024-02-02
    Publishing country England
    Document type Editorial
    ZDB-ID 2750179-6
    ISSN 2052-2975
    ISSN 2052-2975
    DOI 10.1016/j.nmni.2024.101226
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  9. Article ; Online: Travel-related respiratory symptoms and infections in travellers (2000-22): a systematic review and meta-analysis.

    Lovey, Thibault / Hasler, Robin / Gautret, Philippe / Schlagenhauf, Patricia

    Journal of travel medicine

    2023  Volume 30, Issue 5

    Abstract: Background: Respiratory tract infections (RTIs) are common in travellers due to the year-round or seasonal presence of respiratory pathogen and exposure to crowded environments during the itinerary. No study has systematically examined the burden of RTI ...

    Abstract Background: Respiratory tract infections (RTIs) are common in travellers due to the year-round or seasonal presence of respiratory pathogen and exposure to crowded environments during the itinerary. No study has systematically examined the burden of RTI infections among travellers. The aim of this systematic review and meta-analysis is to evaluate the prevalence of RTIs and symptoms suggestive of RTIs among travellers according to risk groups and/or geographic region, and to describe the spectrum of RTIs.
    Methods: The systematic review and meta-analysis was registered in PROSPERO (CRD42022311261). We searched Medline, Embase, Scopus, Cochrane Central, Web of Science, Science Direct and preprint servers MedRxiv, BioRxiv, SSRN and IEEE Xplore on 1 February 2022. Studies reporting RTIs or symptoms suggestive of RTIs in international travellers after 1 January 2000 were eligible. Data appraisal and extraction were performed by two authors, and proportional meta-analyses were used to obtain estimates of the prevalence of respiratory symptoms and RTIs in travellers and predefined risk groups.
    Findings: A total of 429 articles on travellers' illness were included. Included studies reported 86 841 symptoms suggestive of RTIs and 807 632 confirmed RTIs. Seventy-eight percent of reported respiratory symptoms and 60% of RTIs with available location data were acquired at mass gatherings events. Cough was the most common symptom suggestive of respiratory infections, and the upper respiratory tract was the most common site for RTIs in travellers. The prevalence of RTIs and respiratory symptoms suggestive of RTIs were 10% [8%; 14%] and 37% [27%; 48%], respectively, among travellers. Reporting of RTIs in travellers denoted by publication output was found to correlate with global waves of new respiratory infections.
    Interpretation: This study demonstrates a high burden of RTIs among travellers and indicates that travellers' RTIs reflect respiratory infection outbreaks. These findings have important implications for understanding and managing RTIs among travellers.
    MeSH term(s) Humans ; Travel ; Travel-Related Illness ; Respiratory Tract Infections/epidemiology ; Risk Factors ; Prevalence
    Language English
    Publishing date 2023-06-11
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 1212504-0
    ISSN 1708-8305 ; 1195-1982
    ISSN (online) 1708-8305
    ISSN 1195-1982
    DOI 10.1093/jtm/taad081
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  10. Article: Spotted fever group rickettsiae and

    Kosak, Leonie / Satz, Norbert / Jutzi, Markus / Dobec, Marinko / Schlagenhauf, Patricia

    New microbes and new infections

    2023  Volume 53, Page(s) 101139

    Abstract: Background: The : Methods: Indirect fluorescent antibody tests for SFG rickettsiae and : Results: Out of 121 : Conclusion: Infections with SFG rickettsiae ... ...

    Abstract Background: The
    Methods: Indirect fluorescent antibody tests for SFG rickettsiae and
    Results: Out of 121
    Conclusion: Infections with SFG rickettsiae and
    Language English
    Publishing date 2023-04-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2750179-6
    ISSN 2052-2975
    ISSN 2052-2975
    DOI 10.1016/j.nmni.2023.101139
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