Article ; Online: Triazolopyrimidine derivatives: An updated review on recent advances in synthesis, biological activities and drug delivery aspects.
2023
Abstract: Molecules containing triazolopyrimidine core showed diverse biological activities, including anti-Alzheimer, antidiabetes, anticancer, antimicrobial, antituberculosis, antiviral, antimalarial, anti-inflammatory, anti-parkinsonism activities, and ... ...
Abstract | Molecules containing triazolopyrimidine core showed diverse biological activities, including anti-Alzheimer, antidiabetes, anticancer, antimicrobial, antituberculosis, antiviral, antimalarial, anti-inflammatory, anti-parkinsonism activities, and treatment of glaucoma. Triazolopyrimidines have around 8 isomeric structures including the most stable 1,2,4-triazolo[1,5-a] pyrimidine ones. Triazolopyrimidines were obtained by using various chemical reactions, among them a) 1,2,4-triazole nucleus annulation to pyrimidine, b) pyrimidines annulation to 1,2,4-triazole structure, c) 1,2,4-triazolo[l,5-a] pyrimidines rearrangement, and d) pyrimido-tetrazine rearrangement. This review discusses synthetic methods, recent pharmacological actions and drug delivery perspectives of triazolopyrimidines. |
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Language | English |
Publishing date | 2023-02-28 |
Publishing country | United Arab Emirates |
Document type | Journal Article |
ZDB-ID | 1319315-6 |
ISSN | 1875-533X ; 0929-8673 |
ISSN (online) | 1875-533X |
ISSN | 0929-8673 |
DOI | 10.2174/0929867330666230228120416 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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